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Showing 181 to 185 of 185 entries
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Distinct Signaling Functions of Rap1 Isoforms in NO Release From Endothelium.

Frontiers in cell and developmental biology

Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.
PMID: 34222255
Front Cell Dev Biol. 2021 Jun 17;9:687598. doi: 10.3389/fcell.2021.687598. eCollection 2021.

Small GTPase Rap1 plays a prominent role in endothelial cell (EC) homeostasis by promoting NO release. Endothelial deletion of the two highly homologous Rap1 isoforms, Rap1A and Rap1B, leads to endothelial dysfunction

Made by cells for cells - extracellular vesicles as next-generation mainstream medicines.

Journal of cell science

Phan TH, Kim SY, Rudge C, Chrzanowski W.
PMID: 35019142
J Cell Sci. 2022 Jan 01;135(1). doi: 10.1242/jcs.259166. Epub 2022 Jan 12.

Current medicine has only taken us so far in reducing disease and tissue damage. Extracellular vesicles (EVs), which are membranous nanostructures produced naturally by cells, have been hailed as a next-generation medicine. EVs deliver various biomolecules, including proteins, lipids...

Compritol solid lipid nanoparticle formulations enhance the protective effect of betulinic acid derivatives in human Müller cells against oxidative injury.

Experimental eye research

Cheng Z, Li Y, Wang K, Zhu X, Tharkar P, Shu W, Zhang T, Zeng S, Zhu L, Murray M, Chrzanowski W, Zhou F.
PMID: 34953864
Exp Eye Res. 2021 Dec 23;215:108906. doi: 10.1016/j.exer.2021.108906. Epub 2021 Dec 23.

Müller cells maintain homeostatic functions in the retina. Their dysfunction leads to irreversible retinal diseases. Oxidative injury is a leading cause of retinal cytotoxicity. Our previous studies reported several betulinic acid (BA) derivatives can protect Müller cells from oxidative...

Myocardial Viability Assessment Before Surgical Revascularization in Ischemic Cardiomyopathy: JACC Review Topic of the Week.

Journal of the American College of Cardiology

Panza JA, Chrzanowski L, Bonow RO.
PMID: 34474740
J Am Coll Cardiol. 2021 Sep 07;78(10):1068-1077. doi: 10.1016/j.jacc.2021.07.004.

Ischemic cardiomyopathy results from the combination of scar with fibrosis replacement and areas of dysfunctional but viable myocardium that may improve contractile function with revascularization. Observational studies reported that only patients with substantial amounts of myocardial viability had better...

Attrition in Graduate School Versus Other Health Professional Programs: Etiologies and Solutions.

Medical science educator

Chrzanowski SM, Poudyal R.
PMID: 34457484
Med Sci Educ. 2018 Dec 19;29(1):329-331. doi: 10.1007/s40670-018-00673-2. eCollection 2019 Mar.

Data suggests significantly higher attrition rates of graduate students compared to other health professional programs. Several key differences exist between the training paradigm of Ph.D. programs and other health professional fields, such as the dynamics of group training, differences...

Showing 181 to 185 of 185 entries