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Showing 685 to 696 of 698 entries
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Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.

Journal of experimental & clinical cancer research : CR

Schmidt O, Nehls N, Prexler C, von Heyking K, Groll T, Pardon K, Garcia HD, Hensel T, Gürgen D, Henssen AG, Eggert A, Steiger K, Burdach S, Richter GHS.
PMID: 34654445
J Exp Clin Cancer Res. 2021 Oct 15;40(1):322. doi: 10.1186/s13046-021-02125-z.

BACKGROUND: Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated.METHODS: Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 as well as...

Using citizen science to empower older adults to improve a food security initiative in Australia.

Health promotion international

Tuckett AG, Rowbotham S, Hetherington S, Goddard J, King AC.
PMID: 34165525
Health Promot Int. 2021 Jun 24; doi: 10.1093/heapro/daab060. Epub 2021 Jun 24.

Food security is an increasing problem for older adults who are living longer and having to stretch their resources further. Initiatives such as subsidized community market days are increasingly important in bolstering food security amongst these groups but there...

A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype.

Human molecular genetics

Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, Consortium L, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM.
PMID: 34726233
Hum Mol Genet. 2021 Nov 02; doi: 10.1093/hmg/ddab316. Epub 2021 Nov 02.

Pathogenic variants in retinol dehydrogenase 5 (RDH5) attenuate supply of 11-cis-retinal to photoreceptors leading to a range of clinical phenotypes including night blindness due to markedly slowed rod dark adaptation and in some patients, macular atrophy. Current animal models...

Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy.

Child and adolescent psychiatry and mental health

Mehler-Wex C, Kölch M, Kirchheiner J, Antony G, Fegert JM, Gerlach M.
PMID: 19358696
Child Adolesc Psychiatry Ment Health. 2009 Apr 09;3(1):14. doi: 10.1186/1753-2000-3-14.

Most psychotropic drugs used in the treatment of children and adolescents are applied "off label" with a direct risk of under- or overdosing and a delayed risk of long-term side effects. The selection of doses in paediatric psychiatric patients...

EMbedding and Backscattered Scanning Electron Microscopy: A Detailed Protocol for the Whole-Specimen, High-Resolution Analysis of Cardiovascular Tissues.

Frontiers in cardiovascular medicine

Mukhamadiyarov RA, Bogdanov LA, Glushkova TV, Shishkova DK, Kostyunin AE, Koshelev VA, Shabaev AR, Frolov AV, Stasev AN, Lyapin AA, Kutikhin AG.
PMID: 34760942
Front Cardiovasc Med. 2021 Oct 25;8:739549. doi: 10.3389/fcvm.2021.739549. eCollection 2021.

Currently, an ultrastructural analysis of cardiovascular tissues is significantly complicated. Routine histopathological examinations and immunohistochemical staining suffer from a relatively low resolution of light microscopy, whereas the fluorescence imaging of plaques and bioprosthetic heart valves yields considerable background noise...

Adolescent Marijuana Dependence: The Role of Social Bonds and Social Learning Theory.

Journal of psychoactive drugs

Hahlbeck SM, Vito AG.
PMID: 33775242
J Psychoactive Drugs. 2021 Mar 28;1-11. doi: 10.1080/02791072.2021.1903122. Epub 2021 Mar 28.

Using the 2017 National Survey of Drug Use and Health (NSDUH) data, this research examines the extent to which social bonds and social learning theory predict adolescent marijuana dependence. Full information maximum likelihood (FIML) for logistic regression analyses were...

Use of dialysis, tracheostomy, and extracorporeal membrane oxygenation among 842,928 patients hospitalized with COVID-19 in the United States.

medRxiv : the preprint server for health sciences

Burn E, Sena AG, Prats-Uribe A, Spotnitz M, DuVall S, Lynch KE, Matheny ME, Nyberg F, Ahmed WU, Alser O, Alghoul H, Alshammari T, Zhang L, Casajust P, Areia C, Shah K, Reich C, Blacketer C, Andryc A, Fortin S, Natarajan K, Gong M, Golozar A, Morales D, Rijnbeek P, Subbian V, Roel E, Recalde M, Lane JCE, Vizcaya D, Posada JD, Shah NH, Jonnagaddala J, Lai LYH, Avilés-Jurado FX, Hripcsak G, Suchard MA, Ranzani OT, Ryan P, Prieto-Alhambra D, Kostka K, Duarte-Salles T.
PMID: 33269356
medRxiv. 2021 Feb 12; doi: 10.1101/2020.11.25.20229088.

OBJECTIVE: To estimate the proportion of patients hospitalized with COVID-19 who undergo dialysis, tracheostomy, and extracorporeal membrane oxygenation (ECMO).DESIGN: A network cohort study.SETTING: Seven databases from the United States containing routinely-collected patient data: HealthVerity, Premier, IQVIA Hospital CDM, IQVIA...

Response to the Comment on "Proving the Effectiveness of the Fundamentals of Robotic Surgery (FRS) Skills Curriculum: A Single-blinded, Multispecialty, Multi-institutional Randomized Control Trial: Not Only Surgeon's Manual Skills...".

Annals of surgery

Satava RM, Stefanidis D, Levy JS, Smith R, Martin JR, Monfared S, Timsina LR, Darzi AW, Moglia A, Brand TC, Dorin RP, Dumon KR, Francone TD, Georgiou E, Goh AC, Marcet JE, Martino MA, Sudan R, Vale J, Gallagher AG.
PMID: 33278169
Ann Surg. 2021 Dec 01;274(6):e847-e848. doi: 10.1097/SLA.0000000000004658.

No abstract available.

Low sclerostin levels after long-term remission of acromegaly.

Endocrine

Claessen KMJA, Pelsma ICM, Kroon HM, van Lierop AH, Pereira AM, Biermasz NR, Appelman-Dijkstra NM.
PMID: 34448099
Endocrine. 2021 Aug 26; doi: 10.1007/s12020-021-02850-7. Epub 2021 Aug 26.

PURPOSE: Bone health is compromised in acromegaly resulting in vertebral fractures (VFs), regardless of biochemical remission. Sclerostin is a negative inhibitor of bone formation and is associated with increased fracture risk in the general population. Therefore, we compared sclerostin...

Patterns of tau pathology identified with .

Alzheimer's & dementia : the journal of the Alzheimer's Association

Kreisl WC, Lao PJ, Johnson A, Tomljanovic Z, Klein J, Polly K, Maas B, Laing KK, Chesebro AG, Igwe K, Razlighi QR, Honig LS, Yan X, Lee S, Mintz A, Luchsinger JA, Stern Y, Devanand DP, Brickman AM.
PMID: 34057284
Alzheimers Dement. 2021 May 31; doi: 10.1002/alz.12384. Epub 2021 May 31.

No abstract available.

Tissue-Engineered Carotid Artery Interposition Grafts Demonstrate High Primary Patency and Promote Vascular Tissue Regeneration in the Ovine Model.

Polymers

Antonova LV, Krivkina EO, Sevostianova VV, Mironov AV, Rezvova MA, Shabaev AR, Tkachenko VO, Krutitskiy SS, Khanova MY, Sergeeva TY, Matveeva VG, Glushkova TV, Kutikhin AG, Mukhamadiyarov RA, Deeva NS, Akentieva TN, Sinitsky MY, Velikanova EA, Barbarash LS.
PMID: 34451177
Polymers (Basel). 2021 Aug 08;13(16). doi: 10.3390/polym13162637.

Tissue-engineered vascular graft for the reconstruction of small arteries is still an unmet clinical need, despite the fact that a number of promising prototypes have entered preclinical development. Here we test Poly(3-hydroxybutyrate-co-3-hydroxyvalerate)Poly(ε-caprolactone) 4-mm-diameter vascular grafts equipped with vascular endothelial...

Heterologous humoral immunity to human and zoonotic coronaviruses: Aiming for the achilles heel.

Seminars in immunology

Ng KW, Faulkner N, Wrobel AG, Gamblin SJ, Kassiotis G.
PMID: 34716096
Semin Immunol. 2021 Jun;55:101507. doi: 10.1016/j.smim.2021.101507. Epub 2021 Oct 25.

Coronaviruses are evolutionarily successful RNA viruses, common to multiple avian, amphibian and mammalian hosts. Despite their ubiquity and potential impact, knowledge of host immunity to coronaviruses remains incomplete, partly owing to the lack of overt pathogenicity of endemic human...

Showing 685 to 696 of 698 entries