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Simple Synthesis of a Heterocyclophane Exhibiting Anti-c-Met Activity by Acting as a Hatch Blocking Access to the Active Site*.

Chemistry (Weinheim an der Bergstrasse, Germany)

Takimoto T, Sasaki H, Tsue H, Takahashi H, MacKerell AD, Nakamura A, Nakano K, Okazaki E, Betsuyaku T, Tachibana R, Hioki K, Yoluk O, Jo S.
PMID: 33258147
Chemistry. 2021 Jan 21;27(5):1648-1654. doi: 10.1002/chem.202001382. Epub 2020 Dec 15.

A simple approach to the synthesis of heterocyclophane consisting of two 4,4'-bithiazoles has been developed in mild conditions. The heterocyclophane with two short chains was conveniently prepared by Hantzsch thiazoles synthesis using the reaction of 3-tert-butoxycarbonyl-3-azapentanethiocarboxamide with 1,4-dibromobutane-2,3-dione in...

Showing 49 to 49 of 49 entries