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Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist.

Frontiers in pharmacology

Bedini A, Di Cesare Mannelli L, Micheli L, Baiula M, Vaca G, De Marco R, Gentilucci L, Ghelardini C, Spampinato S.
PMID: 32210803
Front Pharmacol. 2020 Mar 05;11:188. doi: 10.3389/fphar.2020.00188. eCollection 2020.

Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potential, although relevant adverse effects have limited their clinical use. Functionally selective KOPr agonists may activate, in a pathway-specific manner, G protein-mediated signaling, that produces antinociception, over...

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Bedini A, Di Cesare Mannelli L, Micheli L, et al. Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. Front Pharmacol. 2020;11:188doi: 10.3389/fphar.2020.00188.
Bedini, A., Di Cesare Mannelli, L., Micheli, L., Baiula, M., Vaca, G., De Marco, R., Gentilucci, L., Ghelardini, C., & Spampinato, S. (2020). Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. Frontiers in pharmacology, 11188. https://doi.org/10.3389/fphar.2020.00188
Bedini, Andrea, et al. "Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist." Frontiers in pharmacology vol. 11 (2020): 188. doi: https://doi.org/10.3389/fphar.2020.00188
Bedini A, Di Cesare Mannelli L, Micheli L, Baiula M, Vaca G, De Marco R, Gentilucci L, Ghelardini C, Spampinato S. Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist. Front Pharmacol. 2020 Mar 05;11:188. doi: 10.3389/fphar.2020.00188. eCollection 2020. PMID: 32210803; PMCID: PMC7066533.
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External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction.

Journal of clinical medicine

Nestelberger T, Lopez-Ayala P, Boeddinghaus J, Strebel I, Rubini Gimenez M, Huber I, Wildi K, Wussler D, Koechlin L, Prepoudis A, Gualandro DM, Puelacher C, Glarner N, Haaf P, Frey S, Bakula A, Wick R, Miró Ò, Martin-Sanchez FJ, Kawecki D, Keller D, Twerenbold R, Mueller C.
PMID: 33803801
J Clin Med. 2021 Mar 18;10(6). doi: 10.3390/jcm10061264.

BACKGROUND: The early non-invasive discrimination of Type 2 versus Type 1 Myocardial Infarction (T2MI, T1MI) is a major unmet clinical need. We aimed to externally validate a recently derived clinical score (Neumann) combing female sex, no radiating chest pain,...

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Nestelberger T, Lopez-Ayala P, Boeddinghaus J, et al. External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction. J Clin Med. 2021;10(6)doi: 10.3390/jcm10061264.
Nestelberger, T., Lopez-Ayala, P., Boeddinghaus, J., Strebel, I., Rubini Gimenez, M., Huber, I., Wildi, K., Wussler, D., Koechlin, L., Prepoudis, A., Gualandro, D. M., Puelacher, C., Glarner, N., Haaf, P., Frey, S., Bakula, A., Wick, R., Miró, �. �., Martin-Sanchez, F. J., Kawecki, D., Keller, D., Twerenbold, R., & Mueller, C. (2021). External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction. Journal of clinical medicine, 10(6), . https://doi.org/10.3390/jcm10061264
Nestelberger, Thomas, et al. "External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction." Journal of clinical medicine vol. 10,6 (2021). doi: https://doi.org/10.3390/jcm10061264
Nestelberger T, Lopez-Ayala P, Boeddinghaus J, Strebel I, Rubini Gimenez M, Huber I, Wildi K, Wussler D, Koechlin L, Prepoudis A, Gualandro DM, Puelacher C, Glarner N, Haaf P, Frey S, Bakula A, Wick R, Miró Ò, Martin-Sanchez FJ, Kawecki D, Keller D, Twerenbold R, Mueller C. External Validation and Extension of a Clinical Score for the Discrimination of Type 2 Myocardial Infarction. J Clin Med. 2021 Mar 18;10(6). doi: 10.3390/jcm10061264. PMID: 33803801; PMCID: PMC8003225.
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Psychological Effects of "Double Crisis" (COVID-19 Pandemic and Earthquakes) on Croatian Medical Students.

Psychiatria Danubina

Romic I, Silovski H, Mance M, Pavlek G, Petrovic I, Figl J, Grbavac D, Moric T, Romic R, Bakula B, Vulic A.
PMID: 34672284
Psychiatr Danub. 2021 Sep;33:120-125.

INTRODUCTION: In 2020. the COVID-19 pandemic presented an additional source of stress and anxiety not just to the general population but also to medical students who are, even under normal circumstances, constantly under pressure due to demanding student duties....

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Romic I, Silovski H, Mance M, et al. Psychological Effects of "Double Crisis" (COVID-19 Pandemic and Earthquakes) on Croatian Medical Students. Psychiatr Danub. 2021;33:120-125
Romic, I., Silovski, H., Mance, M., Pavlek, G., Petrovic, I., Figl, J., Grbavac, D., Moric, T., Romic, R., Bakula, B., & Vulic, A. (2021). Psychological Effects of "Double Crisis" (COVID-19 Pandemic and Earthquakes) on Croatian Medical Students. Psychiatria Danubina, 33120-125.
Romic, Ivan, et al. "Psychological Effects of "Double Crisis" (COVID-19 Pandemic and Earthquakes) on Croatian Medical Students." Psychiatria Danubina vol. 33 (2021): 120-125.
Romic I, Silovski H, Mance M, Pavlek G, Petrovic I, Figl J, Grbavac D, Moric T, Romic R, Bakula B, Vulic A. Psychological Effects of "Double Crisis" (COVID-19 Pandemic and Earthquakes) on Croatian Medical Students. Psychiatr Danub. 2021 Sep;33:120-125. PMID: 34672284.
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Hypertriglyceridemia-induced pancreatitis treated with continuous insulin infusion-Case series.

Clinical endocrinology

Marić N, Mačković M, Bakula M, Mucić K, Udiljak N, Marušić M.
PMID: 34263462
Clin Endocrinol (Oxf). 2022 Feb;96(2):139-143. doi: 10.1111/cen.14554. Epub 2021 Jul 14.

OBJECTIVE: There are no definitive treatment guidelines for hypertriglyceridemia (HTG)-induced acute pancreatitis (AP). The aim of this retrospective study was to evaluate the efficacy of insulin in decreasing triglyceride (TG) levels in patients with HTG-induced AP.DESIGN: We included 17...

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Marić N, Mačković M, Bakula M, et al. Hypertriglyceridemia-induced pancreatitis treated with continuous insulin infusion-Case series. Clin Endocrinol (Oxf). 2021;96(2):139-143doi: 10.1111/cen.14554.
Marić, N., Mačković, M., Bakula, M., Mucić, K., Udiljak, N., & Marušić, M. (2022). Hypertriglyceridemia-induced pancreatitis treated with continuous insulin infusion-Case series. Clinical endocrinology, 96(2), 139-143. https://doi.org/10.1111/cen.14554
Marić, Nikolina, et al. "Hypertriglyceridemia-induced pancreatitis treated with continuous insulin infusion-Case series." Clinical endocrinology vol. 96,2 (2022): 139-143. doi: https://doi.org/10.1111/cen.14554
Marić N, Mačković M, Bakula M, Mucić K, Udiljak N, Marušić M. Hypertriglyceridemia-induced pancreatitis treated with continuous insulin infusion-Case series. Clin Endocrinol (Oxf). 2022 Feb;96(2):139-143. doi: 10.1111/cen.14554. Epub 2021 Jul 14. PMID: 34263462.
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Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases.

Developmental and comparative immunology

Ryu J, Fu Z, Akula S, Olsson AK, Hellman L.
PMID: 34826501
Dev Comp Immunol. 2021 Nov 23;128:104324. doi: 10.1016/j.dci.2021.104324. Epub 2021 Nov 23.

Granzyme B (GzmB) is primarily expressed by mammalian cytotoxic T cells and serves as one of the key components in the defense against viral infection by the induction of apoptosis in virus infected cells. By direct cell to cell...

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Ryu J, Fu Z, Akula S, et al. Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases. Dev Comp Immunol. 2021;128:104324doi: 10.1016/j.dci.2021.104324.
Ryu, J., Fu, Z., Akula, S., Olsson, A. K., & Hellman, L. (2021). Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases. Developmental and comparative immunology, 128104324. https://doi.org/10.1016/j.dci.2021.104324
Ryu, Jinhye, et al. "Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases." Developmental and comparative immunology vol. 128 (2021): 104324. doi: https://doi.org/10.1016/j.dci.2021.104324
Ryu J, Fu Z, Akula S, Olsson AK, Hellman L. Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases. Dev Comp Immunol. 2021 Nov 23;128:104324. doi: 10.1016/j.dci.2021.104324. Epub 2021 Nov 23. PMID: 34826501.
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Is There Any Impact Of The Gutkha Ban on Users and Vendors in Rangareddy District? A Cross Sectional Study.

Asian Pacific journal of cancer prevention : APJCP

Reddy P, Anjum Sh, Monica M, Yadav Rao K, Akula Sh, Sai Pravallika T.
PMID: 28032731
Asian Pac J Cancer Prev. 2016 Nov 01;17(11):5005-5009. doi: 10.22034/APJCP.2016.17.11.5005.

Introduction: Gutkha contains harmful and carcinogenic chemicals and oral cancer caused by tobacco usage has been reported as a major preventable cause of death worldwide by the World Health Organization. The Telangana state government implemented a ban on gutkha...

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Reddy P, Anjum Sh, Monica M, et al. Is There Any Impact Of The Gutkha Ban on Users and Vendors in Rangareddy District? A Cross Sectional Study. Asian Pac J Cancer Prev. 2016;17(11):5005-5009doi: 10.22034/APJCP.2016.17.11.5005.
Reddy, P., Anjum, S. h., Monica, M., Yadav Rao, K., Akula, S. h., & Sai Pravallika, T. (2016). Is There Any Impact Of The Gutkha Ban on Users and Vendors in Rangareddy District? A Cross Sectional Study. Asian Pacific journal of cancer prevention : APJCP, 17(11), 5005-5009. https://doi.org/10.22034/APJCP.2016.17.11.5005
Reddy, Parthasarathi, et al. "Is There Any Impact Of The Gutkha Ban on Users and Vendors in Rangareddy District? A Cross Sectional Study." Asian Pacific journal of cancer prevention : APJCP vol. 17,11 (2016): 5005-5009. doi: https://doi.org/10.22034/APJCP.2016.17.11.5005
Reddy P, Anjum Sh, Monica M, Yadav Rao K, Akula Sh, Sai Pravallika T. Is There Any Impact Of The Gutkha Ban on Users and Vendors in Rangareddy District? A Cross Sectional Study. Asian Pac J Cancer Prev. 2016 Nov 01;17(11):5005-5009. doi: 10.22034/APJCP.2016.17.11.5005. PMID: 28032731; PMCID: PMC5454711.
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Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends.

Chemistry, an Asian journal

Baguli S, Mondal S, Mandal C, Goswami S, Mukherjee D.
PMID: 34825506
Chem Asian J. 2022 Jan 03;17(1):e202100962. doi: 10.1002/asia.202100962. Epub 2021 Nov 25.

The electron-rich cyclopentadienyl and the analogous indenyl and fluorenyl ligands (collectively denoted here as Cp') have been impactful in stabilizing electron-deficient metal centers including the highly electropositive alkaline earths. Being in the s-block, the group 2 metals follow a...

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Baguli S, Mondal S, Mandal C, et al. Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends. Chem Asian J. 2021;17(1):e202100962doi: 10.1002/asia.202100962.
Baguli, S., Mondal, S., Mandal, C., Goswami, S., & Mukherjee, D. (2022). Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends. Chemistry, an Asian journal, 17(1), e202100962. https://doi.org/10.1002/asia.202100962
Baguli, Sudip, et al. "Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends." Chemistry, an Asian journal vol. 17,1 (2022): e202100962. doi: https://doi.org/10.1002/asia.202100962
Baguli S, Mondal S, Mandal C, Goswami S, Mukherjee D. Cyclopentadienyl Complexes of the Alkaline Earths in Light of the Periodic Trends. Chem Asian J. 2022 Jan 03;17(1):e202100962. doi: 10.1002/asia.202100962. Epub 2021 Nov 25. PMID: 34825506.
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Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.

Neurology

Ebrahimi-Fakhari D, Alecu JE, Ziegler M, Geisel G, Jordan C, D'Amore A, Yeh RC, Akula SK, Saffari A, Prabhu SP, Sahin M, Yang E.
PMID: 34544818
Neurology. 2021 Nov 09;97(19):e1942-e1954. doi: 10.1212/WNL.0000000000012836. Epub 2021 Sep 20.

BACKGROUND AND OBJECTIVES: AP-4-associated hereditary spastic paraplegia (AP-4-HSP: SPG47, SPG50, SPG51, SPG52) is an emerging cause of childhood-onset hereditary spastic paraplegia and mimic of cerebral palsy. This study aims to define the spectrum of brain MRI findings in AP-4-HSP...

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Ebrahimi-Fakhari D, Alecu JE, Ziegler M, et al. Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia. Neurology. 2021;97(19):e1942-e1954doi: 10.1212/WNL.0000000000012836.
Ebrahimi-Fakhari, D., Alecu, J. E., Ziegler, M., Geisel, G., Jordan, C., D'Amore, A., Yeh, R. C., Akula, S. K., Saffari, A., Prabhu, S. P., Sahin, M., Yang, E. (2021). Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia. Neurology, 97(19), e1942-e1954. https://doi.org/10.1212/WNL.0000000000012836
Ebrahimi-Fakhari, Darius, et al. "Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia." Neurology vol. 97,19 (2021): e1942-e1954. doi: https://doi.org/10.1212/WNL.0000000000012836
Ebrahimi-Fakhari D, Alecu JE, Ziegler M, Geisel G, Jordan C, D'Amore A, Yeh RC, Akula SK, Saffari A, Prabhu SP, Sahin M, Yang E. Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia. Neurology. 2021 Nov 09;97(19):e1942-e1954. doi: 10.1212/WNL.0000000000012836. Epub 2021 Sep 20. PMID: 34544818; PMCID: PMC8601212.
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Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes.

Developmental and comparative immunology

Fu Z, Akula S, Olsson AK, Hellman L.
PMID: 34919980
Dev Comp Immunol. 2021 Dec 15;129:104337. doi: 10.1016/j.dci.2021.104337. Epub 2021 Dec 15.

Serine proteases are major granule constituents of cells from several mammalian hematopoietic cell lineages. Despite the relatively extensive knowledge about these mammalian proteases, very little is known about their bird, reptile and amphibian homologs. In order to close this...

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Fu Z, Akula S, Olsson AK, et al. Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes. Dev Comp Immunol. 2021;129:104337doi: 10.1016/j.dci.2021.104337.
Fu, Z., Akula, S., Olsson, A. K., & Hellman, L. (2021). Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes. Developmental and comparative immunology, 129104337. https://doi.org/10.1016/j.dci.2021.104337
Fu, Zhirong, et al. "Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes." Developmental and comparative immunology vol. 129 (2021): 104337. doi: https://doi.org/10.1016/j.dci.2021.104337
Fu Z, Akula S, Olsson AK, Hellman L. Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes. Dev Comp Immunol. 2021 Dec 15;129:104337. doi: 10.1016/j.dci.2021.104337. Epub 2021 Dec 15. PMID: 34919980.
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Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis.

Diabetology international

Papadopoulos VP, Koutroulos MV, Zikoudi DG, Bakola SA, Avramidou P, Touzlatzi N, Filippou DK.
PMID: 33777611
Diabetol Int. 2021 Mar 23;1-15. doi: 10.1007/s13340-021-00502-9. Epub 2021 Mar 23.

AIMS: COVID-19 is associated with diabetic ketoacidosis (DKA), hyperglycaemic hyperosmolar state (HHS) and euglycaemic DKA (EDKA); however, evidence regarding parameters affecting outcome and mortality rates is scarce.METHODS: A systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar...

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Papadopoulos VP, Koutroulos MV, Zikoudi DG, et al. Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis. Diabetol Int. 2021;1-15doi: 10.1007/s13340-021-00502-9.
Papadopoulos, V. P., Koutroulos, M. V., Zikoudi, D. G., Bakola, S. A., Avramidou, P., Touzlatzi, N., & Filippou, D. K. (2021). Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis. Diabetology international, 1-15. https://doi.org/10.1007/s13340-021-00502-9
Papadopoulos, Vasileios P, et al. "Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis." Diabetology international vol. (2021): 1-15. doi: https://doi.org/10.1007/s13340-021-00502-9
Papadopoulos VP, Koutroulos MV, Zikoudi DG, Bakola SA, Avramidou P, Touzlatzi N, Filippou DK. Diabetes-related acute metabolic emergencies in COVID-19 patients: a systematic review and meta-analysis. Diabetol Int. 2021 Mar 23;1-15. doi: 10.1007/s13340-021-00502-9. Epub 2021 Mar 23. PMID: 33777611; PMCID: PMC7985576.
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Physico-chemical, amino acid composition, functional and antioxidant properties of roe protein concentrates obtained from Channa striatus and Lates calcarifer.

Food chemistry

Galla NR, Karakala B, Akula S, Pamidighantam PR.
PMID: 29243597
Food Chem. 2012 Jun 01;132(3):1171-1176. doi: 10.1016/j.foodchem.2011.11.055. Epub 2011 Nov 18.

Roe protein concentrates prepared from Channa striatus (CRPC) and Lates calcarifer (LRPC) were investigated for physico-chemical characteristics, amino acid composition, functional properties and antioxidant activity. Channa and Lates roes yielded 20.7% and 22.5% of protein concentrates possessing 90.2% and...

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Galla NR, Karakala B, Akula S, et al. Physico-chemical, amino acid composition, functional and antioxidant properties of roe protein concentrates obtained from Channa striatus and Lates calcarifer. Food Chem. 2011;132(3):1171-1176doi: 10.1016/j.foodchem.2011.11.055.
Galla, N. R., Karakala, B., Akula, S., & Pamidighantam, P. R. (2012). Physico-chemical, amino acid composition, functional and antioxidant properties of roe protein concentrates obtained from Channa striatus and Lates calcarifer. Food chemistry, 132(3), 1171-1176. https://doi.org/10.1016/j.foodchem.2011.11.055
Galla, Narsing Rao, et al. "Physico-chemical, amino acid composition, functional and antioxidant properties of roe protein concentrates obtained from Channa striatus and Lates calcarifer." Food chemistry vol. 132,3 (2012): 1171-1176. doi: https://doi.org/10.1016/j.foodchem.2011.11.055
Galla NR, Karakala B, Akula S, Pamidighantam PR. Physico-chemical, amino acid composition, functional and antioxidant properties of roe protein concentrates obtained from Channa striatus and Lates calcarifer. Food Chem. 2012 Jun 01;132(3):1171-1176. doi: 10.1016/j.foodchem.2011.11.055. Epub 2011 Nov 18. PMID: 29243597.
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Structurally Modulated Graphitic Carbon Nanofiber and Heteroatom (N,F) Engineering toward Metal-Free ORR Electrocatalysts for Polymer Electrolyte Membrane Fuel Cells.

ACS applied materials & interfaces

Akula S, Sahu AK.
PMID: 32031776
ACS Appl Mater Interfaces. 2020 Mar 11;12(10):11438-11449. doi: 10.1021/acsami.9b18790. Epub 2020 Feb 26.

The present study designates the heteroatom (N,F)-doped various graphitic carbon nanofibers (GNFs) viz. GNF-linear segmented platelets, antlers, herringbone type, and their structural deformations from pristine fiber with many open-edge active centers as metal-free, cost-effective electrocatalysts for oxygen reduction reaction...

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Akula S, Sahu AK. Structurally Modulated Graphitic Carbon Nanofiber and Heteroatom (N,F) Engineering toward Metal-Free ORR Electrocatalysts for Polymer Electrolyte Membrane Fuel Cells. ACS Appl Mater Interfaces. 2020;12(10):11438-11449doi: 10.1021/acsami.9b18790.
Akula, S., & Sahu, A. K. (2020). Structurally Modulated Graphitic Carbon Nanofiber and Heteroatom (N,F) Engineering toward Metal-Free ORR Electrocatalysts for Polymer Electrolyte Membrane Fuel Cells. ACS applied materials & interfaces, 12(10), 11438-11449. https://doi.org/10.1021/acsami.9b18790
Akula, Srinu, and Sahu, Akhila Kumar. "Structurally Modulated Graphitic Carbon Nanofiber and Heteroatom (N,F) Engineering toward Metal-Free ORR Electrocatalysts for Polymer Electrolyte Membrane Fuel Cells." ACS applied materials & interfaces vol. 12,10 (2020): 11438-11449. doi: https://doi.org/10.1021/acsami.9b18790
Akula S, Sahu AK. Structurally Modulated Graphitic Carbon Nanofiber and Heteroatom (N,F) Engineering toward Metal-Free ORR Electrocatalysts for Polymer Electrolyte Membrane Fuel Cells. ACS Appl Mater Interfaces. 2020 Mar 11;12(10):11438-11449. doi: 10.1021/acsami.9b18790. Epub 2020 Feb 26. PMID: 32031776.
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