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Med Chem Remote: The Frontiers in Medicinal Chemistry 2021.

ChemMedChem

Knaup FH, Meyners C, Charalampidou A, Krajczy P, Purder PL, Ross T, Hausch F.
PMID: 34101362
ChemMedChem. 2021 Aug 05;16(15):2411-2416. doi: 10.1002/cmdc.202100355. Epub 2021 Jun 07.

Digital, but delicious! The Frontiers in Medicinal Chemistry 2021 meeting, originally intended to take place in Darmstadt, carried on as an online event from March 8-10 this year. Even with pandemic restrictions, the event co-presented by the Medicinal Chemistry...

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Knaup FH, Meyners C, Charalampidou A, et al. Med Chem Remote: The Frontiers in Medicinal Chemistry 2021. ChemMedChem. 2021;16(15):2411-2416doi: 10.1002/cmdc.202100355.
Knaup, F. H., Meyners, C., Charalampidou, A., Krajczy, P., Purder, P. L., Ross, T., & Hausch, F. (2021). Med Chem Remote: The Frontiers in Medicinal Chemistry 2021. ChemMedChem, 16(15), 2411-2416. https://doi.org/10.1002/cmdc.202100355
Knaup, Fabian H, et al. "Med Chem Remote: The Frontiers in Medicinal Chemistry 2021." ChemMedChem vol. 16,15 (2021): 2411-2416. doi: https://doi.org/10.1002/cmdc.202100355
Knaup FH, Meyners C, Charalampidou A, Krajczy P, Purder PL, Ross T, Hausch F. Med Chem Remote: The Frontiers in Medicinal Chemistry 2021. ChemMedChem. 2021 Aug 05;16(15):2411-2416. doi: 10.1002/cmdc.202100355. Epub 2021 Jun 07. PMID: 34101362.
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Implementing Clinic First Guiding Actions Across 4 Family Medicine Residency Clinics.

Academic medicine : journal of the Association of American Medical Colleges

Adam P, Hersch D, Peek CJ.
PMID: 34039853
Acad Med. 2021 May 25; doi: 10.1097/ACM.0000000000004180. Epub 2021 May 25.

PROBLEM: Family medicine faculty and residents have observed that continuity clinic is often unsatisfying, attributed to a lack of patient and team continuity and erratic clinic schedules pieced together after the prioritization of hospital service and rotation schedules.APPROACH: In...

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Adam P, Hersch D, Peek CJ. Implementing Clinic First Guiding Actions Across 4 Family Medicine Residency Clinics. Acad Med. 2021;doi: 10.1097/ACM.0000000000004180.
Adam, P., Hersch, D., & Peek, C. J. (2021). Implementing Clinic First Guiding Actions Across 4 Family Medicine Residency Clinics. Academic medicine : journal of the Association of American Medical Colleges, . https://doi.org/10.1097/ACM.0000000000004180
Adam, Patricia, et al. "Implementing Clinic First Guiding Actions Across 4 Family Medicine Residency Clinics." Academic medicine : journal of the Association of American Medical Colleges vol. (2021). doi: https://doi.org/10.1097/ACM.0000000000004180
Adam P, Hersch D, Peek CJ. Implementing Clinic First Guiding Actions Across 4 Family Medicine Residency Clinics. Acad Med. 2021 May 25; doi: 10.1097/ACM.0000000000004180. Epub 2021 May 25. PMID: 34039853.
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Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.

Autophagy

Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM.
PMID: 34024231
Autophagy. 2021 Dec;17(12):4119-4140. doi: 10.1080/15548627.2021.1904489. Epub 2021 May 24.

Current disease-modifying therapies for Huntington disease (HD) focus on lowering mutant HTT (huntingtin; mHTT) levels, and the immunosuppressant drug rapamycin is an intriguing therapeutic for aging and neurological disorders. Rapamycin interacts with FKBP1A/FKBP12 and FKBP5/FKBP51, inhibiting the MTORC1 complex...

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Bailus BJ, Scheeler SM, Simons J, et al. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 2021;17(12):4119-4140doi: 10.1080/15548627.2021.1904489.
Bailus, B. J., Scheeler, S. M., Simons, J., Sanchez, M. A., Tshilenge, K. T., Creus-Muncunill, J., Naphade, S., Lopez-Ramirez, A., Zhang, N., Lakshika Madushani, K., Moroz, S., Loureiro, A., Schreiber, K. H., Hausch, F., Kennedy, B. K., Ehrlich, M. E., & Ellerby, L. M. (2021). Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy, 17(12), 4119-4140. https://doi.org/10.1080/15548627.2021.1904489
Bailus, Barbara J, et al. "Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels." Autophagy vol. 17,12 (2021): 4119-4140. doi: https://doi.org/10.1080/15548627.2021.1904489
Bailus BJ, Scheeler SM, Simons J, Sanchez MA, Tshilenge KT, Creus-Muncunill J, Naphade S, Lopez-Ramirez A, Zhang N, Lakshika Madushani K, Moroz S, Loureiro A, Schreiber KH, Hausch F, Kennedy BK, Ehrlich ME, Ellerby LM. Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels. Autophagy. 2021 Dec;17(12):4119-4140. doi: 10.1080/15548627.2021.1904489. Epub 2021 May 24. PMID: 34024231.
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Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Oliveira BC, de Oliveira BGRB, Deutsch G, Pessanha FS, de Castilho SR.
PMID: 34563097
Wound Repair Regen. 2021 Nov;29(6):920-926. doi: 10.1111/wrr.12969. Epub 2021 Sep 25.

To investigate whether the addition of human recombinant epidermal growth factor (h-EGF) to 2% carboxymethyl cellulose gel is more effective in diabetic wound healing than standard treatment, a pilot, double-blind, randomized and controlled clinical trial with therapeutic intervention was...

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Oliveira BC, de Oliveira BGRB, Deutsch G, et al. Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial. Wound Repair Regen. 2021;29(6):920-926doi: 10.1111/wrr.12969.
Oliveira, B. C., de Oliveira, B. G. R. B., Deutsch, G., Pessanha, F. S., & de Castilho, S. R. (2021). Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 29(6), 920-926. https://doi.org/10.1111/wrr.12969
Oliveira, Bianca Campos, et al. "Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial." Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society vol. 29,6 (2021): 920-926. doi: https://doi.org/10.1111/wrr.12969
Oliveira BC, de Oliveira BGRB, Deutsch G, Pessanha FS, de Castilho SR. Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double-blind, randomized clinical controlled trial. Wound Repair Regen. 2021 Nov;29(6):920-926. doi: 10.1111/wrr.12969. Epub 2021 Sep 25. PMID: 34563097.
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Factors involved in treatment decision making for women diagnosed with ductal carcinoma in situ: A qualitative study.

Breast (Edinburgh, Scotland)

Hatton A, Heriot N, Zalcberg J, Ayton D, Evans J, Roder D, Chua BH, Hersch J, Lippey J, Fox J, Saunders C, Mann GB, Synnot J, Bell RJ.
PMID: 34624754
Breast. 2021 Dec;60:123-130. doi: 10.1016/j.breast.2021.09.007. Epub 2021 Oct 01.

Whilst some of the diversity in management of women with ductal carcinoma in situ (DCIS) may be explained by tumour characteristics, the role of patient preference and the factors underlying those preferences have been less frequently examined. We have...

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Hatton A, Heriot N, Zalcberg J, et al. Factors involved in treatment decision making for women diagnosed with ductal carcinoma in situ: A qualitative study. Breast. 2021;60:123-130doi: 10.1016/j.breast.2021.09.007.
Hatton, A., Heriot, N., Zalcberg, J., Ayton, D., Evans, J., Roder, D., Chua, B. H., Hersch, J., Lippey, J., Fox, J., Saunders, C., Mann, G. B., Synnot, J., & Bell, R. J. (2021). Factors involved in treatment decision making for women diagnosed with ductal carcinoma in situ: A qualitative study. Breast (Edinburgh, Scotland), 60123-130. https://doi.org/10.1016/j.breast.2021.09.007
Hatton, Amy, et al. "Factors involved in treatment decision making for women diagnosed with ductal carcinoma in situ: A qualitative study." Breast (Edinburgh, Scotland) vol. 60 (2021): 123-130. doi: https://doi.org/10.1016/j.breast.2021.09.007
Hatton A, Heriot N, Zalcberg J, Ayton D, Evans J, Roder D, Chua BH, Hersch J, Lippey J, Fox J, Saunders C, Mann GB, Synnot J, Bell RJ. Factors involved in treatment decision making for women diagnosed with ductal carcinoma in situ: A qualitative study. Breast. 2021 Dec;60:123-130. doi: 10.1016/j.breast.2021.09.007. Epub 2021 Oct 01. PMID: 34624754; PMCID: PMC8503564.
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DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography.

Journal of neural engineering

Yalaz M, Noor S, McIntyre C, Butz M, Schnitzler A, Deuschl G, Höft M.
PMID: 33503598
J Neural Eng. 2021 Jan 27; doi: 10.1088/1741-2552/abe099. Epub 2021 Jan 27.

The aim of the present study was to investigate the accuracy of localization and rotational orientation detection of a directional deep brain stimulation (DBS) electrode using a state-of-the-art magnetoencephalography (MEG) scanner. A directional DBS electrode along with its stimulator...

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Yalaz M, Noor S, McIntyre C, et al. DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography. J Neural Eng. 2021;doi: 10.1088/1741-2552/abe099.
Yalaz, M., Noor, S., McIntyre, C., Butz, M., Schnitzler, A., Deuschl, G., & Höft, M. (2021). DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography. Journal of neural engineering, . https://doi.org/10.1088/1741-2552/abe099
Yalaz, Mevlüt, et al. "DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography." Journal of neural engineering vol. (2021). doi: https://doi.org/10.1088/1741-2552/abe099
Yalaz M, Noor S, McIntyre C, Butz M, Schnitzler A, Deuschl G, Höft M. DBS electrode localization and rotational orientation detection using SQUID-based magnetoencephalography. J Neural Eng. 2021 Jan 27; doi: 10.1088/1741-2552/abe099. Epub 2021 Jan 27. PMID: 33503598.
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Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor.

Movement disorders clinical practice

Buechele F, Baumann CR, Lees A, Deuschl G.
PMID: 35005063
Mov Disord Clin Pract. 2021 Sep 08;9(1):38-41. doi: 10.1002/mdc3.13333. eCollection 2022 Jan.

No abstract available.

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Buechele F, Baumann CR, Lees A, et al. Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor. Mov Disord Clin Pract. 2021;9(1):38-41doi: 10.1002/mdc3.13333.
Buechele, F., Baumann, C. R., Lees, A., & Deuschl, G. (2022). Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor. Movement disorders clinical practice, 9(1), 38-41. https://doi.org/10.1002/mdc3.13333
Buechele, Fabian, et al. "Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor." Movement disorders clinical practice vol. 9,1 (2022): 38-41. doi: https://doi.org/10.1002/mdc3.13333
Buechele F, Baumann CR, Lees A, Deuschl G. Encouraging a Generation of Tremor Researchers: Macdonald Critchley's Paper on Essential Tremor. Mov Disord Clin Pract. 2021 Sep 08;9(1):38-41. doi: 10.1002/mdc3.13333. eCollection 2022 Jan. PMID: 35005063; PMCID: PMC8721832.
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White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly.

Frontiers in neurology

Becktepe JS, Busse J, Jensen-Kondering U, Toedt I, Wolff S, Zeuner KE, Berg D, Granert O, Deuschl G.
PMID: 34262526
Front Neurol. 2021 Jun 28;12:694286. doi: 10.3389/fneur.2021.694286. eCollection 2021.

No abstract available.

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Becktepe JS, Busse J, Jensen-Kondering U, et al. White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly. Front Neurol. 2021;12:694286doi: 10.3389/fneur.2021.694286.
Becktepe, J. S., Busse, J., Jensen-Kondering, U., Toedt, I., Wolff, S., Zeuner, K. E., Berg, D., Granert, O., & Deuschl, G. (2021). White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly. Frontiers in neurology, 12694286. https://doi.org/10.3389/fneur.2021.694286
Becktepe, Jos S, et al. "White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly." Frontiers in neurology vol. 12 (2021): 694286. doi: https://doi.org/10.3389/fneur.2021.694286
Becktepe JS, Busse J, Jensen-Kondering U, Toedt I, Wolff S, Zeuner KE, Berg D, Granert O, Deuschl G. White Matter Hyperintensities Are Associated With Severity of Essential Tremor in the Elderly. Front Neurol. 2021 Jun 28;12:694286. doi: 10.3389/fneur.2021.694286. eCollection 2021. PMID: 34262526; PMCID: PMC8273287.
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A pathophysiological compass to personalize antianginal drug treatment.

Nature reviews. Cardiology

Bertero E, Heusch G, Münzel T, Maack C.
PMID: 34234310
Nat Rev Cardiol. 2021 Dec;18(12):838-852. doi: 10.1038/s41569-021-00573-w. Epub 2021 Jul 07.

Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The underlying pathophysiological processes are manifold and encompass atherosclerosis of epicardial coronary arteries, vasospasm of large or small vessels and...

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Bertero E, Heusch G, Münzel T, et al. A pathophysiological compass to personalize antianginal drug treatment. Nat Rev Cardiol. 2021;18(12):838-852doi: 10.1038/s41569-021-00573-w.
Bertero, E., Heusch, G., Münzel, T., & Maack, C. (2021). A pathophysiological compass to personalize antianginal drug treatment. Nature reviews. Cardiology, 18(12), 838-852. https://doi.org/10.1038/s41569-021-00573-w
Bertero, Edoardo, et al. "A pathophysiological compass to personalize antianginal drug treatment." Nature reviews. Cardiology vol. 18,12 (2021): 838-852. doi: https://doi.org/10.1038/s41569-021-00573-w
Bertero E, Heusch G, Münzel T, Maack C. A pathophysiological compass to personalize antianginal drug treatment. Nat Rev Cardiol. 2021 Dec;18(12):838-852. doi: 10.1038/s41569-021-00573-w. Epub 2021 Jul 07. PMID: 34234310.
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Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia.

The journals of gerontology. Series A, Biological sciences and medical sciences

Wadley VG, Bull TP, Zhang Y, Barba C, Bryan RN, Crowe M, Desiderio L, Deutsch G, Erus G, Geldmacher DS, Go R, Lassen-Greene CL, Mamaeva OA, Marson DC, McLaughlin M, Nasrallah IM, Owsley C, Passler J, Perry RT, Pilonieta G, Steward KA, Kennedy RE.
PMID: 33313639
J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1829-1838. doi: 10.1093/gerona/glaa312.

BACKGROUND: Cognitive processing speed is important for performing everyday activities in persons with mild cognitive impairment (MCI). However, its role in daily function has not been examined while simultaneously accounting for contributions of Alzheimer's disease (AD) risk biomarkers. We...

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Wadley VG, Bull TP, Zhang Y, et al. Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia. J Gerontol A Biol Sci Med Sci. 2021;76(10):1829-1838doi: 10.1093/gerona/glaa312.
Wadley, V. G., Bull, T. P., Zhang, Y., Barba, C., Bryan, R. N., Crowe, M., Desiderio, L., Deutsch, G., Erus, G., Geldmacher, D. S., Go, R., Lassen-Greene, C. L., Mamaeva, O. A., Marson, D. C., McLaughlin, M., Nasrallah, I. M., Owsley, C., Passler, J., Perry, R. T., Pilonieta, G., Steward, K. A., & Kennedy, R. E. (2021). Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia. The journals of gerontology. Series A, Biological sciences and medical sciences, 76(10), 1829-1838. https://doi.org/10.1093/gerona/glaa312
Wadley, Virginia G, et al. "Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia." The journals of gerontology. Series A, Biological sciences and medical sciences vol. 76,10 (2021): 1829-1838. doi: https://doi.org/10.1093/gerona/glaa312
Wadley VG, Bull TP, Zhang Y, Barba C, Bryan RN, Crowe M, Desiderio L, Deutsch G, Erus G, Geldmacher DS, Go R, Lassen-Greene CL, Mamaeva OA, Marson DC, McLaughlin M, Nasrallah IM, Owsley C, Passler J, Perry RT, Pilonieta G, Steward KA, Kennedy RE. Cognitive Processing Speed Is Strongly Related to Driving Skills, Financial Abilities, and Other Instrumental Activities of Daily Living in Persons With Mild Cognitive Impairment and Mild Dementia. J Gerontol A Biol Sci Med Sci. 2021 Sep 13;76(10):1829-1838. doi: 10.1093/gerona/glaa312. PMID: 33313639; PMCID: PMC8522472.
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Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series.

The Journal of asthma : official journal of the Association for the Care of Asthma

Mosnaim G, Bizik BK, Wilson C, Bensch G.
PMID: 33974467
J Asthma. 2021 May 11;1-6. doi: 10.1080/02770903.2021.1914648. Epub 2021 May 11.

OBJECTIVE: Despite the availability of various treatment options, a large proportion of patients with asthma have uncontrolled asthma in the United States. Consequently, the economic burden of suboptimal asthma control is anticipated to substantially grow in the next 20...

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Mosnaim G, Bizik BK, Wilson C, et al. Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series. J Asthma. 2021;1-6doi: 10.1080/02770903.2021.1914648.
Mosnaim, G., Bizik, B. K., Wilson, C., & Bensch, G. (2021). Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series. The Journal of asthma : official journal of the Association for the Care of Asthma, 1-6. https://doi.org/10.1080/02770903.2021.1914648
Mosnaim, Giselle, et al. "Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series." The Journal of asthma : official journal of the Association for the Care of Asthma vol. (2021): 1-6. doi: https://doi.org/10.1080/02770903.2021.1914648
Mosnaim G, Bizik BK, Wilson C, Bensch G. Efficacy and safety of add-on tiotropium in the management of uncontrolled asthma: a patient case series. J Asthma. 2021 May 11;1-6. doi: 10.1080/02770903.2021.1914648. Epub 2021 May 11. PMID: 33974467.
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Cardiac PET/MRI-an update.

European journal of hybrid imaging

Rischpler C, Nekolla SG, Heusch G, Umutlu L, Rassaf T, Heusch P, Herrmann K, Nensa F.
PMID: 34191143
Eur J Hybrid Imaging. 2019 Jan 22;3(1):2. doi: 10.1186/s41824-018-0050-2.

It is now about 8 years since the first whole-body integrated PET/MRI has been installed. First, reports on technical characteristics and system performance were published. Early after, reports on the first use of PET/MRI in oncological patients were released....

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Rischpler C, Nekolla SG, Heusch G, et al. Cardiac PET/MRI-an update. Eur J Hybrid Imaging. 2019;3(1):2doi: 10.1186/s41824-018-0050-2.
Rischpler, C., Nekolla, S. G., Heusch, G., Umutlu, L., Rassaf, T., Heusch, P., Herrmann, K., & Nensa, F. (2019). Cardiac PET/MRI-an update. European journal of hybrid imaging, 3(1), 2. https://doi.org/10.1186/s41824-018-0050-2
Rischpler, C, et al. "Cardiac PET/MRI-an update." European journal of hybrid imaging vol. 3,1 (2019): 2. doi: https://doi.org/10.1186/s41824-018-0050-2
Rischpler C, Nekolla SG, Heusch G, Umutlu L, Rassaf T, Heusch P, Herrmann K, Nensa F. Cardiac PET/MRI-an update. Eur J Hybrid Imaging. 2019 Jan 22;3(1):2. doi: 10.1186/s41824-018-0050-2. PMID: 34191143; PMCID: PMC8212244.
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