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Showing 217 to 221 of 221 entries
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Rapidly increasing SARS-CoV-2 seroprevalence and limited clinical disease in three Malian communities: a prospective cohort study.

medRxiv : the preprint server for health sciences

Sagara I, Woodford J, Kone M, Assadou MH, Katile A, Attaher O, Zeguime A, Doucoure M, Higbee E, Lane J, Doritchamou J, Zaidi I, Esposito D, Kwan J, Sadtler K, Dicko A, Duffy P.
PMID: 33948607
medRxiv. 2021 Apr 29; doi: 10.1101/2021.04.26.21256016.

BACKGROUND: The extent of SARS-CoV-2 exposure and transmission in Mali and the surrounding region is not well understood, although infection has been confirmed in nearly 14,000 symptomatic individuals and their contacts since the first case in March 2020. We...

ecDNA hubs drive cooperative intermolecular oncogene expression.

Nature

Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY.
PMID: 34819668
Nature. 2021 Nov 24; doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24.

Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation

Severe Acute Respiratory Syndrome Coronavirus 2 Seroassay Performance and Optimization in a Population With High Background Reactivity in Mali.

The Journal of infectious diseases

Woodford J, Sagara I, Dicko A, Zeguime A, Doucoure M, Kwan J, Zaidi I, Doritchamou J, Snow-Smith M, Alani N, Renn J, Kosik I, Holly J, Yewdell J, Esposito D, Sadtler K, Duffy P.
PMID: 34612499
J Infect Dis. 2021 Dec 15;224(12):2001-2009. doi: 10.1093/infdis/jiab498.

BACKGROUND: False positivity may hinder the utility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests in sub-Saharan Africa.METHODS: From 312 Malian samples collected before 2020, we measured antibodies to the commonly tested SARS-CoV-2 antigens and 4 other...

Hydrogels: 3D Drug Delivery Systems for Nanoparticles and Extracellular Vesicles.

Biomedicines

Chabria Y, Duffy GP, Lowery AJ, Dwyer RM.
PMID: 34829923
Biomedicines. 2021 Nov 15;9(11). doi: 10.3390/biomedicines9111694.

Synthetic and naturally occurring nano-sized particles present versatile vehicles for the delivery of therapy in a range of clinical settings. Their small size and modifiable physicochemical properties support refinement of targeting capabilities, immune response, and therapeutic cargo, but rapid...

Metastatic medullary thyroid carcinoma presenting as ectopic Cushing's syndrome.

Endocrinology, diabetes & metabolism case reports

Forde HE, Mehigan-Farrelly N, Ryan K, Moran T, Greally M, Duffy AG, Byrne MM.
PMID: 33899746
Endocrinol Diabetes Metab Case Rep. 2021 Apr 01;2021. doi: 10.1530/EDM-20-0207. Epub 2021 Apr 01.

SUMMARY: A 41-year-old male presented to the Emergency Department with a 6-month history of back and hip pain. Skeletal survey revealed bilateral pubic rami fractures and MRI of the spine demonstrated multiple thoracic and lumbar fractures. Secondary work up...

Showing 217 to 221 of 221 entries