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Showing 37 to 48 of 60 entries
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Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Damotte V, van der Lee SJ, Chouraki V, Grenier-Boley B, Simino J, Adams H, Tosto G, White C, Terzikhan N, Cruchaga C, Knol MJ, Li S, Schraen S, Grove ML, Satizabal C, Amin N, Berr C, Younkin S, Gottesman RF, Buée L, Beiser A, Knopman DS, Uitterlinden A, DeCarli C, Bressler J, DeStefano A, Dartigues JF, Yang Q, Boerwinkle E, Tzourio C, Fornage M, Ikram MA, Amouyel P, de Jager P, Reitz C, Mosley TH, Lambert JC, Seshadri S, van Duijn CM.
PMID: 34002480
Alzheimers Dement. 2021 Oct;17(10):1663-1674. doi: 10.1002/alz.12333. Epub 2021 May 18.

INTRODUCTION: There is increasing interest in plasma amyloid beta (Aβ) as an endophenotype of Alzheimer's disease (AD). Identifying the genetic determinants of plasma Aβ levels may elucidate important biological processes that determine plasma Aβ measures.METHODS: We included 12,369 non-demented...

Executive function deficits in patients with dementia of the Alzheimer's type: a study with a Tower of London task.

Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

Rainville C, Amieva H, Lafont S, Dartigues JF, Orgogozo JM, Fabrigoule C.
PMID: 14591853
Arch Clin Neuropsychol. 2002 Aug;17(6):513-30.

A growing number of studies report a deterioration of the executive function (EF) in dementia of the Alzheimer type (DAT). To evaluate EFs in DAT, a new version of the Tower of London (TOL) task, originally developed by Shallice...

Immunosurveillance in esophageal carcinoma: The decisive impact of regulatory T cells.

Oncoimmunology

Vacchelli E, Semeraro M, Adam J, Dartigues P, Zitvogel L, Kroemer G.
PMID: 27057430
Oncoimmunology. 2015 Jul 01;5(2):e1064581. doi: 10.1080/2162402X.2015.1064581. eCollection 2016 Feb.

Neoadjuvant radiochemotherapy of esophageal carcinomas causes a variable degree of depletion of tumor-infiltrating FOXP3

Playing board games, cognitive decline and dementia: a French population-based cohort study.

BMJ open

Dartigues JF, Foubert-Samier A, Le Goff M, Viltard M, Amieva H, Orgogozo JM, Barberger-Gateau P, Helmer C.
PMID: 23988362
BMJ Open. 2013 Aug 29;3(8):e002998. doi: 10.1136/bmjopen-2013-002998.

OBJECTIVES: To study the relationship between board game playing and risk of subsequent dementia in the Paquid cohort.DESIGN: A prospective population-based study.SETTING: In the Bordeaux area in South Western France.PARTICIPANTS: 3675 non-demented participants at baseline.PRIMARY OUTCOME MEASURE: The risk...

Evolution of dementia diagnosis over time (1988-2013): Evidence from French and English cohorts. Implication for secular trends analyses.

Alzheimer's & dementia (Amsterdam, Netherlands)

Grasset L, Matthews FE, Pérès K, Foubert-Samier A, Helmer C, Dartigues JF, Brayne C.
PMID: 30310851
Alzheimers Dement (Amst). 2018 Aug 09;10:490-497. doi: 10.1016/j.dadm.2018.07.005. eCollection 2018.

INTRODUCTION: The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia.METHODS: Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées...

People with Dementia in Sub-Saharan Africa: From Support to Abuse by Caregivers: Results of EPIDEMCA-FU Program in Congo.

Dementia and geriatric cognitive disorders extra

Kehoua G, Dubreuil CM, Ndamba-Bandzouzi B, Guerchet M, Mbelesso P, Dartigues JF, Preux PM.
PMID: 31097954
Dement Geriatr Cogn Dis Extra. 2019 Apr 03;9(1):163-175. doi: 10.1159/000489846. eCollection 2019.

BACKGROUND/AIMS: Dementia is an emerging public health problem in sub-Saharan Africa (SSA). In SSA, the stigma suffered by people with dementia (PWD) can be strongly linked to pejorative social representations, interfering in social relationships with informal caregivers. The objective...

Outcomes of Transplant-Eligible Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma After Second-Line Salvage Chemotherapy: The Gustave Roussy Experience.

Clinical lymphoma, myeloma & leukemia

Rassy E, Danu A, Ibrahim T, Lazarovici J, Ghez D, Michot JM, Arfi-Rouche J, Rossignol J, Vergé V, Dartigues P, Ribrag V.
PMID: 33277224
Clin Lymphoma Myeloma Leuk. 2021 Apr;21(4):e373-e380. doi: 10.1016/j.clml.2020.11.008. Epub 2020 Nov 13.

INTRODUCTION: After failure of frontline therapy, patients with relapsed/refractory diffuse large B-cell lymphoma (RR-DLBCL) that does not respond to first-line salvage chemotherapy can be recommended second-line salvage chemotherapy. The available literature in this regard is weak, although many centers...

Dose-Adjusted Etoposide, Doxorubicin, and Cyclophosphamide With Vincristine and Prednisone Plus Rituximab Therapy in Children and Adolescents With Primary Mediastinal B-Cell Lymphoma: A Multicenter Phase II Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Burke GAA, Minard-Colin V, Aupérin A, Alexander S, Pillon M, Delgado R, Zsíros J, Uyttebroeck A, Dartigues P, Miles RR, Kazanowska B, Chiang AK, Haouy S, Bollard CM, Csoka M, Wheatley K, Barkauskas DA, Adamson PC, Vassal G, Patte C, Gross TG.
PMID: 34570655
J Clin Oncol. 2021 Nov 20;39(33):3716-3724. doi: 10.1200/JCO.21.00920. Epub 2021 Sep 27.

PURPOSE: A dose-adjusted etoposide, doxorubicin, and cyclophosphamide with vincristine and prednisone plus rituximab (DA-EPOCH-R) regimen has been shown to deliver excellent survival for adults with primary mediastinal large B-cell lymphoma (PMLBL) without the use of radiotherapy. No international prospective...

Molecular targeted therapy of .

Therapeutic advances in medical oncology

Ducreux M, Chamseddine A, Laurent-Puig P, Smolenschi C, Hollebecque A, Dartigues P, Samallin E, Boige V, Malka D, Gelli M.
PMID: 31244912
Ther Adv Med Oncol. 2019 Jun 18;11:1758835919856494. doi: 10.1177/1758835919856494. eCollection 2019.

Over the past two decades, the molecular characterization of metastatic colorectal cancer (mCRC) has been revolutionized by the routine implementation of

Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation.

Molecular psychiatry

Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, Amin N, Amouyel P, Beecham GW, Below JE, Campion D, Cantwell L, Charbonnier C, Chung J, Crane PK, Cruchaga C, Cupples LA, Dartigues JF, Debette S, Deleuze JF, Fulton L, Gabriel SB, Genin E, Gibbs RA, Goate A, Grenier-Boley B, Gupta N, Haines JL, Havulinna AS, Helisalmi S, Hiltunen M, Howrigan DP, Ikram MA, Kaprio J, Konrad J, Kuzma A, Lander ES, Lathrop M, Lehtimäki T, Lin H, Mattila K, Mayeux R, Muzny DM, Nasser W, Neale B, Nho K, Nicolas G, Patel D, Pericak-Vance MA, Perola M, Psaty BM, Quenez O, Rajabli F, Redon R, Reitz C, Remes AM, Salomaa V, Sarnowski C, Schmidt H, Schmidt M, Schmidt R, Soininen H, Thornton TA, Tosto G, Tzourio C, van der Lee SJ, van Duijn CM, Valladares O, Vardarajan B, Wang LS, Wang W, Wijsman E, Wilson RK, Witten D, Worley KC, Zhang X, Bellenguez C, Lambert JC, Kurki MI, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj AC, Fornage M, Farrer LA.
PMID: 31636380
Mol Psychiatry. 2020 Aug;25(8):1901-1903. doi: 10.1038/s41380-019-0529-7.

A correction to this paper has been published and can be accessed via a link at the top of the paper.

Self-Reported Vision Impairment and Frailty among Older People with Low Cognitive Performance in Central Africa: EPIDEMCA Population-Based Study.

Dementia and geriatric cognitive disorders

Gbessemehlan A, Kehoua G, Helmer C, Delcourt C, Tchalla A, Mbelesso P, Ndamba-Bandzouzi B, Dartigues JF, Houinato D, Preux PM, Guerchet M.
PMID: 34808622
Dement Geriatr Cogn Disord. 2021;50(4):326-332. doi: 10.1159/000518601. Epub 2021 Oct 14.

INTRODUCTION: Very little is known about the impact of vision impairment (VI) on physical health in late-life in sub-Saharan Africa populations, whereas many older people experience it. We investigated the association between self-reported VI and frailty in Central African...

Self-Rated Health and Frailty in Older Adults from the Population-Based Three-City Bordeaux Cohort.

Gerontology

Pilleron S, Le Goff M, Ajana S, Helmer C, Pérès K, Dartigues JF, Tabue-Teguo M, Féart C.
PMID: 34818256
Gerontology. 2021 Oct 18;1-8. doi: 10.1159/000518864. Epub 2021 Oct 18.

INTRODUCTION: This study aimed to investigate whether self-rated health (SRH) predict frailty and its components among community dwellers aged 75 years and older.METHODS: We ran a cross-sectional and prospective analysis from 643 and 379 participants of the Bordeaux Center...

Showing 37 to 48 of 60 entries