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Showing 157 to 168 of 168 entries
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Limit on the electric-dipole moment of 199Hg using synchronous optical pumping.

Physical review. A, Atomic, molecular, and optical physics

Fortson EN, Heckel BR, Jacobs JP, Klipstein WM, Lamoreaux SK.
PMID: 9912652
Phys Rev A. 1995 Nov;52(5):3521-3540. doi: 10.1103/physreva.52.3521.

No abstract available.

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance.

Frontiers in immunology

Nikolouli E, Hardtke-Wolenski M, Hapke M, Beckstette M, Geffers R, Floess S, Jaeckel E, Huehn J.
PMID: 28702031
Front Immunol. 2017 Jun 28;8:748. doi: 10.3389/fimmu.2017.00748. eCollection 2017.

Regulatory T cells (Tregs) are critical for the maintenance of immune homeostasis and self-tolerance and can be therapeutically used for prevention of unwanted immune responses such as allotransplant rejection. Tregs are characterized by expression of the transcription factor Foxp3,...

The vascular response to acute hyperglycaemia: What is the role of exercise capacity?.

The Journal of physiology

Heckel AR, Cilhoroz BT, Rosenberg J.
PMID: 34089519
J Physiol. 2021 Jun 05; doi: 10.1113/JP281813. Epub 2021 Jun 05.

No abstract available.

Quantification of polyreactive immunoglobulin G facilitates the diagnosis of autoimmune hepatitis.

Hepatology (Baltimore, Md.)

Taubert R, Engel B, Diestelhorst J, Hupa-Breier KL, Behrendt P, Baerlecken NT, Sühs KW, Janik MK, Zachou K, Sebode M, Schramm C, Londoño MC, Habes S, Oo YH, Lalanne C, Pape S, Schubert M, Hust M, Dübel S, Thevis M, Jonigk D, Beimdiek J, Buettner FFR, Drenth JPH, Muratori L, Adams DH, Dyson JK, Renand A, Graupera I, Lohse AW, Dalekos GN, Milkiewicz P, Stangel M, Maasoumy B, Witte T, Wedemeyer H, Manns MP, Jaeckel E.
PMID: 34473365
Hepatology. 2022 Jan;75(1):13-27. doi: 10.1002/hep.32134. Epub 2021 Dec 05.

BACKGROUND AND AIMS: Detection of autoantibodies is a mainstay of diagnosing autoimmune hepatitis (AIH). However, conventional autoantibodies for the workup of AIH lack either sensitivity or specificity, leading to substantial diagnostic uncertainty. We aimed to identify more accurate serological...

Thermodynamic Relations among Isotropic Material Properties in Conditions of Plane Shear Stress.

Entropy (Basel, Switzerland)

Porporato A, Calabrese S, Hueckel T.
PMID: 33267010
Entropy (Basel). 2019 Mar 19;21(3). doi: 10.3390/e21030295.

We present new general relationships among the material properties of an isotropic material kept in homogeneous stress conditions with hydrostatic pressure and plane shear. The derivation is not limited to the proximity of the zero shear-stress and -strain condition,...

T cell receptor repertoires within liver allografts are different to those in the peripheral blood.

Journal of hepatology

Mederacke YS, Nienen M, Jarek M, Geffers R, Hupa-Breier K, Babel N, Reinke P, Mederacke I, Vondran FWR, Jonigk D, Wedemeyer H, Jaeckel E.
PMID: 33347951
J Hepatol. 2021 May;74(5):1167-1175. doi: 10.1016/j.jhep.2020.12.014. Epub 2020 Dec 18.

BACKGROUND & AIMS: T cells are the main mediators of allogeneic immune responses. Specific T cell clones can be tracked by their unique T cell receptor (TCR), but specificity and function remain elusive and have not been investigated in...

The Detrimental Role of Regulatory T Cells in Nonalcoholic Steatohepatitis.

Hepatology communications

Dywicki J, Buitrago-Molina LE, Noyan F, Davalos-Misslitz AC, Hupa-Breier KL, Lieber M, Hapke M, Schlue J, Falk CS, Raha S, Prinz I, Koenecke C, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E.
PMID: 34532981
Hepatol Commun. 2021 Aug 25; doi: 10.1002/hep4.1807. Epub 2021 Aug 25.

Nonalcoholic steatohepatitis (NASH) is induced by steatosis and metabolic inflammation. While involvement of the innate immune response has been shown, the role of the adaptive immune response in NASH remains controversial. Likewise, the role of regulatory T cells (Treg)...

4-Week repeated dose rat GLP toxicity study of oncolytic ECHO-7 virus Rigvir administered intramuscularly with a 4-week recovery period.

Toxicology reports

Piwoni K, Jaeckel G, Rasa A, Alberts P.
PMID: 33537211
Toxicol Rep. 2021 Jan 19;8:230-238. doi: 10.1016/j.toxrep.2021.01.009. eCollection 2021.

The oncolytic ECHO-7 virus Rigvir was registered in Latvia in 2004 and later in Georgia, Armenia and Uzbekistan. No severe adverse events have been observed. During drug development good laboratory practice (GLP) pre-clinical toxicology studies are generally required by...

Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling.

Pain

Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM.
PMID: 34252907
Pain. 2021 Jul 09; doi: 10.1097/j.pain.0000000000002320. Epub 2021 Jul 09.

ABSTRACT: The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for...

Antagonism of the mu-delta opioid receptor heterodimer enhances opioid antinociception by activating Src and calcium/calmodulin-dependent protein kinase II signaling.

Pain

Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM.
PMID: 34252907
Pain. 2022 Jan 01;163(1):146-158. doi: 10.1097/j.pain.0000000000002320.

ABSTRACT: The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for...

Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model.

Journal of hepatology

Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR, Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD.
PMID: 34453962
J Hepatol. 2021 Dec;75(6):1420-1433. doi: 10.1016/j.jhep.2021.08.011. Epub 2021 Aug 25.

BACKGROUND & AIMS: Therapeutic targeting of injuries that require transient restoration of proteins by mRNA delivery is an attractive approach that, until recently, has remained poorly explored. In this study, we examined the therapeutic utility of mRNA delivery for...

Increasing the diversity of your graduate program: Translating best practices into success.

Burt MA, Haacker R, Batchelor RL, Denning AS.
UIID-AD: 3597
2016;1169-1172. doi: 10.1175/BAMS-D-15-00004.1.

Despite awareness in the geosciences that our field has a substantial lack of diversity in our workforce and student body, and countless efforts to broaden participation, graduate enrollment in the atmospheric sciences by students who are from traditionally underrepresented...

Showing 157 to 168 of 168 entries