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Showing 13 to 24 of 115 entries
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Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development.

Molecular & cellular proteomics : MCP

Blazev R, Ashwood C, Abrahams JL, Chung LH, Francis D, Yang P, Watt KI, Qian H, Quaife-Ryan GA, Hudson JE, Gregorevic P, Thaysen-Andersen M, Parker BL.
PMID: 33583770
Mol Cell Proteomics. 2020 Dec 19;20:100030. doi: 10.1074/mcp.RA120.002166. Epub 2020 Dec 19.

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the development of multicellular organisms. These glycan modifications enable communication between cells and the extracellular matrix via interactions with...

Consensus International Council for Commonality in Blood Banking Automation-International Society for Cell & Gene Therapy statement on standard nomenclature abbreviations for the tissue of origin of mesenchymal stromal cells.

Cytotherapy

Viswanathan S, Ciccocioppo R, Galipeau J, Krampera M, Le Blanc K, Martin I, Moniz K, Nolta J, Phinney DG, Shi Y, Szczepiorkowski ZM, Tarte K, Weiss DJ, Ashford P.
PMID: 34116944
Cytotherapy. 2021 Dec;23(12):1060-1063. doi: 10.1016/j.jcyt.2021.04.009. Epub 2021 Jun 09.

The Cellular Therapy Coding and Labeling Advisory Group of the International Council for Commonality in Blood Banking Automation and the International Society for Cell & Gene Therapy mesenchymal stromal cell (MSC) committee are providing specific recommendations on abbreviating tissue...

Venoms for all occasions: The functional toxin profiles of different anatomical regions in sea anemones are related to their ecological function.

Molecular ecology

Ashwood LM, Undheim EAB, Madio B, Hamilton BR, Daly M, Hurwood DA, King GF, Prentis PJ.
PMID: 34837433
Mol Ecol. 2021 Nov 27; doi: 10.1111/mec.16286. Epub 2021 Nov 27.

The phylum Cnidaria is the oldest extant venomous group and is defined by the presence of nematocysts, specialized organelles responsible for venom production and delivery. Although toxin peptides and the cells housing nematocysts are distributed across the entire animal,...

Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome.

Communications biology

Neier K, Grant TE, Palmer RL, Chappell D, Hakam SM, Yasui KM, Rolston M, Settles ML, Hunter SS, Madany A, Ashwood P, Durbin-Johnson B, LaSalle JM, Yasui DH.
PMID: 34916612
Commun Biol. 2021 Dec 16;4(1):1408. doi: 10.1038/s42003-021-02915-3.

Rett syndrome (RTT) is a regressive neurodevelopmental disorder in girls, characterized by multisystem complications including gut dysbiosis and altered metabolism. While RTT is known to be caused by mutations in the X-linked gene MECP2, the intermediate molecular pathways of...

Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline.

Pharmacology research & perspectives

Dashwood A, Cheesman E, Wong YW, Haqqani H, Beard N, Hay K, Spratt M, Chan W, Molenaar P.
PMID: 33929079
Pharmacol Res Perspect. 2021 May;9(3):e00760. doi: 10.1002/prp2.760.

Omecamtiv mecarbil (OM) is a novel medicine for systolic heart failure, targeting myosin to enhance cardiomyocyte performance. To assist translation to clinical practice we investigated OMs effect on explanted human failing hearts, specifically; contractile dynamics, interaction with the β

Integrated Glycoproteomics Identifies a Role of N-Glycosylation and Galectin-1 on Myogenesis and Muscle Development.

Molecular & cellular proteomics : MCP

Blazev R, Ashwood C, Abrahams JL, Chung LH, Francis D, Yang P, Watt KI, Qian H, Quaife-Ryan GA, Hudson JE, Gregorevic P, Thaysen-Andersen M, Parker BL.
PMID: 33583770
Mol Cell Proteomics. 2021;20:100030. doi: 10.1074/mcp.RA120.002166. Epub 2020 Dec 19.

Many cell surface and secreted proteins are modified by the covalent addition of glycans that play an important role in the development of multicellular organisms. These glycan modifications enable communication between cells and the extracellular matrix via interactions with...

FlyWire: online community for whole-brain connectomics.

Nature methods

Dorkenwald S, McKellar CE, Macrina T, Kemnitz N, Lee K, Lu R, Wu J, Popovych S, Mitchell E, Nehoran B, Jia Z, Bae JA, Mu S, Ih D, Castro M, Ogedengbe O, Halageri A, Kuehner K, Sterling AR, Ashwood Z, Zung J, Brittain D, Collman F, Schneider-Mizell C, Jordan C, Silversmith W, Baker C, Deutsch D, Encarnacion-Rivera L, Kumar S, Burke A, Bland D, Gager J, Hebditch J, Koolman S, Moore M, Morejohn S, Silverman B, Willie K, Willie R, Yu SC, Murthy M, Seung HS.
PMID: 34949809
Nat Methods. 2021 Dec 23; doi: 10.1038/s41592-021-01330-0. Epub 2021 Dec 23.

Due to advances in automated image acquisition and analysis, whole-brain connectomes with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated reconstructions will require many person-years of effort, due to the huge volumes of data involved....

Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure.

ACS pharmacology & translational science

Dashwood A, Cheesman E, Beard N, Haqqani H, Wong YW, Molenaar P.
PMID: 32832863
ACS Pharmacol Transl Sci. 2020 Jun 01;3(4):563-582. doi: 10.1021/acsptsci.0c00003. eCollection 2020 Aug 14.

Heart failure (HF) is a global pandemic with significant mortality and morbidity. Despite current medications, 50% of individuals die within 5 years of diagnosis. Of these deaths, 30-50% will be a result of sudden cardiac death from ventricular arrhythmias....

Anti-.

Frontiers in psychiatry

Hughes HK, Ashwood P.
PMID: 30534090
Front Psychiatry. 2018 Nov 26;9:627. doi: 10.3389/fpsyt.2018.00627. eCollection 2018.

The gut microbiota are known to have a profound influence on both mucosal and systemic immunity and are important for gastrointestinal (GI) function. In addition, new evidence shows that the microbiota significantly influence neurodevelopment and behavior. Immune dysfunction and...

Overlapping evidence of innate immune dysfunction in psychotic and affective disorders.

Brain, behavior, & immunity - health

Hughes HK, Ashwood P.
PMID: 34589829
Brain Behav Immun Health. 2020 Jan 26;2:100038. doi: 10.1016/j.bbih.2020.100038. eCollection 2020 Feb.

Disturbances of the immune system and immune responses after activation are a common finding in neuropsychiatric disorders. Psychotic and affective disorders such as major depressive disorder (MDD), schizophrenia (SCZ) and bipolar disorder (BD) also share high rates of comorbidity...

A Rare Case of Severe Nontropical Isolated Right Ventricular Endomyocardial Fibrosis.

JACC. Case reports

Laher S, Wong YW, Platts D, Prabhu A, Thomson B, Hamilton-Craig C, Godbolt D, Cheesman E, Dashwood A.
PMID: 34317112
JACC Case Rep. 2020 Nov 18;2(13):2078-2084. doi: 10.1016/j.jaccas.2020.09.042. eCollection 2020 Nov.

We present a case of late presentation nontropical endomyocardial fibrosis isolated to the right ventricle and tricuspid valve (TV). In response to deteriorating hemodynamics, surgical debulking and TV removal were performed before initiation of centralized venoarterial extracorporeal membrane oxygenation...

Musculoskeletal Attendances to a Minor Injury Department During a Pandemic.

Cureus

Dowell RJ, Ashwood N, Hind J.
PMID: 33728156
Cureus. 2021 Feb 05;13(2):e13143. doi: 10.7759/cureus.13143.

INTRODUCTION: As coronavirus disease 2019 (COVID-19) became a public health emergency of international concern, countries across the globe began to instate strict social distancing restrictions or "lockdowns". During these times emergency departments in the United Kingdom (UK) recorded a...

Showing 13 to 24 of 115 entries