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Showing 13 to 24 of 29 entries
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Predicting Direct-Specimen SARS-CoV-2 Assay Performance Using Residual Patient Samples.

The journal of applied laboratory medicine

Schroeder LF, Bachman MA, Idoni A, Gegenheimer-Holmes J, Kronick SL, Valdez R, Lephart PR.
PMID: 34755849
J Appl Lab Med. 2021 Nov 10; doi: 10.1093/jalm/jfab159. Epub 2021 Nov 10.

BACKGROUND: Diagnostic sensitivities of point-of-care SARS-CoV-2 assays depend on specimen type and population-specific viral loads. Evaluation of these assays require 'direct' specimens from paired-swab studies rather than more accessible residual specimens in viral transport media (VTM).METHODS: Residual VTM and...

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.

NPJ vaccines

Brar G, Farhat NA, Sukhina A, Lam AK, Kim YH, Hsu T, Tong L, Lin WW, Ware CF, Blackman MA, Sun R, Wu TT.
PMID: 33298958
NPJ Vaccines. 2020 Nov 05;5(1):102. doi: 10.1038/s41541-020-00251-x.

Vaccines based on live attenuated viruses often induce broad, multifaceted immune responses. However, they also usually sacrifice immunogenicity for attenuation. It is particularly difficult to elicit an effective vaccine for herpesviruses due to an armament of immune evasion genes...

Variation in red cell transfusion practice in the intensive care unit: a multicentre cohort study.

Critical care (London, England)

Hébert PC, Wells G, Martin C, Tweeddale M, Marshall J, Blajchman M, Pagliarello G, Sandham D, Schweitzer I, Boisvert D, Calder L.
PMID: 11056725
Crit Care. 1999;3(2):57-63. doi: 10.1186/cc310.

OBJECTIVES: To determine the degree of interinstitutional transfusion practice variation and reasons why red cells are administered in critically ill patients. STUDY DESIGN: Multicentre cohort study combined with a cross-sectional survey of physicians requesting red cell transfusions for patients...

Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged.

Immunity & ageing : I & A

Connor LM, Kohlmeier JE, Ryan L, Roberts AD, Cookenham T, Blackman MA, Woodland DL.
PMID: 23244347
Immun Ageing. 2012 Dec 18;9(1):28. doi: 10.1186/1742-4933-9-28.

BACKGROUND: Virus-specific memory CD8+ T cells persist long after infection is resolved and are important for mediating recall responses to secondary infection. Although the number of memory T cells remains relatively constant over time, little is known about the...

Correction to: Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.

Immunity & ageing : I & A

Lanzer KG, Cookenham T, Reiley WW, Blackman MA.
PMID: 30166990
Immun Ageing. 2018 Aug 21;15:18. doi: 10.1186/s12979-018-0123-x. eCollection 2018.

[This corrects the article DOI: 10.1186/s12979-018-0122-y.].

Pre-Clinical Pregnancy Models for Evaluating Zika Vaccines.

Tropical medicine and infectious disease

Kim IJ, Blackman MA, Lin JS.
PMID: 30959955
Trop Med Infect Dis. 2019 Apr 07;4(2). doi: 10.3390/tropicalmed4020058.

Zika virus (ZIKV) infection during pregnancy can result in a variety of developmental abnormalities in the fetus, referred to as Congenital Zika Syndrome (CZS). The effects of CZS can range from the loss of the viable fetus to a...

Epidemiological and Microbiome Associations Between .

Open forum infectious diseases

Collingwood A, Blostein F, Seekatz AM, Wobus CE, Woods RJ, Foxman B, Bachman MA.
PMID: 32010736
Open Forum Infect Dis. 2020 Jan 12;7(1):ofaa012. doi: 10.1093/ofid/ofaa012. eCollection 2020 Jan.

No abstract available.

Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection.

Immunity & ageing : I & A

Lanzer KG, Cookenham T, Reiley WW, Blackman MA.
PMID: 30093911
Immun Ageing. 2018 Aug 08;15:17. doi: 10.1186/s12979-018-0122-y. eCollection 2018.

BACKGROUND: A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of...

Correction: Early dysregulation of the memory CD8+ T cell repertoire leads to compromised immune responses to secondary viral infection in the aged.

Immunity & ageing : I & A

Connor LM, Kohlmeier JE, Ryan L, Roberts AD, Cookenham T, Quinn A, Blackman MA, Woodland DL.
PMID: 24228632
Immun Ageing. 2013 Oct 11;10(1):40. doi: 10.1186/1742-4933-10-40.

No abstract available.

Complete Genome Sequence of Klebsiella pneumoniae Strain ATCC 43816 KPPR1, a Rifampin-Resistant Mutant Commonly Used in Animal, Genetic, and Molecular Biology Studies.

Genome announcements

Broberg CA, Wu W, Cavalcoli JD, Miller VL, Bachman MA.
PMID: 25291761
Genome Announc. 2014 Sep 25;2(5). doi: 10.1128/genomeA.00924-14.

Klebsiella pneumoniae is an urgent public health threat due to the spread of carbapenem-resistant strains causing serious, and frequently fatal, infections. To facilitate genetic, molecular, and immunological studies of this pathogen, we report the complete chromosomal sequence of a...

Management of CMV, EBV, and HIV viral load quality control data using Unity Real Time.

Journal of clinical microbiology

Newton DW, VandePoele N, Yundt-Pacheco JC, Gauthier D, Bachman MA.
PMID: 34669458
J Clin Microbiol. 2021 Oct 20;JCM0167521. doi: 10.1128/JCM.01675-21. Epub 2021 Oct 20.

Quality control (QC) rules (Westgard rules) are applied to viral load testing to identify runs that should be reviewed or repeated, but this requires balancing the patient safety benefits of error detection with the cost and inefficiency of false...

Cannabidiol (CBD) Inhibited Rhodamine-123 Efflux in Cultured Vascular Endothelial Cells and Astrocytes Under Hypoxic Conditions.

Frontiers in behavioral neuroscience

Auzmendi J, Palestro P, Blachman A, Gavernet L, Merelli A, Talevi A, Calabrese GC, Ramos AJ, Lazarowski A.
PMID: 32256321
Front Behav Neurosci. 2020 Mar 17;14:32. doi: 10.3389/fnbeh.2020.00032. eCollection 2020.

Despite the constant development of new antiepileptic drugs (AEDs), more than 30% of patients develop refractory epilepsy (RE) characterized by a multidrug-resistant (MDR) phenotype. The "transporters hypothesis" indicates that the mechanism of this MDR phenotype is the overexpression of...

Showing 13 to 24 of 29 entries