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Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.

Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents

Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S.
PMID: 29527108
Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8. Epub 2017 Nov 13.

Dehydroacetic acid is a common pyrone derivative used commercially as an antibacterial and antifungal agent. Based on the synthesis of dehydroacetic acid (

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Baldwin AG, Bevan J, Brough D, et al. Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Med Chem Res. 2017;27(3):884-889doi: 10.1007/s00044-017-2110-8.
Baldwin, A. G., Bevan, J., Brough, D., Ledder, R., & Freeman, S. (2018). Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 27(3), 884-889. https://doi.org/10.1007/s00044-017-2110-8
Baldwin, Alex G, et al. "Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid." Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents vol. 27,3 (2018): 884-889. doi: https://doi.org/10.1007/s00044-017-2110-8
Baldwin AG, Bevan J, Brough D, Ledder R, Freeman S. Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid. Med Chem Res. 2018;27(3):884-889. doi: 10.1007/s00044-017-2110-8. Epub 2017 Nov 13. PMID: 29527108; PMCID: PMC5835058.
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Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava.

Data in brief

Rice KM, Manne NDPK, Arvapalli R, Ginjupalli GK, Blough ER.
PMID: 28971124
Data Brief. 2017 Sep 06;15:63-71. doi: 10.1016/j.dib.2017.09.001. eCollection 2017 Dec.

Diabetes is a multifaceted disease with various etiologies. The complexity of this pathology creates a myriad of factors that must be considered when addressing surgical outcomes and prognosis. Of vital importance to cardiovascular surgery is the viability of homographic...

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Rice KM, Manne NDPK, Arvapalli R, et al. Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava. Data Brief. 2017;15:63-71doi: 10.1016/j.dib.2017.09.001.
Rice, K. M., Manne, N. D. P. K., Arvapalli, R., Ginjupalli, G. K., & Blough, E. R. (2017). Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava. Data in brief, 1563-71. https://doi.org/10.1016/j.dib.2017.09.001
Rice, Kevin M, et al. "Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava." Data in brief vol. 15 (2017): 63-71. doi: https://doi.org/10.1016/j.dib.2017.09.001
Rice KM, Manne NDPK, Arvapalli R, Ginjupalli GK, Blough ER. Diabetes alters vascular mechanotransduction data: Pressure-induced regulation of mTor and associated signaling in the rat inferior vena cava. Data Brief. 2017 Sep 06;15:63-71. doi: 10.1016/j.dib.2017.09.001. eCollection 2017 Dec. PMID: 28971124; PMCID: PMC5612793.
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Parents' Constructions of the 'Problem' during Assessment and Diagnosis of their Child for an Autistic Spectrum Disorder.

Journal of health psychology

Avdi E, Griffin C, Brough S.
PMID: 22049014
J Health Psychol. 2000 Mar;5(2):241-54. doi: 10.1177/135910530000500214.

The majority of studies on the effects of a diagnosis of learning disability in the family have employed traditional 'loss' and 'stress reaction' paradigms. In contrast to this approach, the current analysis employed a form of discourse analysis to...

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Avdi E, Griffin C, Brough S. Parents' Constructions of the 'Problem' during Assessment and Diagnosis of their Child for an Autistic Spectrum Disorder. J Health Psychol. 2000;5(2):241-54doi: 10.1177/135910530000500214.
Avdi, E., Griffin, C., & Brough, S. (2000). Parents' Constructions of the 'Problem' during Assessment and Diagnosis of their Child for an Autistic Spectrum Disorder. Journal of health psychology, 5(2), 241-54. https://doi.org/10.1177/135910530000500214
Avdi, E, et al. "Parents' Constructions of the 'Problem' during Assessment and Diagnosis of their Child for an Autistic Spectrum Disorder." Journal of health psychology vol. 5,2 (2000): 241-54. doi: https://doi.org/10.1177/135910530000500214
Avdi E, Griffin C, Brough S. Parents' Constructions of the 'Problem' during Assessment and Diagnosis of their Child for an Autistic Spectrum Disorder. J Health Psychol. 2000 Mar;5(2):241-54. doi: 10.1177/135910530000500214. PMID: 22049014.
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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

Frontiers in immunology

Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P.
PMID: 26635802
Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015.

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus...

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Garg AD, Galluzzi L, Apetoh L, et al. Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Front Immunol. 2015;6:588doi: 10.3389/fimmu.2015.00588.
Garg, A. D., Galluzzi, L., Apetoh, L., Baert, T., Birge, R. B., Bravo-San Pedro, J. M., Breckpot, K., Brough, D., Chaurio, R., Cirone, M., Coosemans, A., Coulie, P. G., De Ruysscher, D., Dini, L., de Witte, P., Dudek-Peric, A. M., Faggioni, A., Fucikova, J., Gaipl, U. S., Golab, J., Gougeon, M. L., Hamblin, M. R., Hemminki, A., Herrmann, M., Hodge, J. W., Kepp, O., Kroemer, G., Krysko, D. V., Land, W. G., Madeo, F., Manfredi, A. A., Mattarollo, S. R., Maueroder, C., Merendino, N., Multhoff, G., Pabst, T., Ricci, J. E., Riganti, C., Romano, E., Rufo, N., Smyth, M. J., Sonnemann, J., Spisek, R., Stagg, J., Vacchelli, E., Vandenabeele, P., Vandenberk, L., Van den Eynde, B. J., Van Gool, S., Velotti, F., Zitvogel, L., & Agostinis, P. (2015). Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in immunology, 6588. https://doi.org/10.3389/fimmu.2015.00588
Garg, Abhishek D, et al. "Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death." Frontiers in immunology vol. 6 (2015): 588. doi: https://doi.org/10.3389/fimmu.2015.00588
Garg AD, Galluzzi L, Apetoh L, Baert T, Birge RB, Bravo-San Pedro JM, Breckpot K, Brough D, Chaurio R, Cirone M, Coosemans A, Coulie PG, De Ruysscher D, Dini L, de Witte P, Dudek-Peric AM, Faggioni A, Fucikova J, Gaipl US, Golab J, Gougeon ML, Hamblin MR, Hemminki A, Herrmann M, Hodge JW, Kepp O, Kroemer G, Krysko DV, Land WG, Madeo F, Manfredi AA, Mattarollo SR, Maueroder C, Merendino N, Multhoff G, Pabst T, Ricci JE, Riganti C, Romano E, Rufo N, Smyth MJ, Sonnemann J, Spisek R, Stagg J, Vacchelli E, Vandenabeele P, Vandenberk L, Van den Eynde BJ, Van Gool S, Velotti F, Zitvogel L, Agostinis P. Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Front Immunol. 2015 Nov 20;6:588. doi: 10.3389/fimmu.2015.00588. eCollection 2015. PMID: 26635802; PMCID: PMC4653610.
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Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Scientific reports

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ.
PMID: 30131505
Sci Rep. 2018 Aug 21;8(1):12771. doi: 10.1038/s41598-018-30922-8.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

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Holme H, Gulati A, Brough R, et al. Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. Sci Rep. 2018;8(1):12771doi: 10.1038/s41598-018-30922-8.
Holme, H., Gulati, A., Brough, R., Fleuren, E. D. G., Bajrami, I., Campbell, J., Chong, I. Y., Costa-Cabral, S., Elliott, R., Fenton, T., Frankum, J., Jones, S. E., Menon, M., Miller, R., Pemberton, H. N., Postel-Vinay, S., Rafiq, R., Selfe, J. L., von Kriegsheim, A., Munoz, A. G., Rodriguez, J., Shipley, J., van der Graaf, W. T. A., Williamson, C. T., Ryan, C. J., Pettitt, S., Ashworth, A., Strauss, S. J., & Lord, C. J. (2018). Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. Scientific reports, 8(1), 12771. https://doi.org/10.1038/s41598-018-30922-8
Holme, Harriett, et al. "Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness." Scientific reports vol. 8,1 (2018): 12771. doi: https://doi.org/10.1038/s41598-018-30922-8
Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ. Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness. Sci Rep. 2018 Aug 21;8(1):12771. doi: 10.1038/s41598-018-30922-8. PMID: 30131505; PMCID: PMC6104100.
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Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields: Outcomes with Poly-4-Hydroxybutyrate Mesh.

Plastic and reconstructive surgery

Christopher AN, Morris MP, Jia H, Broach R, Fischer JP.
PMID: 34757999
Plast Reconstr Surg. 2021 Dec 01;148(6):1367-1375. doi: 10.1097/PRS.0000000000008579.

BACKGROUND: Hernia repair in the setting of contamination poses unique challenges, including complications such as recurrence and mesh infection. The ideal contaminated hernia repair including type of mesh use remains controversial. Poly-4-hydroxybutyrate is a biosynthetic scaffold for soft-tissue reinforcement...

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Christopher AN, Morris MP, Jia H, et al. Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields: Outcomes with Poly-4-Hydroxybutyrate Mesh. Plast Reconstr Surg. 2021;148(6):1367-1375doi: 10.1097/PRS.0000000000008579.
Christopher, A. N., Morris, M. P., Jia, H., Broach, R., & Fischer, J. P. (2021). Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields: Outcomes with Poly-4-Hydroxybutyrate Mesh. Plastic and reconstructive surgery, 148(6), 1367-1375. https://doi.org/10.1097/PRS.0000000000008579
Christopher, Adrienne N, et al. "Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields: Outcomes with Poly-4-Hydroxybutyrate Mesh." Plastic and reconstructive surgery vol. 148,6 (2021): 1367-1375. doi: https://doi.org/10.1097/PRS.0000000000008579
Christopher AN, Morris MP, Jia H, Broach R, Fischer JP. Resorbable Synthetic Ventral Hernia Repair in Contaminated Fields: Outcomes with Poly-4-Hydroxybutyrate Mesh. Plast Reconstr Surg. 2021 Dec 01;148(6):1367-1375. doi: 10.1097/PRS.0000000000008579. PMID: 34757999.
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Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei.

Frontiers in neuroscience

Brougher J, Aziz U, Adari N, Chaturvedi M, Jules A, Shah I, Syed S, Thorn CA.
PMID: 34975384
Front Neurosci. 2021 Dec 16;15:782786. doi: 10.3389/fnins.2021.782786. eCollection 2021.

No abstract available.

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Brougher J, Aziz U, Adari N, et al. Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei. Front Neurosci. 2021;15:782786doi: 10.3389/fnins.2021.782786.
Brougher, J., Aziz, U., Adari, N., Chaturvedi, M., Jules, A., Shah, I., Syed, S., & Thorn, C. A. (2021). Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei. Frontiers in neuroscience, 15782786. https://doi.org/10.3389/fnins.2021.782786
Brougher, Jackson, et al. "Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei." Frontiers in neuroscience vol. 15 (2021): 782786. doi: https://doi.org/10.3389/fnins.2021.782786
Brougher J, Aziz U, Adari N, Chaturvedi M, Jules A, Shah I, Syed S, Thorn CA. Self-Administration of Right Vagus Nerve Stimulation Activates Midbrain Dopaminergic Nuclei. Front Neurosci. 2021 Dec 16;15:782786. doi: 10.3389/fnins.2021.782786. eCollection 2021. PMID: 34975384; PMCID: PMC8716493.
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Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft-A preclinical study.

Artificial organs

Stone JP, Amin KR, Geraghty A, Kerr J, Shaw M, Dabare D, Wong JK, Brough D, Entwistle TR, Montero-Fernandez A, Fildes JE.
PMID: 34662442
Artif Organs. 2021 Oct 18; doi: 10.1111/aor.14089. Epub 2021 Oct 18.

INTRODUCTION: Recent experimental evidence suggests normothermic machine perfusion of the vascularized composite allograft results in improved preservation compared to static cold storage, with less reperfusion injury in the immediate post-operative period. However, metabolic acidosis is a common feature of...

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Stone JP, Amin KR, Geraghty A, et al. Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft-A preclinical study. Artif Organs. 2021;doi: 10.1111/aor.14089.
Stone, J. P., Amin, K. R., Geraghty, A., Kerr, J., Shaw, M., Dabare, D., Wong, J. K., Brough, D., Entwistle, T. R., Montero-Fernandez, A., & Fildes, J. E. (2021). Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft-A preclinical study. Artificial organs, . https://doi.org/10.1111/aor.14089
Stone, John P, et al. "Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft-A preclinical study." Artificial organs vol. (2021). doi: https://doi.org/10.1111/aor.14089
Stone JP, Amin KR, Geraghty A, Kerr J, Shaw M, Dabare D, Wong JK, Brough D, Entwistle TR, Montero-Fernandez A, Fildes JE. Renal hemofiltration prevents metabolic acidosis and reduces inflammation during normothermic machine perfusion of the vascularized composite allograft-A preclinical study. Artif Organs. 2021 Oct 18; doi: 10.1111/aor.14089. Epub 2021 Oct 18. PMID: 34662442.
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Iodine Intake for Pregnant and Breastfeeding Women and Their Infants Remains a Global Concern.

The Journal of nutrition

Brough L.
PMID: 34718675
J Nutr. 2021 Dec 03;151(12):3604-3605. doi: 10.1093/jn/nxab364.

No abstract available.

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Brough L. Iodine Intake for Pregnant and Breastfeeding Women and Their Infants Remains a Global Concern. J Nutr. 2021;151(12):3604-3605doi: 10.1093/jn/nxab364.
Brough, L. (2021). Iodine Intake for Pregnant and Breastfeeding Women and Their Infants Remains a Global Concern. The Journal of nutrition, 151(12), 3604-3605. https://doi.org/10.1093/jn/nxab364
Brough, Louise. "Iodine Intake for Pregnant and Breastfeeding Women and Their Infants Remains a Global Concern." The Journal of nutrition vol. 151,12 (2021): 3604-3605. doi: https://doi.org/10.1093/jn/nxab364
Brough L. Iodine Intake for Pregnant and Breastfeeding Women and Their Infants Remains a Global Concern. J Nutr. 2021 Dec 03;151(12):3604-3605. doi: 10.1093/jn/nxab364. PMID: 34718675.
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An empirical study of factors associated with height-for-age .

The British journal of nutrition

Dusingizimana T, Weber JL, Ramilan T, Iversen PO, Brough L.
PMID: 33298231
Br J Nutr. 2021 Oct 28;126(8):1203-1214. doi: 10.1017/S0007114520004961. Epub 2020 Dec 10.

We aimed to identify the factors influencing child height-for-age z-scores (HAZ) as a measure of child nutritional status in Rwanda, and to examine the role of child feeding and health practices. We conducted a cross-sectional study involving 379 children...

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Dusingizimana T, Weber JL, Ramilan T, et al. An empirical study of factors associated with height-for-age . Br J Nutr. 2020;126(8):1203-1214doi: 10.1017/S0007114520004961.
Dusingizimana, T., Weber, J. L., Ramilan, T., Iversen, P. O., & Brough, L. (2021). An empirical study of factors associated with height-for-age . The British journal of nutrition, 126(8), 1203-1214. https://doi.org/10.1017/S0007114520004961
Dusingizimana, Theogene, et al. "An empirical study of factors associated with height-for-age ." The British journal of nutrition vol. 126,8 (2021): 1203-1214. doi: https://doi.org/10.1017/S0007114520004961
Dusingizimana T, Weber JL, Ramilan T, Iversen PO, Brough L. An empirical study of factors associated with height-for-age . Br J Nutr. 2021 Oct 28;126(8):1203-1214. doi: 10.1017/S0007114520004961. Epub 2020 Dec 10. PMID: 33298231.
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Iodine status of postpartum women and their infants aged 3, 6 and 12 months: Mother and Infant Nutrition Investigation (MINI).

The British journal of nutrition

Jin Y, Coad J, Skeaff SA, Zhou SJ, Brough L.
PMID: 33858523
Br J Nutr. 2021 Apr 16;1-10. doi: 10.1017/S000711452100129X. Epub 2021 Apr 16.

To alleviate the re-emergence of iodine deficiency in New Zealand, two strategies, the mandatory fortification of bread with iodised salt (2009) and a government-subsidised iodine supplement for breast-feeding women (2010), were introduced. Few studies have investigated mother and infant...

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Jin Y, Coad J, Skeaff SA, et al. Iodine status of postpartum women and their infants aged 3, 6 and 12 months: Mother and Infant Nutrition Investigation (MINI). Br J Nutr. 2021;1-10doi: 10.1017/S000711452100129X.
Jin, Y., Coad, J., Skeaff, S. A., Zhou, S. J., & Brough, L. (2021). Iodine status of postpartum women and their infants aged 3, 6 and 12 months: Mother and Infant Nutrition Investigation (MINI). The British journal of nutrition, 1-10. https://doi.org/10.1017/S000711452100129X
Jin, Ying, et al. "Iodine status of postpartum women and their infants aged 3, 6 and 12 months: Mother and Infant Nutrition Investigation (MINI)." The British journal of nutrition vol. (2021): 1-10. doi: https://doi.org/10.1017/S000711452100129X
Jin Y, Coad J, Skeaff SA, Zhou SJ, Brough L. Iodine status of postpartum women and their infants aged 3, 6 and 12 months: Mother and Infant Nutrition Investigation (MINI). Br J Nutr. 2021 Apr 16;1-10. doi: 10.1017/S000711452100129X. Epub 2021 Apr 16. PMID: 33858523.
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Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?.

Brain communications

Rivers-Auty J, Mather AE, Peters R, Lawrence CB, Brough D.
PMID: 33134914
Brain Commun. 2020 Jul 24;2(2):fcaa109. doi: 10.1093/braincomms/fcaa109. eCollection 2020.

Epidemiological evidence suggests non-steroidal anti-inflammatory drugs reduce the risk of Alzheimer's disease. However, clinical trials have found no evidence of non-steroidal anti-inflammatory drug efficacy. This incongruence may be due to the wrong non-steroidal anti-inflammatory drugs being tested in robust...

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Rivers-Auty J, Mather AE, Peters R, et al. Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?. Brain Commun. 2020;2(2):fcaa109doi: 10.1093/braincomms/fcaa109.
Rivers-Auty, J., Mather, A. E., Peters, R., Lawrence, C. B., & Brough, D. (2020). Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?. Brain communications, 2(2), fcaa109. https://doi.org/10.1093/braincomms/fcaa109
Rivers-Auty, Jack, et al. "Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?." Brain communications vol. 2,2 (2020): fcaa109. doi: https://doi.org/10.1093/braincomms/fcaa109
Rivers-Auty J, Mather AE, Peters R, Lawrence CB, Brough D. Anti-inflammatories in Alzheimer's disease-potential therapy or spurious correlate?. Brain Commun. 2020 Jul 24;2(2):fcaa109. doi: 10.1093/braincomms/fcaa109. eCollection 2020. PMID: 33134914; PMCID: PMC7585697.
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