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Showing 157 to 159 of 159 entries
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High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape.

Nature

Schmidt F, Weisblum Y, Rutkowska M, Poston D, DaSilva J, Zhang F, Bednarski E, Cho A, Schaefer-Babajew DJ, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD.
PMID: 34544114
Nature. 2021 Dec;600(7889):512-516. doi: 10.1038/s41586-021-04005-0. Epub 2021 Sep 20.

The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key determinants of neutralization breadth and the genetic barrier to viral escape

Cite
Schmidt F, Weisblum Y, Rutkowska M, et al. High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Nature. 2021;600(7889):512-516doi: 10.1038/s41586-021-04005-0.
Schmidt, F., Weisblum, Y., Rutkowska, M., Poston, D., DaSilva, J., Zhang, F., Bednarski, E., Cho, A., Schaefer-Babajew, D. J., Gaebler, C., Caskey, M., Nussenzweig, M. C., Hatziioannou, T., & Bieniasz, P. D. (2021). High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Nature, 600(7889), 512-516. https://doi.org/10.1038/s41586-021-04005-0
Schmidt, Fabian, et al. "High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape." Nature vol. 600,7889 (2021): 512-516. doi: https://doi.org/10.1038/s41586-021-04005-0
Schmidt F, Weisblum Y, Rutkowska M, Poston D, DaSilva J, Zhang F, Bednarski E, Cho A, Schaefer-Babajew DJ, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Nature. 2021 Dec;600(7889):512-516. doi: 10.1038/s41586-021-04005-0. Epub 2021 Sep 20. PMID: 34544114.
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Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination.

Nature

Cho A, Muecksch F, Schaefer-Babajew D, Wang Z, Finkin S, Gaebler C, Ramos V, Cipolla M, Mendoza P, Agudelo M, Bednarski E, DaSilva J, Shimeliovich I, Dizon J, Daga M, Millard KG, Turroja M, Schmidt F, Zhang F, Tanfous TB, Jankovic M, Oliveria TY, Gazumyan A, Caskey M, Bieniasz PD, Hatziioannou T, Nussenzweig MC.
PMID: 34619745
Nature. 2021 Dec;600(7889):517-522. doi: 10.1038/s41586-021-04060-7. Epub 2021 Oct 07.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time, memory B cells express increasingly broad and potent antibodies that are resistant to mutations found...

Cite
Cho A, Muecksch F, Schaefer-Babajew D, et al. Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination. Nature. 2021;600(7889):517-522doi: 10.1038/s41586-021-04060-7.
Cho, A., Muecksch, F., Schaefer-Babajew, D., Wang, Z., Finkin, S., Gaebler, C., Ramos, V., Cipolla, M., Mendoza, P., Agudelo, M., Bednarski, E., DaSilva, J., Shimeliovich, I., Dizon, J., Daga, M., Millard, K. G., Turroja, M., Schmidt, F., Zhang, F., Tanfous, T. B., Jankovic, M., Oliveria, T. Y., Gazumyan, A., Caskey, M., Bieniasz, P. D., Hatziioannou, T., & Nussenzweig, M. C. (2021). Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination. Nature, 600(7889), 517-522. https://doi.org/10.1038/s41586-021-04060-7
Cho, Alice, et al. "Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination." Nature vol. 600,7889 (2021): 517-522. doi: https://doi.org/10.1038/s41586-021-04060-7
Cho A, Muecksch F, Schaefer-Babajew D, Wang Z, Finkin S, Gaebler C, Ramos V, Cipolla M, Mendoza P, Agudelo M, Bednarski E, DaSilva J, Shimeliovich I, Dizon J, Daga M, Millard KG, Turroja M, Schmidt F, Zhang F, Tanfous TB, Jankovic M, Oliveria TY, Gazumyan A, Caskey M, Bieniasz PD, Hatziioannou T, Nussenzweig MC. Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination. Nature. 2021 Dec;600(7889):517-522. doi: 10.1038/s41586-021-04060-7. Epub 2021 Oct 07. PMID: 34619745.
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Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape.

eLife

Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Herlands L, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP.
PMID: 34874007
Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73027.

The emergence of SARS-CoV-2 variants threatens current vaccines and therapeutic antibodies and urgently demands powerful new therapeutics that can resist viral escape. We therefore generated a large nanobody repertoire to saturate the distinct and highly conserved available epitope space...

Cite
Mast FD, Fridy PC, Ketaren NE, et al. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. Elife. 2021;10doi: 10.7554/eLife.73027.
Mast, F. D., Fridy, P. C., Ketaren, N. E., Wang, J., Jacobs, E. Y., Olivier, J. P., Sanyal, T., Molloy, K. R., Schmidt, F., Rutkowska, M., Weisblum, Y., Rich, L. M., Vanderwall, E. R., Dambrauskas, N., Vigdorovich, V., Keegan, S., Jiler, J. B., Stein, M. E., Olinares, P. D. B., Herlands, L., Hatziioannou, T., Sather, D. N., Debley, J. S., Fenyö, D., Sali, A., Bieniasz, P. D., Aitchison, J. D., Chait, B. T., & Rout, M. P. (2021). Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. eLife, 10. https://doi.org/10.7554/eLife.73027
Mast, Fred D, et al. "Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.73027
Mast FD, Fridy PC, Ketaren NE, Wang J, Jacobs EY, Olivier JP, Sanyal T, Molloy KR, Schmidt F, Rutkowska M, Weisblum Y, Rich LM, Vanderwall ER, Dambrauskas N, Vigdorovich V, Keegan S, Jiler JB, Stein ME, Olinares PDB, Herlands L, Hatziioannou T, Sather DN, Debley JS, Fenyö D, Sali A, Bieniasz PD, Aitchison JD, Chait BT, Rout MP. Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escape. Elife. 2021 Dec 07;10. doi: 10.7554/eLife.73027. PMID: 34874007; PMCID: PMC8651292.
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Showing 157 to 159 of 159 entries