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(-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment.

Organic letters

Davies SG, Fletcher AM, Roberts PM, Thomson JE, Zimmer D.
PMID: 28306263
Org Lett. 2017 Apr 07;19(7):1638-1641. doi: 10.1021/acs.orglett.7b00434. Epub 2017 Mar 17.

(-)-Pseudodistomin E has been prepared for the first time, allowing its structure and absolute configuration to be confirmed. The established conjugate addition of lithium (S)-N-allyl-N-(α-methyl-p-methoxybenzyl)amide to methyl (E,E)-hepta-2,5-dienoate generated the C(2)-stereocenter, and iodolactonisation of a derivative generated the remaining...

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Davies SG, Fletcher AM, Roberts PM, et al. (-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment. Org Lett. 2017;19(7):1638-1641doi: 10.1021/acs.orglett.7b00434.
Davies, S. G., Fletcher, A. M., Roberts, P. M., Thomson, J. E., & Zimmer, D. (2017). (-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment. Organic letters, 19(7), 1638-1641. https://doi.org/10.1021/acs.orglett.7b00434
Davies, Stephen G, et al. "(-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment." Organic letters vol. 19,7 (2017): 1638-1641. doi: https://doi.org/10.1021/acs.orglett.7b00434
Davies SG, Fletcher AM, Roberts PM, Thomson JE, Zimmer D. (-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment. Org Lett. 2017 Apr 07;19(7):1638-1641. doi: 10.1021/acs.orglett.7b00434. Epub 2017 Mar 17. PMID: 28306263.
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Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif.

Organic & biomolecular chemistry

Fletcher BE, Peach MJG, Evans NH.
PMID: 28275772
Org Biomol Chem. 2017 Mar 28;15(13):2797-2803. doi: 10.1039/c7ob00284j.

The synthesis of hydrogen bond templated rotaxanes using the CuAAC click reaction has been achieved in yields of up to 47%, employing near stoichiometric equivalents of macrocycle and readily prepared azide and alkyne half-axle components. Interlocked structure formation has...

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Fletcher BE, Peach MJG, Evans NH. Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif. Org Biomol Chem. 2017;15(13):2797-2803doi: 10.1039/c7ob00284j.
Fletcher, B. E., Peach, M. J. G., & Evans, N. H. (2017). Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif. Organic & biomolecular chemistry, 15(13), 2797-2803. https://doi.org/10.1039/c7ob00284j
Fletcher, Beth E, et al. "Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif." Organic & biomolecular chemistry vol. 15,13 (2017): 2797-2803. doi: https://doi.org/10.1039/c7ob00284j
Fletcher BE, Peach MJG, Evans NH. Rapidly accessible "click" rotaxanes utilizing a single amide hydrogen bond templating motif. Org Biomol Chem. 2017 Mar 28;15(13):2797-2803. doi: 10.1039/c7ob00284j. PMID: 28275772.
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Dementias show differential physiological responses to salient sounds.

Frontiers in behavioral neuroscience

Fletcher PD, Nicholas JM, Shakespeare TJ, Downey LE, Golden HL, Agustus JL, Clark CN, Mummery CJ, Schott JM, Crutch SJ, Warren JD.
PMID: 25859194
Front Behav Neurosci. 2015 Mar 24;9:73. doi: 10.3389/fnbeh.2015.00073. eCollection 2015.

Abnormal responsiveness to salient sensory signals is often a prominent feature of dementia diseases, particularly the frontotemporal lobar degenerations, but has been little studied. Here we assessed processing of one important class of salient signals, looming sounds, in canonical...

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Fletcher PD, Nicholas JM, Shakespeare TJ, et al. Dementias show differential physiological responses to salient sounds. Front Behav Neurosci. 2015;9:73doi: 10.3389/fnbeh.2015.00073.
Fletcher, P. D., Nicholas, J. M., Shakespeare, T. J., Downey, L. E., Golden, H. L., Agustus, J. L., Clark, C. N., Mummery, C. J., Schott, J. M., Crutch, S. J., & Warren, J. D. (2015). Dementias show differential physiological responses to salient sounds. Frontiers in behavioral neuroscience, 973. https://doi.org/10.3389/fnbeh.2015.00073
Fletcher, Phillip D, et al. "Dementias show differential physiological responses to salient sounds." Frontiers in behavioral neuroscience vol. 9 (2015): 73. doi: https://doi.org/10.3389/fnbeh.2015.00073
Fletcher PD, Nicholas JM, Shakespeare TJ, Downey LE, Golden HL, Agustus JL, Clark CN, Mummery CJ, Schott JM, Crutch SJ, Warren JD. Dementias show differential physiological responses to salient sounds. Front Behav Neurosci. 2015 Mar 24;9:73. doi: 10.3389/fnbeh.2015.00073. eCollection 2015. PMID: 25859194; PMCID: PMC4373266.
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Decompression of Neglected Compartment Syndrome of the Arm.

Journal of orthopaedic case reports

Fletcher MD.
PMID: 27299052
J Orthop Case Rep. 2015 Apr-Jun;5(2):75-7. doi: 10.13107/jocr.2250-0685.281.

INTRODUCTION: Compartment syndrome of the arm is rare, and delay in diagnosis or treatment can be devastating. A case is reported of compartment syndrome of the whole arm occurring in a remote location and arrival at hospital 15 hours...

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Fletcher MD. Decompression of Neglected Compartment Syndrome of the Arm. J Orthop Case Rep. 2015;5(2):75-7doi: 10.13107/jocr.2250-0685.281.
Fletcher, M. D. (2015). Decompression of Neglected Compartment Syndrome of the Arm. Journal of orthopaedic case reports, 5(2), 75-7. https://doi.org/10.13107/jocr.2250-0685.281
Fletcher, M D. "Decompression of Neglected Compartment Syndrome of the Arm." Journal of orthopaedic case reports vol. 5,2 (2015): 75-7. doi: https://doi.org/10.13107/jocr.2250-0685.281
Fletcher MD. Decompression of Neglected Compartment Syndrome of the Arm. J Orthop Case Rep. 2015 Apr-Jun;5(2):75-7. doi: 10.13107/jocr.2250-0685.281. PMID: 27299052; PMCID: PMC4722599.
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The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers.

Frontiers in psychology

Newman HJ, Howells KL, Fletcher D.
PMID: 27375544
Front Psychol. 2016 Jun 07;7:868. doi: 10.3389/fpsyg.2016.00868. eCollection 2016.

The general and sport psychology research converge to point to a complex relationship between depressive experiences and human performance. The purpose of this study was to explore the depressive experiences of top level athletes and the relationship of such...

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Newman HJ, Howells KL, Fletcher D. The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers. Front Psychol. 2016;7:868doi: 10.3389/fpsyg.2016.00868.
Newman, H. J., Howells, K. L., & Fletcher, D. (2016). The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers. Frontiers in psychology, 7868. https://doi.org/10.3389/fpsyg.2016.00868
Newman, Hannah J H, et al. "The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers." Frontiers in psychology vol. 7 (2016): 868. doi: https://doi.org/10.3389/fpsyg.2016.00868
Newman HJ, Howells KL, Fletcher D. The Dark Side of Top Level Sport: An Autobiographic Study of Depressive Experiences in Elite Sport Performers. Front Psychol. 2016 Jun 07;7:868. doi: 10.3389/fpsyg.2016.00868. eCollection 2016. PMID: 27375544; PMCID: PMC4896110.
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A Process Model of Parenting and Adolescents' Friendship Competence.

Social development (Oxford, England)

Cook EC, Fletcher AC.
PMID: 24882948
Soc Dev. 2012 Aug 01;21(3):461-481. doi: 10.1111/j.1467-9507.2011.00642.x.

This study examined the prospective relationship between negative parenting behaviors and adolescents' friendship competence in a community sample of 416 two-parent families in the Southeastern USA. Adolescents' externalizing problems and their emotional insecurity with parents were examined as mediators....

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Cook EC, Fletcher AC. A Process Model of Parenting and Adolescents' Friendship Competence. Soc Dev. 2012;21(3):461-481doi: 10.1111/j.1467-9507.2011.00642.x.
Cook, E. C., & Fletcher, A. C. (2012). A Process Model of Parenting and Adolescents' Friendship Competence. Social development (Oxford, England), 21(3), 461-481. https://doi.org/10.1111/j.1467-9507.2011.00642.x
Cook, Emily C, and Fletcher, Anne C. "A Process Model of Parenting and Adolescents' Friendship Competence." Social development (Oxford, England) vol. 21,3 (2012): 461-481. doi: https://doi.org/10.1111/j.1467-9507.2011.00642.x
Cook EC, Fletcher AC. A Process Model of Parenting and Adolescents' Friendship Competence. Soc Dev. 2012 Aug 01;21(3):461-481. doi: 10.1111/j.1467-9507.2011.00642.x. PMID: 24882948; PMCID: PMC4039634.
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Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins.

Organic & biomolecular chemistry

Davies SG, Fletcher AM, Lee JA, Roberts PM, Souleymanou MY, Thomson JE, Zammit CM.
PMID: 24647746
Org Biomol Chem. 2014 May 07;12(17):2702-28. doi: 10.1039/c4ob00274a.

The diastereoselective Ireland-Claisen rearrangement of a range of substituted allyl β-amino esters gave the corresponding enantiopure α-substituted-β-amino esters with good diastereoselectivity. The application of this methodology in the asymmetric synthesis of a range of C(5)-substituted 1,2-anti-1,5-syn-transpentacins was demonstrated by...

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Davies SG, Fletcher AM, Lee JA, et al. Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins. Org Biomol Chem. 2014;12(17):2702-28doi: 10.1039/c4ob00274a.
Davies, S. G., Fletcher, A. M., Lee, J. A., Roberts, P. M., Souleymanou, M. Y., Thomson, J. E., & Zammit, C. M. (2014). Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins. Organic & biomolecular chemistry, 12(17), 2702-28. https://doi.org/10.1039/c4ob00274a
Davies, Stephen G, et al. "Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins." Organic & biomolecular chemistry vol. 12,17 (2014): 2702-28. doi: https://doi.org/10.1039/c4ob00274a
Davies SG, Fletcher AM, Lee JA, Roberts PM, Souleymanou MY, Thomson JE, Zammit CM. Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins. Org Biomol Chem. 2014 May 07;12(17):2702-28. doi: 10.1039/c4ob00274a. PMID: 24647746.
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Opioid-Free Anesthesia Benefit-Risk Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Journal of clinical medicine

Salomé A, Harkouk H, Fletcher D, Martinez V.
PMID: 34065937
J Clin Med. 2021 May 12;10(10). doi: 10.3390/jcm10102069.

Opioid-free anesthesia (OFA) is used in surgery to avoid opioid-related side effects. However, uncertainty exists in the balance between OFA benefits and risks. We searched for randomized controlled trials (RCTs) comparing OFA to opioid-based anesthesia (OBA) in five international...

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Salomé A, Harkouk H, Fletcher D, et al. Opioid-Free Anesthesia Benefit-Risk Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2021;10(10)doi: 10.3390/jcm10102069.
Salomé, A., Harkouk, H., Fletcher, D., & Martinez, V. (2021). Opioid-Free Anesthesia Benefit-Risk Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of clinical medicine, 10(10), . https://doi.org/10.3390/jcm10102069
Salomé, Arthur, et al. "Opioid-Free Anesthesia Benefit-Risk Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." Journal of clinical medicine vol. 10,10 (2021). doi: https://doi.org/10.3390/jcm10102069
Salomé A, Harkouk H, Fletcher D, Martinez V. Opioid-Free Anesthesia Benefit-Risk Balance: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2021 May 12;10(10). doi: 10.3390/jcm10102069. PMID: 34065937; PMCID: PMC8150912.
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The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons.

Drug testing and analysis

Kronstrand R, Norman C, Vikingsson S, Biemans A, Valencia Crespo B, Edwards D, Fletcher D, Gilbert N, Persson M, Reid R, Semenova O, Al Teneiji F, Wu X, Dahlén J, NicDaéid N, Tarbah F, Sutcliffe OB, McKenzie C, Gréen H.
PMID: 34811926
Drug Test Anal. 2021 Nov 22; doi: 10.1002/dta.3203. Epub 2021 Nov 22.

Early warning systems detect new psychoactive substances (NPS), while dedicated monitoring programs and routine drug and toxicology testing identify fluctuations in prevalence. We report the increasing prevalence of the synthetic cannabinoid receptor agonist (SCRA) ADB-BUTINACA (N-[1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-butyl-1H-indazole-3-carbox-amide). ADB-BUTINACA was first...

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Kronstrand R, Norman C, Vikingsson S, et al. The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons. Drug Test Anal. 2021;doi: 10.1002/dta.3203.
Kronstrand, R., Norman, C., Vikingsson, S., Biemans, A., Valencia Crespo, B., Edwards, D., Fletcher, D., Gilbert, N., Persson, M., Reid, R., Semenova, O., Al Teneiji, F., Wu, X., Dahlén, J., NicDaéid, N., Tarbah, F., Sutcliffe, O. B., McKenzie, C., & Gréen, H. (2021). The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons. Drug testing and analysis, . https://doi.org/10.1002/dta.3203
Kronstrand, Robert, et al. "The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons." Drug testing and analysis vol. (2021). doi: https://doi.org/10.1002/dta.3203
Kronstrand R, Norman C, Vikingsson S, Biemans A, Valencia Crespo B, Edwards D, Fletcher D, Gilbert N, Persson M, Reid R, Semenova O, Al Teneiji F, Wu X, Dahlén J, NicDaéid N, Tarbah F, Sutcliffe OB, McKenzie C, Gréen H. The metabolism of the synthetic cannabinoids ADB-BUTINACA and ADB-4en-PINACA and their detection in forensic toxicology casework and infused papers seized in prisons. Drug Test Anal. 2021 Nov 22; doi: 10.1002/dta.3203. Epub 2021 Nov 22. PMID: 34811926.
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Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship.

The journal of applied laboratory medicine

Dickerson JA, Fletcher AH, Procop G, Keren DF, Singh IR, Garcia JJ, Carpenter RB, Miles J, Jackson B, Astion ML.
PMID: 32630981
J Appl Lab Med. 2017 Sep 01;2(2):259-268. doi: 10.1373/jalm.2017.023606.

Appropriate utilization of clinical laboratory services is important for patient care and requires institutional stewardship. Clinical laboratory stewardship programs are dedicated to improving the ordering, retrieval, and interpretation of appropriate laboratory tests. In addition, these programs focus on developing,...

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Dickerson JA, Fletcher AH, Procop G, et al. Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship. J Appl Lab Med. 2017;2(2):259-268doi: 10.1373/jalm.2017.023606.
Dickerson, J. A., Fletcher, A. H., Procop, G., Keren, D. F., Singh, I. R., Garcia, J. J., Carpenter, R. B., Miles, J., Jackson, B., & Astion, M. L. (2017). Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship. The journal of applied laboratory medicine, 2(2), 259-268. https://doi.org/10.1373/jalm.2017.023606
Dickerson, Jane A, et al. "Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship." The journal of applied laboratory medicine vol. 2,2 (2017): 259-268. doi: https://doi.org/10.1373/jalm.2017.023606
Dickerson JA, Fletcher AH, Procop G, Keren DF, Singh IR, Garcia JJ, Carpenter RB, Miles J, Jackson B, Astion ML. Transforming Laboratory Utilization Review into Laboratory Stewardship: Guidelines by the PLUGS National Committee for Laboratory Stewardship. J Appl Lab Med. 2017 Sep 01;2(2):259-268. doi: 10.1373/jalm.2017.023606. PMID: 32630981.
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How alternative urban stream channel designs influence ecohydraulic conditions.

Journal of environmental management

Anim DO, Fletcher TD, Vietz GJ, Burns MJ, Pasternack GB.
PMID: 31247371
J Environ Manage. 2019 Oct 01;247:242-252. doi: 10.1016/j.jenvman.2019.06.095. Epub 2019 Jun 25.

Streams draining urban catchments ubiquitously undergo negative physical and ecosystem changes, recognized to be primarily driven by frequent stormwater runoff input. The common management intervention is rehabilitation of channel morphology. Despite engineering design intentions, ecohydraulic benefits of urban channel...

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Anim DO, Fletcher TD, Vietz GJ, et al. How alternative urban stream channel designs influence ecohydraulic conditions. J Environ Manage. 2019;247:242-252doi: 10.1016/j.jenvman.2019.06.095.
Anim, D. O., Fletcher, T. D., Vietz, G. J., Burns, M. J., & Pasternack, G. B. (2019). How alternative urban stream channel designs influence ecohydraulic conditions. Journal of environmental management, 247242-252. https://doi.org/10.1016/j.jenvman.2019.06.095
Anim, Desmond O, et al. "How alternative urban stream channel designs influence ecohydraulic conditions." Journal of environmental management vol. 247 (2019): 242-252. doi: https://doi.org/10.1016/j.jenvman.2019.06.095
Anim DO, Fletcher TD, Vietz GJ, Burns MJ, Pasternack GB. How alternative urban stream channel designs influence ecohydraulic conditions. J Environ Manage. 2019 Oct 01;247:242-252. doi: 10.1016/j.jenvman.2019.06.095. Epub 2019 Jun 25. PMID: 31247371.
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An Evaluation of the Source and Content of Dupuytren's Disease Information Available on the Internet.

Cureus

Plusch K, Carfagno J, Givner D, Fletcher D, Aita D, Gallant GG, Abboudi J, Beredjiklian P.
PMID: 34909317
Cureus. 2021 Nov 08;13(11):e19356. doi: 10.7759/cureus.19356. eCollection 2021 Nov.

Introduction The internet continues to expand in both size and number of users, and patients are using the internet with increasing frequency to research orthopedic conditions and treatment options. Despite the prevalence of patients searching for medical information, the...

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Plusch K, Carfagno J, Givner D, et al. An Evaluation of the Source and Content of Dupuytren's Disease Information Available on the Internet. Cureus. 2021;13(11):e19356doi: 10.7759/cureus.19356.
Plusch, K., Carfagno, J., Givner, D., Fletcher, D., Aita, D., Gallant, G. G., Abboudi, J., & Beredjiklian, P. (2021). An Evaluation of the Source and Content of Dupuytren's Disease Information Available on the Internet. Cureus, 13(11), e19356. https://doi.org/10.7759/cureus.19356
Plusch, Kyle, et al. "An Evaluation of the Source and Content of Dupuytren's Disease Information Available on the Internet." Cureus vol. 13,11 (2021): e19356. doi: https://doi.org/10.7759/cureus.19356
Plusch K, Carfagno J, Givner D, Fletcher D, Aita D, Gallant GG, Abboudi J, Beredjiklian P. An Evaluation of the Source and Content of Dupuytren's Disease Information Available on the Internet. Cureus. 2021 Nov 08;13(11):e19356. doi: 10.7759/cureus.19356. eCollection 2021 Nov. PMID: 34909317; PMCID: PMC8653955.
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Showing 109 to 120 of 361 entries