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Showing 1393 to 1404 of 3124 entries
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Psychographic Segmentation: Another Lever for Precision Population Brain Health.

Frontiers in aging neuroscience

Smith E, Ibanez A, Lavretsky H, Berk M, Eyre HA.
PMID: 34955814
Front Aging Neurosci. 2021 Dec 08;13:783297. doi: 10.3389/fnagi.2021.783297. eCollection 2021.

Dementia prevention interventions that address modifiable risk factors for dementia require extensive lifestyle and behavior changes. Strategies are needed to enhance engagement and personalization of the experience at a population level. Precision Population Brain Health aims to improve brain...

Partial Polymer Blend for Fused Filament Fabrication with High Thermal Stability.

Polymers

Harris M, Potgieter J, Mohsin H, Chen JQ, Ray S, Arif KM.
PMID: 34641168
Polymers (Basel). 2021 Sep 30;13(19). doi: 10.3390/polym13193353.

The materials for large scale fused filament fabrication (FFF) are not yet designed to resist thermal degradation. This research presents a novel polymer blend of polylactic acid with polypropylene for FFF, purposefully designed with minimum feasible chemical grafting and...

The Role of Ablation in Prevention of Recurrent Implantable Cardioverter Defibrillator Shocks in Patients With Tetralogy of Fallot.

CJC open

Kawada S, Chakraborty P, Downar E, Sanchez AP, Sathananthan G, Bhaskaran A, Kugamoorthy P, Albertini L, Oechslin EN, Silversides C, Wald RM, Roche SL, Swan L, Alonso-Gonzalez R, Thorne S, Harris L, Hickey E, Nanthakumar K, Mondésert B, Khairy P, Nair K.
PMID: 34027366
CJC Open. 2021 Jan 28;3(5):619-626. doi: 10.1016/j.cjco.2021.01.005. eCollection 2021 May.

BACKGROUND: Implantable cardioverter defibrillators (ICDs) are effective in preventing arrhythmic sudden cardiac death in patients with tetralogy of Fallot (TOF). Although ICD therapies for malignant ventricular arrhythmias can be life-saving, shocks could have deleterious consequences. Substrate-based ablation therapy has...

NRF2 activation inhibits valproic acid-induced neural tube defects in mice.

Neurotoxicology and teratology

Piorczynski TB, Lapehn S, Ringer KP, Allen SA, Johnson GA, Call K, Lucas SM, Harris C, Hansen JM.
PMID: 34737154
Neurotoxicol Teratol. 2021 Oct 29;89:107039. doi: 10.1016/j.ntt.2021.107039. Epub 2021 Oct 29.

Valproic acid (VPA) is a widely prescribed medication that has traditionally been used to treat epilepsy, yet embryonic exposure to VPA increases the risk of the fetus developing neural tube defects (NTDs). While the mechanism by which VPA causes...

A Synthetic Peptide CTL Vaccine Targeting Nucleocapsid Confers Protection from SARS-CoV-2 Challenge in Rhesus Macaques.

Vaccines

Harris PE, Brasel T, Massey C, Herst CV, Burkholz S, Lloyd P, Blankenberg T, Bey TM, Carback R, Hodge T, Ciotlos S, Wang L, Comer JE, Rubsamen RM.
PMID: 34070152
Vaccines (Basel). 2021 May 18;9(5). doi: 10.3390/vaccines9050520.

BACKGROUND: Persistent transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has given rise to a COVID-19 pandemic. Several vaccines, conceived in 2020, that evoke protective spike antibody responses are being deployed in mass public health vaccination programs. Recent...

Effect of the Histone Deacetylase Inhibitor FRM-0334 on Progranulin Levels in Patients With Progranulin Gene Haploinsufficiency: A Randomized Clinical Trial.

JAMA network open

Ljubenkov PA, Edwards L, Iaccarino L, La Joie R, Rojas JC, Koestler M, Harris B, Boeve BF, Borroni B, van Swieten JC, Grossman M, Pasquier F, Frisoni GB, Mummery CJ, Vandenberghe R, Le Ber I, Hannequin D, McGinnis SM, Auriacombe S, Onofrj M, Goodman IJ, Riordan HJ, Wisniewski G, Hesterman J, Marek K, Haynes BA, Patzke H, Koenig G, Hilt D, Moebius H, Boxer AL.
PMID: 34559230
JAMA Netw Open. 2021 Sep 01;4(9):e2125584. doi: 10.1001/jamanetworkopen.2021.25584.

IMPORTANCE: Histone deacetylase inhibitors have been repeatedly shown to elevate progranulin levels in preclinical models. This report describes the first randomized clinical trial of a histone deacetylase inhibitor in frontotemporal dementia (FTD) resulting from progranulin (GRN) gene variations.OBJECTIVE: To...

Effect of switching from natalizumab to moderate- vs high-efficacy DMT in clinical practice.

Neurology. Clinical practice

Hersh CM, Harris H, Conway D, Hua LH.
PMID: 33510948
Neurol Clin Pract. 2020 Dec;10(6):e53-e65. doi: 10.1212/CPJ.0000000000000809.

OBJECTIVE: To assess the real-world comparative effectiveness of switching from natalizumab (NTZ) to a moderate-efficacy (Mod) disease-modifying therapy (DMT) vs high-efficacy therapy (HET) in patients with multiple sclerosis (MS).METHODS: Patients discontinuing NTZ at two MS centers (n = 556)...

Engineering temporal dynamics in microbial communities.

Current opinion in microbiology

Ronda C, Wang HH.
PMID: 34739926
Curr Opin Microbiol. 2021 Oct 30;65:47-55. doi: 10.1016/j.mib.2021.10.009. Epub 2021 Oct 30.

Microbial communities are a key part to tackling global challenges in human health, environmental conservation, and sustainable agriculture in the coming decade. Recent advances in synthetic biology to study and modify microbial communities have led to important insights into...

The LHC Olympics 2020 a community challenge for anomaly detection in high energy physics.

Reports on progress in physics. Physical Society (Great Britain)

Kasieczka G, Nachman B, Shih D, Amram O, Andreassen A, Benkendorfer K, Bortolato B, Brooijmans G, Canelli F, Collins JH, Dai B, De Freitas FF, Dillon BM, Dinu IM, Dong Z, Donini J, Duarte J, Faroughy DA, Gonski J, Harris P, Kahn A, Kamenik JF, Khosa CK, Komiske P, Le Pottier L, Martín-Ramiro P, Matevc A, Metodiev E, Mikuni V, Murphy CW, Ochoa I, Park SE, Pierini M, Rankin D, Sanz V, Sarda N, Seljak U, Smolkovic A, Stein G, Suarez CM, Szewc M, Thaler J, Tsan S, Udrescu SM, Vaslin L, Vlimant JR, Williams D, Yunus M.
PMID: 34736231
Rep Prog Phys. 2021 Dec 07;84(12). doi: 10.1088/1361-6633/ac36b9.

A new paradigm for data-driven, model-agnostic new physics searches at colliders is emerging, and aims to leverage recent breakthroughs in anomaly detection and machine learning. In order to develop and benchmark new anomaly detection methods within this framework, it...

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Wagner AJ, Ravi V, Riedel RF, Ganjoo K, Van Tine BA, Chugh R, Cranmer L, Gordon EM, Hornick JL, Du H, Grigorian B, Schmid AN, Hou S, Harris K, Kwiatkowski DJ, Desai NP, Dickson MA.
PMID: 34637337
J Clin Oncol. 2021 Nov 20;39(33):3660-3670. doi: 10.1200/JCO.21.01728. Epub 2021 Oct 12.

No abstract available.

Platypus and echidna genomes reveal mammalian biology and evolution.

Nature

Zhou Y, Shearwin-Whyatt L, Li J, Song Z, Hayakawa T, Stevens D, Fenelon JC, Peel E, Cheng Y, Pajpach F, Bradley N, Suzuki H, Nikaido M, Damas J, Daish T, Perry T, Zhu Z, Geng Y, Rhie A, Sims Y, Wood J, Haase B, Mountcastle J, Fedrigo O, Li Q, Yang H, Wang J, Johnston SD, Phillippy AM, Howe K, Jarvis ED, Ryder OA, Kaessmann H, Donnelly P, Korlach J, Lewin HA, Graves J, Belov K, Renfree MB, Grutzner F, Zhou Q, Zhang G.
PMID: 33408411
Nature. 2021 Apr;592(7856):756-762. doi: 10.1038/s41586-020-03039-0. Epub 2021 Jan 06.

Egg-laying mammals (monotremes) are the only extant mammalian outgroup to therians (marsupial and eutherian animals) and provide key insights into mammalian evolution

Prevalence and factors associated with chronic venous insufficiency, leg ulceration and deep-vein thrombosis among people who inject drugs in London, UK.

Drug and alcohol review

Doran J, Hope V, Wright T, Scott J, Ciccarone D, Harris M.
PMID: 34605086
Drug Alcohol Rev. 2021 Oct 03; doi: 10.1111/dar.13389. Epub 2021 Oct 03.

INTRODUCTION: People who inject drugs (PWID) are vulnerable to a range of harms, including vascular conditions such as chronic venous insufficiency (CVI), leg ulcers and deep vein thrombosis (DVT). The extent of vascular conditions has rarely been studied, despite...

Showing 1393 to 1404 of 3124 entries