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Showing 25 to 36 of 282 entries
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Modeling human T1D-associated autoimmune processes.

Molecular metabolism

Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ.
PMID: 34902607
Mol Metab. 2021 Dec 10;56:101417. doi: 10.1016/j.molmet.2021.101417. Epub 2021 Dec 10.

BACKGROUND: Type 1 diabetes (T1D) is an autoimmune disease characterized by impaired immune tolerance to β-cell antigens and progressive destruction of insulin-producing β-cells. Animal models have provided valuable insights for understanding the etiology and pathogenesis of this disease, but...

Serotonin drives striatal synaptic plasticity in a sex-related manner.

Neurobiology of disease

Campanelli F, Marino G, Barsotti N, Natale G, Calabrese V, Cardinale A, Ghiglieri V, Maddaloni G, Usiello A, Calabresi P, Pasqualetti M, Picconi B.
PMID: 34280523
Neurobiol Dis. 2021 Oct;158:105448. doi: 10.1016/j.nbd.2021.105448. Epub 2021 Jul 16.

INTRODUCTION: Plasticity at corticostriatal synapses is a key substrate for a variety of brain functions - including motor control, learning and reward processing - and is often disrupted in disease conditions. Despite intense research pointing toward a dynamic interplay...

Neural architectures in the light of comparative connectomics.

Current opinion in neurobiology

Barsotti E, Correia A, Cardona A.
PMID: 34837731
Curr Opin Neurobiol. 2021 Nov 24;71:139-149. doi: 10.1016/j.conb.2021.10.006. Epub 2021 Nov 24.

Since the Cambrian, animals diversified from a few body forms or bauplans, into many extinct and all extant species. A characteristic neural architecture serves each bauplan. How the connectome of each animal differs from that of closely related species...

DRPLA: An unusual disease or an underestimated cause of ataxia in Brazil?.

Parkinsonism & related disorders

Pinto WBVR, Salomão RPA, Bergamasco NC, da Cunha Ribas G, da Graça FF, Lopes-Cendes I, Bonadia L, de Souza PVS, Bulle Oliveira AS, Saraiva-Pereira ML, Jardim LB, Tumas V, Junior WM, França MC, Pedroso JL, Barsottini OGP, Teive HAG.
PMID: 34700111
Parkinsonism Relat Disord. 2021 Nov;92:67-71. doi: 10.1016/j.parkreldis.2021.10.004. Epub 2021 Oct 11.

BACKGROUND: Dentatorubral-pallidoluysian atrophy (DRPLA) is a rare autosomal dominant spinocerebellar ataxia caused by pathological expansion of CAG trinucleotide repeats in the ATN1 gene. Most cases were described in patients from Japanese ancestry who presented with adult-onset progressive cerebellar ataxia...

Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.

Cell chemical biology

Olszewski K, Barsotti A, Feng XJ, Momcilovic M, Liu KG, Kim JI, Morris K, Lamarque C, Gaffney J, Yu X, Patel JP, Rabinowitz JD, Shackelford DB, Poyurovsky MV.
PMID: 34715056
Cell Chem Biol. 2021 Oct 22; doi: 10.1016/j.chembiol.2021.10.007. Epub 2021 Oct 22.

Efforts to target glucose metabolism in cancer have been limited by the poor potency and specificity of existing anti-glycolytic agents and a poor understanding of the glucose dependence of cancer subtypes in vivo. Here, we present an extensively characterized...

A Real-World Application of Liquid Biopsy in Metastatic Colorectal Cancer: The Poseidon Study.

Cancers

Procaccio L, Bergamo F, Daniel F, Rasola C, Munari G, Biason P, Crucitta S, Barsotti G, Zanella G, Angerilli V, Magro C, Paccagnella S, Di Antonio V, Loupakis F, Danesi R, Zagonel V, Del Re M, Lonardi S, Fassan M.
PMID: 34680277
Cancers (Basel). 2021 Oct 13;13(20). doi: 10.3390/cancers13205128.

BACKGROUND: First-line decision making is the key to the successful care of mCRC patients and METHODS: A monoinstitutional prospective head-to-head comparison of LB versus (vs.) STB testing was performed in a real-world setting. Selection criteria included: mCRC diagnosis with...

Predictors of Function, Activity, and Participation of Stroke Patients Undergoing Intensive Rehabilitation: A Multicenter Prospective Observational Study Protocol.

Frontiers in neurology

Hakiki B, Paperini A, Castagnoli C, Hochleitner I, Verdesca S, Grippo A, Scarpino M, Maiorelli A, Mosca IE, Gemignani P, Borsotti M, Gabrielli MA, Salvadori E, Poggesi A, Lucidi G, Falsini C, Gentilini M, Martini M, Luisi MLE, Biffi B, Mainardi P, Barretta T, Pancani S, Mannini A, Campagnini S, Bagnoli S, Ingannato A, Nacmias B, Macchi C, Carrozza MC, Cecchi F.
PMID: 33897593
Front Neurol. 2021 Apr 08;12:632672. doi: 10.3389/fneur.2021.632672. eCollection 2021.

No abstract available.

Commentary: Progressive Encephalomyelitis with Rigidity and Myoclonus and Myasthenia Gravis Comorbid Status with Thymoma.

Movement disorders clinical practice

Balint B, Ogawa T, Ogaki K, Daida K, Nishimaki T, Ando M, Kawajiri S, Wada R, Noda K, Hattori N, Okuma Y, Barsottini O.
PMID: 34514037
Mov Disord Clin Pract. 2021 Sep 03;8:S14-S15. doi: 10.1002/mdc3.13303. eCollection 2021 Aug.

No abstract available.

Guanylin, Uroguanylin and Guanylate Cyclase-C Are Expressed in the Gastrointestinal Tract of Horses.

Frontiers in physiology

Cappelli K, Gialletti R, Tesei B, Bassotti G, Fettucciari K, Capomaccio S, Bonfili L, Cuccioloni M, Eleuteri AM, Spaterna A, Laus F.
PMID: 31611814
Front Physiol. 2019 Sep 27;10:1237. doi: 10.3389/fphys.2019.01237. eCollection 2019.

Guanylate cyclase-C (GC-C) is a multifunctional receptor encoded by the

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course.

Journal of clinical medicine

Cavagna L, Trallero-Araguás E, Meloni F, Cavazzana I, Rojas-Serrano J, Feist E, Zanframundo G, Morandi V, Meyer A, Pereira da Silva JA, Matos Costa CJ, Molberg O, Andersson H, Codullo V, Mosca M, Barsotti S, Neri R, Scirè C, Govoni M, Furini F, Lopez-Longo FJ, Martinez-Barrio J, Schneider U, Lorenz HM, Doria A, Ghirardello A, Ortego-Centeno N, Confalonieri M, Tomietto P, Pipitone N, Rodriguez Cambron AB, Blázquez Cañamero MÁ, Voll RE, Wendel S, Scarpato S, Maurier F, Limonta M, Colombelli P, Giannini M, Geny B, Arrigoni E, Bravi E, Migliorini P, Mathieu A, Piga M, Drott U, Delbrueck C, Bauhammer J, Cagnotto G, Vancheri C, Sambataro G, De Langhe E, Sainaghi PP, Monti C, Gigli Berzolari F, Romano M, Bonella F, Specker C, Schwarting A, Villa Blanco I, Selmi C, Ceribelli A, Nuno L, Mera-Varela A, Perez Gomez N, Fusaro E, Parisi S, Sinigaglia L, Del Papa N, Benucci M, Cimmino MA, Riccieri V, Conti F, Sebastiani GD, Iuliano A, Emmi G, Cammelli D, Sebastiani M, Manfredi A, Bachiller-Corral J, Sifuentes Giraldo WA, Paolazzi G, Saketkoo LA, Giorgi R, Salaffi F, Cifrian J, Caporali R, Locatelli F, Marchioni E, Pesci A, Dei G, Pozzi MR, Claudia L, Distler J, Knitza J, Schett G, Iannone F, Fornaro M, Franceschini F, Quartuccio L, Gerli R, Bartoloni E, Bellando Randone S, Zampogna G, Gonzalez Perez MI, Mejia M, Vicente E, Triantafyllias K, Lopez-Mejias R, Matucci-Cerinic M, Selva-O'Callaghan A, Castañeda S, Montecucco C, Gonzalez-Gay MA.
PMID: 31752231
J Clin Med. 2019 Nov 18;8(11). doi: 10.3390/jcm8112013.

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases...

Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Borsotti E, Barberio B, D'Incà R, Bonitta G, Cavallaro F, Spina L, Pastorelli L, Rondonotti E, Samperi L, Dinelli M, Vecchi M, Tontini GE.
PMID: 33129712
Dig Liver Dis. 2021 Jul;53(7):846-851. doi: 10.1016/j.dld.2020.09.024. Epub 2020 Oct 28.

BACKGROUND AND AIMS: Microscopic colitis (MC) is the most frequent condition in subjects undergoing ileocolonoscopy for chronic non-bloody diarrhea (CNBD) in Western countries. Emerging evidence has shown a negative association between MC and colorectal cancer. Within this prospective multi-center...

Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus.

Journal of translational autoimmunity

Madley R, Nauman G, Danzl N, Borsotti C, Khosravi Maharlooei M, Li HW, Chavez E, Creusot RJ, Nakayama M, Roep B, Sykes M.
PMID: 32875283
J Transl Autoimmun. 2020 Aug 09;3:100061. doi: 10.1016/j.jtauto.2020.100061. eCollection 2020.

During T cell development in mice, thymic negative selection deletes cells with the potential to recognize and react to self-antigens. In human T cell-dependent autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, T cells reactive...

Showing 25 to 36 of 282 entries