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Showing 13 to 24 of 33 entries
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Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer.

Cancers

Timaxian C, Vogel CFA, Orcel C, Vetter D, Durochat C, Chinal C, NGuyen P, Aknin ML, Mercier-Nomé F, Davy M, Raymond-Letron I, Van TN, Diermeier SD, Godefroy A, Gary-Bobo M, Molina F, Balabanian K, Lazennec G.
PMID: 34070438
Cancers (Basel). 2021 May 25;13(11). doi: 10.3390/cancers13112584.

Chemokines present in the tumor microenvironment are essential for the control of tumor progression. We show here that several ligands of the chemokine receptor Cxcr2 were up-regulated in the PyMT (polyoma middle T oncogene) model of breast cancer. Interestingly,...

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

[Posterior meniscus root tears].

Der Orthopade

Balke M, Metzlaff S, Faber S, Niethammer T, Roessler PP, Henkelmann R, Diermeier T, Kurme A, Winkler PW, Colcuc S, Zimmermann GR, Petersen W.
PMID: 34767042
Orthopade. 2021 Dec;50(12):1039-1050. doi: 10.1007/s00132-021-04192-8.

Meniscus root tears are radial tears in the region of the posterior insertion zones. Medial root injuries usually occur in individuals > 50 years of age without adequate trauma and are associated with obesity and varus deformities. The root...

Single-Cell RNA-Seq Reveals Heterogeneous lncRNA Expression in Xenografted Triple-Negative Breast Cancer Cells.

Biology

Pinkney HR, Black MA, Diermeier SD.
PMID: 34681087
Biology (Basel). 2021 Sep 30;10(10). doi: 10.3390/biology10100987.

Breast cancer is the most commonly diagnosed cancer in the world, with triple-negative breast cancer (TNBC) making up 12% of these diagnoses. TNBC tumours are highly heterogeneous in both inter-tumour and intra-tumour gene expression profiles, where they form subclonal...

Functional Screening Techniques to Identify Long Non-Coding RNAs as Therapeutic Targets in Cancer.

Cancers

Lucere KM, O'Malley MMR, Diermeier SD.
PMID: 33317042
Cancers (Basel). 2020 Dec 09;12(12). doi: 10.3390/cancers12123695.

Recent technological advancements such as CRISPR/Cas-based systems enable multiplexed, high-throughput screening for new therapeutic targets in cancer. While numerous functional screens have been performed on protein-coding genes to date, long non-coding RNAs (lncRNAs) represent an emerging class of potential...

Understanding Failure and Improving Treatment Using HDAC Inhibitors for Prostate Cancer.

Biomedicines

Rana Z, Diermeier S, Hanif M, Rosengren RJ.
PMID: 32019149
Biomedicines. 2020 Jan 30;8(2). doi: 10.3390/biomedicines8020022.

Novel treatment regimens are required for castration-resistant prostate cancers (CRPCs) that become unresponsive to standard treatments, such as docetaxel and enzalutamide. Histone deacetylase (HDAC) inhibitors showed promising results in hematological malignancies, but they failed in solid tumors such as...

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X.
PMID: 34791665
Ann N Y Acad Sci. 2021 Dec;1506(1):118-141. doi: 10.1111/nyas.14713. Epub 2021 Nov 17.

The human transcriptome contains many types of noncoding RNAs, which rival the number of protein-coding species. From long noncoding RNAs (lncRNAs) that are over 200 nucleotides long to piwi-interacting RNAs (piRNAs) of only 20 nucleotides, noncoding RNAs play important...

Inactivation and regeneration of peroxidase in heat-treated plant tissues.

Biochemische Zeitschrift

HERRLINGER F, KIERMEIER F.
PMID: 18887940
Biochem Z. 1948;318(4):413-24.

No abstract available.

Antisense Oligonucleotide-mediated Knockdown in Mammary Tumor Organoids.

Bio-protocol

Diermeier SD, Spector DL.
PMID: 28932764
Bio Protoc. 2017 Aug 20;7(16). doi: 10.21769/BioProtoc.2511.

Primary mammary tumor organoids grown in 3D are an excellent system to study tumor biology. They resemble the organization and physiology of native epithelia more closely than cancer cell lines grown in 2D, and additionally model interactions with the...

Micro-bias and macro-performance.

The European physical journal. B

Seaver SM, Moreira AA, Sales-Pardo M, Malmgren RD, Diermeier D, Amaral LA.
PMID: 24860255
Eur Phys J B. 2009 Feb 01;67(3):369-375. doi: 10.1140/epjb/e2008-00406-4.

We use agent-based modeling to investigate the effect of conservatism and partisanship on the efficiency with which large populations solve the density classification task - a paradigmatic problem for information aggregation and consensus building. We find that conservative agents...

Treatment After Anterior Cruciate Ligament Injury: Panther Symposium ACL Treatment Consensus Group.

Orthopaedic journal of sports medicine

Diermeier T, Rothrauff BB, Engebretsen L, Lynch AD, Ayeni OR, Paterno MV, Xerogeanes JW, Fu FH, Karlsson J, Musahl V, Brown CH, Chmielewski TL, Clatworthy M, Villa SD, Ernlund L, Fink C, Getgood A, Hewett TE, Ishibashi Y, Johnson DL, Macalena JA, Marx RG, Menetrey J, Meredith SJ, Onishi K, Rauer T, Rothrauff BB, Schmitt LC, Seil R, Senorski EH, Siebold R, Snyder-Mackler L, Spalding T, Svantesson E, Wilk KE.
PMID: 32637434
Orthop J Sports Med. 2020 Jun 24;8(6):2325967120931097. doi: 10.1177/2325967120931097. eCollection 2020 Jun.

Treatment strategies for anterior cruciate ligament (ACL) injuries continue to evolve. Evidence supporting best-practice guidelines for the management of ACL injury is to a large extent based on studies with low-level evidence. An international consensus group of experts was...

Anti-Proliferative, Anti-Angiogenic and Safety Profiles of Novel HDAC Inhibitors for the Treatment of Metastatic Castration-Resistant Prostate Cancer.

Pharmaceuticals (Basel, Switzerland)

Rana Z, Diermeier S, Walsh FP, Hanif M, Hartinger CG, Rosengren RJ.
PMID: 34681244
Pharmaceuticals (Basel). 2021 Oct 04;14(10). doi: 10.3390/ph14101020.

Metastatic castration-resistant prostate cancer (CRPC) has a five-year survival rate of 28%. As histone deacetylases (HDACs) are overexpressed in CRPC, the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) was trialled in CRPC patients but found to be toxic and inefficacious....

Showing 13 to 24 of 33 entries