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Showing 25 to 36 of 206 entries
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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells.

Molecular cancer research : MCR

Zhou L, Pei X, Zhang Y, Ning Y, Li L, Hu X, Chalasani SL, Sharma K, Nkwocha J, Yu J, Bandyopadhyay D, Sebti SM, Grant S.
PMID: 34782371
Mol Cancer Res. 2021 Nov 15; doi: 10.1158/1541-7786.MCR-21-0366. Epub 2021 Nov 15.

The relationship between the checkpoint kinase Chk1 and the STAT3 pathway was examined in multiple myeloma cells. Gene expression profiling of U266 cells exposed to low (nmol/L) Chk1 inhibitor [PF-477736 (PF)] concentrations revealed STAT3 pathway-related gene downregulation (e.g., BCL-X

'Pain-free TRUS B': a phase 3 double-blind placebo-controlled randomized trial of methoxyflurane with periprostatic local anaesthesia to reduce the discomfort of transrectal ultrasonography-guided prostate biopsy (ANZUP 1501).

BJU international

Hayne D, Grummet J, Espinoza D, McCombie SP, Chalasani V, Ford KS, Frydenberg M, Gilling P, Gordon B, Hawks C, Konstantatos A, Martin AJ, Nixon A, O'Brien C, Patel MI, Sengupta S, Shahbaz S, Subramaniam S, Williams S, Woo HH, Stockler MR, Davis ID, Buchan N.
PMID: 34273231
BJU Int. 2021 Jul 17; doi: 10.1111/bju.15552. Epub 2021 Jul 17.

OBJECTIVE: To determine whether the addition of inhaled methoxyflurane to periprostatic infiltration of local anaesthetic (PILA) during transrectal ultrasonography-guided prostate biopsies (TRUSBs) improved pain and other aspects of the experience.PATIENTS AND METHODS: We conducted a multicentre, placebo-controlled, double-blind, randomized...

Ultrastructural changes in methicillin-resistant Staphylococcus aureus (MRSA) induced by a novel cyclic peptide ASP-1 from Bacillus subtilis: A scanning electron microscopy (SEM) study.

Revista Argentina de microbiologia

Deshmukh R, Chalasani AG, Chattopadhyay D, Roy U.
PMID: 33608109
Rev Argent Microbiol. 2021 Oct-Dec;53(4):281-286. doi: 10.1016/j.ram.2020.11.006. Epub 2021 Feb 16.

Increasing antimicrobial resistance among Staphylococcus aureus necessitates a new antimicrobial with a different site of action. We have isolated a novel cyclic peptide-1 (ASP-1) from Bacillussubtilis with potent activity against methicillin-resistant S. aureus (MRSA) at a minimum inhibitory concentration...

Transcriptomic Analysis Reveals the MicroRNAs Responsible for Liver Regeneration Associated With Mortality in Alcohol-Associated Hepatitis.

Hepatology (Baltimore, Md.)

Yang Z, Zhang T, Kusumanchi P, Tang Q, Sun Z, Radaeva S, Peiffer B, Shah VH, Kamath P, Gores GJ, Sanyal A, Chalasani N, Jiang Y, Huda N, Ma J, Liangpunsakul S.
PMID: 34096637
Hepatology. 2021 Nov;74(5):2436-2451. doi: 10.1002/hep.31994. Epub 2021 Jul 26.

BACKGROUND AND AIMS: We conducted a comprehensive serum transcriptomic analysis to explore the roles of microRNAs (miRNAs) in alcohol-associated hepatitis (AH) pathogenesis and their prognostic significance.APPROACH AND RESULTS: Serum miRNA profiling was performed in 15 controls, 20 heavy drinkers...

Circulating high density lipoprotein distinguishes alcoholic hepatitis from heavy drinkers and predicts 90-day outcome: lipoproteins in alcoholic hepatitis.

Journal of clinical lipidology

Mathur K, Vilar-Gomez E, Connelly MA, He H, Sanyal AJ, Chalasani N, Jiang ZG.
PMID: 34756674
J Clin Lipidol. 2021 Nov-Dec;15(6):805-813. doi: 10.1016/j.jacl.2021.10.002. Epub 2021 Oct 20.

BACKGROUND: Alcohol-associated liver disease (ALD) and alcoholic hepatitis (AH) significantly impact the liver, an organ central to the lipid and lipoprotein metabolism.OBJECTIVE: To define changes in the lipid and lipoprotein profiles in subjects with alcoholic hepatitis (AH) versus heavy...

Immune Responses to COVID-19 mRNA Vaccines in Patients with Solid Tumors on Active, Immunosuppressive Cancer Therapy.

medRxiv : the preprint server for health sciences

Shroff RT, Chalasani P, Wei R, Pennington D, Quirk G, Schoenle MV, Peyton KL, Uhrlaub JL, Ripperger TJ, Jergović M, Dalgai S, Wolf A, Whitmer R, Hammad H, Carrier A, Scott AJ, Nikolich-Žugich J, Worobey M, Sprissler R, Dake M, LaFleur BJ, Bhattacharya D.
PMID: 34013289
medRxiv. 2021 May 14; doi: 10.1101/2021.05.13.21257129.

Vaccines against SARS-CoV-2 have shown high efficacy, but immunocompromised participants were excluded from controlled clinical trials. We evaluated immune responses to the Pfizer/BioNTech mRNA vaccine in solid tumor patients (n=52) on active cytotoxic anti-cancer therapy. These responses were compared...

Attendance at a Transitional Liver Clinic May Be Associated with Reduced Readmissions for Patients with Liver Disease.

The American journal of medicine

Yoder L, Mladenovic A, Pike F, Vuppalanchi R, Hanson H, Corbito L, Desai AP, Chalasani N, Orman ES.
PMID: 34655539
Am J Med. 2021 Oct 14; doi: 10.1016/j.amjmed.2021.09.016. Epub 2021 Oct 14.

INTRODUCTION: Patients with liver disease have high rates of early hospital readmission, but there are no studies of effective, scalable interventions to reduce this risk. In this study, we examined the impact of a Physician Assistant (PA)-led post-discharge Transitional...

Effects of Rare Microbiome Taxa Filtering on Statistical Analysis.

Frontiers in microbiology

Cao Q, Sun X, Rajesh K, Chalasani N, Gelow K, Katz B, Shah VH, Sanyal AJ, Smirnova E.
PMID: 33510727
Front Microbiol. 2021 Jan 12;11:607325. doi: 10.3389/fmicb.2020.607325. eCollection 2020.

No abstract available.

Sex disparities in waitlisting and liver transplant for acute liver failure.

JHEP reports : innovation in hepatology

Nephew LD, Zia Z, Ghabril M, Orman E, Lammert C, Kubal C, Chalasani N.
PMID: 33511336
JHEP Rep. 2020 Nov 01;3(1):100200. doi: 10.1016/j.jhepr.2020.100200. eCollection 2021 Feb.

BACKGROUND & AIMS: Sex disparities in liver transplantation (LT) for chronic liver disease have been described. It is unclear if similar disparities exist for acute liver failure (ALF).METHODS: Adults waitlisted for LT from 2002 to 2016 with ALF were...

Clinicopathological and Molecular Characteristics of Pleomorphic Invasive Lobular Carcinoma.

International journal of breast cancer

Segar JM, Pandey R, Farr KJ, Nagle R, LeBeau L, Gonzalez VJ, Chalasani P.
PMID: 33299611
Int J Breast Cancer. 2020 Nov 22;2020:8816824. doi: 10.1155/2020/8816824. eCollection 2020.

Pleomorphic invasive lobular carcinoma (PILC) is a distinct morphological and biologically aggressive variant of invasive lobular carcinoma (ILC). We hypothesized that was due to de novo activation of PI3K/Akt/mTOR pathway in PILC resulting in higher proliferation rate and markers...

Causality Assessment for Suspected Drug-Induced Liver Injury in Patients With Underlying Chronic Liver Disease.

Clinical liver disease

Dakhoul L, Chalasani N.
PMID: 30992960
Clin Liver Dis (Hoboken). 2017 Mar 30;9(3):63-65. doi: 10.1002/cld.619. eCollection 2017 Mar.

No abstract available.

Potential Psychotropic and COVID-19 Drug Interactions: A Comparison of Integrated Evidence From Six Database Programs.

Cureus

Shareef J, Belagodu Sridhar S, Thomas S, Shariff A, Chalasani S.
PMID: 35028218
Cureus. 2021 Dec 10;13(12):e20319. doi: 10.7759/cureus.20319. eCollection 2021 Dec.

Background Drug interactions are a significant issue in mental illnesses and coronavirus disease 2019 (COVID-19) infections. Inconsistency in drug interaction resources makes prescribing challenging for healthcare professionals. To assess the scope, completeness, and consistency of drug-drug interactions (DDIs) between...

Showing 25 to 36 of 206 entries