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Showing 25 to 36 of 192 entries
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The Value of Dimensional Models of Early Experience: Thinking Clearly About Concepts and Categories.

Perspectives on psychological science : a journal of the Association for Psychological Science

McLaughlin KA, Sheridan MA, Humphreys KL, Belsky J, Ellis BJ.
PMID: 34491864
Perspect Psychol Sci. 2021 Nov;16(6):1463-1472. doi: 10.1177/1745691621992346. Epub 2021 Sep 07.

We review the three prevailing approaches-specificity, cumulative risk, and dimensional models-to conceptualizing the developmental consequences of early-life adversity and address fundamental problems with the characterization of these frameworks in a recent

Adjacent level fracture incidence in single fraction high dose spinal radiosurgery.

Annals of translational medicine

Lockney DT, Hopkins B, Lockney NA, Coleman CZ, Rubin E, Lis E, Yamada Y, Schmitt A, Higginson D, Bilsky MH, Laufer I.
PMID: 31297376
Ann Transl Med. 2019 May;7(10):211. doi: 10.21037/atm.2019.04.68.

BACKGROUND: Vertebral body compression fracture (VCF) is a complication following spinal stereotactic radiosurgery (SRS). However, the incidence of VCF in vertebrae adjacent to the level of SRS is unknown. This study aimed to determine the incidence of adjacent level...

Streamlined approval of biosimilars: moving on from the confirmatory efficacy trial.

Drug discovery today

Bielsky MC, Cook A, Wallington A, Exley A, Kauser S, Hay JL, Both L, Brown D.
PMID: 32916269
Drug Discov Today. 2020 Sep 09; doi: 10.1016/j.drudis.2020.09.006. Epub 2020 Sep 09.

Licensing of biosimilars is essential to promote patient access to 21st-century biological medicines. Regulatory approval of biosimilars is based on the totality of evidence from a head-to-head comparison with reference products (RPs). A clinical efficacy trial is usually required,...

Common and Unique Genetic Background between Attention-Deficit/Hyperactivity Disorder and Excessive Body Weight.

Genes

Dmitrzak-Weglarz M, Paszynska E, Bilska K, Szczesniewska P, Bryl E, Duda J, Dutkiewicz A, Tyszkiewicz-Nwafor M, Czerski P, Hanc T, Slopien A.
PMID: 34573389
Genes (Basel). 2021 Sep 13;12(9). doi: 10.3390/genes12091407.

Comorbidity studies show that children with ADHD have a higher risk of being overweight and obese than healthy children. This study aimed to assess the genetic alternations that differ between and are shared by ADHD and excessive body weight...

Sepsis Fluid Metric Compliance and its Impact on Outcomes of Patients with Congestive Heart Failure, End-Stage Renal Disease or Obesity.

The Journal of emergency medicine

Boccio E, Haimovich AD, Jacob V, Maciejewski KR, Wira CR, Belsky J.
PMID: 34088547
J Emerg Med. 2021 Nov;61(5):466-480. doi: 10.1016/j.jemermed.2021.03.004. Epub 2021 Jun 02.

BACKGROUND: Emergency physicians express concern administering a 30-cc/kg fluid bolus to septic shock patients with pre-existing congestive heart failure (CHF), end-stage renal disease (ESRD), or obesity, due to the perceived risk of precipitating a fluid overload state.OBJECTIVE: Our aim...

Uncovering Diagnostic Value of Mitogenome for Identification of Cryptic Species .

Frontiers in microbiology

Wyrębek J, Molcan T, Myszczyński K, van Diepeningen AD, Stakheev AA, Żelechowski M, Bilska K, Kulik T.
PMID: 34531839
Front Microbiol. 2021 Aug 31;12:714651. doi: 10.3389/fmicb.2021.714651. eCollection 2021.

Fungal complexes are often composed of morphologically nearly indistinguishable species with high genetic similarity. However, despite their close relationship, they can exhibit distinct phenotypic differences in pathogenicity and production of mycotoxins. Many plant pathogenic and toxigenic fungi have been...

Prescribing Patterns of Oral Opioid Analgesic for Long Bone Fracture at Tertiary Care Children's Hospital Emergency Departments and Urgent Cares.

Pediatric emergency care

Wang GS, Reese J, Bakel LA, Leonard J, Bos T, Bielsky A, Nickels S, Bajaj L.
PMID: 32384393
Pediatr Emerg Care. 2021 Dec 01;37(12):e1524-e1527. doi: 10.1097/PEC.0000000000002105.

OBJECTIVES: Disparities in opioid prescribing in children can lead to underprescribing and poorly controlled pain. On the contrary, unnecessary overprescribing can increase the risk for misuse, abuse, and diversion. The primary objective of this study was to compare the...

The effects of hysteroscopic morcellation of endometrial polyps on frozen embryo transfer outcomes.

European journal of obstetrics, gynecology, and reproductive biology

Kavoussi SK, Esqueda AS, West BT, Chen SH, London K, Lebovic DI, Barsky M, Kavoussi MM, Gilkey MS, Chen J, Wininger JD, Jatinen E, Machen GL, Kavoussi PK.
PMID: 34837853
Eur J Obstet Gynecol Reprod Biol. 2021 Dec;267:241-244. doi: 10.1016/j.ejogrb.2021.11.420. Epub 2021 Nov 19.

OBJECTIVE(S): To determine if hysteroscopic removal of endometrial polyps, specifically via morcellation of polyps, affects implantation rate (IR), clinical pregnancy rate (CPR), spontaneous abortion (SAB) rate, and live birth rate (LBR) in first frozen embryo transfer (FET) cycles.STUDY DESIGN:...

Clinical Reliability of Genomic Data Obtained from Spinal Metastatic Tumor Samples.

Neuro-oncology

Barzilai O, Martin A, Reiner AS, Laufer I, Schmitt A, Bilsky MH.
PMID: 34999837
Neuro Oncol. 2022 Jan 06; doi: 10.1093/neuonc/noac009. Epub 2022 Jan 06.

PURPOSE: The role of tumor genomic profiling is rapidly growing as it results in targeted, personalized, cancer therapy. Though routinely used in clinical practice, there are no data exploring the reliability of genomic data obtained from spine metastases samples...

Factors Associated With Antibiotic Prescribing and Outcomes for Pediatric Pneumonia in the Emergency Department.

Pediatric emergency care

Lipshaw MJ, Florin TA, Krueger S, Belsky MA, Epperson T, Crotty EJ, Lipscomb J, Jacobs J, Rattan MS, Ruddy RM, Shah SS, Ambroggio L.
PMID: 31290801
Pediatr Emerg Care. 2021 Dec 01;37(12):e1033-e1038. doi: 10.1097/PEC.0000000000001892.

OBJECTIVES: Chest radiographs (CXRs) are often performed in children with respiratory illness to inform the decision to prescribe antibiotics. Our objective was to determine the factors associated with clinicians' plans to treat with antibiotics prior to knowledge of CXR...

CRIS: complete reconstruction of immunoglobulin .

Bioinformatics advances

Islam R, Bilenky M, Weng AP, Connors JM, Hirst M.
PMID: 34806017
Bioinform Adv. 2021 Sep 09;1(1):vbab021. doi: 10.1093/bioadv/vbab021. eCollection 2021.

MOTIVATION: B cells display remarkable diversity in producing B-cell receptors through recombination of immunoglobulin (Ig) RESULTS: CRIS extracts RNA-seq reads aligned to Ig gene loci, performs assembly of Ig transcripts and aligns the resulting contigs to reference Ig sequences...

Disorganization, COMT, and Children's Social Behavior: The Norwegian Hypothesis of Legacy of Disorganized Attachment.

Frontiers in psychology

Li Z, Hygen BW, Widaman KF, Berg-Nielsen TS, Wichstrøm L, Belsky J.
PMID: 27462283
Front Psychol. 2016 Jul 12;7:1013. doi: 10.3389/fpsyg.2016.01013. eCollection 2016.

Why is disorganized attachment associated with punitive-controlling behavior in some, but caregiving-controlling in others? Hygen et al. (2014) proposed that variation in the Catechol-O-methyl transferase(COMT) Val158Met genotype explains this variation, providing preliminary data to this effect. We offer a...

Showing 25 to 36 of 192 entries