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Showing 673 to 684 of 698 entries
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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.

Nature communications

Schmelz K, Toedling J, Huska M, Cwikla MC, Kruetzfeldt LM, Proba J, Ambros PF, Ambros IM, Boral S, Lodrini M, Chen CY, Burkert M, Guergen D, Szymansky A, Astrahantseff K, Kuenkele A, Haase K, Fischer M, Deubzer HE, Hertwig F, Hundsdoerfer P, Henssen AG, Schwarz RF, Schulte JH, Eggert A.
PMID: 34815394
Nat Commun. 2021 Nov 23;12(1):6804. doi: 10.1038/s41467-021-26870-z.

Intratumour heterogeneity is a major cause of treatment failure in cancer. We present in-depth analyses combining transcriptomic and genomic profiling with ultra-deep targeted sequencing of multiregional biopsies in 10 patients with neuroblastoma, a devastating childhood tumour. We observe high...

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Molecular psychiatry

Chiotis K, Savitcheva I, Poulakis K, Saint-Aubert L, Wall A, Antoni G, Nordberg A.
PMID: 32616831
Mol Psychiatry. 2021 Oct;26(10):5875-5887. doi: 10.1038/s41380-020-0815-4. Epub 2020 Jul 03.

Cross-sectional studies have indicated potential for positron emission tomography (PET) in imaging tau pathology in Alzheimer's disease (AD); however, its prognostic utility remains unproven. In a longitudinal, multi-modal, prognostic study of cognitive decline, 20 patients with a clinical biomarker-based...

The role of extracorporeal membrane oxygenation in adult liver transplant patients: A qualitative systematic review of literature.

Artificial organs

Reid TD, Kratzke IM, Dayal D, Raff L, Serrano P, Kumar A, Zendel A, Herdman V, Gallaher J, Carlson R, Charles AG, Desai CS.
PMID: 34816462
Artif Organs. 2021 Nov 23; doi: 10.1111/aor.14120. Epub 2021 Nov 23.

BACKGROUND: A paucity of evidence exists regarding risks and benefits of extracorporeal membrane oxygenation (ECMO) in adult liver transplantation.METHODS: This was a systematic review conducted from January 1, 2000 to April 24, 2020 of adult liver transplant recipients (pre-...

High b-value diffusion tractography: Abnormal axonal network organization associated with medication-refractory epilepsy.

NeuroImage

Gleichgerrcht E, Keller SS, Bryant L, Moss H, Kellermann TS, Biswas S, Marson AG, Wilmskoetter J, Jensen JH, Bonilha L.
PMID: 34974117
Neuroimage. 2021 Dec 30;248:118866. doi: 10.1016/j.neuroimage.2021.118866. Epub 2021 Dec 30.

Diffusion magnetic resonance imaging (dMRI) tractography has played a critical role in characterizing patterns of aberrant brain network reorganization among patients with epilepsy. However, the accuracy of dMRI tractography is hampered by the complex biophysical properties of white matter...

The gender gap and healthcare: associations between gender roles and factors affecting healthcare access in Central Malawi, June-August 2017.

Archives of public health = Archives belges de sante publique

Azad AD, Charles AG, Ding Q, Trickey AW, Wren SM.
PMID: 33292511
Arch Public Health. 2020 Nov 17;78(1):119. doi: 10.1186/s13690-020-00497-w.

BACKGROUND: Women in low and middle-income countries (LMICs) do not have equal access to resources, such as education, employment, or healthcare compared to men. We sought to explore health disparities and associations between gender prioritization, sociocultural factors, and household...

Comparison of Clinical and Radiographic Outcomes After Standalone Versus Cage and Plate Constructs for Anterior Cervical Discectomy and Fusion.

International journal of spine surgery

Fayed I, Conte AG, Keating G, Cobourn KD, Altshuler M, Makariou E, Spitz SM, Anaizi AN, Nair MN, Voyadzis JM, Sandhu FA.
PMID: 33963034
Int J Spine Surg. 2021 Jun;15(3):403-412. doi: 10.14444/8060. Epub 2021 May 07.

BACKGROUND: Anterior cervical discectomy and fusion (ACDF) has conventionally been performed using an allograft cage with a plate-and-screw construct. Recently, standalone cages have gained popularity due to theorized decreases in operative time and postoperative dysphagia. Few studies have compared...

Ground-Based LiDAR Improves Phenotypic Repeatability of Above-Ground Biomass and Crop Growth Rate in Wheat.

Plant phenomics (Washington, D.C.)

Deery DM, Rebetzke GJ, Jimenez-Berni JA, Condon AG, Smith DJ, Bechaz KM, Bovill WD.
PMID: 33313565
Plant Phenomics. 2020 May 26;2020:8329798. doi: 10.34133/2020/8329798. eCollection 2020.

Highly repeatable, nondestructive, and high-throughput measures of above-ground biomass (AGB) and crop growth rate (CGR) are important for wheat improvement programs. This study evaluates the repeatability of destructive AGB and CGR measurements in comparison to two previously described methods...

Predictors of multi-drug resistance in burn wound colonization following burn injury in a resource-limited setting.

Burns : journal of the International Society for Burn Injuries

Gallaher JR, Banda W, Lachiewicz AM, Krysiak R, Purcell LN, Charles AG.
PMID: 33371978
Burns. 2021 Sep;47(6):1308-1313. doi: 10.1016/j.burns.2020.12.007. Epub 2020 Dec 10.

INTRODUCTION: Bacterial resistance to antibiotics is growing dramatically worldwide due to several contributing factors, including inappropriate antibiotic utilization in the clinical setting and widespread use in the food production industry. Consequently, it is imperative to characterize antibiotic resistance in...

Publisher Correction to: The gender gap and healthcare: associations between gender roles and factors affecting healthcare access in Central Malawi, June-August 2017.

Archives of public health = Archives belges de sante publique

Azad AD, Charles AG, Ding Q, Trickey AW, Wren SM.
PMID: 33579368
Arch Public Health. 2021 Feb 12;79(1):19. doi: 10.1186/s13690-021-00538-y.

No abstract available.

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis.

Journal of experimental & clinical cancer research : CR

Schmidt O, Nehls N, Prexler C, von Heyking K, Groll T, Pardon K, Garcia HD, Hensel T, Gürgen D, Henssen AG, Eggert A, Steiger K, Burdach S, Richter GHS.
PMID: 34654445
J Exp Clin Cancer Res. 2021 Oct 15;40(1):322. doi: 10.1186/s13046-021-02125-z.

BACKGROUND: Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated.METHODS: Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 as well as...

ecDNA hubs drive cooperative intermolecular oncogene expression.

Nature

Hung KL, Yost KE, Xie L, Shi Q, Helmsauer K, Luebeck J, Schöpflin R, Lange JT, Chamorro González R, Weiser NE, Chen C, Valieva ME, Wong IT, Wu S, Dehkordi SR, Duffy CV, Kraft K, Tang J, Belk JA, Rose JC, Corces MR, Granja JM, Li R, Rajkumar U, Friedlein J, Bagchi A, Satpathy AT, Tjian R, Mundlos S, Bafna V, Henssen AG, Mischel PS, Liu Z, Chang HY.
PMID: 34819668
Nature. 2021 Nov 24; doi: 10.1038/s41586-021-04116-8. Epub 2021 Nov 24.

Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high expression of oncogenes through gene amplification and altered gene regulation

Replicating infant-specific reactive astrocyte functions in the injured adult brain.

Progress in neurobiology

Teo L, Boghdadi AG, Homman-Ludiye J, Mundinano IC, Kwan WC, Bourne JA.
PMID: 34147584
Prog Neurobiol. 2021 Sep;204:102108. doi: 10.1016/j.pneurobio.2021.102108. Epub 2021 Jun 17.

Infants and adults respond differently to brain injuries. Specifically, improved neuronal sparing along with reduced astrogliosis and glial scarring often observed earlier in life, likely contributes to improved long-term outcomes. Understanding the underlying mechanisms could enable the recapitulation of...

Showing 673 to 684 of 698 entries