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Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury.

Brain sciences

Cordero K, Coronel GG, Serrano-Illán M, Cruz-Bracero J, Figueroa JD, De León M.
PMID: 29495419
Brain Sci. 2018 Feb 26;8(3). doi: 10.3390/brainsci8030038.

Traumatic spinal cord injury (SCI) results in debilitating autonomic dysfunctions, paralysis and significant sensorimotor impairments. A key component of SCI is the generation of free radicals that contributes to the high levels of oxidative stress observed. This study investigates...

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Cordero K, Coronel GG, Serrano-Illán M, et al. Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury. Brain Sci. 2018;8(3)doi: 10.3390/brainsci8030038.
Cordero, K., Coronel, G. G., Serrano-Illán, M., Cruz-Bracero, J., Figueroa, J. D., & De León, M. (2018). Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury. Brain sciences, 8(3), . https://doi.org/10.3390/brainsci8030038
Cordero, Kathia, et al. "Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury." Brain sciences vol. 8,3 (2018). doi: https://doi.org/10.3390/brainsci8030038
Cordero K, Coronel GG, Serrano-Illán M, Cruz-Bracero J, Figueroa JD, De León M. Effects of Dietary Vitamin E Supplementation in Bladder Function and Spasticity during Spinal Cord Injury. Brain Sci. 2018 Feb 26;8(3). doi: 10.3390/brainsci8030038. PMID: 29495419; PMCID: PMC5870356.
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Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review.

Journal of the American College of Cardiology

Ernault AC, Meijborg VMF, Coronel R.
PMID: 34674819
J Am Coll Cardiol. 2021 Oct 26;78(17):1730-1745. doi: 10.1016/j.jacc.2021.08.037.

Obesity is a significant risk factor for arrhythmic cardiovascular death. Interactions between epicardial adipose tissue (EAT) and myocytes are thought to play a key role in the development of arrhythmias. In this review, the authors investigate the influence of...

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Ernault AC, Meijborg VMF, Coronel R. Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021;78(17):1730-1745doi: 10.1016/j.jacc.2021.08.037.
Ernault, A. C., Meijborg, V. M. F., & Coronel, R. (2021). Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 78(17), 1730-1745. https://doi.org/10.1016/j.jacc.2021.08.037
Ernault, Auriane C, et al. "Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review." Journal of the American College of Cardiology vol. 78,17 (2021): 1730-1745. doi: https://doi.org/10.1016/j.jacc.2021.08.037
Ernault AC, Meijborg VMF, Coronel R. Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Oct 26;78(17):1730-1745. doi: 10.1016/j.jacc.2021.08.037. PMID: 34674819.
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Crucial contribution of the universities to SARS-CoV-2 surveillance in Ecuador: Lessons for developing countries.

One health (Amsterdam, Netherlands)

Santander-Gordon D, Iturralde GA, Freire-Paspuel B, Zambrano-Mila MS, Morales-Jadan D, Vallejo-Janeta PA, Coronel B, Galvis H, Jaramillo-Vivanco T, Bilvao CD, Paredes-Espinosa MB, Rodriguez AS, Laglaguano JC, Herrera H, Tito-Alvarez AM, Ortiz-Prado E, Rivera-Olivero IA, Henriquez-Trujillo AR, Lozada T, Garcia-Bereguiain MA.
PMID: 34056057
One Health. 2021 Dec;13:100267. doi: 10.1016/j.onehlt.2021.100267. Epub 2021 May 25.

COVID-19 pandemic has challenged public health systems worldwide, particularly affecting developing countries in Latin America like Ecuador. In this report, we exposed the fundamental role of the Ecuadorian universities to improve COVID-19 surveillance in the country, with an overall...

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Santander-Gordon D, Iturralde GA, Freire-Paspuel B, et al. Crucial contribution of the universities to SARS-CoV-2 surveillance in Ecuador: Lessons for developing countries. One Health. 2021;13:100267doi: 10.1016/j.onehlt.2021.100267.
Santander-Gordon, D., Iturralde, G. A., Freire-Paspuel, B., Zambrano-Mila, M. S., Morales-Jadan, D., Vallejo-Janeta, P. A., Coronel, B., Galvis, H., Jaramillo-Vivanco, T., Bilvao, C. D., Paredes-Espinosa, M. B., Rodriguez, A. S., Laglaguano, J. C., Herrera, H., Tito-Alvarez, A. M., Ortiz-Prado, E., Rivera-Olivero, I. A., Henriquez-Trujillo, A. R., Lozada, T., Garcia-Bereguiain, M. A. (2021). Crucial contribution of the universities to SARS-CoV-2 surveillance in Ecuador: Lessons for developing countries. One health (Amsterdam, Netherlands), 13100267. https://doi.org/10.1016/j.onehlt.2021.100267
Santander-Gordon, Daniela, et al. "Crucial contribution of the universities to SARS-CoV-2 surveillance in Ecuador: Lessons for developing countries." One health (Amsterdam, Netherlands) vol. 13 (2021): 100267. doi: https://doi.org/10.1016/j.onehlt.2021.100267
Santander-Gordon D, Iturralde GA, Freire-Paspuel B, Zambrano-Mila MS, Morales-Jadan D, Vallejo-Janeta PA, Coronel B, Galvis H, Jaramillo-Vivanco T, Bilvao CD, Paredes-Espinosa MB, Rodriguez AS, Laglaguano JC, Herrera H, Tito-Alvarez AM, Ortiz-Prado E, Rivera-Olivero IA, Henriquez-Trujillo AR, Lozada T, Garcia-Bereguiain MA. Crucial contribution of the universities to SARS-CoV-2 surveillance in Ecuador: Lessons for developing countries. One Health. 2021 Dec;13:100267. doi: 10.1016/j.onehlt.2021.100267. Epub 2021 May 25. PMID: 34056057; PMCID: PMC8146272.
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Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection.

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

Coronel M, Coronel E, Romero L, Ge PS.
PMID: 34278090
VideoGIE. 2021 Apr 05;6(7):297-300. doi: 10.1016/j.vgie.2021.02.013. eCollection 2021 Jul.

Video 1Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection.

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Coronel M, Coronel E, Romero L, et al. Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection. VideoGIE. 2021;6(7):297-300doi: 10.1016/j.vgie.2021.02.013.
Coronel, M., Coronel, E., Romero, L., & Ge, P. S. (2021). Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection. VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy, 6(7), 297-300. https://doi.org/10.1016/j.vgie.2021.02.013
Coronel, Martin, et al. "Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection." VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy vol. 6,7 (2021): 297-300. doi: https://doi.org/10.1016/j.vgie.2021.02.013
Coronel M, Coronel E, Romero L, Ge PS. Combination of a dynamic rigidizing overtube and a novel injectable needle-type knife to facilitate colorectal endoscopic submucosal dissection. VideoGIE. 2021 Apr 05;6(7):297-300. doi: 10.1016/j.vgie.2021.02.013. eCollection 2021 Jul. PMID: 34278090; PMCID: PMC8267954.
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Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes.

Journal of neuro-oncology

Rosso DA, Rosato M, Iturrizaga J, González N, Shiromizu CM, Keitelman IA, Coronel JV, Gómez FD, Amaral MM, Rabadan AT, Salamone GV, Jancic CC.
PMID: 34125375
J Neurooncol. 2021 Jul;153(3):403-415. doi: 10.1007/s11060-021-03787-7. Epub 2021 Jun 14.

PURPOSE: γδ T lymphocytes are non-conventional T cells that participate in protective immunity and tumor surveillance. In healthy humans, the main subset of circulating γδ T cells express the TCRVγ9Vδ2. This subset responds to non-peptide prenyl-pyrophosphate antigens such as...

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Rosso DA, Rosato M, Iturrizaga J, et al. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021;153(3):403-415doi: 10.1007/s11060-021-03787-7.
Rosso, D. A., Rosato, M., Iturrizaga, J., González, N., Shiromizu, C. M., Keitelman, I. A., Coronel, J. V., Gómez, F. D., Amaral, M. M., Rabadan, A. T., Salamone, G. V., & Jancic, C. C. (2021). Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. Journal of neuro-oncology, 153(3), 403-415. https://doi.org/10.1007/s11060-021-03787-7
Rosso, David A, et al. "Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes." Journal of neuro-oncology vol. 153,3 (2021): 403-415. doi: https://doi.org/10.1007/s11060-021-03787-7
Rosso DA, Rosato M, Iturrizaga J, González N, Shiromizu CM, Keitelman IA, Coronel JV, Gómez FD, Amaral MM, Rabadan AT, Salamone GV, Jancic CC. Glioblastoma cells potentiate the induction of the Th1-like profile in phosphoantigen-stimulated γδ T lymphocytes. J Neurooncol. 2021 Jul;153(3):403-415. doi: 10.1007/s11060-021-03787-7. Epub 2021 Jun 14. PMID: 34125375.
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Nutritional and Bioactive Characterization of .

Biology

Caballero S, Mereles L, Burgos-Edwards A, Alvarenga N, Coronel E, Villalba R, Heinichen O.
PMID: 34943266
Biology (Basel). 2021 Dec 19;10(12). doi: 10.3390/biology10121351.

The "Kurugua" (

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Caballero S, Mereles L, Burgos-Edwards A, et al. Nutritional and Bioactive Characterization of . Biology (Basel). 2021;10(12)doi: 10.3390/biology10121351.
Caballero, S., Mereles, L., Burgos-Edwards, A., Alvarenga, N., Coronel, E., Villalba, R., & Heinichen, O. (2021). Nutritional and Bioactive Characterization of . Biology, 10(12), . https://doi.org/10.3390/biology10121351
Caballero, Silvia, et al. "Nutritional and Bioactive Characterization of ." Biology vol. 10,12 (2021). doi: https://doi.org/10.3390/biology10121351
Caballero S, Mereles L, Burgos-Edwards A, Alvarenga N, Coronel E, Villalba R, Heinichen O. Nutritional and Bioactive Characterization of . Biology (Basel). 2021 Dec 19;10(12). doi: 10.3390/biology10121351. PMID: 34943266.
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Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Uthman L, Li X, Baartscheer A, Schumacher CA, Baumgart P, Hermanides J, Preckel B, Hollmann MW, Coronel R, Zuurbier CJ, Weber NC.
PMID: 34896968
Biomed Pharmacother. 2021 Dec 09;146:112515. doi: 10.1016/j.biopha.2021.112515. Epub 2021 Dec 09.

Inflammation causing oxidative stress in endothelial cells contributes to heart failure development. Sodium/glucose cotransporter 2 inhibitors (SGLT2i's) were shown to reduce heart failure hospitalization and oxidative stress. However, how inflammation causes oxidative stress in endothelial cells, and how SGLT2i's...

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Uthman L, Li X, Baartscheer A, et al. Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na. Biomed Pharmacother. 2021;146:112515doi: 10.1016/j.biopha.2021.112515.
Uthman, L., Li, X., Baartscheer, A., Schumacher, C. A., Baumgart, P., Hermanides, J., Preckel, B., Hollmann, M. W., Coronel, R., Zuurbier, C. J., & Weber, N. C. (2021). Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 146112515. https://doi.org/10.1016/j.biopha.2021.112515
Uthman, Laween, et al. "Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 146 (2021): 112515. doi: https://doi.org/10.1016/j.biopha.2021.112515
Uthman L, Li X, Baartscheer A, Schumacher CA, Baumgart P, Hermanides J, Preckel B, Hollmann MW, Coronel R, Zuurbier CJ, Weber NC. Empagliflozin reduces oxidative stress through inhibition of the novel inflammation/NHE/[Na. Biomed Pharmacother. 2021 Dec 09;146:112515. doi: 10.1016/j.biopha.2021.112515. Epub 2021 Dec 09. PMID: 34896968.
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Low-cost 3D-printed inverted microscope to detect Mycobacterium tuberculosis in a MODS culture.

Tuberculosis (Edinburgh, Scotland)

Salguedo M, Zarate G, Coronel J, Comina G, Gilman RH, Sheen P, Oberhelman R, Zimic M.
PMID: 34864388
Tuberculosis (Edinb). 2021 Nov 30;132:102158. doi: 10.1016/j.tube.2021.102158. Epub 2021 Nov 30.

MODS, an assay for diagnosis of tuberculosis and drug-susceptibility, is based in the microscopic observation of the characteristic cords of Mycobacterium tuberculosis colonies grown in liquid media. An inverted optical microscope (100× magnification) is required to observe and interpret...

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Salguedo M, Zarate G, Coronel J, et al. Low-cost 3D-printed inverted microscope to detect Mycobacterium tuberculosis in a MODS culture. Tuberculosis (Edinb). 2021;132:102158doi: 10.1016/j.tube.2021.102158.
Salguedo, M., Zarate, G., Coronel, J., Comina, G., Gilman, R. H., Sheen, P., Oberhelman, R., & Zimic, M. (2021). Low-cost 3D-printed inverted microscope to detect Mycobacterium tuberculosis in a MODS culture. Tuberculosis (Edinburgh, Scotland), 132102158. https://doi.org/10.1016/j.tube.2021.102158
Salguedo, Mario, et al. "Low-cost 3D-printed inverted microscope to detect Mycobacterium tuberculosis in a MODS culture." Tuberculosis (Edinburgh, Scotland) vol. 132 (2021): 102158. doi: https://doi.org/10.1016/j.tube.2021.102158
Salguedo M, Zarate G, Coronel J, Comina G, Gilman RH, Sheen P, Oberhelman R, Zimic M. Low-cost 3D-printed inverted microscope to detect Mycobacterium tuberculosis in a MODS culture. Tuberculosis (Edinb). 2021 Nov 30;132:102158. doi: 10.1016/j.tube.2021.102158. Epub 2021 Nov 30. PMID: 34864388.
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Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis.

ACG case reports journal

Coronel M, Lanke G, Cambell D, Coronel E, Tzeng CD, Foo W, Lee JH.
PMID: 33324708
ACG Case Rep J. 2020 Dec 07;7(12):e00483. doi: 10.14309/crj.0000000000000483. eCollection 2020 Dec.

Situs inversus totalis (SIT) is a rare anomaly characterized by the transposition of organs. We present a case of a 67-year-old White woman with a history of SIT, who presented with fatigue, jaundice, and abnormal liver enzymes. Endoscopic ultrasound...

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Coronel M, Lanke G, Cambell D, et al. Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis. ACG Case Rep J. 2020;7(12):e00483doi: 10.14309/crj.0000000000000483.
Coronel, M., Lanke, G., Cambell, D., Coronel, E., Tzeng, C. D., Foo, W., & Lee, J. H. (2020). Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis. ACG case reports journal, 7(12), e00483. https://doi.org/10.14309/crj.0000000000000483
Coronel, Martin, et al. "Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis." ACG case reports journal vol. 7,12 (2020): e00483. doi: https://doi.org/10.14309/crj.0000000000000483
Coronel M, Lanke G, Cambell D, Coronel E, Tzeng CD, Foo W, Lee JH. Performing Endoscopic Retrograde Cholagiopancreatpgraphy and Endoscopic Ultrasound for Management of Malignant Bile Duct Obstruction in a Patient With a Situs Inversus Totalis. ACG Case Rep J. 2020 Dec 07;7(12):e00483. doi: 10.14309/crj.0000000000000483. eCollection 2020 Dec. PMID: 33324708; PMCID: PMC7725251.
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Comet 41P/Tuttle-Giacobini-Kresak, 45P/Honda-Mrkos-Pajdusakova, and 46P/Wirtanen: Water Production Activity over 21 Years with SOHO/SWAN.

The planetary science journal

Combi MR, Mäkinen T, Bertaux JL, Quémerais E, Ferron S, Coronel R.
PMID: 33294844
Planet Sci J. 2020 Dec;1(3). doi: 10.3847/psj/abb026. Epub 2020 Dec 04.

In 2017, 2018, and 2019, comets 46P/Wirtanen, 45P/Honda-Mrkos-Pajdusakova, and 41P/Tuttle-Giacobini-Kresak all had perihelion passages. Their hydrogen comae were observed by the Solar Wind ANisotropies (SWAN) all-sky hydrogen Lyman-alpha camera on the SOlar and Heliospheric Observer (SOHO) satellite: comet 46P...

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Combi MR, Mäkinen T, Bertaux JL, et al. Comet 41P/Tuttle-Giacobini-Kresak, 45P/Honda-Mrkos-Pajdusakova, and 46P/Wirtanen: Water Production Activity over 21 Years with SOHO/SWAN. Planet Sci J. 2020;1(3)doi: 10.3847/psj/abb026.
Combi, M. R., Mäkinen, T., Bertaux, J. L., Quémerais, E., Ferron, S., & Coronel, R. (2020). Comet 41P/Tuttle-Giacobini-Kresak, 45P/Honda-Mrkos-Pajdusakova, and 46P/Wirtanen: Water Production Activity over 21 Years with SOHO/SWAN. The planetary science journal, 1(3), . https://doi.org/10.3847/psj/abb026
Combi, M R, et al. "Comet 41P/Tuttle-Giacobini-Kresak, 45P/Honda-Mrkos-Pajdusakova, and 46P/Wirtanen: Water Production Activity over 21 Years with SOHO/SWAN." The planetary science journal vol. 1,3 (2020). doi: https://doi.org/10.3847/psj/abb026
Combi MR, Mäkinen T, Bertaux JL, Quémerais E, Ferron S, Coronel R. Comet 41P/Tuttle-Giacobini-Kresak, 45P/Honda-Mrkos-Pajdusakova, and 46P/Wirtanen: Water Production Activity over 21 Years with SOHO/SWAN. Planet Sci J. 2020 Dec;1(3). doi: 10.3847/psj/abb026. Epub 2020 Dec 04. PMID: 33294844; PMCID: PMC7720819.
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Genomic signatures of pre-resistance in Mycobacterium tuberculosis.

Nature communications

Torres Ortiz A, Coronel J, Vidal JR, Bonilla C, Moore DAJ, Gilman RH, Balloux F, Kon OM, Didelot X, Grandjean L.
PMID: 34911948
Nat Commun. 2021 Dec 15;12(1):7312. doi: 10.1038/s41467-021-27616-7.

Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a view to pre-empt the emergence of resistance, we hypothesized that pre-existing polymorphisms in susceptible genotypes (pre-resistance mutations)...

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Torres Ortiz A, Coronel J, Vidal JR, et al. Genomic signatures of pre-resistance in Mycobacterium tuberculosis. Nat Commun. 2021;12(1):7312doi: 10.1038/s41467-021-27616-7.
Torres Ortiz, A., Coronel, J., Vidal, J. R., Bonilla, C., Moore, D. A. J., Gilman, R. H., Balloux, F., Kon, O. M., Didelot, X., & Grandjean, L. (2021). Genomic signatures of pre-resistance in Mycobacterium tuberculosis. Nature communications, 12(1), 7312. https://doi.org/10.1038/s41467-021-27616-7
Torres Ortiz, Arturo, et al. "Genomic signatures of pre-resistance in Mycobacterium tuberculosis." Nature communications vol. 12,1 (2021): 7312. doi: https://doi.org/10.1038/s41467-021-27616-7
Torres Ortiz A, Coronel J, Vidal JR, Bonilla C, Moore DAJ, Gilman RH, Balloux F, Kon OM, Didelot X, Grandjean L. Genomic signatures of pre-resistance in Mycobacterium tuberculosis. Nat Commun. 2021 Dec 15;12(1):7312. doi: 10.1038/s41467-021-27616-7. PMID: 34911948.
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A left lateral body position increases pulmonary vein stress in healthy humans.

Physiological reports

Gottlieb LA, El Hamrani D, Naulin J, Sanchez Y Blanco L, Lamy J, Kachenoura N, Quesson B, Cochet H, Coronel R, Dekker LR.
PMID: 34558216
Physiol Rep. 2021 Sep;9(18):e15022. doi: 10.14814/phy2.15022.

Pulmonary vein (PV) stretch is proarrhythmic for atrial fibrillation (AF). AF patients often report that a left lateral (LL) body position can trigger arrhythmia symptoms. Because the PV myocardium is thought to trigger AF, we hypothesized that the LL...

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Gottlieb LA, El Hamrani D, Naulin J, et al. A left lateral body position increases pulmonary vein stress in healthy humans. Physiol Rep. 2021;9(18):e15022doi: 10.14814/phy2.15022.
Gottlieb, L. A., El Hamrani, D., Naulin, J., Sanchez Y Blanco, L., Lamy, J., Kachenoura, N., Quesson, B., Cochet, H., Coronel, R., & Dekker, L. R. (2021). A left lateral body position increases pulmonary vein stress in healthy humans. Physiological reports, 9(18), e15022. https://doi.org/10.14814/phy2.15022
Gottlieb, Lisa A, et al. "A left lateral body position increases pulmonary vein stress in healthy humans." Physiological reports vol. 9,18 (2021): e15022. doi: https://doi.org/10.14814/phy2.15022
Gottlieb LA, El Hamrani D, Naulin J, Sanchez Y Blanco L, Lamy J, Kachenoura N, Quesson B, Cochet H, Coronel R, Dekker LR. A left lateral body position increases pulmonary vein stress in healthy humans. Physiol Rep. 2021 Sep;9(18):e15022. doi: 10.14814/phy2.15022. PMID: 34558216; PMCID: PMC8461032.
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