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Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Bleach R, Madden SF, Hawley J, Charmsaz S, Selli C, Sheehan KM, Young LS, Sims AH, Souček P, Hill AD, McIlroy M.
PMID: 34016642
Clin Cancer Res. 2021 Jul 15;27(14):3980-3989. doi: 10.1158/1078-0432.CCR-20-4135. Epub 2021 May 20.

PURPOSE: There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic steroid precursors, acting via the androgen receptor (AR), promote an endocrine-resistant breast cancer phenotype.EXPERIMENTAL...

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Bleach R, Madden SF, Hawley J, et al. Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy. Clin Cancer Res. 2021;27(14):3980-3989doi: 10.1158/1078-0432.CCR-20-4135.
Bleach, R., Madden, S. F., Hawley, J., Charmsaz, S., Selli, C., Sheehan, K. M., Young, L. S., Sims, A. H., Souček, P., Hill, A. D., & McIlroy, M. (2021). Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(14), 3980-3989. https://doi.org/10.1158/1078-0432.CCR-20-4135
Bleach, Rachel, et al. "Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy." Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,14 (2021): 3980-3989. doi: https://doi.org/10.1158/1078-0432.CCR-20-4135
Bleach R, Madden SF, Hawley J, Charmsaz S, Selli C, Sheehan KM, Young LS, Sims AH, Souček P, Hill AD, McIlroy M. Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy. Clin Cancer Res. 2021 Jul 15;27(14):3980-3989. doi: 10.1158/1078-0432.CCR-20-4135. Epub 2021 May 20. PMID: 34016642.
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Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

De Somma E, O'Mahony J, Brown RA, Brooks BL, Yeh EA, Cardenas de La Parra A, Arnold D, Collins DL, Maranzano J, Narayanan S, Marrie RA, Bar-Or A, Banwell B, Till C.
PMID: 34872458
Child Neuropsychol. 2021 Dec 06;1-22. doi: 10.1080/09297049.2021.2002289. Epub 2021 Dec 06.

Long-term cognitive deficits have been observed in some children who experience an acquired demyelinating syndrome (ADS). We examined changes in cognitive functioning over the first two years following incident ADS andtested whether normalized brain and thalamic volume accounted for...

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De Somma E, O'Mahony J, Brown RA, et al. Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child Neuropsychol. 2021;1-22doi: 10.1080/09297049.2021.2002289.
De Somma, E., O'Mahony, J., Brown, R. A., Brooks, B. L., Yeh, E. A., Cardenas de La Parra, A., Arnold, D., Collins, D. L., Maranzano, J., Narayanan, S., Marrie, R. A., Bar-Or, A., Banwell, B., & Till, C. (2021). Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 1-22. https://doi.org/10.1080/09297049.2021.2002289
De Somma, Elisea, et al. "Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study." Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence vol. (2021): 1-22. doi: https://doi.org/10.1080/09297049.2021.2002289
De Somma E, O'Mahony J, Brown RA, Brooks BL, Yeh EA, Cardenas de La Parra A, Arnold D, Collins DL, Maranzano J, Narayanan S, Marrie RA, Bar-Or A, Banwell B, Till C. Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child Neuropsychol. 2021 Dec 06;1-22. doi: 10.1080/09297049.2021.2002289. Epub 2021 Dec 06. PMID: 34872458.
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Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission.

Neuropharmacology

Melkumyan M, Snyder AE, Bingaman SS, Arnold AC, Silberman Y.
PMID: 34896402
Neuropharmacology. 2021 Dec 10;205:108918. doi: 10.1016/j.neuropharm.2021.108918. Epub 2021 Dec 10.

The Central Amygdala (CeA) has been heavily implicated in many aspects of alcohol use disorder. Ethanol (EtOH) has been shown to modulate glutamatergic transmission in the lateral subdivision of the CeA, however, the exact mechanism of this modulation is...

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Melkumyan M, Snyder AE, Bingaman SS, et al. Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission. Neuropharmacology. 2021;205:108918doi: 10.1016/j.neuropharm.2021.108918.
Melkumyan, M., Snyder, A. E., Bingaman, S. S., Arnold, A. C., & Silberman, Y. (2021). Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission. Neuropharmacology, 205108918. https://doi.org/10.1016/j.neuropharm.2021.108918
Melkumyan, Mariam, et al. "Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission." Neuropharmacology vol. 205 (2021): 108918. doi: https://doi.org/10.1016/j.neuropharm.2021.108918
Melkumyan M, Snyder AE, Bingaman SS, Arnold AC, Silberman Y. Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission. Neuropharmacology. 2021 Dec 10;205:108918. doi: 10.1016/j.neuropharm.2021.108918. Epub 2021 Dec 10. PMID: 34896402.
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Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses.

Progress in neuro-psychopharmacology & biological psychiatry

Nguyen KT, Gates CA, Hassell JE, Foxx CL, Salazar SN, Luthens AK, Arnold AL, Elam BL, Elsayed AI, Leblanc M, Adams SC, Lowry CA, Reuter JD.
PMID: 33891978
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110331. doi: 10.1016/j.pnpbp.2021.110331. Epub 2021 Apr 21.

Over sixteen million people suffer from a depressive episode annually in the United States, with females affected at twice the rate of males. Little is known about the effects of exposure to high altitude on the risk of development...

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Nguyen KT, Gates CA, Hassell JE, et al. Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses. Prog Neuropsychopharmacol Biol Psychiatry. 2021;111:110331doi: 10.1016/j.pnpbp.2021.110331.
Nguyen, K. T., Gates, C. A., Hassell, J. E., Foxx, C. L., Salazar, S. N., Luthens, A. K., Arnold, A. L., Elam, B. L., Elsayed, A. I., Leblanc, M., Adams, S. C., Lowry, C. A., & Reuter, J. D. (2021). Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses. Progress in neuro-psychopharmacology & biological psychiatry, 111110331. https://doi.org/10.1016/j.pnpbp.2021.110331
Nguyen, Kadi T, et al. "Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses." Progress in neuro-psychopharmacology & biological psychiatry vol. 111 (2021): 110331. doi: https://doi.org/10.1016/j.pnpbp.2021.110331
Nguyen KT, Gates CA, Hassell JE, Foxx CL, Salazar SN, Luthens AK, Arnold AL, Elam BL, Elsayed AI, Leblanc M, Adams SC, Lowry CA, Reuter JD. Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110331. doi: 10.1016/j.pnpbp.2021.110331. Epub 2021 Apr 21. PMID: 33891978.
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A non-immunological role for γ-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption.

Science advances

Ewanchuk BW, Arnold CR, Balce DR, Premnath P, Orsetti TL, Warren AL, Olsen A, Krawetz RJ, Yates RM.
PMID: 33893096
Sci Adv. 2021 Apr 23;7(17). doi: 10.1126/sciadv.abd3684. Print 2021 Apr.

The extracellular bone resorbing lacuna of the osteoclast shares many characteristics with the degradative lysosome of antigen-presenting cells. γ-Interferon-inducible lysosomal thiol reductase (GILT) enhances antigen processing within lysosomes through direct reduction of antigen disulfides and maintenance of cysteine protease...

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Ewanchuk BW, Arnold CR, Balce DR, et al. A non-immunological role for γ-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption. Sci Adv. 2021;7(17)doi: 10.1126/sciadv.abd3684.
Ewanchuk, B. W., Arnold, C. R., Balce, D. R., Premnath, P., Orsetti, T. L., Warren, A. L., Olsen, A., Krawetz, R. J., & Yates, R. M. (2021). A non-immunological role for γ-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption. Science advances, 7(17), . https://doi.org/10.1126/sciadv.abd3684
Ewanchuk, Benjamin W, et al. "A non-immunological role for γ-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption." Science advances vol. 7,17 (2021). doi: https://doi.org/10.1126/sciadv.abd3684
Ewanchuk BW, Arnold CR, Balce DR, Premnath P, Orsetti TL, Warren AL, Olsen A, Krawetz RJ, Yates RM. A non-immunological role for γ-interferon-inducible lysosomal thiol reductase (GILT) in osteoclastic bone resorption. Sci Adv. 2021 Apr 23;7(17). doi: 10.1126/sciadv.abd3684. Print 2021 Apr. PMID: 33893096; PMCID: PMC8064644.
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Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Ostheimer C, Mäurer M, Ebert N, Schmitt D, Krug D, Baumann R, Henkenberens C, Giordano FA, Sautter L, López G, Fleischmann DF, Niyazi M, Käsmann L, Kaul D, Thieme AH, Billiet C, Dobiasch S, Arnold CR, Oertel M, Haussmann J, Gauer T, Goy Y, Suess C, Ziegler S, Panje CM, Baues C, Trommer M, Skripcak T, Medenwald D.
PMID: 33674905
Strahlenther Onkol. 2021 Jun;197(6):560-561. doi: 10.1007/s00066-021-01750-z.

No abstract available.

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Ostheimer C, Mäurer M, Ebert N, et al. Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group. Strahlenther Onkol. 2021;197(6):560-561doi: 10.1007/s00066-021-01750-z.
Ostheimer, C., Mäurer, M., Ebert, N., Schmitt, D., Krug, D., Baumann, R., Henkenberens, C., Giordano, F. A., Sautter, L., López, G., Fleischmann, D. F., Niyazi, M., Käsmann, L., Kaul, D., Thieme, A. H., Billiet, C., Dobiasch, S., Arnold, C. R., Oertel, M., Haussmann, J., Gauer, T., Goy, Y., Suess, C., Ziegler, S., Panje, C. M., Baues, C., Trommer, M., Skripcak, T., & Medenwald, D. (2021). Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 197(6), 560-561. https://doi.org/10.1007/s00066-021-01750-z
Ostheimer, C, et al. "Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group." Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] vol. 197,6 (2021): 560-561. doi: https://doi.org/10.1007/s00066-021-01750-z
Ostheimer C, Mäurer M, Ebert N, Schmitt D, Krug D, Baumann R, Henkenberens C, Giordano FA, Sautter L, López G, Fleischmann DF, Niyazi M, Käsmann L, Kaul D, Thieme AH, Billiet C, Dobiasch S, Arnold CR, Oertel M, Haussmann J, Gauer T, Goy Y, Suess C, Ziegler S, Panje CM, Baues C, Trommer M, Skripcak T, Medenwald D. Correction to: Prognostic impact of gross tumor volume during radical radiochemotherapy of locally advanced non-small cell lung cancer-results from the NCT03055715 multicenter cohort study of the Young DEGRO Trial Group. Strahlenther Onkol. 2021 Jun;197(6):560-561. doi: 10.1007/s00066-021-01750-z. PMID: 33674905; PMCID: PMC8154766.
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The renin-angiotensin system and cardiovascular autonomic control in aging.

Peptides

Miller AJ, Arnold AC.
PMID: 34973286
Peptides. 2021 Dec 29;150:170733. doi: 10.1016/j.peptides.2021.170733. Epub 2021 Dec 29.

Aging is the greatest independent risk factor for developing hypertension and cardiovascular-related diseases including systolic hypertension, vascular disease, ischemic events, arrhythmias, and heart failure. Age-related cardiovascular risk is associated with dysfunction of peripheral organ systems, such as the heart...

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Miller AJ, Arnold AC. The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides. 2021;150:170733doi: 10.1016/j.peptides.2021.170733.
Miller, A. J., & Arnold, A. C. (2021). The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides, 150170733. https://doi.org/10.1016/j.peptides.2021.170733
Miller, Amanda J, and Arnold, Amy C. "The renin-angiotensin system and cardiovascular autonomic control in aging." Peptides vol. 150 (2021): 170733. doi: https://doi.org/10.1016/j.peptides.2021.170733
Miller AJ, Arnold AC. The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides. 2021 Dec 29;150:170733. doi: 10.1016/j.peptides.2021.170733. Epub 2021 Dec 29. PMID: 34973286.
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Neural-latency noise places limits on human sensitivity to the timing of events.

Cognition

Yarrow K, Kohl C, Segasby T, Kaur Bansal R, Rowe P, Arnold DH.
PMID: 34998243
Cognition. 2022 Jan 05;222:105012. doi: 10.1016/j.cognition.2021.105012. Epub 2022 Jan 05.

The brain-time account posits that the physical timing of sensory-evoked neural activity determines the perceived timing of corresponding sensory events. A canonical model formalises this account for tasks such as simultaneity and order judgements: Signals arrive at a decision...

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Yarrow K, Kohl C, Segasby T, et al. Neural-latency noise places limits on human sensitivity to the timing of events. Cognition. 2022;222:105012doi: 10.1016/j.cognition.2021.105012.
Yarrow, K., Kohl, C., Segasby, T., Kaur Bansal, R., Rowe, P., & Arnold, D. H. (2022). Neural-latency noise places limits on human sensitivity to the timing of events. Cognition, 222105012. https://doi.org/10.1016/j.cognition.2021.105012
Yarrow, Kielan, et al. "Neural-latency noise places limits on human sensitivity to the timing of events." Cognition vol. 222 (2022): 105012. doi: https://doi.org/10.1016/j.cognition.2021.105012
Yarrow K, Kohl C, Segasby T, Kaur Bansal R, Rowe P, Arnold DH. Neural-latency noise places limits on human sensitivity to the timing of events. Cognition. 2022 Jan 05;222:105012. doi: 10.1016/j.cognition.2021.105012. Epub 2022 Jan 05. PMID: 34998243.
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The renin-angiotensin system and cardiovascular autonomic control in aging.

Peptides

Miller AJ, Arnold AC.
PMID: 34973286
Peptides. 2021 Dec 29;150:170733. doi: 10.1016/j.peptides.2021.170733. Epub 2021 Dec 29.

Aging is the greatest independent risk factor for developing hypertension and cardiovascular-related diseases including systolic hypertension, vascular disease, ischemic events, arrhythmias, and heart failure. Age-related cardiovascular risk is associated with dysfunction of peripheral organ systems, such as the heart...

Cite
Miller AJ, Arnold AC. The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides. 2021;150:170733doi: 10.1016/j.peptides.2021.170733.
Miller, A. J., & Arnold, A. C. (2021). The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides, 150170733. https://doi.org/10.1016/j.peptides.2021.170733
Miller, Amanda J, and Arnold, Amy C. "The renin-angiotensin system and cardiovascular autonomic control in aging." Peptides vol. 150 (2021): 170733. doi: https://doi.org/10.1016/j.peptides.2021.170733
Miller AJ, Arnold AC. The renin-angiotensin system and cardiovascular autonomic control in aging. Peptides. 2021 Dec 29;150:170733. doi: 10.1016/j.peptides.2021.170733. Epub 2021 Dec 29. PMID: 34973286.
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Convergent and discriminant validity of five interest inventories.

Journal of Vocational Behavior

Savickas, Taber, Spokane.
UIID-EM: 76
2002;61:139-184. doi: 10.1006/jvbe.2002.1878.

Investigated whether interest inventories that purport to measure the same constructs actually yield scores that correspond. The study examined the empirical relation of scores for similarly and same-named scales on 5 widely used interest inventories: the Campbell Interest and...

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Savickas, Taber, Spokane. Convergent and discriminant validity of five interest inventories. 2002;61:139-184doi: 10.1006/jvbe.2002.1878.
Savickas, Taber, & Spokane. (2002). Convergent and discriminant validity of five interest inventories. Journal of Vocational Behavior, 61139-184. https://doi.org/10.1006/jvbe.2002.1878
Savickas, Mark L, et al. "Convergent and discriminant validity of five interest inventories." Journal of Vocational Behavior vol. 61 (2002): 139-184. doi: https://doi.org/10.1006/jvbe.2002.1878
Savickas, Taber, Spokane. Convergent and discriminant validity of five interest inventories. 2002;61:139-184. doi: 10.1006/jvbe.2002.1878. UIID-EM: 76.
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Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics.

Flores G, Mendoza FS, Fuentes-Afflick E, Mendoza JA, Pachter L, Espinoza J, Fernandez CR, Arnold DD, Brown NM, Gonzalez KM, Lopez C, Owen MC, Parks KM, Reynolds KL, Russell CJ.
UIID-AD: 4363
2016; doi: 10.1186/s12939-016-0494-6.

BACKGROUND: The number of racial/ethnic minority children will exceed the number of white children in the USA by 2018. Although 38% of Americans are minorities, only 12% of pediatricians, 5% of medical-school faculty, and 3% of medical-school professors are...

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Flores G, Mendoza FS, Fuentes-Afflick E, et al. Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics. 2016;doi: 10.1186/s12939-016-0494-6.
Flores, G., Mendoza, F. S., Fuentes-Afflick, E., Mendoza, J. A., Pachter, L., Espinoza, J., Fernandez, C. R., Arnold, D. D., Brown, N. M., Gonzalez, K. M., Lopez, C., Owen, M. C., Parks, K. M., Reynolds, K. L., & Russell, C. J. (2016). Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics. . https://doi.org/10.1186/s12939-016-0494-6
Flores, G, et al. "Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics." vol. (2016). doi: https://doi.org/10.1186/s12939-016-0494-6
Flores G, Mendoza FS, Fuentes-Afflick E, Mendoza JA, Pachter L, Espinoza J, Fernandez CR, Arnold DD, Brown NM, Gonzalez KM, Lopez C, Owen MC, Parks KM, Reynolds KL, Russell CJ. Hot topics, urgent priorities, and ensuring success for racial/ethnic minority young investigators in academic pediatrics. 2016; doi: 10.1186/s12939-016-0494-6. UIID-AD: 4363.
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The early education of socioeconomically disadvantaged children.

Arnold DH, Doctoroff GL.
UIID-AD: 186
2003;54:517-545. doi: 10.1146/annurev.psych.54.111301.145442.

This chapter reviews selected research on the education of low-socioeconomic status (SES) children from birth through the first years of elementary school. Themes include the importance of early academic skills and interest to later achievement; the benefits of integrating...

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Arnold DH, Doctoroff GL. The early education of socioeconomically disadvantaged children. 2003;54:517-545doi: 10.1146/annurev.psych.54.111301.145442.
Arnold, D. H., & Doctoroff, G. L. (2003). The early education of socioeconomically disadvantaged children. 54517-545. https://doi.org/10.1146/annurev.psych.54.111301.145442
Arnold, D H, and Doctoroff, G L. "The early education of socioeconomically disadvantaged children." vol. 54 (2003): 517-545. doi: https://doi.org/10.1146/annurev.psych.54.111301.145442
Arnold DH, Doctoroff GL. The early education of socioeconomically disadvantaged children. 2003;54:517-545. doi: 10.1146/annurev.psych.54.111301.145442. UIID-AD: 186.
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