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Showing 1477 to 1488 of 1488 entries
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2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of .

Pharmaceuticals (Basel, Switzerland)

Amrane D, Arnold CS, Hutter S, Sanz-Serrano J, Collia M, Azqueta A, Paloque L, Cohen A, Amanzougaghene N, Tajeri S, Franetich JF, Mazier D, Benoit-Vical F, Verhaeghe P, Azas N, Vanelle P, Botté C, Primas N.
PMID: 34451821
Pharmaceuticals (Basel). 2021 Jul 26;14(8). doi: 10.3390/ph14080724.

The malaria parasite harbors a relict plastid called the apicoplast. Although not photosynthetic, the apicoplast retains unusual, non-mammalian metabolic pathways that are essential to the parasite, opening up a new perspective for the development of novel antimalarials which display...

CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.

Cell reports

Rieger MA, King DM, Crosby H, Liu Y, Cohen BA, Dougherty JD.
PMID: 33357440
Cell Rep. 2020 Dec 22;33(12):108531. doi: 10.1016/j.celrep.2020.108531.

CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we define its CNS targets, which...

Time and cost of administering COVID-19 mRNA vaccines in the United States.

Human vaccines & immunotherapeutics

Yarnoff B, Bodhaine S, Cohen E, Buck PO.
PMID: 34613860
Hum Vaccin Immunother. 2021 Oct 06;1-5. doi: 10.1080/21645515.2021.1974289. Epub 2021 Oct 06.

In early 2020, the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) outbreak a global pandemic. In response, two novel messenger RNA (mRNA)-based vaccines: mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) were rapidly developed. A thorough understanding of the...

HIV-1 Vpu Promotes Phagocytosis of Infected CD4.

mBio

Cong L, Sugden SM, Leclair P, Lim CJ, Pham TNQ, Cohen ÉA.
PMID: 34425695
mBio. 2021 Aug 31;12(4):e0192021. doi: 10.1128/mBio.01920-21. Epub 2021 Aug 24.

Human immunodeficiency virus (HIV) remodels the cell surface of infected cells to facilitate viral dissemination and promote immune evasion. The membrane-associated viral protein U (Vpu) accessory protein encoded by HIV-1 plays a key role in this process by altering...

Trochlear Dysplasia as Shown by Increased Sulcus Angle Is Associated With Osteochondral Damage in Patients With Patellar Instability.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

Fones L, Jimenez AE, Cheng C, Chevalier N, Brimacombe MB, Cohen A, Pace JL.
PMID: 33964393
Arthroscopy. 2021 Dec;37(12):3469-3476. doi: 10.1016/j.arthro.2021.04.054. Epub 2021 May 05.

PURPOSE: The primary study objective was to describe the incidence of osteochondral damage (OD) in our cohort of patients with patellar instability (PI). The secondary objective was to assess for associations between patient demographic characteristics, duration of PI, and...

HIV-1 Vpu Promotes Phagocytosis of Infected CD4.

mBio

Cong L, Sugden SM, Leclair P, Lim CJ, Pham TNQ, Cohen ÉA.
PMID: 34425695
mBio. 2021 Aug 31;12(4):e0192021. doi: 10.1128/mBio.01920-21. Epub 2021 Aug 24.

Human immunodeficiency virus (HIV) remodels the cell surface of infected cells to facilitate viral dissemination and promote immune evasion. The membrane-associated viral protein U (Vpu) accessory protein encoded by HIV-1 plays a key role in this process by altering...

Atrial fibrillation and stroke: are we looking in the right direction?.

Cardiovascular research

Hatem SN, Cohen A.
PMID: 34897438
Cardiovasc Res. 2022 Jan 07;118(1):e4-e5. doi: 10.1093/cvr/cvab341.

No abstract available.

Use of a covered self-expanding metal airway stent for severe dynamic collapse within a bronchial aortic graft conduit in a post-lung transplant patient.

Respiratory medicine case reports

Priebe R, Duong DK, Simoff MJ, Mendoza JD, Debiane L, Peralta AR, Cohen A.
PMID: 33786302
Respir Med Case Rep. 2021 Mar 19;33:101392. doi: 10.1016/j.rmcr.2021.101392. eCollection 2021.

We present a novel case in which a self-expanding, covered metal airway stent was utilized for severe dynamic collapse within a cadaveric aortic bronchial graft conduit in a post-lung transplant recipient with thoracic situs inversus.

Standard CMOS Fabrication of a Sensitive Fully Depleted Electrolyte-Insulator-Semiconductor Field Effect Transistor for Biosensor Applications.

Sensors (Basel, Switzerland)

Shalev G, Cohen A, Doron A, Machauf A, Horesh M, Virobnik U, Ullien D, Levy I.
PMID: 22408530
Sensors (Basel). 2009;9(6):4366-79. doi: 10.3390/s90604366. Epub 2009 Jun 04.

Microfabricated semiconductor devices are becoming increasingly relevant for detection of biological and chemical components. The integration of active biological materials together with sensitive transducers offers the possibility of generating highly sensitive, specific, selective and reliable biosensors. This paper presents...

Total Hip Arthroplasty After Hip Arthroscopy Has Increased Complications and Revision Risk.

The Journal of arthroplasty

Lemme NJ, Veeramani A, Yang DS, Tabaddor RR, Daniels AH, Cohen EM.
PMID: 34456089
J Arthroplasty. 2021 Dec;36(12):3922-3927.e2. doi: 10.1016/j.arth.2021.07.020. Epub 2021 Aug 04.

BACKGROUND: There has been an increase in hip arthroscopy (HA) over the last decade. After HA, some patients may ultimately require a total hip arthroplasty (THA). However, there is a scarcity of research investigating the outcomes in patients undergoing...

EVALUATING STUDENT SUPPORT FOR OPEN ENDED SUGGESTIONS ON COURSE EVALUATIONS: INTRODUCING THE QESO (QUANTITATIVE EVALUATION OF STUDENT OPINION) METHOD.

Arora V, Hughey A, Olack S, Cohen A, Bruckner H.
UIID-AD: 1321
2010;25:444-444.

No abstract available.

Measurement of social capital among clinical research trainees.

Rubio DM, Primack BA, Switzer GE, Seltzer DL, Kapoor WN, Colditz JB, Cohen E, Robinson GF.
UIID-AD: 2850
2014;7:33-7. doi: 10.1111/cts.12112.

While physical and human capital are established as important predictors of success among early-career clinical investigators, less is known about the role of social capital. The authors aimed to develop a brief scale to assess social capital in this...

Showing 1477 to 1488 of 1488 entries