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Showing 25 to 36 of 247 entries
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Does rotational thromboelastometry accurately predict coagulation status in patients with lupus anticoagulant?.

International journal of laboratory hematology

Hensch L, Kostousov V, Bruzdoski K, Losos M, Pereira M, de Guzman M, Hui S, Teruya J.
PMID: 29756268
Int J Lab Hematol. 2018 Oct;40(5):521-526. doi: 10.1111/ijlh.12852. Epub 2018 May 13.

INTRODUCTION: Rotational thromboelastometry (ROTEM) is increasingly used as a tool for monitoring coagulation status. However, ROTEM is susceptible to misinterpretation due to particular coagulation abnormalities. Here, we report the effects of lupus anticoagulant (LA) on ROTEM.METHODS: A prospective observational...

Myocardial ischaemia-reperfusion injury and cardioprotection in perspective.

Nature reviews. Cardiology

Heusch G.
PMID: 32620851
Nat Rev Cardiol. 2020 Dec;17(12):773-789. doi: 10.1038/s41569-020-0403-y. Epub 2020 Jul 03.

Despite the increasing use and success of interventional coronary reperfusion strategies, morbidity and mortality from acute myocardial infarction are still substantial. Myocardial infarct size is a major determinant of prognosis in these patients. Therefore, cardioprotective strategies aim to reduce...

Deciphering the Network Effects of Deep Brain Stimulation in Parkinson's Disease.

Neurology and therapy

Gonzalez-Escamilla G, Koirala N, Bange M, Glaser M, Pintea B, Dresel C, Deuschl G, Muthuraman M, Groppa S.
PMID: 35000133
Neurol Ther. 2022 Jan 09; doi: 10.1007/s40120-021-00318-4. Epub 2022 Jan 09.

INTRODUCTION: Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an established therapy for Parkinson's disease (PD). However, a more detailed characterization of the targeted network and its grey matter (GM) terminals that drive the clinical outcome is needed....

A pathophysiological compass to personalize antianginal drug treatment.

Nature reviews. Cardiology

Bertero E, Heusch G, Münzel T, Maack C.
PMID: 34234310
Nat Rev Cardiol. 2021 Dec;18(12):838-852. doi: 10.1038/s41569-021-00573-w. Epub 2021 Jul 07.

Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The underlying pathophysiological processes are manifold and encompass atherosclerosis of epicardial coronary arteries, vasospasm of large or small vessels and...

Indications for transfusion in the management of sickle cell disease.

Hematology. American Society of Hematology. Education Program

Han H, Hensch L, Tubman VN.
PMID: 34889416
Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):696-703. doi: 10.1182/hematology.2021000307.

The transfusion of red blood cells (RBCs) is a crucial treatment for sickle cell disease (SCD). While often beneficial, the frequent use of transfusions is associated with numerous complications. Transfusions should be offered with specific guidelines in mind. Here...

Relationship between regional white matter hyperintensities and alpha oscillations in older adults.

Neurobiology of aging

Kumral D, Cesnaite E, Beyer F, Hofmann SM, Hensch T, Sander C, Hegerl U, Haufe S, Villringer A, Witte AV, Nikulin VV.
PMID: 35007997
Neurobiol Aging. 2021 Oct 20;112:1-11. doi: 10.1016/j.neurobiolaging.2021.10.006. Epub 2021 Oct 20.

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7-13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by...

Reprint of: the paradox of α-adrenergic coronary vasoconstriction revisited.

Journal of molecular and cellular cardiology

Heusch G.
PMID: 22420694
J Mol Cell Cardiol. 2012 Apr;52(4):832-9. doi: 10.1016/j.yjmcc.2011.12.010.

Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α(1)-adrenoceptors; the constriction of the resistive microcirculation largely by α(2)-adrenoceptors, but also by α(1)-adrenoceptors. There...

Study design of a randomised, placebo-controlled trial of nintedanib in children and adolescents with fibrosing interstitial lung disease.

ERJ open research

Deterding R, Griese M, Deutsch G, Warburton D, DeBoer EM, Cunningham S, Clement A, Schwerk N, Flaherty KR, Brown KK, Voss F, Schmid U, Schlenker-Herceg R, Verri D, Dumistracel M, Schiwek M, Stowasser S, Tetzlaff K, Clerisme-Beaty E, Young LR.
PMID: 34164554
ERJ Open Res. 2021 Jun 21;7(2). doi: 10.1183/23120541.00805-2020. eCollection 2021 Apr.

Childhood interstitial lung disease (chILD) comprises >200 rare respiratory disorders, with no currently approved therapies and variable prognosis. Nintedanib reduces the rate of forced vital capacity (FVC) decline in adults with progressive fibrosing interstitial lung diseases (ILDs). We present...

Changing Gears - DBS For Dopaminergic Desensitization in Parkinson's Disease?.

Annals of neurology

Weiss D, Volkmann J, Fasano A, Kühn A, Krack P, Deuschl G.
PMID: 34235776
Ann Neurol. 2021 Nov;90(5):699-710. doi: 10.1002/ana.26164. Epub 2021 Jul 20.

In Parkinson's disease, both motor and neuropsychiatric complications unfold as a consequence of both incremental striatal dopaminergic denervation and intensifying long-term dopaminergic treatment. Together, this leads to 'dopaminergic sensitization' steadily increasing motor and behavioral responses to dopaminergic medication that...

Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides.

Chemical science

Kolos JM, Pomplun S, Jung S, Rieß B, Purder PL, Voll AM, Merz S, Gnatzy M, Geiger TM, Quist-Løkken I, Jatzlau J, Knaus P, Holien T, Bracher A, Meyners C, Czodrowski P, Krewald V, Hausch F.
PMID: 34820091
Chem Sci. 2021 Nov 03;12(44):14758-14765. doi: 10.1039/d1sc04638a. eCollection 2021 Nov 17.

Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic [4.3.1] aza-amides, robustly leading to a 2...

Cerebral Perfusion and Sensory Testing Results Differ in Interstitial Cystitis/Bladder Pain Syndrome Patients with and without Fibromyalgia: A Site-Specific MAPP Network Study.

Journal of pain research

Deutsch G, Deshpande H, Lai HH, Kutch JJ, Ness TJ.
PMID: 34992450
J Pain Res. 2021 Dec 23;14:3887-3895. doi: 10.2147/JPR.S343695. eCollection 2021.

PURPOSE: Fibromyalgia is a common co-morbidity in patients with interstitial cystitis/bladder pain syndrome. Quantitative sensory testing measures and regional cerebral blood flow measures have been noted to differ from healthy controls in both subjects with fibromyalgia and those with...

Guidelines should be guidelines: Time to leave the terms "consensus" and "position" for other purposes.

European journal of neurology

, Aleksovska K, Bassetti CLA, Berger T, Carvalho V, Costa J, Deuschl G, Frederiksen KS, Jaarsma J, Kobulashvili T, Leone MA, Pavlakova L, Romoli M, Vignatelli L.
PMID: 34022083
Eur J Neurol. 2021 Aug;28(8):2461-2466. doi: 10.1111/ene.14933. Epub 2021 Jun 17.

No abstract available.

Showing 25 to 36 of 247 entries