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Showing 505 to 514 of 514 entries
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Evaluating the reproducibility of research in obstetrics and gynecology.

European journal of obstetrics, gynecology, and reproductive biology

Rauh S, Bowers A, Rorah D, Tritz D, Pate H, Frye L, Vassar M.
PMID: 34954422
Eur J Obstet Gynecol Reprod Biol. 2021 Dec 20;269:24-29. doi: 10.1016/j.ejogrb.2021.12.021. Epub 2021 Dec 20.

OBJECTIVE: Reproducibility is a core tenet of scientific research. A reproducible study is one where the results can be recreated by using the same methodology and materials as the original researchers. Unfortunately, reproducibility is not a standard to which...

Assessment of romiplostim immunogenicity in pediatric patients in clinical trials and in a global postmarketing registry.

Blood advances

Bowers C, Mytych DT, Lawrence T, Wang K, Barger TE, Eisen M, Bennett CM, Tarantino MD.
PMID: 34638135
Blood Adv. 2021 Dec 14;5(23):4969-4979. doi: 10.1182/bloodadvances.2021005105.

Development of first-generation thrombopoietins (TPOs) was halted due to antibodies that neutralized endogenous TPO, causing protracted thrombocytopenia in some patients. The second-generation TPO receptor agonist romiplostim, having no homology to TPO, was developed to circumvent potential immunogenicity. We examined...

Lewy Body Dementias: Controversies and Drug Development.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Chiu SY, Bowers D, Armstrong MJ.
PMID: 34859379
Neurotherapeutics. 2021 Dec 02; doi: 10.1007/s13311-021-01161-z. Epub 2021 Dec 02.

Lewy body dementia (LBD) is one of the most common neurodegenerative dementias. Clinical trials for symptomatic and disease-modifying therapies in LBD remain a national research priority, but there are many challenges in both past and active drug developments in...

Quality Improvement Intervention to Reduce Thirty-Day Hospital Readmission Rates Among Patients With Systemic Lupus Erythematosus.

Arthritis care & research

Bowers E, Griffith M, Kolfenbach J, Pearson D, Hammes A, Weinstein E.
PMID: 32860731
Arthritis Care Res (Hoboken). 2022 Jan;74(1):126-130. doi: 10.1002/acr.24435. Epub 2021 Dec 17.

OBJECTIVE: Systemic lupus erythematosus (SLE) has one of the highest 30-day hospital readmission rates among chronic diseases in the US. This quality improvement initiative developed and assessed the feasibility of a multidisciplinary postdischarge intervention to reduce 30-day readmission rates...

Over 67 GHz bandwidth hybrid silicon electroabsorption modulator with asymmetric segmented electrode for 1.3 μm transmission.

Optics express

Tang Y, Peters JD, Bowers JE.
PMID: 22565772
Opt Express. 2012 May 07;20(10):11529-35. doi: 10.1364/OE.20.011529.

A distributed III-V-on-Si electroabsorption modulator based on an asymmetric segmented electrode has been developed on the hybrid silicon platform for the 1.3 μm transmission window. The measured modulation response shows a 2 dB drop at 67 GHz and an...

Socioeconomic Inequalities Increase the Probability of Ketoacidosis at Diagnosis of Type 1 Diabetes: A 2014-2016 Nationwide Study of 2,679 Italian Children.

Frontiers in pediatrics

Gesuita R, Maffeis C, Bonfanti R, Cardella F, Citriniti F, D'Annunzio G, Franzese A, Iafusco D, Iannilli A, Lombardo F, Maltoni G, Patera IP, Piccinno E, Predieri B, Rabbone I, Ripoli C, Toni S, Schiaffini R, Bowers R, Cherubini V.
PMID: 33194905
Front Pediatr. 2020 Oct 22;8:575020. doi: 10.3389/fped.2020.575020. eCollection 2020.

This study aims to compare the frequency of Diabetic Ketoacidosis (DKA) at diagnosis in 2014-2016 with the one previously reported in 2004-2013; and to assess the association between family socioeconomic status and DKA at type 1 diabetes (T1D) diagnosis...

Engaging Underrepresented Adolescents in Authentic Scientific Settings: Scientist Role Models and Improving Psychosocial Outcomes.

Journal of STEM outreach

Chávez NR, Race A, Bowers M, Kane S, Sistrunk C.
PMID: 33912814
J STEM Outreach. 2019 Nov;2(1). doi: 10.15695/jstem/v2i1.18. Epub 2019 Nov 11.

There is a critical need for more effective comprehensive programs to increase the number of underrepresented minority students pursuing scientific careers. Science education often is fragmented, delivered with single-focused approaches - traditional classroom lectures, or hands-on-activities, or conducting research....

Laterality of motor symptom onset and facial expressivity in Parkinson disease using face digitization.

Laterality

Ratajska AM, Nisenzon AN, Lopez FV, Clark AL, Gokcay D, Okun MS, Bowers D.
PMID: 34225573
Laterality. 2022 Jan;27(1):57-70. doi: 10.1080/1357650X.2021.1946077. Epub 2021 Jul 05.

The onset of motor symptoms in Parkinson disease (PD) is typically unilateral. Previous work has suggested that laterality of motor symptoms may also influence non-motor symptoms including cognition and emotion perception. In line with hemispheric differences in emotion processing,...

Substance Use and Utilization of Prenatal and Postpartum Care.

Journal of addiction medicine

Nidey N, Kair LR, Wilder C, Froehlich TE, Weber S, Folger A, Marcotte M, Tabb K, Bowers K.
PMID: 33758116
J Addict Med. 2021 Mar 19; doi: 10.1097/ADM.0000000000000843. Epub 2021 Mar 19.

OBJECTIVES: Prenatal and postpartum care for women with substance use is important due to increased risk of poor health outcomes. The influence of substance use on perinatal care utilization is not well characterized, especially postpartum care. The objective of...

Role of long interspersed nuclear element-1 in the regulation of chromatin landscapes and genome dynamics.

Experimental biology and medicine (Maywood, N.J.)

Ramos KS, Bojang P, Bowers E.
PMID: 34304633
Exp Biol Med (Maywood). 2021 Oct;246(19):2082-2097. doi: 10.1177/15353702211031247. Epub 2021 Jul 25.

LINE-1 retrotransposon, the most active mobile element of the human genome, is subject to tight regulatory control. Stressful environments and disease modify the recruitment of regulatory proteins leading to unregulated activation of LINE-1. The activation of LINE-1 influences genome...

Showing 505 to 514 of 514 entries