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Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases.

Bioorganic & medicinal chemistry

Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, Yamanaka K, Orita T, Doi S, Iwanaga T, Ikegashira K, Hantani Y, Nakanishi I, Adachi T.
PMID: 34274549
Bioorg Med Chem. 2021 Aug 15;44:116283. doi: 10.1016/j.bmc.2021.116283. Epub 2021 Jul 08.

A fragment-based lead discovery approach was applied to Pyruvate Dehydrogenase Kinases (PDHKs) to discover inhibitors against the ATP binding site with novel chemotypes. X-ray fragment screening toward PDHK4 provided a fragment hit 1 with a characteristic interaction in a...

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Akaki T, Bessho Y, Ito T, et al. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem. 2021;44:116283doi: 10.1016/j.bmc.2021.116283.
Akaki, T., Bessho, Y., Ito, T., Fujioka, S., Ubukata, M., Mori, G., Yamanaka, K., Orita, T., Doi, S., Iwanaga, T., Ikegashira, K., Hantani, Y., Nakanishi, I., & Adachi, T. (2021). Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorganic & medicinal chemistry, 44116283. https://doi.org/10.1016/j.bmc.2021.116283
Akaki, Tatsuo, et al. "Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases." Bioorganic & medicinal chemistry vol. 44 (2021): 116283. doi: https://doi.org/10.1016/j.bmc.2021.116283
Akaki T, Bessho Y, Ito T, Fujioka S, Ubukata M, Mori G, Yamanaka K, Orita T, Doi S, Iwanaga T, Ikegashira K, Hantani Y, Nakanishi I, Adachi T. Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases. Bioorg Med Chem. 2021 Aug 15;44:116283. doi: 10.1016/j.bmc.2021.116283. Epub 2021 Jul 08. PMID: 34274549.
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An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach.

Viruses

Patel RT, Gallamoza BM, Kulkarni P, Sherer ML, Haas NA, Lemanski E, Malik I, Hekmatyar K, Parcells MS, Schwarz JM.
PMID: 34207958
Viruses. 2021 Jun 11;13(6). doi: 10.3390/v13061123.

Since Zika virus (ZIKV) first emerged as a public health concern in 2015, our ability to identify and track the long-term neurological sequelae of prenatal Zika virus (ZIKV) infection in humans has been limited. Our lab has developed a...

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Patel RT, Gallamoza BM, Kulkarni P, et al. An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach. Viruses. 2021;13(6)doi: 10.3390/v13061123.
Patel, R. T., Gallamoza, B. M., Kulkarni, P., Sherer, M. L., Haas, N. A., Lemanski, E., Malik, I., Hekmatyar, K., Parcells, M. S., & Schwarz, J. M. (2021). An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach. Viruses, 13(6), . https://doi.org/10.3390/v13061123
Patel, Rita T, et al. "An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach." Viruses vol. 13,6 (2021). doi: https://doi.org/10.3390/v13061123
Patel RT, Gallamoza BM, Kulkarni P, Sherer ML, Haas NA, Lemanski E, Malik I, Hekmatyar K, Parcells MS, Schwarz JM. An Examination of the Long-Term Neurodevelopmental Impact of Prenatal Zika Virus Infection in a Rat Model Using a High Resolution, Longitudinal MRI Approach. Viruses. 2021 Jun 11;13(6). doi: 10.3390/v13061123. PMID: 34207958; PMCID: PMC8230645.
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Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.

Metabolites

Okahashi N, Ueda M, Matsuda F, Arita M.
PMID: 33810392
Metabolites. 2021 Mar 26;11(4). doi: 10.3390/metabo11040197.

Lipid A is a characteristic molecule of Gram-negative bacteria that elicits an immune response in mammalian cells. The presence of structurally diverse lipid A types in the human gut bacteria has been suggested before, and this appears associated with...

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Okahashi N, Ueda M, Matsuda F, et al. Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Metabolites. 2021;11(4)doi: 10.3390/metabo11040197.
Okahashi, N., Ueda, M., Matsuda, F., & Arita, M. (2021). Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Metabolites, 11(4), . https://doi.org/10.3390/metabo11040197
Okahashi, Nobuyuki, et al. "Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry." Metabolites vol. 11,4 (2021). doi: https://doi.org/10.3390/metabo11040197
Okahashi N, Ueda M, Matsuda F, Arita M. Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry. Metabolites. 2021 Mar 26;11(4). doi: 10.3390/metabo11040197. PMID: 33810392; PMCID: PMC8065654.
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Correction: Early Detection of Dengue Fever Outbreaks Using a Surveillance App (Mozzify): Cross-sectional Mixed Methods Usability Study.

JMIR public health and surveillance

Herbuela VRDM, Karita T, Carvajal TM, Ho HT, Lorena JMO, Regalado RA, Sobrepeña GD, Watanabe K.
PMID: 33886493
JMIR Public Health Surveill. 2021 Apr 22;7(4):e29795. doi: 10.2196/29795.

[This corrects the article DOI: 10.2196/19034.].

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Herbuela VRDM, Karita T, Carvajal TM, et al. Correction: Early Detection of Dengue Fever Outbreaks Using a Surveillance App (Mozzify): Cross-sectional Mixed Methods Usability Study. JMIR Public Health Surveill. 2021;7(4):e29795doi: 10.2196/29795.
Herbuela, V. R. D. M., Karita, T., Carvajal, T. M., Ho, H. T., Lorena, J. M. O., Regalado, R. A., Sobrepeña, G. D., & Watanabe, K. (2021). Correction: Early Detection of Dengue Fever Outbreaks Using a Surveillance App (Mozzify): Cross-sectional Mixed Methods Usability Study. JMIR public health and surveillance, 7(4), e29795. https://doi.org/10.2196/29795
Herbuela, Von Ralph Dane Marquez, et al. "Correction: Early Detection of Dengue Fever Outbreaks Using a Surveillance App (Mozzify): Cross-sectional Mixed Methods Usability Study." JMIR public health and surveillance vol. 7,4 (2021): e29795. doi: https://doi.org/10.2196/29795
Herbuela VRDM, Karita T, Carvajal TM, Ho HT, Lorena JMO, Regalado RA, Sobrepeña GD, Watanabe K. Correction: Early Detection of Dengue Fever Outbreaks Using a Surveillance App (Mozzify): Cross-sectional Mixed Methods Usability Study. JMIR Public Health Surveill. 2021 Apr 22;7(4):e29795. doi: 10.2196/29795. PMID: 33886493; PMCID: PMC8103298.
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Is It a Real Obesity Paradox?.

Chest

Watanabe J, Aita T, Saito K, Iwasaki Y, Fujieda T, Yoshioka T.
PMID: 34366056
Chest. 2021 Aug;160(2):e247-e248. doi: 10.1016/j.chest.2021.03.037.

No abstract available.

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Watanabe J, Aita T, Saito K, et al. Is It a Real Obesity Paradox?. Chest. 2021;160(2):e247-e248doi: 10.1016/j.chest.2021.03.037.
Watanabe, J., Aita, T., Saito, K., Iwasaki, Y., Fujieda, T., & Yoshioka, T. (2021). Is It a Real Obesity Paradox?. Chest, 160(2), e247-e248. https://doi.org/10.1016/j.chest.2021.03.037
Watanabe, Jun, et al. "Is It a Real Obesity Paradox?." Chest vol. 160,2 (2021): e247-e248. doi: https://doi.org/10.1016/j.chest.2021.03.037
Watanabe J, Aita T, Saito K, Iwasaki Y, Fujieda T, Yoshioka T. Is It a Real Obesity Paradox?. Chest. 2021 Aug;160(2):e247-e248. doi: 10.1016/j.chest.2021.03.037. PMID: 34366056.
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Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma.

Journal of the Egyptian National Cancer Institute

Makino W, Heianna J, Ishikawa K, Kusada T, Maemoto H, Ariga T, Matayoshi A, Nakasone T, Hirakawa H, Agena S, Yamashita Y, Maeda H, Murayama S.
PMID: 34927227
J Egypt Natl Canc Inst. 2021 Dec 20;33(1):40. doi: 10.1186/s43046-021-00098-w.

BACKGROUND: Postoperative chemoradiotherapy is recommended for patients with head and neck squamous cell carcinoma with positive margins or extracapsular extension at high risk of recurrence. However, high-dose radiotherapy in the head and neck region often causes severe acute and...

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Makino W, Heianna J, Ishikawa K, et al. Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma. J Egypt Natl Canc Inst. 2021;33(1):40doi: 10.1186/s43046-021-00098-w.
Makino, W., Heianna, J., Ishikawa, K., Kusada, T., Maemoto, H., Ariga, T., Matayoshi, A., Nakasone, T., Hirakawa, H., Agena, S., Yamashita, Y., Maeda, H., & Murayama, S. (2021). Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma. Journal of the Egyptian National Cancer Institute, 33(1), 40. https://doi.org/10.1186/s43046-021-00098-w
Makino, Wataru, et al. "Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma." Journal of the Egyptian National Cancer Institute vol. 33,1 (2021): 40. doi: https://doi.org/10.1186/s43046-021-00098-w
Makino W, Heianna J, Ishikawa K, Kusada T, Maemoto H, Ariga T, Matayoshi A, Nakasone T, Hirakawa H, Agena S, Yamashita Y, Maeda H, Murayama S. Patterns of recurrence after low-dose postoperative radiotherapy for head and neck squamous cell carcinoma. J Egypt Natl Canc Inst. 2021 Dec 20;33(1):40. doi: 10.1186/s43046-021-00098-w. PMID: 34927227.
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Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase.

Acta crystallographica. Section F, Structural biology communications

Murakawa T, Suzuki M, Arima T, Sugahara M, Tanaka T, Tanaka R, Iwata S, Nango E, Tono K, Hayashi H, Fukui K, Yano T, Tanizawa K, Okajima T.
PMID: 34605440
Acta Crystallogr F Struct Biol Commun. 2021 Oct 01;77:356-363. doi: 10.1107/S2053230X21008967. Epub 2021 Sep 21.

Recent advances in serial femtosecond X-ray crystallography (SFX) using X-ray free-electron lasers have paved the way for determining radiation-damage-free protein structures under nonfreezing conditions. However, the large-scale preparation of high-quality microcrystals of uniform size is a prerequisite for SFX,...

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Murakawa T, Suzuki M, Arima T, et al. Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase. Acta Crystallogr F Struct Biol Commun. 2021;77:356-363doi: 10.1107/S2053230X21008967.
Murakawa, T., Suzuki, M., Arima, T., Sugahara, M., Tanaka, T., Tanaka, R., Iwata, S., Nango, E., Tono, K., Hayashi, H., Fukui, K., Yano, T., Tanizawa, K., & Okajima, T. (2021). Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase. Acta crystallographica. Section F, Structural biology communications, 77356-363. https://doi.org/10.1107/S2053230X21008967
Murakawa, Takeshi, et al. "Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase." Acta crystallographica. Section F, Structural biology communications vol. 77 (2021): 356-363. doi: https://doi.org/10.1107/S2053230X21008967
Murakawa T, Suzuki M, Arima T, Sugahara M, Tanaka T, Tanaka R, Iwata S, Nango E, Tono K, Hayashi H, Fukui K, Yano T, Tanizawa K, Okajima T. Microcrystal preparation for serial femtosecond X-ray crystallography of bacterial copper amine oxidase. Acta Crystallogr F Struct Biol Commun. 2021 Oct 01;77:356-363. doi: 10.1107/S2053230X21008967. Epub 2021 Sep 21. PMID: 34605440; PMCID: PMC8488853.
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Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer.

Journal of Cancer

Takashima Y, Komatsu S, Nishibeppu K, Kiuchi J, Ohashi T, Shimizu H, Arita T, Yamamoto Y, Konishi H, Morimura R, Shiozaki A, Kuriu Y, Ikoma H, Kubota T, Fujiwara H, Okamoto K, Otsuji E.
PMID: 34476010
J Cancer. 2021 Aug 13;12(19):5960-5966. doi: 10.7150/jca.58154. eCollection 2021.

No abstract available.

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Takashima Y, Komatsu S, Nishibeppu K, et al. Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer. J Cancer. 2021;12(19):5960-5966doi: 10.7150/jca.58154.
Takashima, Y., Komatsu, S., Nishibeppu, K., Kiuchi, J., Ohashi, T., Shimizu, H., Arita, T., Yamamoto, Y., Konishi, H., Morimura, R., Shiozaki, A., Kuriu, Y., Ikoma, H., Kubota, T., Fujiwara, H., Okamoto, K., & Otsuji, E. (2021). Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer. Journal of Cancer, 12(19), 5960-5966. https://doi.org/10.7150/jca.58154
Takashima, Yusuke, et al. "Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer." Journal of Cancer vol. 12,19 (2021): 5960-5966. doi: https://doi.org/10.7150/jca.58154
Takashima Y, Komatsu S, Nishibeppu K, Kiuchi J, Ohashi T, Shimizu H, Arita T, Yamamoto Y, Konishi H, Morimura R, Shiozaki A, Kuriu Y, Ikoma H, Kubota T, Fujiwara H, Okamoto K, Otsuji E. Clinical impact of postoperative interval until adjuvant chemotherapy following curative gastrectomy for advanced gastric cancer. J Cancer. 2021 Aug 13;12(19):5960-5966. doi: 10.7150/jca.58154. eCollection 2021. PMID: 34476010; PMCID: PMC8408116.
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Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells.

Genes & development

Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
PMID: 34992147
Genes Dev. 2022 Jan 06; doi: 10.1101/gad.348782.121. Epub 2022 Jan 06.

The placenta is a highly evolved, specialized organ in mammals. It differs from other organs in that it functions only for fetal maintenance during gestation. Therefore, there must be intrinsic mechanisms that guarantee its unique functions. To address this...

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Hada M, Miura H, Tanigawa A, et al. Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells. Genes Dev. 2022;doi: 10.1101/gad.348782.121.
Hada, M., Miura, H., Tanigawa, A., Matoba, S., Inoue, K., Ogonuki, N., Hirose, M., Watanabe, N., Nakato, R., Fujiki, K., Hasegawa, A., Sakashita, A., Okae, H., Miura, K., Shikata, D., Arima, T., Shirahige, K., Hiratani, I., & Ogura, A. (2022). Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells. Genes & development, . https://doi.org/10.1101/gad.348782.121
Hada, Masashi, et al. "Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells." Genes & development vol. (2022). doi: https://doi.org/10.1101/gad.348782.121
Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A. Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells. Genes Dev. 2022 Jan 06; doi: 10.1101/gad.348782.121. Epub 2022 Jan 06. PMID: 34992147.
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Showing 1117 to 1125 of 1125 entries