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Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates.

Journal of the National Cancer Institute

Ugai T, Väyrynen JP, Haruki K, Akimoto N, Lau MC, Zhong R, Kishikawa J, Väyrynen SA, Zhao M, Fujiyoshi K, Dias Costa A, Borowsky J, Arima K, Guerriero JL, Fuchs CS, Zhang X, Song M, Wang M, Giannakis M, Meyerhardt JA, Nowak JA, Ogino S.
PMID: 34264325
J Natl Cancer Inst. 2022 Jan 11;114(1):68-77. doi: 10.1093/jnci/djab142.

BACKGROUND: Biological evidence indicates that smoking can influence macrophage functions and polarization, thereby promoting tumor evolution. We hypothesized that the association of smoking with colorectal cancer incidence might differ by macrophage infiltrates.METHODS: Using the Nurses' Health Study and the...

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Ugai T, Väyrynen JP, Haruki K, et al. Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates. J Natl Cancer Inst. 2022;114(1):68-77doi: 10.1093/jnci/djab142.
Ugai, T., Väyrynen, J. P., Haruki, K., Akimoto, N., Lau, M. C., Zhong, R., Kishikawa, J., Väyrynen, S. A., Zhao, M., Fujiyoshi, K., Dias Costa, A., Borowsky, J., Arima, K., Guerriero, J. L., Fuchs, C. S., Zhang, X., Song, M., Wang, M., Giannakis, M., Meyerhardt, J. A., Nowak, J. A., & Ogino, S. (2022). Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates. Journal of the National Cancer Institute, 114(1), 68-77. https://doi.org/10.1093/jnci/djab142
Ugai, Tomotaka, et al. "Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates." Journal of the National Cancer Institute vol. 114,1 (2022): 68-77. doi: https://doi.org/10.1093/jnci/djab142
Ugai T, Väyrynen JP, Haruki K, Akimoto N, Lau MC, Zhong R, Kishikawa J, Väyrynen SA, Zhao M, Fujiyoshi K, Dias Costa A, Borowsky J, Arima K, Guerriero JL, Fuchs CS, Zhang X, Song M, Wang M, Giannakis M, Meyerhardt JA, Nowak JA, Ogino S. Smoking and Incidence of Colorectal Cancer Subclassified by Tumor-Associated Macrophage Infiltrates. J Natl Cancer Inst. 2022 Jan 11;114(1):68-77. doi: 10.1093/jnci/djab142. PMID: 34264325.
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Umbilical Cord Blood or HLA-Haploidentical Transplantation: Real-World Outcomes versus Randomized Trial Outcomes.

Transplantation and cellular therapy

O'Donnell PV, Brunstein CG, Fuchs EJ, Zhang MJ, Allbee-Johnson M, Antin JH, Leifer ES, Elmariah H, Grunwald MR, Hashmi H, Horowitz MM, Magenau JM, Majhail N, Milano F, Morris LE, Rezvani AR, McGuirk JP, Jones RJ, Eapen M.
PMID: 34775146
Transplant Cell Ther. 2021 Nov 11; doi: 10.1016/j.jtct.2021.11.002. Epub 2021 Nov 11.

Randomized clinical trials offer the highest-quality data for modifying clinical practice. Results of a phase III randomized trial of nonmyeloablative transplantation for adults with high-risk hematologic malignancies with 2 umbilical cord blood (UCB) units (n = 183) or HLA-haploidentical...

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O'Donnell PV, Brunstein CG, Fuchs EJ, et al. Umbilical Cord Blood or HLA-Haploidentical Transplantation: Real-World Outcomes versus Randomized Trial Outcomes. Transplant Cell Ther. 2021;doi: 10.1016/j.jtct.2021.11.002.
O'Donnell, P. V., Brunstein, C. G., Fuchs, E. J., Zhang, M. J., Allbee-Johnson, M., Antin, J. H., Leifer, E. S., Elmariah, H., Grunwald, M. R., Hashmi, H., Horowitz, M. M., Magenau, J. M., Majhail, N., Milano, F., Morris, L. E., Rezvani, A. R., McGuirk, J. P., Jones, R. J., & Eapen, M. (2021). Umbilical Cord Blood or HLA-Haploidentical Transplantation: Real-World Outcomes versus Randomized Trial Outcomes. Transplantation and cellular therapy, . https://doi.org/10.1016/j.jtct.2021.11.002
O'Donnell, Paul V, et al. "Umbilical Cord Blood or HLA-Haploidentical Transplantation: Real-World Outcomes versus Randomized Trial Outcomes." Transplantation and cellular therapy vol. (2021). doi: https://doi.org/10.1016/j.jtct.2021.11.002
O'Donnell PV, Brunstein CG, Fuchs EJ, Zhang MJ, Allbee-Johnson M, Antin JH, Leifer ES, Elmariah H, Grunwald MR, Hashmi H, Horowitz MM, Magenau JM, Majhail N, Milano F, Morris LE, Rezvani AR, McGuirk JP, Jones RJ, Eapen M. Umbilical Cord Blood or HLA-Haploidentical Transplantation: Real-World Outcomes versus Randomized Trial Outcomes. Transplant Cell Ther. 2021 Nov 11; doi: 10.1016/j.jtct.2021.11.002. Epub 2021 Nov 11. PMID: 34775146.
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Development, Validation, and Reproducibility of Food Group-Based Frequency Questionnaires for Clinical Use in Brazil: A Pre-Hypertension and Hypertension Diet Assessment.

Nutrients

Rossato SL, Mosele F, Moreira LB, Rodrigues MP, Lima RF, Fuchs FD, Fuchs SC.
PMID: 34836136
Nutrients. 2021 Oct 29;13(11). doi: 10.3390/nu13113881.

The Blood pressure control diet is well described; however, it has not been implemented in clinical care, possibly due to the impracticability of the diet assessment in these contexts. In order to facilitate the dietary assessment, we developed and...

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Rossato SL, Mosele F, Moreira LB, et al. Development, Validation, and Reproducibility of Food Group-Based Frequency Questionnaires for Clinical Use in Brazil: A Pre-Hypertension and Hypertension Diet Assessment. Nutrients. 2021;13(11)doi: 10.3390/nu13113881.
Rossato, S. L., Mosele, F., Moreira, L. B., Rodrigues, M. P., Lima, R. F., Fuchs, F. D., & Fuchs, S. C. (2021). Development, Validation, and Reproducibility of Food Group-Based Frequency Questionnaires for Clinical Use in Brazil: A Pre-Hypertension and Hypertension Diet Assessment. Nutrients, 13(11), . https://doi.org/10.3390/nu13113881
Rossato, Sinara L, et al. "Development, Validation, and Reproducibility of Food Group-Based Frequency Questionnaires for Clinical Use in Brazil: A Pre-Hypertension and Hypertension Diet Assessment." Nutrients vol. 13,11 (2021). doi: https://doi.org/10.3390/nu13113881
Rossato SL, Mosele F, Moreira LB, Rodrigues MP, Lima RF, Fuchs FD, Fuchs SC. Development, Validation, and Reproducibility of Food Group-Based Frequency Questionnaires for Clinical Use in Brazil: A Pre-Hypertension and Hypertension Diet Assessment. Nutrients. 2021 Oct 29;13(11). doi: 10.3390/nu13113881. PMID: 34836136; PMCID: PMC8622104.
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Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Väyrynen SA, Zhang J, Yuan C, Väyrynen JP, Dias Costa A, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais L, Reilly E, Rahma O, Clancy T, Wang J, Linehan DC, Aguirre AJ, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM.
PMID: 33262135
Clin Cancer Res. 2021 Feb 15;27(4):1069-1081. doi: 10.1158/1078-0432.CCR-20-3141. Epub 2020 Dec 01.

PURPOSE: Although abundant myeloid cell populations in the pancreatic ductal adenocarcinoma (PDAC) microenvironment have been postulated to suppress antitumor immunity, the composition of these populations, their spatial locations, and how they relate to patient outcomes are poorly understood.EXPERIMENTAL DESIGN:...

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Väyrynen SA, Zhang J, Yuan C, et al. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2020;27(4):1069-1081doi: 10.1158/1078-0432.CCR-20-3141.
Väyrynen, S. A., Zhang, J., Yuan, C., Väyrynen, J. P., Dias Costa, A., Williams, H., Morales-Oyarvide, V., Lau, M. C., Rubinson, D. A., Dunne, R. F., Kozak, M. M., Wang, W., Agostini-Vulaj, D., Drage, M. G., Brais, L., Reilly, E., Rahma, O., Clancy, T., Wang, J., Linehan, D. C., Aguirre, A. J., Fuchs, C. S., Coussens, L. M., Chang, D. T., Koong, A. C., Hezel, A. F., Ogino, S., Nowak, J. A., & Wolpin, B. M. (2021). Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(4), 1069-1081. https://doi.org/10.1158/1078-0432.CCR-20-3141
Väyrynen, Sara A, et al. "Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,4 (2021): 1069-1081. doi: https://doi.org/10.1158/1078-0432.CCR-20-3141
Väyrynen SA, Zhang J, Yuan C, Väyrynen JP, Dias Costa A, Williams H, Morales-Oyarvide V, Lau MC, Rubinson DA, Dunne RF, Kozak MM, Wang W, Agostini-Vulaj D, Drage MG, Brais L, Reilly E, Rahma O, Clancy T, Wang J, Linehan DC, Aguirre AJ, Fuchs CS, Coussens LM, Chang DT, Koong AC, Hezel AF, Ogino S, Nowak JA, Wolpin BM. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Clin Cancer Res. 2021 Feb 15;27(4):1069-1081. doi: 10.1158/1078-0432.CCR-20-3141. Epub 2020 Dec 01. PMID: 33262135; PMCID: PMC8345232.
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KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma.

Future oncology (London, England)

Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK.
PMID: 33975465
Future Oncol. 2021 Aug;17(22):2847-2855. doi: 10.2217/fon-2021-0176. Epub 2021 May 12.

Current guidelines recommend two-drug cytotoxic chemotherapy with a fluoropyrimidine (fluorouracil or capecitabine) and a platinum-based agent (oxaliplatin or cisplatin) as first-line treatment for advanced gastric cancer. Pembrolizumab monotherapy has demonstrated durable antitumor activity in patients with advanced programmed death...

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Tabernero J, Bang YJ, Van Cutsem E, et al. KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma. Future Oncol. 2021;17(22):2847-2855doi: 10.2217/fon-2021-0176.
Tabernero, J., Bang, Y. J., Van Cutsem, E., Fuchs, C. S., Janjigian, Y. Y., Bhagia, P., Li, K., Adelberg, D., & Qin, S. K. (2021). KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma. Future oncology (London, England), 17(22), 2847-2855. https://doi.org/10.2217/fon-2021-0176
Tabernero, Josep, et al. "KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma." Future oncology (London, England) vol. 17,22 (2021): 2847-2855. doi: https://doi.org/10.2217/fon-2021-0176
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK. KEYNOTE-859: a Phase III study of pembrolizumab plus chemotherapy in gastric/gastroesophageal junction adenocarcinoma. Future Oncol. 2021 Aug;17(22):2847-2855. doi: 10.2217/fon-2021-0176. Epub 2021 May 12. PMID: 33975465.
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Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer.

Cancer immunology, immunotherapy : CII

Ugai T, Väyrynen JP, Lau MC, Borowsky J, Akimoto N, Väyrynen SA, Zhao M, Zhong R, Haruki K, Dias Costa A, Fujiyoshi K, Arima K, Wu K, Chan AT, Cao Y, Song M, Fuchs CS, Wang M, Lennerz JK, Ng K, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S.
PMID: 34529108
Cancer Immunol Immunother. 2021 Sep 16; doi: 10.1007/s00262-021-03056-6. Epub 2021 Sep 16.

BACKGROUND: Despite heightened interest in early-onset colorectal cancer (CRC) diagnosed before age 50, little is known on immune cell profiles of early-onset CRC. It also remains to be studied whether CRCs diagnosed at or shortly after age 50 are...

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Ugai T, Väyrynen JP, Lau MC, et al. Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer Immunol Immunother. 2021;doi: 10.1007/s00262-021-03056-6.
Ugai, T., Väyrynen, J. P., Lau, M. C., Borowsky, J., Akimoto, N., Väyrynen, S. A., Zhao, M., Zhong, R., Haruki, K., Dias Costa, A., Fujiyoshi, K., Arima, K., Wu, K., Chan, A. T., Cao, Y., Song, M., Fuchs, C. S., Wang, M., Lennerz, J. K., Ng, K., Meyerhardt, J. A., Giannakis, M., Nowak, J. A., & Ogino, S. (2021). Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer immunology, immunotherapy : CII, . https://doi.org/10.1007/s00262-021-03056-6
Ugai, Tomotaka, et al. "Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer." Cancer immunology, immunotherapy : CII vol. (2021). doi: https://doi.org/10.1007/s00262-021-03056-6
Ugai T, Väyrynen JP, Lau MC, Borowsky J, Akimoto N, Väyrynen SA, Zhao M, Zhong R, Haruki K, Dias Costa A, Fujiyoshi K, Arima K, Wu K, Chan AT, Cao Y, Song M, Fuchs CS, Wang M, Lennerz JK, Ng K, Meyerhardt JA, Giannakis M, Nowak JA, Ogino S. Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer. Cancer Immunol Immunother. 2021 Sep 16; doi: 10.1007/s00262-021-03056-6. Epub 2021 Sep 16. PMID: 34529108.
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Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury.

The Journal of infectious diseases

Jiang W, Luo Z, Stephenson S, Li H, Di Germanio C, Norris PJ, Fuchs D, Zetterberg H, Gisslen M, Price RW.
PMID: 33320240
J Infect Dis. 2021 May 20;223(9):1612-1620. doi: 10.1093/infdis/jiaa765.

Human immunodeficiency virus (HIV) infection is associated with increased systemic microbial translocation, neuroinflammation, and occasionally, neuronal injury. Whether systemic lipopolysaccharide (LPS) penetrates into the brain and contributes to neuroinflammation remain unknown in HIV. Here, we measured plasma and cerebrospinal...

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Jiang W, Luo Z, Stephenson S, et al. Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury. J Infect Dis. 2021;223(9):1612-1620doi: 10.1093/infdis/jiaa765.
Jiang, W., Luo, Z., Stephenson, S., Li, H., Di Germanio, C., Norris, P. J., Fuchs, D., Zetterberg, H., Gisslen, M., & Price, R. W. (2021). Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury. The Journal of infectious diseases, 223(9), 1612-1620. https://doi.org/10.1093/infdis/jiaa765
Jiang, Wei, et al. "Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury." The Journal of infectious diseases vol. 223,9 (2021): 1612-1620. doi: https://doi.org/10.1093/infdis/jiaa765
Jiang W, Luo Z, Stephenson S, Li H, Di Germanio C, Norris PJ, Fuchs D, Zetterberg H, Gisslen M, Price RW. Cerebrospinal Fluid and Plasma Lipopolysaccharide Levels in Human Immunodeficiency Virus Type 1 Infection and Associations With Inflammation, Blood-Brain Barrier Permeability, and Neuronal Injury. J Infect Dis. 2021 May 20;223(9):1612-1620. doi: 10.1093/infdis/jiaa765. PMID: 33320240; PMCID: PMC8136977.
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Taphonomic patterns mimic biologic structures: diagenetic Liesegang rings in Mesozoic coleoids and coprolites.

PeerJ

Klug C, Di Silvestro G, Hoffmann R, Schweigert G, Fuchs D, Clements T, Gueriau P.
PMID: 33520466
PeerJ. 2021 Jan 14;9:e10703. doi: 10.7717/peerj.10703. eCollection 2021.

Because of physiology of coleoids, their fossils preserve soft-tissue-remains more often than other cephalopods. Sometimes, the phosphatized soft-tissues, particularly parts of the muscular mantle, display dark circular patterns. Here, we showcase that these patterns, here documented for fossil coleoids...

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Klug C, Di Silvestro G, Hoffmann R, et al. Taphonomic patterns mimic biologic structures: diagenetic Liesegang rings in Mesozoic coleoids and coprolites. PeerJ. 2021;9:e10703doi: 10.7717/peerj.10703.
Klug, C., Di Silvestro, G., Hoffmann, R., Schweigert, G., Fuchs, D., Clements, T., & Gueriau, P. (2021). Taphonomic patterns mimic biologic structures: diagenetic Liesegang rings in Mesozoic coleoids and coprolites. PeerJ, 9e10703. https://doi.org/10.7717/peerj.10703
Klug, Christian, et al. "Taphonomic patterns mimic biologic structures: diagenetic Liesegang rings in Mesozoic coleoids and coprolites." PeerJ vol. 9 (2021): e10703. doi: https://doi.org/10.7717/peerj.10703
Klug C, Di Silvestro G, Hoffmann R, Schweigert G, Fuchs D, Clements T, Gueriau P. Taphonomic patterns mimic biologic structures: diagenetic Liesegang rings in Mesozoic coleoids and coprolites. PeerJ. 2021 Jan 14;9:e10703. doi: 10.7717/peerj.10703. eCollection 2021. PMID: 33520466; PMCID: PMC7811783.
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Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers.

JAMA network open

Cheng E, Soulos PR, Irwin ML, Cespedes Feliciano EM, Presley CJ, Fuchs CS, Meyerhardt JA, Gross CP.
PMID: 34919133
JAMA Netw Open. 2021 Dec 01;4(12):e2139593. doi: 10.1001/jamanetworkopen.2021.39593.

IMPORTANCE: Disadvantaged neighborhood-level and individual-level socioeconomic status (SES) have each been associated with suboptimal cancer care and inferior outcomes. However, independent or synergistic associations between neighborhood and individual socioeconomic disadvantage have not been fully examined, and prior studies using...

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Cheng E, Soulos PR, Irwin ML, et al. Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Netw Open. 2021;4(12):e2139593doi: 10.1001/jamanetworkopen.2021.39593.
Cheng, E., Soulos, P. R., Irwin, M. L., Cespedes Feliciano, E. M., Presley, C. J., Fuchs, C. S., Meyerhardt, J. A., & Gross, C. P. (2021). Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA network open, 4(12), e2139593. https://doi.org/10.1001/jamanetworkopen.2021.39593
Cheng, En, et al. "Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers." JAMA network open vol. 4,12 (2021): e2139593. doi: https://doi.org/10.1001/jamanetworkopen.2021.39593
Cheng E, Soulos PR, Irwin ML, Cespedes Feliciano EM, Presley CJ, Fuchs CS, Meyerhardt JA, Gross CP. Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Netw Open. 2021 Dec 01;4(12):e2139593. doi: 10.1001/jamanetworkopen.2021.39593. PMID: 34919133; PMCID: PMC8683967.
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Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.

Hepatology (Baltimore, Md.)

Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M.
PMID: 34387896
Hepatology. 2021 Aug 13; doi: 10.1002/hep.32112. Epub 2021 Aug 13.

BACKGROUND AND AIMS: Increased fatty acid (FA) flux from adipose tissue to the liver contributes to the development of NAFLD. Because free FAs are key lipotoxic triggers accelerating disease progression, inhibiting adipose triglyceride lipase (ATGL)/patatin-like phospholipase domain containing 2...

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Fuchs CD, Radun R, Dixon ED, et al. Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2021;doi: 10.1002/hep.32112.
Fuchs, C. D., Radun, R., Dixon, E. D., Mlitz, V., Timelthaler, G., Halilbasic, E., Herac, M., Jonker, J. W., Ronda, O. A. H. O., Tardelli, M., Haemmerle, G., Zimmermann, R., Scharnagl, H., Stojakovic, T., Verkade, H. J., & Trauner, M. (2021). Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology (Baltimore, Md.), . https://doi.org/10.1002/hep.32112
Fuchs, Claudia D, et al. "Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice." Hepatology (Baltimore, Md.) vol. (2021). doi: https://doi.org/10.1002/hep.32112
Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. Hepatology. 2021 Aug 13; doi: 10.1002/hep.32112. Epub 2021 Aug 13. PMID: 34387896.
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Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women.

Open forum infectious diseases

Summers NA, Huynh TT, Dunn RC, Cross SL, Fuchs CJ.
PMID: 34514019
Open Forum Infect Dis. 2021 Jul 30;8(9):ofab404. doi: 10.1093/ofid/ofab404. eCollection 2021 Sep.

BACKGROUND: Progression along the HIV care continuum has been a key focus for improving outcomes for people with HIV (PWH). Transgender women with HIV (TGWWH) have not made the same progress as their cisgender counterparts.METHODS: All PWH identifying as...

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Summers NA, Huynh TT, Dunn RC, et al. Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open Forum Infect Dis. 2021;8(9):ofab404doi: 10.1093/ofid/ofab404.
Summers, N. A., Huynh, T. T., Dunn, R. C., Cross, S. L., & Fuchs, C. J. (2021). Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open forum infectious diseases, 8(9), ofab404. https://doi.org/10.1093/ofid/ofab404
Summers, Nathan A, et al. "Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women." Open forum infectious diseases vol. 8,9 (2021): ofab404. doi: https://doi.org/10.1093/ofid/ofab404
Summers NA, Huynh TT, Dunn RC, Cross SL, Fuchs CJ. Effects of Gender-Affirming Hormone Therapy on Progression Along the HIV Care Continuum in Transgender Women. Open Forum Infect Dis. 2021 Jul 30;8(9):ofab404. doi: 10.1093/ofid/ofab404. eCollection 2021 Sep. PMID: 34514019; PMCID: PMC8415531.
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Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance.

Hepatology (Baltimore, Md.)

Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M.
PMID: 34927748
Hepatology. 2021 Dec 20; doi: 10.1002/hep.32289. Epub 2021 Dec 20.

BACKGROUND AND AIMS: LPS clearance is delayed in cholestatic liver diseases. While compromised clearance by Kupffer cells (KCs) is involved, the role of LPS uptake into hepatocytes and canalicular excretion remains unclear.APPROACH AND RESULTS: Wild-type (WT) and Bsep knockout...

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Remetic J, Ghallab A, Hobloss Z, et al. Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology. 2021;doi: 10.1002/hep.32289.
Remetic, J., Ghallab, A., Hobloss, Z., Brackhagen, L., Hassan, R., Myllys, M., Radun, R., Mlitz, V., Zhu, C., Baumgartner, M., Schrottmaier, W. C., Mussbacher, M., Timelthaler, G., Scharnagl, H., Stojakovic, T., Assinger, A., Fuchs, C. D., Hengstler, J. G., & Trauner, M. (2021). Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology (Baltimore, Md.), . https://doi.org/10.1002/hep.32289
Remetic, Jelena, et al. "Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance." Hepatology (Baltimore, Md.) vol. (2021). doi: https://doi.org/10.1002/hep.32289
Remetic J, Ghallab A, Hobloss Z, Brackhagen L, Hassan R, Myllys M, Radun R, Mlitz V, Zhu C, Baumgartner M, Schrottmaier WC, Mussbacher M, Timelthaler G, Scharnagl H, Stojakovic T, Assinger A, Fuchs CD, Hengstler JG, Trauner M. Loss of bile salt export pump aggravates lipopolysaccharide-induced liver injury in mice due to impaired hepatic endotoxin clearance. Hepatology. 2021 Dec 20; doi: 10.1002/hep.32289. Epub 2021 Dec 20. PMID: 34927748.
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