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Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus.

Diabetes, metabolic syndrome and obesity : targets and therapy

Cheema AK, Kaur P, Fadel A, Younes N, Zirie M, Rizk NM.
PMID: 32753925
Diabetes Metab Syndr Obes. 2020 Jul 07;13:2409-2431. doi: 10.2147/DMSO.S244432. eCollection 2020.

OBJECTIVE: The objective of the current study is to accomplish a relative exploration of the biological roles of differentially dysregulated genes (DRGs) in type 2 diabetes mellitus (T2DM). The study aimed to determine the impact of these DRGs on...

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Cheema AK, Kaur P, Fadel A, et al. Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020;13:2409-2431doi: 10.2147/DMSO.S244432.
Cheema, A. K., Kaur, P., Fadel, A., Younes, N., Zirie, M., & Rizk, N. M. (2020). Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus. Diabetes, metabolic syndrome and obesity : targets and therapy, 132409-2431. https://doi.org/10.2147/DMSO.S244432
Cheema, Amrita K, et al. "Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus." Diabetes, metabolic syndrome and obesity : targets and therapy vol. 13 (2020): 2409-2431. doi: https://doi.org/10.2147/DMSO.S244432
Cheema AK, Kaur P, Fadel A, Younes N, Zirie M, Rizk NM. Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus. Diabetes Metab Syndr Obes. 2020 Jul 07;13:2409-2431. doi: 10.2147/DMSO.S244432. eCollection 2020. PMID: 32753925; PMCID: PMC7354282.
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Heart-lung transplantation: current indications, prognosis and specific considerations.

Journal of thoracic disease

Le Pavec J, Hascoët S, Fadel E.
PMID: 30505505
J Thorac Dis. 2018 Oct;10(10):5946-5952. doi: 10.21037/jtd.2018.09.115.

Heart-lung transplantation (HLTx) is currently the best treatment for patients who have end-stage heart and lung failure. Idiopathic pulmonary arterial hypertension (IPAH) was the main indication for HLTx in the 1980s. However, when studies showed resolution of right ventricular...

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Le Pavec J, Hascoët S, Fadel E. Heart-lung transplantation: current indications, prognosis and specific considerations. J Thorac Dis. 2018;10(10):5946-5952doi: 10.21037/jtd.2018.09.115.
Le Pavec, J., Hascoët, S., & Fadel, E. (2018). Heart-lung transplantation: current indications, prognosis and specific considerations. Journal of thoracic disease, 10(10), 5946-5952. https://doi.org/10.21037/jtd.2018.09.115
Le Pavec, Jérôme, et al. "Heart-lung transplantation: current indications, prognosis and specific considerations." Journal of thoracic disease vol. 10,10 (2018): 5946-5952. doi: https://doi.org/10.21037/jtd.2018.09.115
Le Pavec J, Hascoët S, Fadel E. Heart-lung transplantation: current indications, prognosis and specific considerations. J Thorac Dis. 2018 Oct;10(10):5946-5952. doi: 10.21037/jtd.2018.09.115. PMID: 30505505; PMCID: PMC6236182.
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Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death.

Cell death discovery

Klöditz K, Fadeel B.
PMID: 30774993
Cell Death Discov. 2019 Feb 08;5:65. doi: 10.1038/s41420-019-0146-x. eCollection 2019.

Macrophage clearance of apoptotic cells has been extensively investigated, but less is known regarding the clearance of cells dying by other forms of programmed cell death, e.g., necroptosis or ferroptosis. Here, we established a model of three different cell...

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Klöditz K, Fadeel B. Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death. Cell Death Discov. 2019;5:65doi: 10.1038/s41420-019-0146-x.
Klöditz, K., & Fadeel, B. (2019). Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death. Cell death discovery, 565. https://doi.org/10.1038/s41420-019-0146-x
Klöditz, Katharina, and Fadeel, Bengt. "Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death." Cell death discovery vol. 5 (2019): 65. doi: https://doi.org/10.1038/s41420-019-0146-x
Klöditz K, Fadeel B. Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death. Cell Death Discov. 2019 Feb 08;5:65. doi: 10.1038/s41420-019-0146-x. eCollection 2019. PMID: 30774993; PMCID: PMC6368547.
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Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.

Gut

Ruivo CF, Bastos N, Adem B, Batista I, Duraes C, Melo CA, Castaldo SA, Campos-Laborie F, Moutinho-Ribeiro P, Morão B, Costa-Pinto A, Silva S, Osorio H, Ciordia S, Costa JL, Goodrich D, Cavadas B, Pereira L, Kouzarides T, Macedo G, Maio R, Carneiro F, Cravo M, Kalluri R, Machado JC, Melo SA.
PMID: 35012996
Gut. 2022 Jan 10; doi: 10.1136/gutjnl-2021-324994. Epub 2022 Jan 10.

OBJECTIVE: Intratumor heterogeneity drives cancer progression and therapy resistance. However, it has yet to be determined whether and how subpopulations of cancer cells interact and how this interaction affects the tumour.DESIGN: We have studied the spontaneous flow of extracellular...

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Ruivo CF, Bastos N, Adem B, et al. Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. Gut. 2022;doi: 10.1136/gutjnl-2021-324994.
Ruivo, C. F., Bastos, N., Adem, B., Batista, I., Duraes, C., Melo, C. A., Castaldo, S. A., Campos-Laborie, F., Moutinho-Ribeiro, P., Morão, B., Costa-Pinto, A., Silva, S., Osorio, H., Ciordia, S., Costa, J. L., Goodrich, D., Cavadas, B., Pereira, L., Kouzarides, T., Macedo, G., Maio, R., Carneiro, F., Cravo, M., Kalluri, R., Machado, J. C., & Melo, S. A. (2022). Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. Gut, . https://doi.org/10.1136/gutjnl-2021-324994
Ruivo, Carolina F, et al. "Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression." Gut vol. (2022). doi: https://doi.org/10.1136/gutjnl-2021-324994
Ruivo CF, Bastos N, Adem B, Batista I, Duraes C, Melo CA, Castaldo SA, Campos-Laborie F, Moutinho-Ribeiro P, Morão B, Costa-Pinto A, Silva S, Osorio H, Ciordia S, Costa JL, Goodrich D, Cavadas B, Pereira L, Kouzarides T, Macedo G, Maio R, Carneiro F, Cravo M, Kalluri R, Machado JC, Melo SA. Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression. Gut. 2022 Jan 10; doi: 10.1136/gutjnl-2021-324994. Epub 2022 Jan 10. PMID: 35012996.
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Constrictive pericarditis following heart transplantation: Reality or fiction?.

Echocardiography (Mount Kisco, N.Y.)

Fadel BM, Mahjoub H, Salem EJ, Kazzi BE, Echahidi N, Mohty D.
PMID: 34755387
Echocardiography. 2021 Nov;38(11):1973-1977. doi: 10.1111/echo.15229. Epub 2021 Nov 09.

Constrictive pericarditis (CP) is a curable cause of diastolic heart failure with prior cardiac surgery being a recognizable etiology. We report a patient who developed CP one year following heart transplantation. Several clinical and imaging related factors may lead...

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Fadel BM, Mahjoub H, Salem EJ, et al. Constrictive pericarditis following heart transplantation: Reality or fiction?. Echocardiography. 2021;38(11):1973-1977doi: 10.1111/echo.15229.
Fadel, B. M., Mahjoub, H., Salem, E. J., Kazzi, B. E., Echahidi, N., & Mohty, D. (2021). Constrictive pericarditis following heart transplantation: Reality or fiction?. Echocardiography (Mount Kisco, N.Y.), 38(11), 1973-1977. https://doi.org/10.1111/echo.15229
Fadel, Bahaa M, et al. "Constrictive pericarditis following heart transplantation: Reality or fiction?." Echocardiography (Mount Kisco, N.Y.) vol. 38,11 (2021): 1973-1977. doi: https://doi.org/10.1111/echo.15229
Fadel BM, Mahjoub H, Salem EJ, Kazzi BE, Echahidi N, Mohty D. Constrictive pericarditis following heart transplantation: Reality or fiction?. Echocardiography. 2021 Nov;38(11):1973-1977. doi: 10.1111/echo.15229. Epub 2021 Nov 09. PMID: 34755387.
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BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.

Journal of medicinal chemistry

Berger M, Wortmann L, Buchgraber P, Lücking U, Zitzmann-Kolbe S, Wengner AM, Bader B, Bömer U, Briem H, Eis K, Rehwinkel H, Bartels F, Moosmayer D, Eberspächer U, Lienau P, Hammer S, Schatz CA, Wang Q, Wang Q, Mumberg D, Nising CF, Siemeister G.
PMID: 34428039
J Med Chem. 2021 Sep 09;64(17):12723-12737. doi: 10.1021/acs.jmedchem.1c00762. Epub 2021 Aug 24.

Eukaryotes have evolved two major pathways to repair potentially lethal DNA double-strand breaks. Homologous recombination represents a precise, DNA-template-based mechanism available during the S and G2 cell cycle phase, whereas non-homologous end joining, which requires DNA-dependent protein kinase (DNA-PK),...

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Berger M, Wortmann L, Buchgraber P, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies. J Med Chem. 2021;64(17):12723-12737doi: 10.1021/acs.jmedchem.1c00762.
Berger, M., Wortmann, L., Buchgraber, P., Lücking, U., Zitzmann-Kolbe, S., Wengner, A. M., Bader, B., Bömer, U., Briem, H., Eis, K., Rehwinkel, H., Bartels, F., Moosmayer, D., Eberspächer, U., Lienau, P., Hammer, S., Schatz, C. A., Wang, Q., Wang, Q., Mumberg, D., Nising, C. F., & Siemeister, G. (2021). BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies. Journal of medicinal chemistry, 64(17), 12723-12737. https://doi.org/10.1021/acs.jmedchem.1c00762
Berger, Markus, et al. "BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies." Journal of medicinal chemistry vol. 64,17 (2021): 12723-12737. doi: https://doi.org/10.1021/acs.jmedchem.1c00762
Berger M, Wortmann L, Buchgraber P, Lücking U, Zitzmann-Kolbe S, Wengner AM, Bader B, Bömer U, Briem H, Eis K, Rehwinkel H, Bartels F, Moosmayer D, Eberspächer U, Lienau P, Hammer S, Schatz CA, Wang Q, Wang Q, Mumberg D, Nising CF, Siemeister G. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies. J Med Chem. 2021 Sep 09;64(17):12723-12737. doi: 10.1021/acs.jmedchem.1c00762. Epub 2021 Aug 24. PMID: 34428039.
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2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway.

Anesthesiology

Apfelbaum JL, Hagberg CA, Connis RT, Abdelmalak BB, Agarkar M, Dutton RP, Fiadjoe JE, Greif R, Klock PA, Mercier D, Myatra SN, O'Sullivan EP, Rosenblatt WH, Sorbello M, Tung A.
PMID: 34762729
Anesthesiology. 2021 Nov 11; doi: 10.1097/ALN.0000000000004002. Epub 2021 Nov 11.

The American Society of Anesthesiologists; All India Difficult Airway Association; European Airway Management Society; European Society of Anaesthesiology and Intensive Care; Italian Society of Anesthesiology, Analgesia, Resuscitation and Intensive Care, Learning, Teaching and Investigation Difficult Airway Group; Society for...

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Apfelbaum JL, Hagberg CA, Connis RT, et al. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology. 2021;doi: 10.1097/ALN.0000000000004002.
Apfelbaum, J. L., Hagberg, C. A., Connis, R. T., Abdelmalak, B. B., Agarkar, M., Dutton, R. P., Fiadjoe, J. E., Greif, R., Klock, P. A., Mercier, D., Myatra, S. N., O'Sullivan, E. P., Rosenblatt, W. H., Sorbello, M., & Tung, A. (2021). 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology, . https://doi.org/10.1097/ALN.0000000000004002
Apfelbaum, Jeffrey L, et al. "2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway." Anesthesiology vol. (2021). doi: https://doi.org/10.1097/ALN.0000000000004002
Apfelbaum JL, Hagberg CA, Connis RT, Abdelmalak BB, Agarkar M, Dutton RP, Fiadjoe JE, Greif R, Klock PA, Mercier D, Myatra SN, O'Sullivan EP, Rosenblatt WH, Sorbello M, Tung A. 2022 American Society of Anesthesiologists Practice Guidelines for Management of the Difficult Airway. Anesthesiology. 2021 Nov 11; doi: 10.1097/ALN.0000000000004002. Epub 2021 Nov 11. PMID: 34762729.
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Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Kinaret PAS, Ndika J, Ilves M, Wolff H, Vales G, Norppa H, Savolainen K, Skoog T, Kere J, Moya S, Handy RD, Karisola P, Fadeel B, Greco D, Alenius H.
PMID: 34026454
Adv Sci (Weinh). 2021 Mar 08;8(10):2004588. doi: 10.1002/advs.202004588. eCollection 2021 May.

Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exposure to a total of 28 engineered nanomaterials (ENM) are...

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Kinaret PAS, Ndika J, Ilves M, et al. Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways. Adv Sci (Weinh). 2021;8(10):2004588doi: 10.1002/advs.202004588.
Kinaret, P. A. S., Ndika, J., Ilves, M., Wolff, H., Vales, G., Norppa, H., Savolainen, K., Skoog, T., Kere, J., Moya, S., Handy, R. D., Karisola, P., Fadeel, B., Greco, D., & Alenius, H. (2021). Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 8(10), 2004588. https://doi.org/10.1002/advs.202004588
Kinaret, Pia A S, et al. "Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 8,10 (2021): 2004588. doi: https://doi.org/10.1002/advs.202004588
Kinaret PAS, Ndika J, Ilves M, Wolff H, Vales G, Norppa H, Savolainen K, Skoog T, Kere J, Moya S, Handy RD, Karisola P, Fadeel B, Greco D, Alenius H. Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways. Adv Sci (Weinh). 2021 Mar 08;8(10):2004588. doi: 10.1002/advs.202004588. eCollection 2021 May. PMID: 34026454; PMCID: PMC8132046.
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Comparison of opponensplasty techniques in isolated low median nerve palsy.

International journal of burns and trauma

Yavari P, Fadaei B, Ghasemi Darestani N, Joni SS, Tavakoli P, Mohammadsharifi G.
PMID: 33224615
Int J Burns Trauma. 2020 Oct 15;10(5):263-268. eCollection 2020.

BACKGROUND: Thumb opposition is a critical operation of thumb. Median nerve palsy interferes with a large number of ordinary activities such as opposition. Opponensplasty for low median nerve injury is performed with various techniques. The purpose of this study...

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Yavari P, Fadaei B, Ghasemi Darestani N, et al. Comparison of opponensplasty techniques in isolated low median nerve palsy. Int J Burns Trauma. 2020;10(5):263-268
Yavari, P., Fadaei, B., Ghasemi Darestani, N., Joni, S. S., Tavakoli, P., & Mohammadsharifi, G. (2020). Comparison of opponensplasty techniques in isolated low median nerve palsy. International journal of burns and trauma, 10(5), 263-268.
Yavari, Pedram, et al. "Comparison of opponensplasty techniques in isolated low median nerve palsy." International journal of burns and trauma vol. 10,5 (2020): 263-268.
Yavari P, Fadaei B, Ghasemi Darestani N, Joni SS, Tavakoli P, Mohammadsharifi G. Comparison of opponensplasty techniques in isolated low median nerve palsy. Int J Burns Trauma. 2020 Oct 15;10(5):263-268. eCollection 2020. PMID: 33224615; PMCID: PMC7675200.
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Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study.

Cardiovascular endocrinology & metabolism

El Tantawy AE, Fadel F, Abdelrahman SM, Nabhan M, Ibrahim R, Fattouh AM, Sayed S, ElKhashab KM, Afdal P, AbdelMassih AF.
PMID: 31942553
Cardiovasc Endocrinol Metab. 2019 Nov 13;8(4):115-118. doi: 10.1097/XCE.0000000000000186. eCollection 2019 Dec.

INTRODUCTION: Left ventricular hypertrophy (LVH) is the commonest myocardial response to chronic kidney disease (CKD); this response has been regarded detrimental as it impairs the blood flow to the deepest layers of the myocardium causing progressive myocardial dysfunction. The...

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El Tantawy AE, Fadel F, Abdelrahman SM, et al. Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study. Cardiovasc Endocrinol Metab. 2019;8(4):115-118doi: 10.1097/XCE.0000000000000186.
El Tantawy, A. E., Fadel, F., Abdelrahman, S. M., Nabhan, M., Ibrahim, R., Fattouh, A. M., Sayed, S., ElKhashab, K. M., Afdal, P., & AbdelMassih, A. F. (2019). Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study. Cardiovascular endocrinology & metabolism, 8(4), 115-118. https://doi.org/10.1097/XCE.0000000000000186
El Tantawy, Amira Esmat, et al. "Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study." Cardiovascular endocrinology & metabolism vol. 8,4 (2019): 115-118. doi: https://doi.org/10.1097/XCE.0000000000000186
El Tantawy AE, Fadel F, Abdelrahman SM, Nabhan M, Ibrahim R, Fattouh AM, Sayed S, ElKhashab KM, Afdal P, AbdelMassih AF. Left ventricular mass index and subendocardial myocardial function in children with chronic kidney disease, a transmural strain and three-dimensional echocardiographic study. Cardiovasc Endocrinol Metab. 2019 Nov 13;8(4):115-118. doi: 10.1097/XCE.0000000000000186. eCollection 2019 Dec. PMID: 31942553; PMCID: PMC6946150.
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Normalized Gaussian path integrals.

Physical review. E

Corazza G, Fadel M.
PMID: 32942447
Phys Rev E. 2020 Aug;102(2):022135. doi: 10.1103/PhysRevE.102.022135.

Path integrals play a crucial role in describing the dynamics of physical systems subject to classical or quantum noise. In fact, when correctly normalized, they express the probability of transition between two states of the system. In this work,...

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Corazza G, Fadel M. Normalized Gaussian path integrals. Phys Rev E. 2020;102(2):022135doi: 10.1103/PhysRevE.102.022135.
Corazza, G., & Fadel, M. (2020). Normalized Gaussian path integrals. Physical review. E, 102(2), 022135. https://doi.org/10.1103/PhysRevE.102.022135
Corazza, Giulio, and Fadel, Matteo. "Normalized Gaussian path integrals." Physical review. E vol. 102,2 (2020): 022135. doi: https://doi.org/10.1103/PhysRevE.102.022135
Corazza G, Fadel M. Normalized Gaussian path integrals. Phys Rev E. 2020 Aug;102(2):022135. doi: 10.1103/PhysRevE.102.022135. PMID: 32942447.
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The role of transcatheter approaches for the treatment of pulmonary homograft dysfunction.

Annals of cardiothoracic surgery

Fadel BM, Mohty D, Alassas K, Alhalees Z.
PMID: 34422567
Ann Cardiothorac Surg. 2021 Jul;10(4):521-523. doi: 10.21037/acs-2020-rp-12.

No abstract available.

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Fadel BM, Mohty D, Alassas K, et al. The role of transcatheter approaches for the treatment of pulmonary homograft dysfunction. Ann Cardiothorac Surg. 2021;10(4):521-523doi: 10.21037/acs-2020-rp-12.
Fadel, B. M., Mohty, D., Alassas, K., & Alhalees, Z. (2021). The role of transcatheter approaches for the treatment of pulmonary homograft dysfunction. Annals of cardiothoracic surgery, 10(4), 521-523. https://doi.org/10.21037/acs-2020-rp-12
Fadel, Bahaa M, et al. "The role of transcatheter approaches for the treatment of pulmonary homograft dysfunction." Annals of cardiothoracic surgery vol. 10,4 (2021): 521-523. doi: https://doi.org/10.21037/acs-2020-rp-12
Fadel BM, Mohty D, Alassas K, Alhalees Z. The role of transcatheter approaches for the treatment of pulmonary homograft dysfunction. Ann Cardiothorac Surg. 2021 Jul;10(4):521-523. doi: 10.21037/acs-2020-rp-12. PMID: 34422567; PMCID: PMC8339613.
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