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Showing 109 to 120 of 705 entries
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Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.

JCI insight

Carniel BF, Marcon F, Rylance J, German EL, Zaidi S, Reiné J, Negera E, Nikolaou E, Pojar S, Solórzano C, Collins AM, Connor V, Bogaert D, Gordon SB, Nakaya HI, Ferreira DM, Jochems SP, Mitsi E.
PMID: 33497364
JCI Insight. 2021 Feb 22;6(4). doi: 10.1172/jci.insight.141088.

Influenza virus infections affect millions of people annually, and current available vaccines provide varying rates of protection. However, the way in which the nasal microbiota, particularly established pneumococcal colonization, shape the response to influenza vaccination is not yet fully...

Five-year maintenance of clinical response and health-related quality of life improvements in patients with moderate-to-severe psoriasis treated with guselkumab: results from VOYAGE 1 and VOYAGE 2.

The British journal of dermatology

Reich K, Gordon KB, Strober BE, Armstrong AW, Miller M, Shen YK, You Y, Han C, Yang YW, Foley P, Griffiths CEM.
PMID: 34105767
Br J Dermatol. 2021 Dec;185(6):1146-1159. doi: 10.1111/bjd.20568. Epub 2021 Sep 08.

BACKGROUND: Psoriasis is a chronic disease requiring long-term therapy.OBJECTIVES: Physician- and patient-reported outcomes were evaluated through week 252 in VOYAGE 1 and VOYAGE 2.METHODS: In total, 1829 patients were randomized at baseline to receive guselkumab 100 mg every 8...

Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination.

Gut

Sundar R, Liu DH, Hutchins GG, Slaney HL, Silva AN, Oosting J, Hayden JD, Hewitt LC, Ng CC, Mangalvedhekar A, Ng SB, Tan IB, Tan P, Grabsch HI.
PMID: 33229445
Gut. 2021 Oct;70(10):1823-1832. doi: 10.1136/gutjnl-2020-320805. Epub 2020 Nov 23.

OBJECTIVE: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis...

Cartilage Tissue Engineering Using Stem Cells and Bioprinting Technology-Barriers to Clinical Translation.

Frontiers in surgery

Francis SL, Di Bella C, Wallace GG, Choong PFM.
PMID: 30547034
Front Surg. 2018 Nov 27;5:70. doi: 10.3389/fsurg.2018.00070. eCollection 2018.

There is no long-term treatment strategy for young and active patients with cartilage defects. Early and effective joint preserving treatments in these patients are crucial in preventing the development of osteoarthritis. Tissue engineering over the past few decades has...

Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking.

Journal of Cancer

Fan XJ, Huang Y, Wu PH, Yin XK, Yu XH, Fu XH, Feng LL, Wang YL, Yi HJ, Chen ZT, Yin JX, Zhang DL, Feng WX, Bai SM, Kim T, Mills GB, Lu YL, Wan XB, Wang L.
PMID: 31598170
J Cancer. 2019 Aug 27;10(20):4978-4988. doi: 10.7150/jca.29372. eCollection 2019.

Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and...

Current clinical methods of measurement of respiratory rate give imprecise values.

ERJ open research

Drummond GB, Fischer D, Arvind DK.
PMID: 33015146
ERJ Open Res. 2020 Sep 28;6(3). doi: 10.1183/23120541.00023-2020. eCollection 2020 Jul.

BACKGROUND: Respiratory rate is a basic clinical measurement used for illness assessment. Errors in measuring respiratory rate are attributed to observer and equipment problems. Previous studies commonly report rate differences ranging from 2 to 6 breaths·minMETHODS: To study why...

Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response.

Science advances

Vinik Y, Ortega FG, Mills GB, Lu Y, Jurkowicz M, Halperin S, Aharoni M, Gutman M, Lev S.
PMID: 33008904
Sci Adv. 2020 Oct 02;6(40). doi: 10.1126/sciadv.aba5714. Print 2020 Oct.

Proteomic profiling of circulating small extracellular vesicles (sEVs) represents a promising, noninvasive approach for early detection and therapeutic monitoring of breast cancer (BC). We describe a relatively low-cost, fast, and reliable method to isolate sEVs from plasma of BC...

The Relevance of Ecological Transitions to Intelligence in Marine Mammals.

Frontiers in psychology

Bauer GB, Cook PF, Harley HE.
PMID: 33013519
Front Psychol. 2020 Sep 08;11:2053. doi: 10.3389/fpsyg.2020.02053. eCollection 2020.

Macphail's comparative approach to intelligence focused on associative processes, an orientation inconsistent with more multifaceted lay and scientific understandings of the term. His ultimate emphasis on associative processes indicated few differences in intelligence among vertebrates. We explore options more...

Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1.

NPJ breast cancer

Bollu LR, Shepherd J, Zhao D, Ma Y, Tahaney W, Speers C, Mazumdar A, Mills GB, Brown PH.
PMID: 31909186
NPJ Breast Cancer. 2020 Jan 03;6:2. doi: 10.1038/s41523-019-0143-5. eCollection 2020.

Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer, and is associated with a poor prognosis due to frequent distant metastasis and lack of effective targeted therapies. Previously, we identified maternal embryonic leucine zipper kinase (MELK)...

Discrepancies Exist between Exercise Prescription and Dose in Elite Women's Basketball Pre-Season.

Sports (Basel, Switzerland)

Staunton C, Wundersitz D, Gordon B, Kingsley M.
PMID: 32438734
Sports (Basel). 2020 May 19;8(5). doi: 10.3390/sports8050070.

This study assessed the influence of exercise prescription on the objectively measured exercise dose in basketball. Intensity (RPE) and volume (sRPE) were prescribed by a professional coach on a drill-by-drill basis during pre-season training for nine elite basketball players....

Letter to the Editor: Response to Luke Fletcher and Philip Peyton regarding "Predictive validity of a novel non-invasive estimation of effective shunt fraction in critically ill patients".

Intensive care medicine experimental

Chang EM, Bretherick A, Drummond GB, Baillie JK.
PMID: 33001347
Intensive Care Med Exp. 2020 Oct 01;8(1):57. doi: 10.1186/s40635-020-00342-y.

No abstract available.

High SARS-CoV-2 seroprevalence in health care workers but relatively low numbers of deaths in urban Malawi.

medRxiv : the preprint server for health sciences

Chibwana MG, Jere KC, Kamn'gona R, Mandolo J, Katunga-Phiri V, Tembo D, Mitole N, Musasa S, Sichone S, Lakudzala A, Sibale L, Matambo P, Kadwala I, Byrne RL, Mbewe A, Henrion MYR, Morton B, Phiri C, Mallewa J, Mwandumba HC, Adams ER, Gordon SB, Jambo KC.
PMID: 32766597
medRxiv. 2020 Aug 05; doi: 10.1101/2020.07.30.20164970.

BACKGROUND: In low-income countries, like Malawi, important public health measures including social distancing or a lockdown have been challenging to implement owing to socioeconomic constraints, leading to predictions that the COVID-19 pandemic would progress rapidly. However, due to limited...

Showing 109 to 120 of 705 entries