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Lyophilised wafers as a drug delivery system for wound healing containing methylcellulose as a viscosity modifier.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 15652198
Int J Pharm. 2005 Jan 31;289(1):51-62. doi: 10.1016/j.ijpharm.2004.10.022. Epub 2004 Dec 30.

Lyophilised wafers have potential as drug delivery systems for suppurating wounds. A dual series of wafers made from low molecular weight sodium alginate (SA) and xanthan gum (XG) respectively, modified with high molecular weight methylcellulose (MC) were produced. The...

Gamma-irradiation of lyophilised wound healing wafers.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 16503387
Int J Pharm. 2006 Apr 26;313(1):78-86. doi: 10.1016/j.ijpharm.2006.01.023. Epub 2006 Feb 28.

Lyophilised wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. They are produced by the freeze-drying of polymer solutions and gels. This study investigates the possibility of sterilising these...

Formulation, stability and thermal analysis of lyophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant.

International journal of pharmaceutics

Matthews KH, Stevens HN, Auffret AD, Humphrey MJ, Eccleston GM.
PMID: 18280068
Int J Pharm. 2008 May 22;356(1):110-20. doi: 10.1016/j.ijpharm.2007.12.043. Epub 2008 Jan 09.

Lyophilised wafers are being developed as topical drug delivery systems for the treatment of chronic wounds. This study describes the formulation of xanthan wafers containing a selective, insoluble MMP-3 inhibitor (UK-370,106) and a non-ionic surfactant, designed to release accurate...

The wheat chloroplast gene for CF(0) subunit I of ATP synthase contains a large intron.

The EMBO journal

Bird CR, Koller B, Auffret AD, Huttly AK, Howe CJ, Dyer TA, Gray JC.
PMID: 16453616
EMBO J. 1985 Jun;4(6):1381-8.

The gene for CF(0) subunit I of ATP synthase has been located in wheat chloroplast DNA, between the genes for CF(0) subunit III and alpha subunit of CF(1). Nucleotide sequencing and analysis of RNA-DNA hybrids indicated that the gene...

Development and mechanical characterization of solvent-cast polymeric films as potential drug delivery systems to mucosal surfaces.

Drug development and industrial pharmacy

Boateng JS, Stevens HN, Eccleston GM, Auffret AD, Humphrey MJ, Matthews KH.
PMID: 19365780
Drug Dev Ind Pharm. 2009 Aug;35(8):986-96. doi: 10.1080/03639040902744704.

Solvent-cast films from three polymers, carboxymethylcellulose (CMC), sodium alginate (SA), and xanthan gum, were prepared by drying the polymeric gels in air. Three methods, (a) passive hydration, (b) vortex hydration with heating, and (c) cold hydration, were investigated to...

Structural comparisons of superoxide dismutases.

European journal of biochemistry

Harris JI, Auffret AD, Northrop FD, Walker JE.
PMID: 7341230
Eur J Biochem. 1980 May;106(1):297-303. doi: 10.1111/j.1432-1033.1980.tb06023.x.
Free Article

The amino-terminal sequences of superoxide dismutase isolated from seven microorganisms have been determined. These include the first sequences of enzyme from anaerobic phototrophes. Five enzymes contain iron and two manganese. The enzymes are all related to each other but...

Biological control of apatite growth in simulated body fluid and human blood serum.

Journal of materials science. Materials in medicine

Juhasz JA, Best SM, Auffret AD, Bonfield W.
PMID: 18157508
J Mater Sci Mater Med. 2008 Apr;19(4):1823-9. doi: 10.1007/s10856-007-3344-7. Epub 2007 Dec 23.

The surface transformation reactions of bioactive ceramics were studied in vitro in standard K9-SBF solution and in human blood serum (HBS)-containing simulated body fluid (SBF). The calcium phosphate ceramics used for this study were stoichiometric hydroxyapatite (HA), beta-tricalcium phosphate...

Alignment of cloned amiE gene of Pseudomonas aeruginosa with the N-terminal sequence of amidase.

Bioscience reports

Clarke PH, Drew RE, Turberville C, Brammar WJ, Ambler RP, Auffret AD.
PMID: 6271281
Biosci Rep. 1981 Apr;1(4):299-307. doi: 10.1007/BF01114869.

A restriction enzyme map was constructed for 5.1-kb fragment of Pseudomonas aeruginosa DNA inserted into plasmid pBR322. Restriction enzyme sites were matched to the N-terminal amino acid sequence of amidase to obtain alignment of the amiE gene within the...

The amino acid sequence of the aliphatic amidase from Pseudomonas aeruginosa.

FEBS letters

Ambler RP, Auffret AD, Clarke PH.
PMID: 3108029
FEBS Lett. 1987 May 11;215(2):285-90. doi: 10.1016/0014-5793(87)80163-1.
Free Article

Amino acid sequence studies show that the aliphatic amidase (EC from Pseudomonas aeruginosa PAC142 consists of a single polypeptide chain of 346 residues, giving an Mr of 38,400. The evidence from the amino acid studies is in complete...

Nucleotide sequence and transcripts of the pea chloroplast gene encoding CFo subunit III of ATP synthase.


Huttly AK, Plant AL, Phillips AL, Auffret AD, Gray JC.
PMID: 2129529
Gene. 1990 Jun 15;90(2):227-33. doi: 10.1016/0378-1119(90)90184-s.

The structure and expression of the pea chloroplast atpH gene, encoding ATP synthase CFo subunit III, have been investigated. The atpH gene is situated between the atpI and atpF genes for CFo subunits IV and I, and encodes a...

Showing 13 to 22 of 22 entries