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Polypharmacy or medication washout: an old tool revisited.

Neuropsychiatric disease and treatment

Hoffman DA, Schiller M, Greenblatt JM, Iosifescu DV.
PMID: 22090799
Neuropsychiatr Dis Treat. 2011;7:639-48. doi: 10.2147/NDT.S24375. Epub 2011 Oct 20.

There has been a rapid increase in the use of polypharmacy in psychiatry possibly due to the introduction of newer drugs, greater availability of these newer drugs, excessive confidence in clinical trial results, widespread prescribing of psychotropic medications by...

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Hoffman DA, Schiller M, Greenblatt JM, et al. Polypharmacy or medication washout: an old tool revisited. Neuropsychiatr Dis Treat. 2011;7:639-48doi: 10.2147/NDT.S24375.
Hoffman, D. A., Schiller, M., Greenblatt, J. M., & Iosifescu, D. V. (2011). Polypharmacy or medication washout: an old tool revisited. Neuropsychiatric disease and treatment, 7639-48. https://doi.org/10.2147/NDT.S24375
Hoffman, Daniel A, et al. "Polypharmacy or medication washout: an old tool revisited." Neuropsychiatric disease and treatment vol. 7 (2011): 639-48. doi: https://doi.org/10.2147/NDT.S24375
Hoffman DA, Schiller M, Greenblatt JM, Iosifescu DV. Polypharmacy or medication washout: an old tool revisited. Neuropsychiatr Dis Treat. 2011;7:639-48. doi: 10.2147/NDT.S24375. Epub 2011 Oct 20. PMID: 22090799; PMCID: PMC3215520.
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Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model.

BioData mining

Tipton L, Cuenco KT, Huang L, Greenblatt RM, Kleerup E, Sciurba F, Duncan SR, Donahoe MP, Morris A, Ghedin E.
PMID: 29983746
BioData Min. 2018 Jun 15;11:12. doi: 10.1186/s13040-018-0173-9. eCollection 2018.

BACKGROUND: Human microbiome studies in clinical settings generally focus on distinguishing the microbiota in health from that in disease at a specific point in time. However, microbiome samples may be associated with disease severity or continuous clinical health indicators...

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Tipton L, Cuenco KT, Huang L, et al. Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min. 2018;11:12doi: 10.1186/s13040-018-0173-9.
Tipton, L., Cuenco, K. T., Huang, L., Greenblatt, R. M., Kleerup, E., Sciurba, F., Duncan, S. R., Donahoe, M. P., Morris, A., & Ghedin, E. (2018). Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData mining, 1112. https://doi.org/10.1186/s13040-018-0173-9
Tipton, Laura, et al. "Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model." BioData mining vol. 11 (2018): 12. doi: https://doi.org/10.1186/s13040-018-0173-9
Tipton L, Cuenco KT, Huang L, Greenblatt RM, Kleerup E, Sciurba F, Duncan SR, Donahoe MP, Morris A, Ghedin E. Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min. 2018 Jun 15;11:12. doi: 10.1186/s13040-018-0173-9. eCollection 2018. PMID: 29983746; PMCID: PMC6003033.
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Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease.

Vaccines

Klinger D, Hill BL, Barda N, Halperin E, Gofrit ON, Greenblatt CL, Rappoport N, Linial M, Bercovier H.
PMID: 34064775
Vaccines (Basel). 2021 May 11;9(5). doi: 10.3390/vaccines9050491.

Bacillus Calmette-Guerin (BCG) is a live attenuated form of

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Klinger D, Hill BL, Barda N, et al. Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease. Vaccines (Basel). 2021;9(5)doi: 10.3390/vaccines9050491.
Klinger, D., Hill, B. L., Barda, N., Halperin, E., Gofrit, O. N., Greenblatt, C. L., Rappoport, N., Linial, M., & Bercovier, H. (2021). Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease. Vaccines, 9(5), . https://doi.org/10.3390/vaccines9050491
Klinger, Danielle, et al. "Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease." Vaccines vol. 9,5 (2021). doi: https://doi.org/10.3390/vaccines9050491
Klinger D, Hill BL, Barda N, Halperin E, Gofrit ON, Greenblatt CL, Rappoport N, Linial M, Bercovier H. Bladder Cancer Immunotherapy by BCG Is Associated with a Significantly Reduced Risk of Alzheimer's Disease and Parkinson's Disease. Vaccines (Basel). 2021 May 11;9(5). doi: 10.3390/vaccines9050491. PMID: 34064775; PMCID: PMC8151667.
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A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost.

American journal of clinical pathology

Lucas F, Mata DA, Greenblatt MB, Means J, Jarolim P.
PMID: 34932068
Am J Clin Pathol. 2021 Dec 21; doi: 10.1093/ajcp/aqab194. Epub 2021 Dec 21.

OBJECTIVES: Poor phlebotomy technique can introduce pseudohyperkalemia without hemolysis, requiring additional workup and placing a significant burden on patients, clinical teams, and laboratories. Such preanalytical biases can be detected through systematic evaluation of potassium concentrations on a per-phlebotomist basis....

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Lucas F, Mata DA, Greenblatt MB, et al. A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost. Am J Clin Pathol. 2021;doi: 10.1093/ajcp/aqab194.
Lucas, F., Mata, D. A., Greenblatt, M. B., Means, J., & Jarolim, P. (2021). A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost. American journal of clinical pathology, . https://doi.org/10.1093/ajcp/aqab194
Lucas, Fabienne, et al. "A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost." American journal of clinical pathology vol. (2021). doi: https://doi.org/10.1093/ajcp/aqab194
Lucas F, Mata DA, Greenblatt MB, Means J, Jarolim P. A Potassium-Based Quality-of-Service Metric Reduces Phlebotomy Errors, Resulting in Improved Patient Safety and Decreased Cost. Am J Clin Pathol. 2021 Dec 21; doi: 10.1093/ajcp/aqab194. Epub 2021 Dec 21. PMID: 34932068.
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Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing.

Science advances

Sun J, Feng H, Xing W, Han Y, Suo J, Yallowitz AR, Qian N, Shi Y, Greenblatt MB, Zou W.
PMID: 33148658
Sci Adv. 2020 Nov 04;6(45). doi: 10.1126/sciadv.aaz1410. Print 2020 Nov.

Bone fracture is repaired predominantly through endochondral ossification. However, the regulation of endochondral ossification by key factors during fracture healing remains largely enigmatic. Here, we identify histone modification enzyme LSD1 as a critical factor regulating endochondral ossification during bone...

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Sun J, Feng H, Xing W, et al. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv. 2020;6(45)doi: 10.1126/sciadv.aaz1410.
Sun, J., Feng, H., Xing, W., Han, Y., Suo, J., Yallowitz, A. R., Qian, N., Shi, Y., Greenblatt, M. B., & Zou, W. (2020). Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Science advances, 6(45), . https://doi.org/10.1126/sciadv.aaz1410
Sun, Jun, et al. "Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing." Science advances vol. 6,45 (2020). doi: https://doi.org/10.1126/sciadv.aaz1410
Sun J, Feng H, Xing W, Han Y, Suo J, Yallowitz AR, Qian N, Shi Y, Greenblatt MB, Zou W. Histone demethylase LSD1 is critical for endochondral ossification during bone fracture healing. Sci Adv. 2020 Nov 04;6(45). doi: 10.1126/sciadv.aaz1410. Print 2020 Nov. PMID: 33148658; PMCID: PMC7673679.
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Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations.

Journal of clinical pharmacology

Elmokadem A, Bruno CD, Housand C, Jordie EB, Chow CR, Lesko LJ, Greenblatt DJ.
PMID: 34328221
J Clin Pharmacol. 2022 Jan;62(1):66-75. doi: 10.1002/jcph.1946. Epub 2021 Aug 26.

Brexpiprazole is an oral antipsychotic agent indicated for use in patients with schizophrenia, or as adjunctive treatment for major depressive disorder. As cytochrome P450 (CYP) 2D6 contributes significantly to brexpiprazole metabolism, there is a label-recommended 50% reduction in dose...

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Elmokadem A, Bruno CD, Housand C, et al. Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. J Clin Pharmacol. 2021;62(1):66-75doi: 10.1002/jcph.1946.
Elmokadem, A., Bruno, C. D., Housand, C., Jordie, E. B., Chow, C. R., Lesko, L. J., & Greenblatt, D. J. (2022). Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. Journal of clinical pharmacology, 62(1), 66-75. https://doi.org/10.1002/jcph.1946
Elmokadem, Ahmed, et al. "Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations." Journal of clinical pharmacology vol. 62,1 (2022): 66-75. doi: https://doi.org/10.1002/jcph.1946
Elmokadem A, Bruno CD, Housand C, Jordie EB, Chow CR, Lesko LJ, Greenblatt DJ. Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. J Clin Pharmacol. 2022 Jan;62(1):66-75. doi: 10.1002/jcph.1946. Epub 2021 Aug 26. PMID: 34328221.
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A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.

Nature chemical biology

Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M.
PMID: 34782742
Nat Chem Biol. 2021 Nov 15; doi: 10.1038/s41589-021-00898-0. Epub 2021 Nov 15.

Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methyltransferase domain, NSD2...

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Dilworth D, Hanley RP, Ferreira de Freitas R, et al. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2021;doi: 10.1038/s41589-021-00898-0.
Dilworth, D., Hanley, R. P., Ferreira de Freitas, R., Allali-Hassani, A., Zhou, M., Mehta, N., Marunde, M. R., Ackloo, S., Carvalho Machado, R. A., Khalili Yazdi, A., Owens, D. D. G., Vu, V., Nie, D. Y., Alqazzaz, M., Marcon, E., Li, F., Chau, I., Bolotokova, A., Qin, S., Lei, M., Liu, Y., Szewczyk, M. M., Dong, A., Kazemzadeh, S., Abramyan, T., Popova, I. K., Hall, N. W., Meiners, M. J., Cheek, M. A., Gibson, E., Kireev, D., Greenblatt, J. F., Keogh, M. C., Min, J., Brown, P. J., Vedadi, M., Arrowsmith, C. H., Barsyte-Lovejoy, D., James, L. I., & Schapira, M. (2021). A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology, . https://doi.org/10.1038/s41589-021-00898-0
Dilworth, David, et al. "A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization." Nature chemical biology vol. (2021). doi: https://doi.org/10.1038/s41589-021-00898-0
Dilworth D, Hanley RP, Ferreira de Freitas R, Allali-Hassani A, Zhou M, Mehta N, Marunde MR, Ackloo S, Carvalho Machado RA, Khalili Yazdi A, Owens DDG, Vu V, Nie DY, Alqazzaz M, Marcon E, Li F, Chau I, Bolotokova A, Qin S, Lei M, Liu Y, Szewczyk MM, Dong A, Kazemzadeh S, Abramyan T, Popova IK, Hall NW, Meiners MJ, Cheek MA, Gibson E, Kireev D, Greenblatt JF, Keogh MC, Min J, Brown PJ, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D, James LI, Schapira M. A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat Chem Biol. 2021 Nov 15; doi: 10.1038/s41589-021-00898-0. Epub 2021 Nov 15. PMID: 34782742.
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Crystal Structure, Electrical Transport, and Magnetic Properties of Niobium Monophosphide.

Inorganic chemistry

Xu J, Greenblatt M, Emge T, Höhn P, Hughbanks T, Tian Y.
PMID: 11666255
Inorg Chem. 1996 Feb 14;35(4):845-849. doi: 10.1021/ic950826f.

Large single crystals of NbP have been prepared. A single-crystal X-ray diffraction study shows that it crystallizes in tetragonal symmetry with space group I4(1)md (No. 109) and lattice parameters a = 3.3324(2) Å, c = 11.3705(7) Å, and Z...

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Xu J, Greenblatt M, Emge T, et al. Crystal Structure, Electrical Transport, and Magnetic Properties of Niobium Monophosphide. Inorg Chem. 1996;35(4):845-849doi: 10.1021/ic950826f.
Xu, J., Greenblatt, M., Emge, T., Höhn, P., Hughbanks, T., & Tian, Y. (1996). Crystal Structure, Electrical Transport, and Magnetic Properties of Niobium Monophosphide. Inorganic chemistry, 35(4), 845-849. https://doi.org/10.1021/ic950826f
Xu, J., et al. "Crystal Structure, Electrical Transport, and Magnetic Properties of Niobium Monophosphide." Inorganic chemistry vol. 35,4 (1996): 845-849. doi: https://doi.org/10.1021/ic950826f
Xu J, Greenblatt M, Emge T, Höhn P, Hughbanks T, Tian Y. Crystal Structure, Electrical Transport, and Magnetic Properties of Niobium Monophosphide. Inorg Chem. 1996 Feb 14;35(4):845-849. doi: 10.1021/ic950826f. PMID: 11666255.
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Electronic Band Structure and Madelung Potential Study of the Nickelates La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10).

Inorganic chemistry

Seo DK, Liang W, Whangbo MH, Zhang Z, Greenblatt M.
PMID: 11666785
Inorg Chem. 1996 Oct 23;35(22):6396-6400. doi: 10.1021/ic960379j.

Tight-binding electronic band structures and Madelung potentials were calculated for La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10) to examine why a metal-to-metal transition occurs in the nickelate Ln(4)Ni(3)O(10) (Ln = La, Nd, Pr). La(4)Ni(3)O(10) and La(3)Ni(2)O(7) are each found to have two...

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Seo DK, Liang W, Whangbo MH, et al. Electronic Band Structure and Madelung Potential Study of the Nickelates La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10). Inorg Chem. 1996;35(22):6396-6400doi: 10.1021/ic960379j.
Seo, D. K., Liang, W., Whangbo, M. H., Zhang, Z., & Greenblatt, M. (1996). Electronic Band Structure and Madelung Potential Study of the Nickelates La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10). Inorganic chemistry, 35(22), 6396-6400. https://doi.org/10.1021/ic960379j
Seo, D.-K., et al. "Electronic Band Structure and Madelung Potential Study of the Nickelates La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10)." Inorganic chemistry vol. 35,22 (1996): 6396-6400. doi: https://doi.org/10.1021/ic960379j
Seo DK, Liang W, Whangbo MH, Zhang Z, Greenblatt M. Electronic Band Structure and Madelung Potential Study of the Nickelates La(2)NiO(4), La(3)Ni(2)O(7), and La(4)Ni(3)O(10). Inorg Chem. 1996 Oct 23;35(22):6396-6400. doi: 10.1021/ic960379j. PMID: 11666785.
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Ovarian function after chemotherapy in young breast cancer survivors.

Current oncology (Toronto, Ont.)

Morarji K, McArdle O, Hui K, Gingras-Hill G, Ahmed S, Greenblatt EM, Warner E, Sridhar S, Ali AMF, Azad A, Hodgson DC.
PMID: 29270058
Curr Oncol. 2017 Dec;24(6):e494-e502. doi: 10.3747/co.24.3335. Epub 2017 Dec 20.

BACKGROUND: As cure rates for breast cancer improve, there is increasing evidence that late effects of treatment-and impaired fertility in particular-are emerging as important concerns among young breast cancer survivors. Older reports have evaluated the occurrence of amenorrhea after...

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Morarji K, McArdle O, Hui K, et al. Ovarian function after chemotherapy in young breast cancer survivors. Curr Oncol. 2017;24(6):e494-e502doi: 10.3747/co.24.3335.
Morarji, K., McArdle, O., Hui, K., Gingras-Hill, G., Ahmed, S., Greenblatt, E. M., Warner, E., Sridhar, S., Ali, A. M. F., Azad, A., & Hodgson, D. C. (2017). Ovarian function after chemotherapy in young breast cancer survivors. Current oncology (Toronto, Ont.), 24(6), e494-e502. https://doi.org/10.3747/co.24.3335
Morarji, K, et al. "Ovarian function after chemotherapy in young breast cancer survivors." Current oncology (Toronto, Ont.) vol. 24,6 (2017): e494-e502. doi: https://doi.org/10.3747/co.24.3335
Morarji K, McArdle O, Hui K, Gingras-Hill G, Ahmed S, Greenblatt EM, Warner E, Sridhar S, Ali AMF, Azad A, Hodgson DC. Ovarian function after chemotherapy in young breast cancer survivors. Curr Oncol. 2017 Dec;24(6):e494-e502. doi: 10.3747/co.24.3335. Epub 2017 Dec 20. PMID: 29270058; PMCID: PMC5736488.
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Osteoclasts are not a source of SLIT3.

Bone research

Li N, Inoue K, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B, Xu R, Greenblatt MB.
PMID: 32133214
Bone Res. 2020 Feb 19;8:11. doi: 10.1038/s41413-020-0086-3. eCollection 2020.

The axon guidance cue SLIT3 was identified as an osteoanabolic agent in two recent reports. However, these reports conflict in their nomination of osteoblasts versus osteoclasts as the key producers of skeletal SLIT3 and additionally offer conflicting data on...

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Li N, Inoue K, Sun J, et al. Osteoclasts are not a source of SLIT3. Bone Res. 2020;8:11doi: 10.1038/s41413-020-0086-3.
Li, N., Inoue, K., Sun, J., Niu, Y., Lalani, S., Yallowitz, A., Yang, X., Zhang, C., Shen, R., Zhao, B., Xu, R., & Greenblatt, M. B. (2020). Osteoclasts are not a source of SLIT3. Bone research, 811. https://doi.org/10.1038/s41413-020-0086-3
Li, Na, et al. "Osteoclasts are not a source of SLIT3." Bone research vol. 8 (2020): 11. doi: https://doi.org/10.1038/s41413-020-0086-3
Li N, Inoue K, Sun J, Niu Y, Lalani S, Yallowitz A, Yang X, Zhang C, Shen R, Zhao B, Xu R, Greenblatt MB. Osteoclasts are not a source of SLIT3. Bone Res. 2020 Feb 19;8:11. doi: 10.1038/s41413-020-0086-3. eCollection 2020. PMID: 32133214; PMCID: PMC7031526.
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Commentary.

Clinical chemistry

Greenblatt MB.
PMID: 29592906
Clin Chem. 2018 Apr;64(4):642-643. doi: 10.1373/clinchem.2017.280776.

No abstract available.

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Greenblatt MB. Commentary. Clin Chem. 2018;64(4):642-643doi: 10.1373/clinchem.2017.280776.
Greenblatt, M. B. (2018). Commentary. Clinical chemistry, 64(4), 642-643. https://doi.org/10.1373/clinchem.2017.280776
Greenblatt, Matthew B. "Commentary." Clinical chemistry vol. 64,4 (2018): 642-643. doi: https://doi.org/10.1373/clinchem.2017.280776
Greenblatt MB. Commentary. Clin Chem. 2018 Apr;64(4):642-643. doi: 10.1373/clinchem.2017.280776. PMID: 29592906.
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