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Showing 241 to 249 of 249 entries
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Systematic Review and Meta-analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder.

Journal of the American Academy of Child and Adolescent Psychiatry

Farhat LC, Vattimo EFQ, Ramakrishnan D, Levine JLS, Johnson JA, Artukoglu BB, Landeros-Weisenberger A, Asbahr FR, Cepeda SL, Comer JS, Fatori D, Franklin ME, Freeman JB, Geller DA, Grant PJ, Goodman WK, Heyman I, Ivarsson T, Lenhard F, Lewin AB, Li F, Merlo LJ, Mohsenabadi H, Peris TS, Piacentini J, Rosa-Alcázar AI, Rosa-Alcázar À, Rozenman M, Sapyta JJ, Serlachius E, Shabani MJ, Shavitt RG, Small BJ, Skarphedinsson G, Swedo SE, Thomsen PH, Turner C, Weidle B, Miguel EC, Storch EA, Mataix-Cols D, Bloch MH.
PMID: 34597773
J Am Acad Child Adolesc Psychiatry. 2021 Sep 28; doi: 10.1016/j.jaac.2021.05.027. Epub 2021 Sep 28.

OBJECTIVE: A lack of universal definitions for response and remission in pediatric obsessive-compulsive disorder (OCD) has hampered the comparability of results across trials. To address this problem, we conducted an individual participant data diagnostic test accuracy meta-analysis to evaluate...

Exercise Training Decreases Hepatic Injury and Metastases Through Changes in Immune Response to Liver Ischemia/Reperfusion in Mice.

Hepatology (Baltimore, Md.)

Yazdani HO, Kaltenmeier C, Morder K, Moon J, Traczek M, Loughran P, Zamora R, Vodovotz Y, Li F, Wang JH, Geller DA, Simmons RL, Tohme S.
PMID: 32924145
Hepatology. 2021 Jun;73(6):2494-2509. doi: 10.1002/hep.31552. Epub 2021 Mar 16.

BACKGROUND AND AIMS: Liver ischemia/reperfusion injury (IRI) induces local and systemic inflammation in which neutrophil extracellular traps (NETs) are major drivers. IRI markedly augments metastatic growth, which is consistent with the notion that the liver IRI can serve as...

Dual blockage of PD-L/PD-1 and IL33/ST2 axes slows tumor growth and improves antitumor immunity by boosting NK cells.

Life sciences

Jovanovic MZ, Geller DA, Gajovic NM, Jurisevic MM, Arsenijevic NN, Jovanovic MM, Supic GM, Vojvodic DV, Jovanovic IP.
PMID: 34890591
Life Sci. 2021 Dec 07;120214. doi: 10.1016/j.lfs.2021.120214. Epub 2021 Dec 07.

AIMS: Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.MAIN METHODS: 4T1 breast cancer and CT26 colon cancer were inducted in...

Does one's geographic location influence their use of sun protection? A survey of 3,185 U.S. Residents.

Preventive medicine reports

Bolick NL, Huang L, Geller AC.
PMID: 33318888
Prev Med Rep. 2020 Nov 28;20:101265. doi: 10.1016/j.pmedr.2020.101265. eCollection 2020 Dec.

To determine if geographical differences exist in practice of sun protective behaviors across the United States, we performed a retrospective, cross-sectional analysis of data from the Health Information National Trends Survey 4 Cycle 3. Self-reported sun protective behaviors and...

Dual blockage of PD-L/PD-1 and IL33/ST2 axes slows tumor growth and improves antitumor immunity by boosting NK cells.

Life sciences

Jovanovic MZ, Geller DA, Gajovic NM, Jurisevic MM, Arsenijevic NN, Jovanovic MM, Supic GM, Vojvodic DV, Jovanovic IP.
PMID: 34890591
Life Sci. 2021 Dec 07;289:120214. doi: 10.1016/j.lfs.2021.120214. Epub 2021 Dec 07.

AIMS: Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet.MAIN METHODS: 4T1 breast cancer and CT26 colon cancer were inducted in...

Active nematic order and dynamic lane formation of microtubules driven by membrane-bound diffusing motors.

Proceedings of the National Academy of Sciences of the United States of America

Memarian FL, Lopes JD, Schwarzendahl FJ, Athani MG, Sarpangala N, Gopinathan A, Beller DA, Dasbiswas K, Hirst LS.
PMID: 34934005
Proc Natl Acad Sci U S A. 2021 Dec 28;118(52). doi: 10.1073/pnas.2117107118.

Dynamic lane formation and long-range active nematic alignment are reported using a geometry in which kinesin motors are directly coupled to a lipid bilayer, allowing for in-plane motor diffusion during microtubule gliding. We use fluorescence microscopy to image protein...

Interferon regulatory factor 1 (IRF-1) downregulates Checkpoint kinase 1 (CHK1) through miR-195 to upregulate apoptosis and PD-L1 expression in Hepatocellular carcinoma (HCC) cells.

British journal of cancer

Yan Y, Zheng L, Du Q, Cui X, Dong K, Guo Y, Geller DA.
PMID: 33772151
Br J Cancer. 2021 Jul;125(1):101-111. doi: 10.1038/s41416-021-01337-6. Epub 2021 Mar 26.

BACKGROUND: CHK1 is considered an oncogene with overexpression in numerous cancers. However, CHK1 signalling regulation in hepatocellular carcinoma (HCC) remains unclear.METHODS: CHEK1 mRNA, protein, pri-miR-195 and miR-195 expression in HCC tissue was determined by qPCR, WB and IF staining...

Teaching Medical Students to Help Patients Manage Their Weight: Outcomes of an Eight-School Randomized Controlled Trial.

Journal of general internal medicine

Ockene JK, Pbert L, Crawford S, Frisard CF, Pendharkar JA, Sadasivam RS, Faro J, Okuliar C, Eno C, Margo K, Shaw MA, Soleymani T, Stadler DD, Warrier S, White K, Geller AC.
PMID: 33835315
J Gen Intern Med. 2021 Oct;36(10):3000-3007. doi: 10.1007/s11606-020-06571-x. Epub 2021 Apr 09.

BACKGROUND: Given the rising rates of obesity there is a pressing need for medical schools to better prepare students for intervening with patients who have overweight or obesity and for prevention efforts.OBJECTIVE: To assess the effect of a multi-modal...

Women's Health and Women's Leadership in Academic Medicine: Hitting the Same Glass Ceiling?.

Carnes M, Morrissey C, Geller SE.
UIID-AD: 1278
2008;17:1453-1462. doi: 10.1089/jwh.2007.0688.

The term "glass ceiling" refers to women's lack of advancement into leadership positions despite no visible barriers. The term has been applied to academic medicine for over a decade but has not previously been applied to the advancement of...

Showing 241 to 249 of 249 entries