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Showing 109 to 120 of 1080 entries
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Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries.

NAR genomics and bioinformatics

Juzenas S, Lindqvist CM, Ito G, Dolshanskaya Y, Halfvarson J, Franke A, Hemmrich-Stanisak G.
PMID: 33575555
NAR Genom Bioinform. 2020 Feb 12;2(1):lqaa008. doi: 10.1093/nargab/lqaa008. eCollection 2020 Mar.

Erythroid-specific miR-451a and miR-486-5p are two of the most dominant microRNAs (miRNAs) in human peripheral blood. In small RNA sequencing libraries, their overabundance reduces diversity as well as complexity and consequently causes negative effects such as missing detectability and...

Brunner syndrome associated MAOA mutations result in NMDAR hyperfunction and increased network activity in human dopaminergic neurons.

Neurobiology of disease

van Rhijn JR, Shi Y, Bormann M, Mossink B, Frega M, Recaioglu H, Hakobjan M, Klein Gunnewiek T, Schoenmaker C, Palmer E, Faivre L, Kittel-Schneider S, Schubert D, Brunner H, Franke B, Nadif Kasri N.
PMID: 34923109
Neurobiol Dis. 2021 Dec 16;163:105587. doi: 10.1016/j.nbd.2021.105587. Epub 2021 Dec 16.

Monoamine neurotransmitter abundance affects motor control, emotion, and cognitive function and is regulated by monoamine oxidases. Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Loss-of-function mutations in the X-linked...

Perceived Institutional Restraint Is Associated With Psychological Distress in Forensic Psychiatric Inpatients.

Frontiers in psychiatry

Franke I, Büsselmann M, Streb J, Dudeck M.
PMID: 31244698
Front Psychiatry. 2019 Jun 11;10:410. doi: 10.3389/fpsyt.2019.00410. eCollection 2019.

No abstract available.

Retraction Note: Detection and replication of epistasis influencing transcription in humans.

Nature

Hemani G, Shakhbazov K, Westra HJ, Esko T, Henders AK, McRae AF, Yang J, Gibson G, Martin NG, Metspalu A, Franke L, Montgomery GW, Visscher PM, Powell JE.
PMID: 34381240
Nature. 2021 Aug;596(7871):306. doi: 10.1038/s41586-021-03766-y.

No abstract available.

Mapping brain asymmetry in health and disease through the ENIGMA consortium.

Human brain mapping

Kong XZ, Postema MC, Guadalupe T, de Kovel C, Boedhoe PSW, Hoogman M, Mathias SR, van Rooij D, Schijven D, Glahn DC, Medland SE, Jahanshad N, Thomopoulos SI, Turner JA, Buitelaar J, van Erp TGM, Franke B, Fisher SE, van den Heuvel OA, Schmaal L, Thompson PM, Francks C.
PMID: 32420672
Hum Brain Mapp. 2022 Jan;43(1):167-181. doi: 10.1002/hbm.25033. Epub 2020 May 18.

Left-right asymmetry of the human brain is one of its cardinal features, and also a complex, multivariate trait. Decades of research have suggested that brain asymmetry may be altered in psychiatric disorders. However, findings have been inconsistent and often...

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.

Human brain mapping

Hoogman M, van Rooij D, Klein M, Boedhoe P, Ilioska I, Li T, Patel Y, Postema MC, Zhang-James Y, Anagnostou E, Arango C, Auzias G, Banaschewski T, Bau CHD, Behrmann M, Bellgrove MA, Brandeis D, Brem S, Busatto GF, Calderoni S, Calvo R, Castellanos FX, Coghill D, Conzelmann A, Daly E, Deruelle C, Dinstein I, Durston S, Ecker C, Ehrlich S, Epstein JN, Fair DA, Fitzgerald J, Freitag CM, Frodl T, Gallagher L, Grevet EH, Haavik J, Hoekstra PJ, Janssen J, Karkashadze G, King JA, Konrad K, Kuntsi J, Lazaro L, Lerch JP, Lesch KP, Louza MR, Luna B, Mattos P, McGrath J, Muratori F, Murphy C, Nigg JT, Oberwelland-Weiss E, O'Gorman Tuura RL, O'Hearn K, Oosterlaan J, Parellada M, Pauli P, Plessen KJ, Ramos-Quiroga JA, Reif A, Reneman L, Retico A, Rosa PGP, Rubia K, Shaw P, Silk TJ, Tamm L, Vilarroya O, Walitza S, Jahanshad N, Faraone SV, Francks C, van den Heuvel OA, Paus T, Thompson PM, Buitelaar JK, Franke B.
PMID: 32420680
Hum Brain Mapp. 2022 Jan;43(1):37-55. doi: 10.1002/hbm.25029. Epub 2020 May 18.

Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders...

Hot topics in interventional cardiology: Proceedings from the society for cardiovascular angiography and interventions (SCAI) 2021 think tank.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Naidu SS, Baron SJ, Eng MH, Sathanandam SK, Zidar DA, Feldman DN, Ing FF, Latif F, Lim MJ, Henry TD, Rao SV, Dangas GD, Hermiller JB, Daggubati R, Shah B, Ang L, Aronow HD, Banerjee S, Box LC, Caputo RP, Cohen MG, Coylewright M, Duffy PL, Goldsweig AM, Hagler DJ, Hawkins BM, Hijazi ZM, Jayasuriya S, Justino H, Klein AJ, Kliger C, Li J, Mahmud E, Messenger JC, Morray BH, Parikh SA, Reilly J, Secemsky E, Shishehbor MH, Szerlip M, Yakubov SJ, Grines CL, Alvarez-Breckenridge J, Baird C, Baker D, Berry C, Bhattacharya M, Bilazarian S, Bowen R, Brounstein K, Cameron C, Cavalcante R, Culbertson C, Diaz P, Emanuele S, Evans E, Fletcher R, Fortune T, Gaiha P, Govender D, Gutfinger D, Haggstrom K, Herzog A, Hite D, Kalich B, Kirkland A, Kohler T, Laurisden H, Livolsi K, Lombardi L, Lowe S, Marhenke K, Meikle J, Moat N, Mueller M, Patarca R, Popma J, Rangwala N, Simonton C, Stokes J, Taber M, Tieche C, Venditto J, West NEJ, Zinn L.
PMID: 34398509
Catheter Cardiovasc Interv. 2021 Nov 01;98(5):904-913. doi: 10.1002/ccd.29898. Epub 2021 Aug 16.

The Society for Cardiovascular Angiography and Interventions (SCAI) Think Tank is a collaborative venture that brings together interventional cardiologists, administrative partners, and select members of the cardiovascular industry community annually for high-level field-wide discussions. The 2021 Think Tank was...

In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures.

Journal of visualized experiments : JoVE

Alfadil E, Bradke F, Dupraz S.
PMID: 34723948
J Vis Exp. 2021 Oct 14;(176). doi: 10.3791/63068.

During neuronal development, axons navigate the cortical environment to reach their final destinations and establish synaptic connections. Growth cones -the sensory structures located at the distal tips of developing axons- execute this process. Studying the structure and dynamics of...

The P-factor and its genomic and neural equivalents: an integrated perspective.

Molecular psychiatry

Sprooten E, Franke B, Greven CU.
PMID: 33526822
Mol Psychiatry. 2021 Feb 01; doi: 10.1038/s41380-021-01031-2. Epub 2021 Feb 01.

Different psychiatric disorders and symptoms are highly correlated in the general population. A general psychopathology factor (or "P-factor") has been proposed to efficiently describe this covariance of psychopathology. Recently, genetic and neuroimaging studies also derived general dimensions that reflect...

Controlled emission time statistics of a dynamic single-electron transistor.

Science advances

Brange F, Schmidt A, Bayer JC, Wagner T, Flindt C, Haug RJ.
PMID: 33523976
Sci Adv. 2021 Jan 06;7(2). doi: 10.1126/sciadv.abe0793. Print 2021 Jan.

Quantum technologies involving qubit measurements based on electronic interferometers rely critically on accurate single-particle emission. However, achieving precisely timed operations requires exquisite control of the single-particle sources in the time domain. Here, we demonstrate accurate control of the emission...

Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide.

HGG advances

Stuart PE, Tsoi LC, Nair RP, Ghosh M, Kabra M, Shaiq PA, Raja GK, Qamar R, Thelma BK, Patrick MT, Parihar A, Singh S, Khandpur S, Kumar U, Wittig M, Degenhardt F, Tejasvi T, Voorhees JJ, Weidinger S, Franke A, Abecasis GR, Sharma VK, Elder JT.
PMID: 34927100
HGG Adv. 2022 Jan 13;3(1). doi: 10.1016/j.xhgg.2021.100069. Epub 2021 Nov 06.

Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that...

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years.

Human brain mapping

Dima D, Modabbernia A, Papachristou E, Doucet GE, Agartz I, Aghajani M, Akudjedu TN, Albajes-Eizagirre A, Alnaes D, Alpert KI, Andersson M, Andreasen NC, Andreassen OA, Asherson P, Banaschewski T, Bargallo N, Baumeister S, Baur-Streubel R, Bertolino A, Bonvino A, Boomsma DI, Borgwardt S, Bourque J, Brandeis D, Breier A, Brodaty H, Brouwer RM, Buitelaar JK, Busatto GF, Buckner RL, Calhoun V, Canales-Rodríguez EJ, Cannon DM, Caseras X, Castellanos FX, Cervenka S, Chaim-Avancini TM, Ching CRK, Chubar V, Clark VP, Conrod P, Conzelmann A, Crespo-Facorro B, Crivello F, Crone EA, Dannlowski U, Dale AM, Davey C, de Geus EJC, de Haan L, de Zubicaray GI, den Braber A, Dickie EW, Di Giorgio A, Doan NT, Dørum ES, Ehrlich S, Erk S, Espeseth T, Fatouros-Bergman H, Fisher SE, Fouche JP, Franke B, Frodl T, Fuentes-Claramonte P, Glahn DC, Gotlib IH, Grabe HJ, Grimm O, Groenewold NA, Grotegerd D, Gruber O, Gruner P, Gur RE, Gur RC, Hahn T, Harrison BJ, Hartman CA, Hatton SN, Heinz A, Heslenfeld DJ, Hibar DP, Hickie IB, Ho BC, Hoekstra PJ, Hohmann S, Holmes AJ, Hoogman M, Hosten N, Howells FM, Hulshoff Pol HE, Huyser C, Jahanshad N, James A, Jernigan TL, Jiang J, Jönsson EG, Joska JA, Kahn R, Kalnin A, Kanai R, Klein M, Klyushnik TP, Koenders L, Koops S, Krämer B, Kuntsi J, Lagopoulos J, Lázaro L, Lebedeva I, Lee WH, Lesch KP, Lochner C, Machielsen MWJ, Maingault S, Martin NG, Martínez-Zalacaín I, Mataix-Cols D, Mazoyer B, McDonald C, McDonald BC, McIntosh AM, McMahon KL, McPhilemy G, Meinert S, Menchón JM, Medland SE, Meyer-Lindenberg A, Naaijen J, Najt P, Nakao T, Nordvik JE, Nyberg L, Oosterlaan J, de la Foz VO, Paloyelis Y, Pauli P, Pergola G, Pomarol-Clotet E, Portella MJ, Potkin SG, Radua J, Reif A, Rinker DA, Roffman JL, Rosa PGP, Sacchet MD, Sachdev PS, Salvador R, Sánchez-Juan P, Sarró S, Satterthwaite TD, Saykin AJ, Serpa MH, Schmaal L, Schnell K, Schumann G, Sim K, Smoller JW, Sommer I, Soriano-Mas C, Stein DJ, Strike LT, Swagerman SC, Tamnes CK, Temmingh HS, Thomopoulos SI, Tomyshev AS, Tordesillas-Gutiérrez D, Trollor JN, Turner JA, Uhlmann A, van den Heuvel OA, van den Meer D, van der Wee NJA, van Haren NEM, Van't Ent D, van Erp TGM, Veer IM, Veltman DJ, Voineskos A, Völzke H, Walter H, Walton E, Wang L, Wang Y, Wassink TH, Weber B, Wen W, West JD, Westlye LT, Whalley H, Wierenga LM, Williams SCR, Wittfeld K, Wolf DH, Worker A, Wright MJ, Yang K, Yoncheva Y, Zanetti MV, Ziegler GC, Thompson PM, Frangou S.
PMID: 33570244
Hum Brain Mapp. 2022 Jan;43(1):452-469. doi: 10.1002/hbm.25320. Epub 2021 Feb 11.

Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of...

Showing 109 to 120 of 1080 entries