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Showing 25 to 36 of 181 entries
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The Alpha variant was not associated with excess nosocomial SARS-CoV-2 infection in a multi-centre UK hospital study.

The Journal of infection

Boshier FAT, Venturini C, Stirrup O, Guerra-Assunção JA, Alcolea-Medina A, Becket AH, Byott M, Charalampous T, Filipe ADS, Frampton D, Glaysher S, Khan T, Kulasegara-Shylini R, Kele B, Monahan IM, Mollett G, Parker M, Pelosi E, Randell P, Roy S, Taylor JF, Weller SJ, Wilson-Davies E, Wade P, Williams R, Copas AJ, Cutino-Moguel T, Freemantle N, Hayward AC, Holmes A, Hughes J, Mahungu TW, Nebbia G, Nastouli E, Partridge DG, Pope CF, Price JR, Robson SC, Saeed K, Shin GY, de Silva TI, Snell LB, Thomson EC, Witney AA, Breuer J.
PMID: 34610391
J Infect. 2021 Dec;83(6):693-700. doi: 10.1016/j.jinf.2021.09.022. Epub 2021 Oct 02.

OBJECTIVES: Recently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in increased transmission within hospitals.METHODS: We collected viral sequences and epidemiological data of patients...

Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family.

Familial cancer

Brown KM, Xu M, Sargen M, Jang H, Zhang M, Zhang T, Zhu B, Jones K, Kim J, Mendoza L, Hayward NK, Tucker MA, Goldstein AM, Yang XR, Stewart DR, Hicks B, Consonni D, Pesatori AC, Fargnoli MC, Peris K, Stratigos A, Menin C, Ghiorzo P, Puig S, Nagore E, Andresson T, Nussinov R, Calista D, Landi MT.
PMID: 34215961
Fam Cancer. 2021 Jul 03; doi: 10.1007/s10689-021-00267-9. Epub 2021 Jul 03.

While several high-penetrance melanoma risk genes are known, variation in these genes fail to explain melanoma susceptibility in a large proportion of high-risk families. As part of a melanoma family sequencing study, including 435 families from Mediterranean populations we...

The Calgary COPD & Asthma Program: The role of the respiratory therapy profession in primary care.

Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR

Slack CL, Hayward K, Markham AW.
PMID: 31164787
Can J Respir Ther. 2018;54(4). doi: 10.29390/cjrt-2018-018. Epub 2018 Feb 01.

Respiratory therapy is a profession with the depth and breadth required to care for clients by "

FRAMe: Familial Risk Assessment of Melanoma-a risk prediction tool to guide CDKN2A germline mutation testing in Australian familial melanoma.

Familial cancer

Holland EA, Lo S, Kelly B, Schmid H, Cust AE, Palmer JM, Drummond M, Hayward NK, Pritchard AL, Mann GJ.
PMID: 32989607
Fam Cancer. 2021 Jul;20(3):231-239. doi: 10.1007/s10689-020-00209-x. Epub 2020 Sep 29.

Germline mutations in CDKN2A greatly increase risk of developing cutaneous melanoma. We have constructed a risk prediction model, Familial Risk Assessment of Melanoma (FRAMe), for estimating the likelihood of carrying a heritable CDKN2A mutation among Australian families, where the...

Neutralisation rate controls the self-assembly of pH-sensitive surfactants.

Soft matter

Hayward DW, Chiappisi L, Teo JH, Prévost S, Schweins R, Gradzielski M.
PMID: 31621749
Soft Matter. 2019 Oct 30;15(42):8611-8620. doi: 10.1039/c9sm00950g.

The degree of ionisation of a weakly acidic surfactant can be continuously modified from nonionic to ionic by adjusting the pH. This property can be used to control the curvature and therefore the morphology of the self-assembled aggregates it...

Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins.

Human brain mapping

Hayward DA, Pomares F, Casey KF, Ismaylova E, Levesque M, Greenlaw K, Vitaro F, Brendgen M, Rénard F, Dionne G, Boivin M, Tremblay RE, Booij L.
PMID: 32881198
Hum Brain Mapp. 2020 Dec 15;41(18):5228-5239. doi: 10.1002/hbm.25188. Epub 2020 Sep 02.

Previous research has shown that the prenatal environment, commonly indexed by birth weight (BW), is a predictor of morphological brain development. We previously showed in monozygotic (MZ) twins associations between BW and brain morphology that were independent of genetics....

The Patient's Perspective in Cirrhosis: Unmet Supportive Care Needs Differ by Disease Severity, Etiology, and Age.

Hepatology communications

Valery PC, Bernardes CM, Mckillen B, Amarasena S, Stuart KA, Hartel G, Clark PJ, Skoien R, Rahman T, Horsfall L, Hayward K, Gupta R, Lee A, Pillay L, Powell EE.
PMID: 34027276
Hepatol Commun. 2021 Feb 06;5(5):891-905. doi: 10.1002/hep4.1681. eCollection 2021 May.

Patients with cirrhosis have significant physical, psychological, and practical needs. We documented patients' perceived need for support with these issues and the differences with increasing liver disease severity, etiology, and age. Using the supportive needs assessment tool for cirrhosis...

Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.

Cancer cell

Newell F, Pires da Silva I, Johansson PA, Menzies AM, Wilmott JS, Addala V, Carlino MS, Rizos H, Nones K, Edwards JJ, Lakis V, Kazakoff SH, Mukhopadhyay P, Ferguson PM, Leonard C, Koufariotis LT, Wood S, Blank CU, Thompson JF, Spillane AJ, Saw RPM, Shannon KF, Pearson JV, Mann GJ, Hayward NK, Scolyer RA, Waddell N, Long GV.
PMID: 34951955
Cancer Cell. 2021 Dec 21; doi: 10.1016/j.ccell.2021.11.012. Epub 2021 Dec 21.

We concurrently examine the whole genome, transcriptome, methylome, and immune cell infiltrates in baseline tumors from 77 patients with advanced cutaneous melanoma treated with anti-PD-1 with or without anti-CTLA-4. We show that high tumor mutation burden (TMB), neoantigen load,...

The Prognostic Impact of Circulating Tumour DNA in Melanoma Patients Treated with Systemic Therapies-Beyond .

Cancers

Marsavela G, Johansson PA, Pereira MR, McEvoy AC, Reid AL, Robinson C, Warburton L, Khattak MA, Meniawy TM, Amanuel B, Millward M, Hayward NK, Ziman MR, Gray ES, Calapre L.
PMID: 33339135
Cancers (Basel). 2020 Dec 16;12(12). doi: 10.3390/cancers12123793.

In this study, we evaluated the predictive value of circulating tumour DNA (ctDNA) to inform therapeutic outcomes in metastatic melanoma patients receiving systemic therapies. We analysed 142 plasma samples from metastatic melanoma patients prior to commencement of systemic therapy:...

Contemporary management of pediatric open skull fractures: a multicenter pediatric trauma center study.

Journal of neurosurgery. Pediatrics

McFall C, Beier AD, Hayward K, Alberto EC, Burd RS, Farr BJ, Mooney DP, Gee K, Upperman JS, Escobar MA, Coufal NG, Harvey HA, Gollin G.
PMID: 33711805
J Neurosurg Pediatr. 2021 Mar 12;1-5. doi: 10.3171/2020.10.PEDS20486. Epub 2021 Mar 12.

OBJECTIVE: The authors sought to evaluate the contemporary management of pediatric open skull fractures and assess the impact of variations in antibiotic and operative management on the incidence of infectious complications.METHODS: The records of children who presented from 2009...

The Use of Extracorporeal Life Support in Children With Immune-Mediated Diseases.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Barreto JA, Mehta A, Thiagarajan RR, Hayward KN, Brogan A, Brogan TV.
PMID: 34261943
Pediatr Crit Care Med. 2022 Jan 01;23(1):e60-e65. doi: 10.1097/PCC.0000000000002801.

OBJECTIVES: To describe the use and outcomes of extracorporeal membrane oxygenation support among children with immune-mediated conditions.DESIGN: Retrospective cohort study.SETTING: The Extracorporeal Life Support Organization registry.PATIENTS: Patients 1 month to 18 years old with International Classification of Diseases, 9th...

A temperature-controlled electric field sample environment for small-angle neutron scattering experiments.

The Review of scientific instruments

Hayward DW, Magro G, Hörmann A, Prévost S, Schweins R, Richardson RM, Gradzielski M.
PMID: 33820030
Rev Sci Instrum. 2021 Mar 01;92(3):033903. doi: 10.1063/5.0040675.

A new sample environment is introduced for the study of soft matter samples in electric fields using small-angle neutron scattering instruments. The sample environment is temperature controlled and features external electrodes, allowing standard quartz cuvettes to be used and...

Showing 25 to 36 of 181 entries