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COX-2 expression and function in the hyperalgesic response to paw inflammation in mice.

Prostaglandins, leukotrienes, and essential fatty acids

Jain NK, Ishikawa TO, Spigelman I, Herschman HR.
PMID: 18829279
Prostaglandins Leukot Essent Fatty Acids. 2008 Dec;79(6):183-90. doi: 10.1016/j.plefa.2008.08.001. Epub 2008 Oct 01.

Peripheral inflammation and edema are often accompanied by primary and secondary hyperalgesia which are mediated by both peripheral and central mechanisms. The role of cyclooxygenase-2 (COX-2)-mediated prostanoid production in hyperalgesia is a topic of substantial current interest. We have...

Two inducible, functional cyclooxygenase-2 genes are present in the rainbow trout genome.

Journal of cellular biochemistry

Ishikawa TO, Herschman HR.
PMID: 17471498
J Cell Biochem. 2007 Dec 15;102(6):1486-92. doi: 10.1002/jcb.21368.

The cyclooxygenases (Cox) catalyze the initial reactions in prostanoid biosynthesis, and produce the common prostanoids precursor, PGH(2). Mammalian species have two Cox isoforms; constitutively expressed cyclooxygenase-1 (Cox-1) and inducible cyclooxygenase-2 (Cox-2). Database searches suggest three Cox genes are present...

A microfluidic platform for sequential ligand labeling and cell binding analysis.

Biomedical microdevices

Sui G, Lee CC, Kamei K, Li HJ, Wang JY, Wang J, Herschman HR, Tseng HR.
PMID: 17195108
Biomed Microdevices. 2007 Jun;9(3):301-5. doi: 10.1007/s10544-006-9033-3.

Developing biochemical and cell biological assay for screening biomolecules, evaluating their characteristics in biological processes, and determining their pharmacological effects represents a key technology in biomedical research. A PDMS-based integrated microfluidic platform was fabricated and tested for facilitating the...

Mineralogy and petrology of comet 81P/Wild 2 nucleus samples.

Science (New York, N.Y.)

Zolensky ME, Zega TJ, Yano H, Wirick S, Westphal AJ, Weisberg MK, Weber I, Warren JL, Velbel MA, Tsuchiyama A, Tsou P, Toppani A, Tomioka N, Tomeoka K, Teslich N, Taheri M, Susini J, Stroud R, Stephan T, Stadermann FJ, Snead CJ, Simon SB, Simionovici A, See TH, Robert F, Rietmeijer FJ, Rao W, Perronnet MC, Papanastassiou DA, Okudaira K, Ohsumi K, Ohnishi I, Nakamura-Messenger K, Nakamura T, Mostefaoui S, Mikouchi T, Meibom A, Matrajt G, Marcus MA, Leroux H, Lemelle L, Le L, Lanzirotti A, Langenhorst F, Krot AN, Keller LP, Kearsley AT, Joswiak D, Jacob D, Ishii H, Harvey R, Hagiya K, Grossman L, Grossman JN, Graham GA, Gounelle M, Gillet P, Genge MJ, Flynn G, Ferroir T, Fallon S, Fakra S, Ebel DS, Dai ZR, Cordier P, Clark B, Chi M, Butterworth AL, Brownlee DE, Bridges JC, Brennan S, Brearley A, Bradley JP, Bleuet P, Bland PA, Bastien R.
PMID: 17170295
Science. 2006 Dec 15;314(5806):1735-9. doi: 10.1126/science.1135842.

The bulk of the comet 81P/Wild 2 (hereafter Wild 2) samples returned to Earth by the Stardust spacecraft appear to be weakly constructed mixtures of nanometer-scale grains, with occasional much larger (over 1 micrometer) ferromagnesian silicates, Fe-Ni sulfides, Fe-Ni...

The sequelae of chronic infection related to retained cuffs of a Tenckhoff catheter.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Harvey R, Marsh J, Chemla ES.
PMID: 17299166
Perit Dial Int. 2007 Mar-Apr;27(2):217-8.

No abstract available.

Service improvement. In the driving seat.

The Health service journal

Castle A, Harvey R, Hallihan A.
PMID: 17380973
Health Serv J. 2007 Feb 15;117(6043):suppl 31, 33, 35.

Overseas manufacturers and healthcare providers can provide valuable lessons to the NHS in embedding a culture of service improvement. A key lesson is that empowering staff unleashes an organisation's most powerful asset. Service improvement has been proven to enhance...

Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography.

Bioorganic & medicinal chemistry letters

Toyokuni T, Kumar JS, Walsh JC, Shapiro A, Talley JJ, Phelps ME, Herschman HR, Barrio JR, Satyamurthy N.
PMID: 16153836
Bioorg Med Chem Lett. 2005 Nov 01;15(21):4699-702. doi: 10.1016/j.bmcl.2005.07.065.

Fluoroalkyl and fluoroaryl analogues of valdecoxib were found to possess potent inhibitory activities against cyclooxygenase-2 comparable to that of the parent valdecoxib. Among them, the fluoromethyl analogue was chosen for 18F-labeling. Thus, 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide (approximately 2000 Ci/mmol at end of...

Functional expression of the gene encoding cytidine triphosphate synthetase from Plasmodium falciparum which contains two novel sequences that are potential antimalarial targets.

Molecular and biochemical parasitology

Yuan P, Hendriks EF, Fernandez HR, O'Sullivan WJ, Stewart TS.
PMID: 16051382
Mol Biochem Parasitol. 2005 Oct;143(2):200-8. doi: 10.1016/j.molbiopara.2005.06.004.

CTP synthetase (E C UTP: ammonia ligase (ADP-forming)) catalyses the formation of CTP from UTP and, in the human parasite Plasmodium falciparum, is the sole source of cytidine nucleotides. It is thus a potential chemotherapeutic target, especially as...

The Dilution of Vaccine Lymph with Glycerine, &c.

The Indian medical gazette

Harvey R.
PMID: 28995936
Ind Med Gaz. 1868 Mar 02;3(3):56-58.

No abstract available.

Small-Pox and Vaccination in Bhurtpoor.

The Indian medical gazette

Harvey R.
PMID: 28996352
Ind Med Gaz. 1870 Mar 01;5(3):51-54.

No abstract available.

Report on the Medico-Legal Returns, Received from the Civil Surgeons in the Bengal Presidency during the Years 1870, 1871, and 1872.

The Indian medical gazette

Harvey R.
PMID: 28997626
Ind Med Gaz. 1876 Mar 01;11(3):57-62.

No abstract available.

Application of the Forceps in Breech Cases.

The Indian medical gazette

Harvey R.
PMID: 28999199
Ind Med Gaz. 1884 Jun;19(6):162-165.

No abstract available.

Showing 25 to 36 of 728 entries