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Showing 241 to 249 of 249 entries
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Cardiopulmonary transit time: A novel PET imaging biomarker of in vivo physiology for risk stratification of heart transplant recipients.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Harms HJ, Bravo PE, Bajaj NS, Zhou W, Gupta A, Tran T, Taqueti VR, Hainer J, Bibbo C, Dorbala S, Blankstein R, Mehra M, Sörensen J, Givertz MM, Di Carli MF.
PMID: 33398793
J Nucl Cardiol. 2021 Jan 04; doi: 10.1007/s12350-020-02465-x. Epub 2021 Jan 04.

BACKGROUND: Myocardial blood flow (MBF) can be quantified using dynamic PET studies. These studies also inherently contain tomographic images of early bolus displacement, which can provide cardiopulmonary transit times (CPTT) as measure of cardiopulmonary physiology. The aim of this...

Molecular cancer research : MCR

Voigt E, Wallenburg M, Wollenzien H, Thompson E, Kumar K, Feiner J, McNally M, Friesen H, Mukherjee M, Afeworki Y, Kareta MS.
PMID: 34593608
Mol Cancer Res. 2021 Dec;19(12):2015-2025. doi: 10.1158/1541-7786.MCR-20-1006. Epub 2021 Sep 30.

Although many cancer prognoses have improved in the past 50 years due to advancements in treatments, there has been little improvement in therapies for small-cell lung cancer (SCLC). One promising avenue to improve treatment for SCLC is to understand...

Long-Term Cognitive Outcome in Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Annals of neurology

Heine J, Kopp UA, Klag J, Ploner CJ, Prüss H, Finke C.
PMID: 34595771
Ann Neurol. 2021 Dec;90(6):949-961. doi: 10.1002/ana.26241. Epub 2021 Oct 21.

OBJECTIVE: Cognitive dysfunction is a core symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis, but detailed studies on prevalence, characteristics of cognitive deficits, and the potential for recovery are missing. Here, we performed a prospective longitudinal study to assess cognitive long-term...

Coronary vasomotor dysfunction in cancer survivors treated with thoracic irradiation.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Groarke JD, Divakaran S, Nohria A, Killoran JH, Dorbala S, Dunne RM, Hainer J, Taqueti VR, Blankstein R, Mamon HJ, Di Carli MF.
PMID: 32691348
J Nucl Cardiol. 2021 Dec;28(6):2976-2987. doi: 10.1007/s12350-020-02255-5. Epub 2020 Jul 20.

BACKGROUND: We sought to test the hypothesis that thoracic radiation therapy (RT) is associated with impaired myocardial flow reserve (MFR), a measure of coronary vasomotor dysfunction.METHODS: We retrospectively studied thirty-five consecutive patients (71% female, mean ± standard deviation (SD)...

Coronary vasomotor dysfunction portends worse outcomes in patients with breast cancer.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Divakaran S, Caron JP, Zhou W, Hainer J, Bibbo CF, Skali H, Taqueti VR, Dorbala S, Blankstein R, Groarke JD, Nohria A, Di Carli MF.
PMID: 34820770
J Nucl Cardiol. 2021 Nov 24; doi: 10.1007/s12350-021-02825-1. Epub 2021 Nov 24.

BACKGROUND: Impaired MFR in the absence of flow-limiting CAD is associated with adverse events. Cardiovascular disease is an important cause of morbidity and mortality in patients with breast cancer. We sought to test the utility of MFR to predict...

Transcriptome and Functions of Granulocytic Myeloid-Derived Suppressor Cells Determine their Association with Disease Severity of COVID-19.

medRxiv : the preprint server for health sciences

Dean MJ, Ochoa JB, Sanchez-Pino M, Zabaleta J, Garai J, Del Valle L, Wyczechowska D, Buckner L, Philbrook P, Majumder R, Heide RV, Dunkenberger L, Thylur R, Nossaman R, Roberts WM, Chapple A, Collins J, Luke B, Johnson R, Koul H, Rees CA, Morris CR, Garcia-Diaz J, Ochoa AC.
PMID: 33791717
medRxiv. 2021 Mar 29; doi: 10.1101/2021.03.26.21254441.

COVID-19 ranges from asymptomatic in 35% of cases to severe in 20% of patients. Differences in the type and degree of inflammation appear to determine the severity of the disease. Recent reports show an increase in circulating monocytic-myeloid-derived suppressor...

Association of inflammatory disease and long-term outcomes among young adults with myocardial infarction: the Mass General Brigham YOUNG-MI Registry.

European journal of preventive cardiology

Weber B, Biery DW, Singh A, Divakaran S, Berman AN, Wu WY, Brown JM, Hainer J, Nasir K, Liao K, Bhatt DL, Di Carli MF, Blankstein R.
PMID: 33784740
Eur J Prev Cardiol. 2021 Mar 30; doi: 10.1093/eurjpc/zwaa154. Epub 2021 Mar 30.

AIMS: Autoimmune systemic inflammatory diseases (SIDs) are associated with an increased risk of cardiovascular (CV) disease, particularly myocardial infarction (MI). However, there are limited data on the prevalence and effects of SID among adults who experience an MI at...

Spatial Correlation and Breast Cancer Risk.

Biomedical physics & engineering express

Fowler EEE, Hathaway C, Tillman F, Weinfurtner R, Sellers TA, Heine J.
PMID: 33304615
Biomed Phys Eng Express. 2019 Jul;5(4). doi: 10.1088/2057-1976/ab1dad. Epub 2019 May 22.

We present a novel method for evaluating local spatial correlation structure in two-dimensional (2D) mammograms and evaluate its capability for risk prediction as one possible application. Two matched case-control studies were analyzed. Study 1 included women (N = 588...

Characterisation of the redox centers of ethylbenzene dehydrogenase.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

Hagel C, Blaum B, Friedrich T, Heider J.
PMID: 34843002
J Biol Inorg Chem. 2021 Nov 29; doi: 10.1007/s00775-021-01917-0. Epub 2021 Nov 29.

Ethylbenzene dehydrogenase (EbDH), the initial enzyme of anaerobic ethylbenzene degradation from the beta-proteobacterium Aromatoleum aromaticum, is a soluble periplasmic molybdenum enzyme consisting of three subunits. It contains a Mo-bis-molybdopterin guanine dinucleotide (Mo-bis-MGD) cofactor and an 4Fe-4S cluster (FS0) in...

Showing 241 to 249 of 249 entries