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Showing 25 to 36 of 225 entries
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Contrast-Enhanced Ultrasound: A Viable Diagnostic Tool in Predicting Treatment Failure after Non-union Revision Surgery for Upper- and Lower-Limb Non-unions.

Ultrasound in medicine & biology

Doll J, Waizenegger S, Schmidmaier G, Weber MA, Fischer C.
PMID: 34433520
Ultrasound Med Biol. 2021 Nov;47(11):3147-3158. doi: 10.1016/j.ultrasmedbio.2021.07.020. Epub 2021 Aug 22.

Non-unions remain a major complication in the treatment of long-bone fractures and affect quality of life considerably. Both early detection and treatment of non-unions are essential to secure subsequent fracture union. Sufficient vascularization plays a key role in the...

Redox Activity of Iron Diazine-Diimine Carbonyl and Dinitrogen Complexes: A Comparative Study of the Influence of the Heterocyclic Ring.

Inorganic chemistry

Doll JS, Regenauer NI, Bothe VP, Wadepohl H, Roşca DA.
PMID: 34913670
Inorg Chem. 2022 Jan 10;61(1):520-532. doi: 10.1021/acs.inorgchem.1c03212. Epub 2021 Dec 16.

A detailed investigation of the electronic structure of diazinediimine iron complexes and their comparison with the pyridine analogues reveals subtle but important differences, imparted by the supporting heterocycle. In the case of LFe(CO)

A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity.

Biology open

Sapkota M, Adnan Qureshi M, Arif Mahmud S, Balikosa Y, Nguyen C, Boll JM, Pellegrino MW.
PMID: 34184732
Biol Open. 2021 May 15;10(5). doi: 10.1242/bio.058613. Epub 2021 May 20.

A dramatic rise of infections with antibiotic-resistant bacterial pathogens continues to challenge the healthcare field due to the lack of effective treatment regimes. As such, there is an urgent need to develop new antimicrobial agents that can combat these...

MC3R links nutritional state to childhood growth and the timing of puberty.

Nature

Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh MN, Porter DT, Melvin A, Ellacott KLJ, Lippert RN, Buller S, Rosmaninho-Salgado J, Dowsett GKC, Ridley KE, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova EG, Trembath RC, Martin HC, Coll AP, Rowitch DH, Wareham NJ, van Heel DA, Timpson N, Simerly RB, Ong KK, Cone RD, Langenberg C, Perry JRB, Yeo GS, O'Rahilly S.
PMID: 34732894
Nature. 2021 Nov;599(7885):436-441. doi: 10.1038/s41586-021-04088-9. Epub 2021 Nov 03.

The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development

Verteporfin-Loaded Lipid Nanoparticles Improve Ovarian Cancer Photodynamic Therapy In Vitro and In Vivo.

Cancers

Michy T, Massias T, Bernard C, Vanwonterghem L, Henry M, Guidetti M, Royal G, Coll JL, Texier I, Josserand V, Hurbin AA.
PMID: 31717427
Cancers (Basel). 2019 Nov 08;11(11). doi: 10.3390/cancers11111760.

Advanced ovarian cancer is the most lethal gynecological cancer, with a high rate of chemoresistance and relapse. Photodynamic therapy offers new prospects for ovarian cancer treatment, but current photosensitizers lack tumor specificity, resulting in low efficacy and significant side-effects....

Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis.

NeuroImage. Clinical

Schaub AC, Kirschner M, Schweinfurth N, Mählmann L, Kettelhack C, Engeli EE, Doll JPK, Borgwardt S, Lang UE, Kaiser S, Walter M, Herdener M, Wrege J, Schmidt A.
PMID: 34544030
Neuroimage Clin. 2021;32:102825. doi: 10.1016/j.nicl.2021.102825. Epub 2021 Sep 16.

Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses. T1-weighted images from 313 participants including 89 healthy controls...

Interactive Graphics in Industry: The Early Days.

IEEE computer graphics and applications

Kasik DJ, Dill JC, Johnson C, Kasik D, Whitton MC.
PMID: 32833624
IEEE Comput Graph Appl. 2020 Sep-Oct;40(5):89-99. doi: 10.1109/MCG.2020.3012228.

Computer graphics has a long history. Industrial organizations and laboratories drove significant improvements as they adapted and assembled basic capabilities into complex interactive applications. Of particular concern in the early days was providing interactive 3-D applications for computer-aided design...

The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice.

Frontiers in pharmacology

Vollaire J, Machuca-Gayet I, Lavaud J, Bellanger A, Bouazza L, El Moghrabi S, Treilleux I, Coll JL, Peyruchaud O, Josserand V, Cohen PA.
PMID: 31275146
Front Pharmacol. 2019 Jun 19;10:667. doi: 10.3389/fphar.2019.00667. eCollection 2019.

Breast cancer with bone metastasis is essentially incurable with current anticancer therapies. The bone morphogenetic protein (BMP) pathway is an attractive therapeutic candidate, as it is involved in the bone turnover and in cancer cell formation and their colonization...

Redox Activity of Iron Diazine-Diimine Carbonyl and Dinitrogen Complexes: A Comparative Study of the Influence of the Heterocyclic Ring.

Inorganic chemistry

Doll JS, Regenauer NI, Bothe VP, Wadepohl H, Roşca DA.
PMID: 34913670
Inorg Chem. 2022 Jan 10;61(1):520-532. doi: 10.1021/acs.inorgchem.1c03212. Epub 2021 Dec 16.

A detailed investigation of the electronic structure of diazinediimine iron complexes and their comparison with the pyridine analogues reveals subtle but important differences, imparted by the supporting heterocycle. In the case of LFe(CO)

In .

Journal of bacteriology

Hunt-Serracín AC, Kazi MI, Boll JM, Boutte CC.
PMID: 34898264
J Bacteriol. 2021 Dec 13;JB0043421. doi: 10.1128/JB.00434-21. Epub 2021 Dec 13.

The stringent response is a broadly conserved stress response system that exhibits functional variability across bacterial clades. Here, we characterize the role of the stringent factor Rel in the non-tuberculous mycobacterial pathogen,

Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma.

OncoTargets and therapy

Jeannot V, Busser B, Vanwonterghem L, Michallet S, Ferroudj S, Cokol M, Coll JL, Ozturk M, Hurbin A.
PMID: 27877053
Onco Targets Ther. 2016 Nov 09;9:6843-6855. doi: 10.2147/OTT.S117743. eCollection 2016.

Development of drug resistance limits the efficacy of targeted therapies. Alternative approaches using different combinations of therapeutic agents to inhibit several pathways could be a more effective strategy for treating cancer. The effects of the approved epidermal growth factor...

The omission of intentional primary site radiation following transoral robotic surgery in 59 patients: No local-regional failures.

Head & neck

Dhere VR, Escott CE, Tian S, Switchenko JM, Bell JP, Stokes WA, McDonald MW, Magliocca KR, Boyce BJ, Kaka AS, Steuer CE, Saba NF, Shin DM, Xiao C, Patel MR, Beitler JJ.
PMID: 34850994
Head Neck. 2022 Feb;44(2):382-390. doi: 10.1002/hed.26928. Epub 2021 Dec 01.

BACKGROUND: We assessed locoregional control with omission of intentional primary site radiation after transoral robotic surgery (TORS) and quantified nontargeted primary site dose.METHODS: Following Institutional Review Board (IRB) approval, patients treated with primary TORS resection for squamous cell carcinomas...

Showing 25 to 36 of 225 entries