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Showing 25 to 36 of 217 entries
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Corrigendum to "Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding" [Neurobiology of Disease 158 (October 2021) DOI: 10.1016/j.nbd.2021.105474].

Neurobiology of disease

Zanardi A, Barbariga M, Conti A, Vegliani F, Curnis F, Alessio M.
PMID: 34865940
Neurobiol Dis. 2022 Jan;162:105575. doi: 10.1016/j.nbd.2021.105575. Epub 2021 Dec 02.

No abstract available.

Introduction of the Concept of Diagnostic Sensitivity and Specificity of Normothermic Perfusion Protocols to Assess High-Risk Donor Livers.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Mergental H, Laing RW, Hodson J, Boteon YL, Attard JA, Walace LL, Neil DAH, Barton D, Schlegel A, Muiesan P, Abradelo M, Isaac JR, Roberts K, Perera MTPR, Afford SC, Mirza DF.
PMID: 34619014
Liver Transpl. 2021 Oct 07; doi: 10.1002/lt.26326. Epub 2021 Oct 07.

Normothermic machine perfusion (NMP) allows objective assessment of donor liver transplantability. Several viability evaluation protocols have been established, consisting of parameters such as perfusate lactate clearance, pH, transaminase levels, and the production and composition of bile. The aims of...

Transitioning to molecular diagnostics in pediatric high-grade glioma: experiences with the 2016 WHO classification of CNS tumors.

Neuro-oncology advances

Baugh JN, Gielen GH, van Vuurden DG, Veldhuijzen van Zanten SEM, Hargrave D, Massimino M, Biassoni V, Morales la Madrid A, Karremann M, Wiese M, Thomale U, Janssens GO, von Bueren AO, Perwein T, Hoving EW, Pietsch T, Andreiuolo F, Kramm CM.
PMID: 34595479
Neurooncol Adv. 2021 Aug 18;3(1):vdab113. doi: 10.1093/noajnl/vdab113. eCollection 2021.

BACKGROUND: Pediatric neuro-oncology was profoundly changed in the wake of the 2016 revision of the WHO Classification of Tumors of the Central Nervous System. Practitioners were challenged to quickly adapt to a system of tumor classification redefined by molecular...

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

The Journal of clinical investigation

Nakanishi T, Pigazzini S, Degenhardt F, Cordioli M, Butler-Laporte G, Maya-Miles D, Bujanda L, Bouysran Y, Niemi ME, Palom A, Ellinghaus D, Khan A, Martínez-Bueno M, Rolker S, Amitrano S, Roade Tato L, Fava F, Spinner CD, Prati D, Bernardo D, Garcia F, Darcis G, Fernández-Cadenas I, Holter JC, Banales JM, Frithiof R, Kiryluk K, Duga S, Asselta R, Pereira AC, Romero-Gómez M, Nafría-Jiménez B, Hov JR, Migeotte I, Renieri A, Planas AM, Ludwig KU, Buti M, Rahmouni S, Alarcón-Riquelme ME, Schulte EC, Franke A, Karlsen TH, Valenti L, Zeberg H, Richards JB, Ganna A.
PMID: 34597274
J Clin Invest. 2021 Dec 01;131(23). doi: 10.1172/JCI152386.

BackgroundThere is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition.MethodsWe combined individual level data from 13,888 COVID-19 patients (n = 7185 hospitalized) from 17 cohorts in 9 countries...

Plasma Neurofilament Light (NfL) in Patients Affected by Niemann-Pick Type C Disease (NPCD).

Journal of clinical medicine

Dardis A, Pavan E, Fabris M, Da Riol RM, Sechi A, Fiumara A, Santoro L, Ormazabal M, Milanic R, Zampieri S, Biasizzo J, Scarpa M.
PMID: 34682919
J Clin Med. 2021 Oct 19;10(20). doi: 10.3390/jcm10204796.

(1) Background: Niemann-Pick type C disease (NPCD) is an autosomal recessive lysosomal storage disorder caused by mutations in the NPC1 or NPC2 genes. The clinical presentation is characterized by visceral and neurological involvement. Apart from a small group of...

Implication of folate deficiency in CYP2U1 loss of function.

The Journal of experimental medicine

Pujol C, Legrand A, Parodi L, Thomas P, Mochel F, Saracino D, Coarelli G, Croon M, Popovic M, Valet M, Villain N, Elshafie S, Issa M, Zuily S, Renaud M, Marelli-Tosi C, Legendre M, Trimouille A, Kemlin I, Mathieu S, Gleeson JG, Lamari F, Galatolo D, Alkouri R, Tse C, Rodriguez D, Ewenczyk C, Fellmann F, Kuntzer T, Blond E, El Hachimi KH, Darios F, Seyer A, Gazi AD, Giavalisco P, Perin S, Boucher JL, Le Corre L, Santorelli FM, Goizet C, Zaki MS, Picaud S, Mourier A, Steculorum SM, Mignot C, Durr A, Trifunovic A, Stevanin G.
PMID: 34546337
J Exp Med. 2021 Nov 01;218(11). doi: 10.1084/jem.20210846. Epub 2021 Sep 21.

Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse, and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of which is known to be involved in a complex...

SARS-CoV2-specific Humoral and T-cell Immune Response After Second Vaccination in Liver Cirrhosis and Transplant Patients.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Ruether DF, Schaub GM, Duengelhoef PM, Haag F, Brehm TT, Fathi A, Wehmeyer M, Jahnke-Triankowski J, Mayer L, Hoffmann A, Fischer L, Addo MM, Lütgehetmann M, Lohse AW, Schulze Zur Wiesch J, Sterneck M.
PMID: 34509643
Clin Gastroenterol Hepatol. 2022 Jan;20(1):162-172.e9. doi: 10.1016/j.cgh.2021.09.003. Epub 2021 Sep 09.

BACKGROUND & AIMS: Detailed information on the immune response after second vaccination of cirrhotic patients and liver transplant (LT) recipients against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is largely missing. We aimed at comparing the vaccine-induced humoral...

Author Correction: Continuous scanning for Bragg coherent X-ray imaging.

Scientific reports

Li N, Dupraz M, Wu L, Leake SJ, Resta A, Carnis J, Labat S, Almog E, Rabkin E, Favre-Nicolin V, Picca FE, Berenguer F, van de Poll R, Hofmann JP, Vlad A, Thomas O, Garreau Y, Coati A, Richard MI.
PMID: 33154457
Sci Rep. 2020 Nov 05;10(1):19420. doi: 10.1038/s41598-020-75649-7.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Percutaneous Femoropopliteal Bypass: 2-Year Results of the DETOUR System.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

Halena G, Krievins DK, Scheinert D, Savlovskis J, Szopiński P, Krämer A, Ouriel K, Schmidt A, Zdunek M, Lyden SP.
PMID: 34465223
J Endovasc Ther. 2022 Feb;29(1):84-95. doi: 10.1177/15266028211034862. Epub 2021 Aug 31.

PURPOSE: This study investigated the 2-year safety and effectiveness of the PQ Bypass DETOUR system as a percutaneous femoropopliteal bypass.MATERIALS AND METHODS: Seventy-eight patients with 82 long-segment femoropopliteal lesions were enrolled in this prospective, single-arm, multicenter study. The DETOUR...

Deferoxamine mesylate improves splicing and GAA activity of the common c.-32-13T>G allele in late-onset PD patient fibroblasts.

Molecular therapy. Methods & clinical development

Buratti E, Peruzzo P, Braga L, Zanin I, Stuani C, Goina E, Romano M, Giacca M, Dardis A.
PMID: 33426149
Mol Ther Methods Clin Dev. 2020 Nov 20;20:227-236. doi: 10.1016/j.omtm.2020.11.011. eCollection 2021 Mar 12.

Pompe disease (PD) is an autosomal recessive lysosomal storage disorder due to deficient activity of the acid alpha glucosidase enzyme (GAA). As a consequence of the enzymatic defect, undigested glycogen accumulates within lysosomes. Most patients affected by the late-onset...

Comment on: Static cold storage compared with normothermic machine perfusion of the liver and effect on ischaemic-type biliary lesions after transplantation: a propensity-score matched study.

The British journal of surgery

Hann A, Raza SS, Sneiders D, Nutu A, Mergental H, Mirza DF, Hartog H, Perera MTP.
PMID: 34672319
Br J Surg. 2021 Oct 21; doi: 10.1093/bjs/znab349. Epub 2021 Oct 21.

No abstract available.

Shocking HIV-1 with immunomodulatory latency reversing agents.

Seminars in immunology

Kula-Pacurar A, Rodari A, Darcis G, Van Lint C.
PMID: 33972164
Semin Immunol. 2021 Jan;51:101478. doi: 10.1016/j.smim.2021.101478. Epub 2021 May 08.

The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to induce subsequent...

Showing 25 to 36 of 217 entries