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Showing 25 to 36 of 214 entries
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Bridging trees for posterior inference on ancestral recombination graphs.

Proceedings. Mathematical, physical, and engineering sciences

Heine K, Beskos A, Jasra A, Balding D, De Iorio M.
PMID: 30602937
Proc Math Phys Eng Sci. 2018 Dec;474(2220):20180568. doi: 10.1098/rspa.2018.0568. Epub 2018 Dec 12.

We present a new Markov chain Monte Carlo algorithm, implemented in the software Arbores, for inferring the history of a sample of DNA sequences. Our principal innovation is a bridging procedure, previously applied only for simple stochastic processes, in...

The old order changeth, yielding place to the new ….

Journal of periodontology

Hine MK.
PMID: 29538817
J Periodontol. 1970 Jul;41(7):370-371. doi: 10.1902/jop.1970.41.7.370.

No abstract available.

Neuronal Receptors Display Cytoskeleton-Independent Directed Motion on the Plasma Membrane.

iScience

Taylor RD, Heine M, Emptage NJ, Andreae LC.
PMID: 30557785
iScience. 2018 Dec 21;10:234-244. doi: 10.1016/j.isci.2018.12.001. Epub 2018 Dec 05.

Directed transport of transmembrane proteins is generally believed to occur via intracellular transport vesicles. However, using single-particle tracking in rat hippocampal neurons with a pH-sensitive quantum dot probe that specifically reports surface movement of receptors, we have identified a...

Multiple faces of pulmonary large cell neuroendocrine carcinoma: update with a focus on practical approach to diagnosis.

Translational lung cancer research

Baine MK, Rekhtman N.
PMID: 32676352
Transl Lung Cancer Res. 2020 Jun;9(3):860-878. doi: 10.21037/tlcr.2020.02.13.

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a rare and aggressive malignancy that is strongly linked to smoking and notoriously difficult to diagnose and treat. Recent molecular data reveal that it represents a biologically heterogeneous group of tumors, characterized...

A modified six-minute walk test (6MWT) for low-resource settings-a cross-sectional study.

Heart & lung : the journal of critical care

Fell B, Hanekom S, Heine M.
PMID: 35007887
Heart Lung. 2022 Jan 07;52:117-122. doi: 10.1016/j.hrtlng.2021.12.008. Epub 2022 Jan 07.

BACKGROUND: The 6 min walk test (6MWT) is a validated tool used to assess functional capacity in a variety of patient populations. Space constraints often limit the practicality of the 6MWT according to the standard (2002) American Thoracic Society...

Health education interventions to promote health literacy in adults with selected non-communicable diseases living in low-to-middle income countries: A systematic review and meta-analysis.

Journal of evaluation in clinical practice

Heine M, Lategan F, Erasmus M, Lombaard CM, Mc Carthy N, Olivier J, van Niekerk M, Hanekom S.
PMID: 33749092
J Eval Clin Pract. 2021 Dec;27(6):1417-1428. doi: 10.1111/jep.13554. Epub 2021 Mar 22.

RATIONALE, AIMS AND OBJECTIVES: Health illiteracy is an important contributor to the burden of non-communicable diseases (NCDs); in particular in settings where health illiteracy is part of a perpetuating system of risk factors. Interventions that promote health literacy may...

Emergency Department Drug Surveillance (EDDS) hospital's urinalysis results compared with expanded re-testing by an independent laboratory, a pilot study.

Drug and alcohol dependence

Schwartz BE, Dezman Z, Billing AS, Heine K, Massey E, Artigiani EE, Motavalli M, Burch G, Gandhi P, Wish ED.
PMID: 34871979
Drug Alcohol Depend. 2021 Nov 26;230:109195. doi: 10.1016/j.drugalcdep.2021.109195. Epub 2021 Nov 26.

INTRODUCTION: Most hospital urine toxicology screens detect a fixed, limited set of common substances. These tests are fast and accurate but may miss emerging trends in substance use in the community and clinical acumen alone is insufficient for identifying...

An automated and combinative method for the predictive ranking of candidate effector proteins of fungal plant pathogens.

Scientific reports

Jones DAB, Rozano L, Debler JW, Mancera RL, Moolhuijzen PM, Hane JK.
PMID: 34611252
Sci Rep. 2021 Oct 05;11(1):19731. doi: 10.1038/s41598-021-99363-0.

Fungal plant-pathogens promote infection of their hosts through the release of 'effectors'-a broad class of cytotoxic or virulence-promoting molecules. Effectors may be recognised by resistance or sensitivity receptors in the host, which can determine disease outcomes. Accurate prediction of...

Association Between Neighborhood-Level Poverty and Incident Atrial Fibrillation: a Retrospective Cohort Study.

Journal of general internal medicine

Essien UR, McCabe ME, Kershaw KN, Youmans QR, Fine MJ, Yancy CW, Khan SS.
PMID: 34240286
J Gen Intern Med. 2021 Jul 08; doi: 10.1007/s11606-021-06976-2. Epub 2021 Jul 08.

BACKGROUND: Atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality. While neighborhood-level factors, such as poverty, have been related to prevalence of AF risk factors, the association between neighborhood poverty and incident AF has been limited.OBJECTIVE:...

Racial/Ethnic Differences in 30-Day Mortality for Heart Failure and Pneumonia in the Veterans Health Administration Using Claims-based, Clinical, and Social Risk-adjustment Variables.

Medical care

Silva GC, Jiang L, Gutman R, Wu WC, Mor V, Fine MJ, Kressin NR, Trivedi AN.
PMID: 34779794
Med Care. 2021 Dec 01;59(12):1082-1089. doi: 10.1097/MLR.0000000000001650.

BACKGROUND: Prior studies have identified lower mortality in Black Veterans compared with White Veterans after hospitalization for common medical conditions, but these studies adjusted for comorbid conditions identified in administrative claims.OBJECTIVES: The objectives of this study were to compare...

Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi.

Microbial genomics

Jones DAB, Moolhuijzen PM, Hane JK.
PMID: 34468307
Microb Genom. 2021 Sep;7(9). doi: 10.1099/mgen.0.000637.

Plant diseases caused by fungal pathogens are typically initiated by molecular interactions between 'effector' molecules released by a pathogen and receptor molecules on or within the plant host cell. In many cases these effector-receptor interactions directly determine host resistance...

DL_FFLUX: A Parallel, Quantum Chemical Topology Force Field.

Journal of chemical theory and computation

Symons BCB, Bane MK, Popelier PLA.
PMID: 34617748
J Chem Theory Comput. 2021 Nov 09;17(11):7043-7055. doi: 10.1021/acs.jctc.1c00595. Epub 2021 Oct 07.

DL_FFLUX is a force field based on quantum chemical topology that can perform molecular dynamics for flexible molecules endowed with polarizable atomic multipole moments (up to hexadecapole). Using the machine learning method kriging (aka Gaussian process regression), DL_FFLUX has...

Showing 25 to 36 of 214 entries