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Showing 13 to 24 of 995 entries
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Asymmetric synthesis of 3,4-annulated indoles through an organocatalytic cascade approach.

Chemical communications (Cambridge, England)

Caruana L, Fochi M, Franchini MC, Ranieri S, Mazzanti A, Bernardi L.
PMID: 24252947
Chem Commun (Camb). 2014 Jan 14;50(4):445-7. doi: 10.1039/c3cc47841f.

Indoles bearing Michael acceptors at the 4-position were engaged in organocatalytic enantioselective cascade reactions with enals. Careful optimisation of the reaction parameters overcame the inherent low reactivity of these substrates, rendering 3,4-ring fused indoles in good yields, excellent enantioselectivities...

In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study.

SpringerPlus

Garzoni C, Uçkay I, Belaieff W, Breilh D, Suvà D, Huggler E, Lew D, Hoffmeyer P, Bernard L.
PMID: 25019039
Springerplus. 2014 Jun 07;3:287. doi: 10.1186/2193-1801-3-287. eCollection 2014.

BACKGROUND: Increased antibiotic resistance against Staphylococcus aureus and low penetration into bone requires regimen optimization of available drugs.METHODS: We evaluate pharmoacokinetic and pharmacodynamic parameters (PK/PD) as well as in vivo interactions of continuous flucloxacillin 12 g/d administration combined with...

Delusional Disorder over the Reproductive Life Span: The Potential Influence of Menopause on the Clinical Course.

Schizophrenia research and treatment

González-Rodríguez A, Molina-Andreu O, Penadés R, Garriga M, Pons A, Catalán R, Bernardo M.
PMID: 26600949
Schizophr Res Treatment. 2015;2015:979605. doi: 10.1155/2015/979605. Epub 2015 Oct 27.

Background and Objectives. Recent evidence supports an association between estrogen levels and severity of psychopathology in schizophrenia women. Our main goal was to investigate whether delusional disorder (DD) women with premenopausal onset and those with postmenopausal onset differ in...

Stimulants for the Control of Hedonic Appetite.

Frontiers in pharmacology

Poulton AS, Hibbert EJ, Champion BL, Nanan RK.
PMID: 27199749
Front Pharmacol. 2016 Apr 25;7:105. doi: 10.3389/fphar.2016.00105. eCollection 2016.

The focus of this paper is treatment of obesity in relation to the management of hedonic appetite. Obesity is a complex condition which may be potentiated by excessive reward seeking in combination with executive functioning deficits that impair cognitive...

Para-aortic and pelvic extended-field radiotherapy for advanced-stage uterine cancer: dosimetric and toxicity comparison between the four-field box and intensity-modulated techniques.

Current oncology (Toronto, Ont.)

Rabinovich A, Bernard L, Ramanakumar AV, Stroian G, Gotlieb WH, Lau S, Bahoric B.
PMID: 26715873
Curr Oncol. 2015 Dec;22(6):405-11. doi: 10.3747/co.22.2727.

BACKGROUND: In patients with advanced-stage endometrial carcinoma (eca), extended-field radiotherapy (efrt) is traditionally delivered by the 3-dimensional conformal (3d-crt) 4-field box technique. In recent years, the use of intensity-modulated radiotherapy (imrt) in gynecologic cancers has increased. We compared the...

Growth and Accumulation of Secondary Metabolites in Perilla as Affected by Photosynthetic Photon Flux Density and Electrical Conductivity of the Nutrient Solution.

Frontiers in plant science

Lu N, Bernardo EL, Tippayadarapanich C, Takagaki M, Kagawa N, Yamori W.
PMID: 28523012
Front Plant Sci. 2017 May 04;8:708. doi: 10.3389/fpls.2017.00708. eCollection 2017.

The global demand for medicinal plants is increasing. The quality of plants grown outdoors, however, is difficult to control. Myriad environmental factors influence plant growth and directly impact biosynthetic pathways, thus affecting the secondary metabolism of bioactive compounds. Plant...

Non-Steroidal Anti-Inflammatory Drugs and Brain Inflammation: Effects on Microglial Functions.

Pharmaceuticals (Basel, Switzerland)

Ajmone-Cat MA, Bernardo A, Greco A, Minghetti L.
PMID: 27713336
Pharmaceuticals (Basel). 2010 Jun 14;3(6):1949-1965. doi: 10.3390/ph3061949.

The term NSAID refers to structurally diverse chemical compounds that share the ability to inhibit the activity of the prostaglandin (PG) biosynthetic enzymes, the cyclooxygenase (COX) isoforms 1 and 2. The suppression of PG synthesis at sites of inflammation...

Kaolin Foliar Application Has a Stimulatory Effect on Phenylpropanoid and Flavonoid Pathways in Grape Berries.

Frontiers in plant science

Conde A, Pimentel D, Neves A, Dinis LT, Bernardo S, Correia CM, Gerós H, Moutinho-Pereira J.
PMID: 27551286
Front Plant Sci. 2016 Aug 08;7:1150. doi: 10.3389/fpls.2016.01150. eCollection 2016.

Drought, elevated air temperature, and high evaporative demand are increasingly frequent during summer in grape growing areas like the Mediterranean basin, limiting grapevine productivity and berry quality. The foliar exogenous application of kaolin, a radiation-reflecting inert mineral, has proven...

Context-dependent functional dispersion across similar ranges of trait space covered by intertidal rocky shore communities.

Ecology and evolution

Valdivia N, Segovia-Rivera V, Fica E, Bonta CC, Aguilera MA, Broitman BR.
PMID: 28331595
Ecol Evol. 2017 Feb 17;7(6):1882-1891. doi: 10.1002/ece3.2762. eCollection 2017 Mar.

Functional diversity is intimately linked with community assembly processes, but its large-scale patterns of variation are often not well understood. Here, we investigated the spatiotemporal changes in multiple trait dimensions ("trait space") along vertical intertidal environmental stress gradients and...

The NGS WikiBook: a dynamic collaborative online training effort with long-term sustainability.

Briefings in bioinformatics

Li JW, Bolser D, Manske M, Giorgi FM, Vyahhi N, Usadel B, Clavijo BJ, Chan TF, Wong N, Zerbino D, Schneider MV.
PMID: 23793381
Brief Bioinform. 2013 Sep;14(5):548-55. doi: 10.1093/bib/bbt045. Epub 2013 Jun 21.

Next-generation sequencing (NGS) is increasingly being adopted as the backbone of biomedical research. With the commercialization of various affordable desktop sequencers, NGS will be reached by increasing numbers of cellular and molecular biologists, necessitating community consensus on bioinformatics protocols...

Relationships among Bacterial Cell Size, Productivity, and Genetic Diversity in Aquatic Environments using Cell Sorting and Flow Cytometry.

Microbial ecology

Bernard L, Courties C, Servais P, Troussellier M, Petit M, Lebaron P.
PMID: 11029083
Microb Ecol. 2000 Aug;40(2):148-158. doi: 10.1007/s002480000046.

The study of relationships between cell size and productivity is of key importance in microbial ecology to understand which members of natural aquatic communities are responsible for the overall activity and/or productivity. Flow sorting of microorganisms from different environmental...

Pediatric implications in bioterrorism: education for healthcare providers.

Disaster management & response : DMR : an official publication of the Emergency Nurses Association

Bernardo LM, Kapsar P.
PMID: 12704321
Disaster Manag Response. 2003 Apr-Jun;1(2):52-3. doi: 10.1016/s1540-2487(03)00002-6.

No abstract available.

Showing 13 to 24 of 995 entries