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Showing 97 to 108 of 705 entries
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A novel homozygous synonymous variant further expands the phenotypic spectrum of POLR3A-related pathologies.

American journal of medical genetics. Part A

Lessel D, Rading K, Campbell SE, Thiele H, Altmüller J, Gordon LB, Kubisch C.
PMID: 34611991
Am J Med Genet A. 2022 Jan;188(1):216-223. doi: 10.1002/ajmg.a.62525. Epub 2021 Oct 05.

Pathogenic biallelic variants in POL3RA have been associated with different disorders characterized by progressive neurological deterioration. These include the 4H leukodystrophy syndrome (hypomyelination, hypogonadotropic hypogonadism, and hypodontia) and adolescent-onset progressive spastic ataxia, as well as Wiedemann-Rautenstrauch syndrome (WRS), a...

Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex.

Cell reports

Lau BK, Murphy-Royal C, Kaur M, Qiao M, Bains JS, Gordon GR, Borgland SL.
PMID: 34407401
Cell Rep. 2021 Aug 17;36(7):109563. doi: 10.1016/j.celrep.2021.109563.

Overconsumption of highly palatable, energy-dense food is considered a key driver of the obesity pandemic. The orbitofrontal cortex (OFC) is critical for reward valuation of gustatory signals, yet how the OFC adapts to obesogenic diets is poorly understood. Here,...

In Situ Tumor Vaccination with Nanoparticle Co-Delivering CpG and STAT3 siRNA to Effectively Induce Whole-Body Antitumor Immune Response.

Advanced materials (Deerfield Beach, Fla.)

Ngamcherdtrakul W, Reda M, Nelson MA, Wang R, Zaidan HY, Bejan DS, Hoang NH, Lane RS, Luoh SW, Leachman SA, Mills GB, Gray JW, Lund AW, Yantasee W.
PMID: 34118167
Adv Mater. 2021 Aug;33(31):e2100628. doi: 10.1002/adma.202100628. Epub 2021 Jun 12.

The success of immunotherapy with immune checkpoint inhibitors (ICIs) in a subset of individuals has been very exciting. However, in many cancers, responses to current ICIs are modest and are seen only in a small subsets of patients. Herein,...

Participants' experience of approach bias modification training with transcranial Direct Current Stimulation as a combination treatment for binge eating disorder.

European eating disorders review : the journal of the Eating Disorders Association

Gordon G, Williamson G, Gkofa V, Schmidt U, Brockmeyer T, Campbell I.
PMID: 34460140
Eur Eat Disord Rev. 2021 Nov;29(6):969-984. doi: 10.1002/erv.2859. Epub 2021 Aug 30.

OBJECTIVE: This study explored participants' experience of approach bias modification training (ABM) with transcranial Direct Current Stimulation (tDCS) for binge eating disorder (BED) within a randomised controlled trial (RCT). A subset of participants who completed the RCT were interviewed...

'Pain-free TRUS B': a phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography-guided prostate biopsy (ANZUP 1501).

BJU international

Hayne D, Grummet J, Espinoza D, McCombie SP, Chalasani V, Ford KS, Frydenberg M, Gilling P, Gordon B, Hawks C, Konstantatos A, Martin AJ, Nixon A, O'Brien C, Patel MI, Sengupta S, Shahbaz S, Subramaniam S, Williams S, Woo HH, Stockler MR, Davis ID, Buchan N.
PMID: 34273231
BJU Int. 2021 Jul 17; doi: 10.1111/bju.15552. Epub 2021 Jul 17.

OBJECTIVE: To determine whether the addition of inhaled methoxyflurane to periprostatic infiltration of local anaesthetic (PILA) during transrectal ultrasonography-guided prostate biopsies (TRUSBs) improved pain and other aspects of the experience.PATIENTS AND METHODS: We conducted a multicentre, placebo-controlled, double-blind, randomized...

Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex.

eLife

Mulholland HN, Hein B, Kaschube M, Smith GB.
PMID: 34878404
Elife. 2021 Dec 08;10. doi: 10.7554/eLife.72456.

Intracortical inhibition plays a critical role in shaping activity patterns in the mature cortex. However, little is known about the structure of inhibition in early development prior to the onset of sensory experience, a time when spontaneous activity exhibits...

Trajectories, risk factors, and impact of persistent pain after major musculoskeletal surgery in adolescents: a replication study.

The journal of pain

Ellyson AM, Gordon G, Zhou C, Rabbitts JA.
PMID: 34974171
J Pain. 2021 Dec 30; doi: 10.1016/j.jpain.2021.12.009. Epub 2021 Dec 30.

Studies have identified high rates of chronic postsurgical pain in adolescents. Characterizing patterns of pain in the transition from acute to chronic following major surgery may pinpoint critical periods of recovery. This observational study modelled pain trajectories over 1-year...

A conceptual model for changes in finger photoplethysmograph signals caused by hand posture and isothermic regulation.

Physiological measurement

Keogh C, Drummond GB, Bates A, Mann J, Arvind DK.
PMID: 34986476
Physiol Meas. 2022 Jan 05; doi: 10.1088/1361-6579/ac482e. Epub 2022 Jan 05.

OBJECTIVE: To observe changes in baseline and pulsatile light absorbance (photoplethysmograph, PPG) in the finger-tip, by raising the hand above the horizontal plane in recumbent subjects. We applied current knowledge of the circulation to the finger-tip, particularly arteriovenous anastomoses...

Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II.

Molecular cancer research : MCR

Kalli M, Li R, Mills GB, Stylianopoulos T, Zervantonakis IK.
PMID: 34782370
Mol Cancer Res. 2021 Nov 15; doi: 10.1158/1541-7786.MCR-21-0266. Epub 2021 Nov 15.

Advanced or metastatic pancreatic cancer is highly resistant to existing therapies, and new treatments are urgently needed to improve patient outcomes. Current studies focus on alternative treatment approaches that target the abnormal microenvironment of pancreatic tumors and the resulting...

Noninvasive Diagnostic Modalities in an Isolated Case of Cardiac Amyloidosis.

Cureus

Lewars J, Wazir H, Gordon B, Faluyi U, Girgis Y.
PMID: 34040908
Cureus. 2021 Apr 21;13(4):e14608. doi: 10.7759/cureus.14608.

Amyloidoses are a family of inherited or acquired disorders characterized by the deposition of insoluble extracellular protein fibrils in various organs and tissues, thereby impairing their function. Amyloidoses are typically misfolded proteins, and on rare occasions, can deposit in...

Five-year maintenance of clinical response and health-related quality of life improvements in patients with moderate-to-severe psoriasis treated with guselkumab: results from VOYAGE 1 and VOYAGE 2.

The British journal of dermatology

Reich K, Gordon KB, Strober BE, Armstrong AW, Miller M, Shen YK, You Y, Han C, Yang YW, Foley P, Griffiths CEM.
PMID: 34105767
Br J Dermatol. 2021 Jun 09; doi: 10.1111/bjd.20568. Epub 2021 Jun 09.

BACKGROUND: Psoriasis is a chronic disease requiring long-term therapy.OBJECTIVES: Physician- and patient-reported outcomes were evaluated through week 252 in VOYAGE 1 and VOYAGE 2.METHODS: In total, 1829 patients were randomized at baseline to receive guselkumab 100 mg every 8...

Current use of inotropes in circulatory shock.

Annals of intensive care

Scheeren TWL, Bakker J, Kaufmann T, Annane D, Asfar P, Boerma EC, Cecconi M, Chew MS, Cholley B, Cronhjort M, De Backer D, Dubin A, Dünser MW, Duranteau J, Gordon AC, Hajjar LA, Hamzaoui O, Hernandez G, Kanoore Edul V, Koster G, Landoni G, Leone M, Levy B, Martin C, Mebazaa A, Monnet X, Morelli A, Payen D, Pearse RM, Pinsky MR, Radermacher P, Reuter DA, Sakr Y, Sander M, Saugel B, Singer M, Squara P, Vieillard-Baron A, Vignon P, Vincent JL, van der Horst ICC, Vistisen ST, Teboul JL.
PMID: 33512597
Ann Intensive Care. 2021 Jan 29;11(1):21. doi: 10.1186/s13613-021-00806-8.

BACKGROUND: Treatment decisions on critically ill patients with circulatory shock lack consensus. In an international survey, we aimed to evaluate the indications, current practice, and therapeutic goals of inotrope therapy in the treatment of patients with circulatory shock.METHODS: From...

Showing 97 to 108 of 705 entries