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Showing 25 to 36 of 159 entries
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Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection .

bioRxiv : the preprint server for biology

Schäfer A, Muecksch F, Lorenzi JCC, Leist SR, Cipolla M, Bournazos S, Schmidt F, Gazumyan A, Baric RS, Robbiani DF, Hatziioannou T, Ravetch JV, Bieniasz PD, Nussenzweig MC, Sheahan TP.
PMID: 32995782
bioRxiv. 2020 Sep 15; doi: 10.1101/2020.09.15.298067.

SARS-CoV-2, the causative agent of COVID-19, is responsible for over 24 million infections and 800,000 deaths since its emergence in December 2019. There are few therapeutic options and no approved vaccines. Here we examine the properties of highly potent...

Social Status May Interfere in the Prognosis of Frontal Fibrosing Alopecia in Female Patients: An Observational Study.

Skin appendage disorders

Papanikou S, Xydeas-Kikemenis A, Nicolaidou E, Chatziioannou A, Rigopoulos D, Stratigos A, Chasapi V.
PMID: 31799262
Skin Appendage Disord. 2019 Nov;5(6):355-358. doi: 10.1159/000501888. Epub 2019 Aug 28.

INTRODUCTION: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia whose incidence has greatly increased worldwide over the last years. The main purpose of the study was to investigate the possible association of the social status of FFA patients with...

Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle.

Frontiers in immunology

Hatzioannou A, Boumpas A, Papadopoulou M, Papafragkos I, Varveri A, Alissafi T, Verginis P.
PMID: 34539668
Front Immunol. 2021 Sep 03;12:731947. doi: 10.3389/fimmu.2021.731947. eCollection 2021.

Regulatory T (Treg) cells, possess a strategic role in the maintenance of immune homeostasis, and their function has been closely linked to development of diverse pathologies including autoimmunity and cancer. Comprehensive studies in various disease contexts revealed an increased...

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.

Nature

Cho A, Muecksch F, Schaefer-Babajew D, Wang Z, Finkin S, Gaebler C, Ramos V, Cipolla M, Mendoza P, Agudelo M, Bednarski E, DaSilva J, Shimeliovich I, Dizon J, Daga M, Millard KG, Turroja M, Schmidt F, Zhang F, Tanfous TB, Jankovic M, Oliveria TY, Gazumyan A, Caskey M, Bieniasz PD, Hatziioannou T, Nussenzweig MC.
PMID: 34619745
Nature. 2021 Dec;600(7889):517-522. doi: 10.1038/s41586-021-04060-7. Epub 2021 Oct 07.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found...

Dual IRE1 RNase functions dictate glioblastoma development.

EMBO molecular medicine

Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E.
PMID: 35014200
EMBO Mol Med. 2022 Jan 11;e15622. doi: 10.15252/emmm.202115622. Epub 2022 Jan 11.

No abstract available.

Tumor DNA methylation profiles correlate with response to anti-PD-1 immune checkpoint inhibitor monotherapy in sarcoma patients.

Journal for immunotherapy of cancer

Starzer AM, Berghoff AS, Hamacher R, Tomasich E, Feldmann K, Hatziioannou T, Traint S, Lamm W, Noebauer-Huhmann IM, Furtner J, Müllauer L, Amann G, Bauer S, Schildhaus HU, Preusser M, Heller G, Brodowicz T.
PMID: 33762319
J Immunother Cancer. 2021 Mar;9(3). doi: 10.1136/jitc-2020-001458.

BACKGROUND: Some sarcomas respond to immune checkpoint inhibition, but predictive biomarkers are unknown. We analyzed tumor DNA methylation profiles in relation to immunological parameters and response to anti-programmed cell death 1 (anti-PD-1) immune checkpoint inhibitor (ICI) therapy in patients...

Integration of Raman spectra with transcriptome data in glioblastoma multiforme defines tumour subtypes and predicts patient outcome.

Journal of cellular and molecular medicine

Le Reste PJ, Pilalis E, Aubry M, McMahon M, Cano L, Etcheverry A, Chatziioannou A, Chevet E, Fautrel A.
PMID: 34773369
J Cell Mol Med. 2021 Dec;25(23):10846-10856. doi: 10.1111/jcmm.16902. Epub 2021 Nov 12.

Raman spectroscopy is an imaging technique that has been applied to assess molecular compositions of living cells to characterize cell types and states. However, owing to the diverse molecular species in cells and challenges of assigning peaks to specific...

Erratum to: Pharmacokinetics, Safety, and Efficacy of Chemoembolization with Doxorubicin-Loaded Tightly Calibrated Small Microspheres in Patients with Hepatocellular Carcinoma.

Cardiovascular and interventional radiology

Malagari K, Kiakidis T, Pomoni M, Moschouris H, Emmanouil E, Spiridopoulos T, Sotirchos V, Tandeles S, Koundouras D, Kelekis A, Filippiadis D, Charokopakis A, Bouma E, Chatziioannou A, Dourakis S, Koskinas J, Karampelas T, Tamvakopoulos K, Kelekis N, Kelekis D.
PMID: 27468837
Cardiovasc Intervent Radiol. 2016 Oct;39(10):1537. doi: 10.1007/s00270-016-1424-0.

No abstract available.

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape.

Nature

Schmidt F, Weisblum Y, Rutkowska M, Poston D, DaSilva J, Zhang F, Bednarski E, Cho A, Schaefer-Babajew DJ, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD.
PMID: 34544114
Nature. 2021 Dec;600(7889):512-516. doi: 10.1038/s41586-021-04005-0. Epub 2021 Sep 20.

The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key determinants of neutralization breadth and the genetic barrier to viral escape

Seasonal cellular stress phenomena and phenotypic plasticity in land snail Helix lucorum populations from different altitudes.

The Journal of experimental biology

Staikou A, Feidantsis K, Gkanatsiou O, Bibos MN, Hatziioannou M, Storey KB, Michaelidis B.
PMID: 34796901
J Exp Biol. 2021 Dec 15;224(24). doi: 10.1242/jeb.243298. Epub 2021 Dec 14.

Temperature, a major abiotic environmental factor, regulates various physiological functions in land snails and therefore determines their biogeographical distribution. Thus, species with different distributions may present different thermal tolerance limits. Additionally, the intense reactivation of snail metabolic rate upon...

Optimization of the Energy Window for PETbox4, a Preclinical PET Tomograph With a Small Inner Diameter.

IEEE transactions on nuclear science

Gu Z, Bao Q, Taschereau R, Wang H, Bai B, Chatziioannou AF.
PMID: 25774063
IEEE Trans Nucl Sci. 2014 Jun 01;61(3):1164-1173. doi: 10.1109/TNS.2014.2321326.

Small animal positron emission tomography (PET) systems are often designed by employing close geometry configurations. Due to the different characteristics caused by geometrical factors, these tomographs require data acquisition protocols that differ from those optimized for conventional large diameter...

Correction: Combined Use of Web-Based and In-Person Education on Ill Health Self-management Skills in Adults With Bipolar Disorder: Protocol for a Mixed Methods Study.

JMIR research protocols

Hatzioannou A, Chatzittofis A, Koutroubas VS, Papastavrou E, Karanikola M.
PMID: 34524966
JMIR Res Protoc. 2021 Sep 15;10(9):e33506. doi: 10.2196/33506.

[This corrects the article DOI: 10.2196/25168.].

Showing 25 to 36 of 159 entries