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Single-dose replicating poxvirus vector-basedRBD vaccine drives robust humoral and T cellimmune response against SARS-CoV-2 infection.

Molecular therapy : the journal of the American Society of Gene Therapy

Boulton S, Poutou J, Martin NT, Azad T, Singaravelu R, Crupi MJF, Jamieson T, He X, Marius R, Petryk J, Tanese de Souza C, Austin B, Taha Z, Whelan J, Khan ST, Pelin A, Rezaei R, Surendran A, Tucker S, Brown EEF, Dave J, Diallo JS, Auer R, Angel JB, Cameron DW, Cailhier JF, Lapointe R, Potts K, Mahoney DJ, Bell JC, Ilkow CS.
PMID: 34687845
Mol Ther. 2021 Oct 20; doi: 10.1016/j.ymthe.2021.10.008. Epub 2021 Oct 20.

The coronavirus disease 2019 (COVID-19) pandemic requires the continued development of safe, long-lasting, and efficacious vaccines for preventive responses to major outbreaks around the world, and especially in isolated and developing countries. To combat severe acute respiratory syndrome coronavirus...

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Boulton S, Poutou J, Martin NT, et al. Single-dose replicating poxvirus vector-basedRBD vaccine drives robust humoral and T cellimmune response against SARS-CoV-2 infection. Mol Ther. 2021;doi: 10.1016/j.ymthe.2021.10.008.
Boulton, S., Poutou, J., Martin, N. T., Azad, T., Singaravelu, R., Crupi, M. J. F., Jamieson, T., He, X., Marius, R., Petryk, J., Tanese de Souza, C., Austin, B., Taha, Z., Whelan, J., Khan, S. T., Pelin, A., Rezaei, R., Surendran, A., Tucker, S., Brown, E. E. F., Dave, J., Diallo, J. S., Auer, R., Angel, J. B., Cameron, D. W., Cailhier, J. F., Lapointe, R., Potts, K., Mahoney, D. J., Bell, J. C., & Ilkow, C. S. (2021). Single-dose replicating poxvirus vector-basedRBD vaccine drives robust humoral and T cellimmune response against SARS-CoV-2 infection. Molecular therapy : the journal of the American Society of Gene Therapy, . https://doi.org/10.1016/j.ymthe.2021.10.008
Boulton, Stephen, et al. "Single-dose replicating poxvirus vector-basedRBD vaccine drives robust humoral and T cellimmune response against SARS-CoV-2 infection." Molecular therapy : the journal of the American Society of Gene Therapy vol. (2021). doi: https://doi.org/10.1016/j.ymthe.2021.10.008
Boulton S, Poutou J, Martin NT, Azad T, Singaravelu R, Crupi MJF, Jamieson T, He X, Marius R, Petryk J, Tanese de Souza C, Austin B, Taha Z, Whelan J, Khan ST, Pelin A, Rezaei R, Surendran A, Tucker S, Brown EEF, Dave J, Diallo JS, Auer R, Angel JB, Cameron DW, Cailhier JF, Lapointe R, Potts K, Mahoney DJ, Bell JC, Ilkow CS. Single-dose replicating poxvirus vector-basedRBD vaccine drives robust humoral and T cellimmune response against SARS-CoV-2 infection. Mol Ther. 2021 Oct 20; doi: 10.1016/j.ymthe.2021.10.008. Epub 2021 Oct 20. PMID: 34687845; PMCID: PMC8527104.
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SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals.

Frontiers in immunology

Chellamuthu P, Angel AN, MacMullan MA, Denny N, Mades A, Santacruz M, Lopez R, Bagos C, Casian JG, Trettner K, Lopez L, Nirema N, Brobeck M, Kojima N, Klausner JD, Turner F, Slepnev V, Ibrayeva A.
PMID: 34956206
Front Immunol. 2021 Dec 09;12:777858. doi: 10.3389/fimmu.2021.777858. eCollection 2021.

BACKGROUND: Developing an understanding of the antibody response, seroprevalence, and seroconversion from natural infection and vaccination against SARS-CoV-2 will give way to a critical epidemiological tool to predict reinfection rates, identify vulnerable communities, and manage future viral outbreaks. To...

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Chellamuthu P, Angel AN, MacMullan MA, et al. SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals. Front Immunol. 2021;12:777858doi: 10.3389/fimmu.2021.777858.
Chellamuthu, P., Angel, A. N., MacMullan, M. A., Denny, N., Mades, A., Santacruz, M., Lopez, R., Bagos, C., Casian, J. G., Trettner, K., Lopez, L., Nirema, N., Brobeck, M., Kojima, N., Klausner, J. D., Turner, F., Slepnev, V., & Ibrayeva, A. (2021). SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals. Frontiers in immunology, 12777858. https://doi.org/10.3389/fimmu.2021.777858
Chellamuthu, Prithivi, et al. "SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals." Frontiers in immunology vol. 12 (2021): 777858. doi: https://doi.org/10.3389/fimmu.2021.777858
Chellamuthu P, Angel AN, MacMullan MA, Denny N, Mades A, Santacruz M, Lopez R, Bagos C, Casian JG, Trettner K, Lopez L, Nirema N, Brobeck M, Kojima N, Klausner JD, Turner F, Slepnev V, Ibrayeva A. SARS-CoV-2 Specific IgG Antibodies Persist Over a 12-Month Period in Oral Mucosal Fluid Collected From Previously Infected Individuals. Front Immunol. 2021 Dec 09;12:777858. doi: 10.3389/fimmu.2021.777858. eCollection 2021. PMID: 34956206; PMCID: PMC8697108.
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Individualized prediction for the occurrence of acute kidney injury during the first postoperative week following cardiac surgery.

Journal of clinical anesthesia

Pérez T, Candela-Toha AM, Khalifi L, Muriel A, Pardo MC.
PMID: 34847490
J Clin Anesth. 2021 Nov 27;77:110596. doi: 10.1016/j.jclinane.2021.110596. Epub 2021 Nov 27.

STUDY OBJECTIVE: To develop individualized dynamic predictions for the occurrence of acute kidney injury (AKI) during the first postoperative week after cardiac surgery.DESIGN: Observational retrospective cohort study.SETTING: Single university teaching hospital in Madrid, Spain.PATIENTS: 3960 cases of major cardiac...

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Pérez T, Candela-Toha AM, Khalifi L, et al. Individualized prediction for the occurrence of acute kidney injury during the first postoperative week following cardiac surgery. J Clin Anesth. 2021;77:110596doi: 10.1016/j.jclinane.2021.110596.
Pérez, T., Candela-Toha, A. M., Khalifi, L., Muriel, A., & Pardo, M. C. (2021). Individualized prediction for the occurrence of acute kidney injury during the first postoperative week following cardiac surgery. Journal of clinical anesthesia, 77110596. https://doi.org/10.1016/j.jclinane.2021.110596
Pérez, Teresa, et al. "Individualized prediction for the occurrence of acute kidney injury during the first postoperative week following cardiac surgery." Journal of clinical anesthesia vol. 77 (2021): 110596. doi: https://doi.org/10.1016/j.jclinane.2021.110596
Pérez T, Candela-Toha AM, Khalifi L, Muriel A, Pardo MC. Individualized prediction for the occurrence of acute kidney injury during the first postoperative week following cardiac surgery. J Clin Anesth. 2021 Nov 27;77:110596. doi: 10.1016/j.jclinane.2021.110596. Epub 2021 Nov 27. PMID: 34847490.
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Subcellular and regional localization of mRNA translation in midbrain dopamine neurons.

Cell reports

Hobson BD, Kong L, Angelo MF, Lieberman OJ, Mosharov EV, Herzog E, Sulzer D, Sims PA.
PMID: 35021090
Cell Rep. 2022 Jan 11;38(2):110208. doi: 10.1016/j.celrep.2021.110208.

Midbrain dopaminergic (mDA) neurons exhibit extensive dendritic and axonal arborizations, but local protein synthesis is not characterized in these neurons. Here, we investigate messenger RNA (mRNA) localization and translation in mDA neuronal axons and dendrites, both of which release...

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Hobson BD, Kong L, Angelo MF, et al. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell Rep. 2022;38(2):110208doi: 10.1016/j.celrep.2021.110208.
Hobson, B. D., Kong, L., Angelo, M. F., Lieberman, O. J., Mosharov, E. V., Herzog, E., Sulzer, D., & Sims, P. A. (2022). Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell reports, 38(2), 110208. https://doi.org/10.1016/j.celrep.2021.110208
Hobson, Benjamin D, et al. "Subcellular and regional localization of mRNA translation in midbrain dopamine neurons." Cell reports vol. 38,2 (2022): 110208. doi: https://doi.org/10.1016/j.celrep.2021.110208
Hobson BD, Kong L, Angelo MF, Lieberman OJ, Mosharov EV, Herzog E, Sulzer D, Sims PA. Subcellular and regional localization of mRNA translation in midbrain dopamine neurons. Cell Rep. 2022 Jan 11;38(2):110208. doi: 10.1016/j.celrep.2021.110208. PMID: 35021090.
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Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD.

Journal of acquired immune deficiency syndromes (1999)

Qian Y, Moore RD, Coburn SB, Davy-Mendez T, Akgün KM, McGinnis KA, Silverberg MJ, Colasanti JA, Cachay ER, Horberg MA, Rabkin CS, Jacobson JM, Gill MJ, Mayor AM, Kirk GD, Gebo KA, Nijhawan AE, Althoff KN.
PMID: 34878432
J Acquir Immune Defic Syndr. 2022 Jan 01;89(1):9-18. doi: 10.1097/QAI.0000000000002812.

BACKGROUND: People with HIV (PWH) have a higher hospitalization rate than the general population. The Veterans Aging Cohort Study (VACS) Index at study entry well predicts hospitalization in PWH, but it is unknown if the time-updated parameter improves hospitalization...

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Qian Y, Moore RD, Coburn SB, et al. Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD. J Acquir Immune Defic Syndr. 2022;89(1):9-18doi: 10.1097/QAI.0000000000002812.
Qian, Y., Moore, R. D., Coburn, S. B., Davy-Mendez, T., Akgün, K. M., McGinnis, K. A., Silverberg, M. J., Colasanti, J. A., Cachay, E. R., Horberg, M. A., Rabkin, C. S., Jacobson, J. M., Gill, M. J., Mayor, A. M., Kirk, G. D., Gebo, K. A., Nijhawan, A. E., & Althoff, K. N. (2022). Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD. Journal of acquired immune deficiency syndromes (1999), 89(1), 9-18. https://doi.org/10.1097/QAI.0000000000002812
Qian, Yuhang, et al. "Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD." Journal of acquired immune deficiency syndromes (1999) vol. 89,1 (2022): 9-18. doi: https://doi.org/10.1097/QAI.0000000000002812
Qian Y, Moore RD, Coburn SB, Davy-Mendez T, Akgün KM, McGinnis KA, Silverberg MJ, Colasanti JA, Cachay ER, Horberg MA, Rabkin CS, Jacobson JM, Gill MJ, Mayor AM, Kirk GD, Gebo KA, Nijhawan AE, Althoff KN. Association of the VACS Index With Hospitalization Among People With HIV in the NA-ACCORD. J Acquir Immune Defic Syndr. 2022 Jan 01;89(1):9-18. doi: 10.1097/QAI.0000000000002812. PMID: 34878432; PMCID: PMC8665227.
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Effective Detection and Monitoring of Glioma Using [.

Biomedicines

Vassileva V, Braga M, Barnes C, Przystal J, Ashek A, Allott L, Brickute D, Abrahams J, Suwan K, Carcaboso AM, Hajitou A, Aboagye EO.
PMID: 34356874
Biomedicines. 2021 Jul 13;9(7). doi: 10.3390/biomedicines9070811.

BACKGROUND: Reprogrammed cellular metabolism is a cancer hallmark. In addition to increased glycolysis, the oxidation of acetate in the citric acid cycle is another common metabolic phenotype. We have recently developed a novel fluorine-18-labelled trimethylacetate-based radiotracer, [METHODS: We evaluated...

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Vassileva V, Braga M, Barnes C, et al. Effective Detection and Monitoring of Glioma Using [. Biomedicines. 2021;9(7)doi: 10.3390/biomedicines9070811.
Vassileva, V., Braga, M., Barnes, C., Przystal, J., Ashek, A., Allott, L., Brickute, D., Abrahams, J., Suwan, K., Carcaboso, A. M., Hajitou, A., & Aboagye, E. O. (2021). Effective Detection and Monitoring of Glioma Using [. Biomedicines, 9(7), . https://doi.org/10.3390/biomedicines9070811
Vassileva, Vessela, et al. "Effective Detection and Monitoring of Glioma Using [." Biomedicines vol. 9,7 (2021). doi: https://doi.org/10.3390/biomedicines9070811
Vassileva V, Braga M, Barnes C, Przystal J, Ashek A, Allott L, Brickute D, Abrahams J, Suwan K, Carcaboso AM, Hajitou A, Aboagye EO. Effective Detection and Monitoring of Glioma Using [. Biomedicines. 2021 Jul 13;9(7). doi: 10.3390/biomedicines9070811. PMID: 34356874; PMCID: PMC8301305.
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Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity.

International journal of cardiology

Alonso Gómez AM, Sierra LT, Mora NM, Toledo E, Alonso A, Uriarte MG, Sanchez CS, Portillo MP, Rodriguez LL, Arellano EE, Schröder H, Salas-Salvadó J.
PMID: 34890763
Int J Cardiol. 2022 Feb 01;348:169-174. doi: 10.1016/j.ijcard.2021.12.004. Epub 2021 Dec 08.

BACKGROUND: Current recommendations for echocardiographic assessment of diastolic function (2016 guidelines of the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) in patients with metabolic syndrome and overweight/obesity result in a significant number of patients with indeterminate...

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Alonso Gómez AM, Sierra LT, Mora NM, et al. Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity. Int J Cardiol. 2021;348:169-174doi: 10.1016/j.ijcard.2021.12.004.
Alonso Gómez, A. M., Sierra, L. T., Mora, N. M., Toledo, E., Alonso, A., Uriarte, M. G., Sanchez, C. S., Portillo, M. P., Rodriguez, L. L., Arellano, E. E., Schröder, H., & Salas-Salvadó, J. (2022). Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity. International journal of cardiology, 348169-174. https://doi.org/10.1016/j.ijcard.2021.12.004
Alonso Gómez, Angel M, et al. "Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity." International journal of cardiology vol. 348 (2022): 169-174. doi: https://doi.org/10.1016/j.ijcard.2021.12.004
Alonso Gómez AM, Sierra LT, Mora NM, Toledo E, Alonso A, Uriarte MG, Sanchez CS, Portillo MP, Rodriguez LL, Arellano EE, Schröder H, Salas-Salvadó J. Left atrial strain improves echocardiographic classification of diastolic function in patients with metabolic syndrome and overweight-obesity. Int J Cardiol. 2022 Feb 01;348:169-174. doi: 10.1016/j.ijcard.2021.12.004. Epub 2021 Dec 08. PMID: 34890763.
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Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections.

Transplantation direct

Stewart ZA, Stern J, Ali NM, Kalia HS, Khalil K, Jonchhe S, Weldon EP, Dieter RA, Lewis TC, Funches N, Crosby S, Seow M, Berger JC, Dagher NN, Gelb BE, Watkins AC, Moazami N, Smith DE, Kon ZN, Chang SH, Reyentovich A, Angel LF, Montgomery RA, Lonze BE.
PMID: 34514117
Transplant Direct. 2021 Sep 07;7(10):e762. doi: 10.1097/TXD.0000000000001222. eCollection 2021 Oct.

Transplanting hepatitis C viremic donor organs into hepatitis C virus (HCV)-negative recipients is becoming increasingly common; however, practices for posttransplant direct-acting antiviral (DAA) treatment vary widely. Protracted insurance authorization processes for DAA therapy often lead to treatment delays.METHODS: At...

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Stewart ZA, Stern J, Ali NM, et al. Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections. Transplant Direct. 2021;7(10):e762doi: 10.1097/TXD.0000000000001222.
Stewart, Z. A., Stern, J., Ali, N. M., Kalia, H. S., Khalil, K., Jonchhe, S., Weldon, E. P., Dieter, R. A., Lewis, T. C., Funches, N., Crosby, S., Seow, M., Berger, J. C., Dagher, N. N., Gelb, B. E., Watkins, A. C., Moazami, N., Smith, D. E., Kon, Z. N., Chang, S. H., Reyentovich, A., Angel, L. F., Montgomery, R. A., & Lonze, B. E. (2021). Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections. Transplantation direct, 7(10), e762. https://doi.org/10.1097/TXD.0000000000001222
Stewart, Zoe A, et al. "Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections." Transplantation direct vol. 7,10 (2021): e762. doi: https://doi.org/10.1097/TXD.0000000000001222
Stewart ZA, Stern J, Ali NM, Kalia HS, Khalil K, Jonchhe S, Weldon EP, Dieter RA, Lewis TC, Funches N, Crosby S, Seow M, Berger JC, Dagher NN, Gelb BE, Watkins AC, Moazami N, Smith DE, Kon ZN, Chang SH, Reyentovich A, Angel LF, Montgomery RA, Lonze BE. Clinical and Financial Implications of 2 Treatment Strategies for Donor-derived Hepatitis C Infections. Transplant Direct. 2021 Sep 07;7(10):e762. doi: 10.1097/TXD.0000000000001222. eCollection 2021 Oct. PMID: 34514117; PMCID: PMC8425828.
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Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas.

The journal of pathology. Clinical research

Castillo-Ecija H, Pascual-Pasto G, Perez-Jaume S, Resa-Pares C, Vila-Ubach M, Monterrubio C, Jimenez-Cabaco A, Baulenas-Farres M, Muñoz-Aznar O, Salvador N, Cuadrado-Vilanova M, Olaciregui NG, Balaguer-Lluna L, Burgueño V, Vicario FJ, Manzanares A, Castañeda A, Santa-Maria V, Cruz O, Celis V, Morales La Madrid A, Garraus M, Gorostegui M, Vancells M, Carrasco R, Krauel L, Torner F, Suñol M, Lavarino C, Mora J, Carcaboso AM.
PMID: 33837665
J Pathol Clin Res. 2021 Jul;7(4):338-349. doi: 10.1002/cjp2.210. Epub 2021 Apr 09.

The goals of this work were to identify factors favoring patient-derived xenograft (PDX) engraftment and study the association between PDX engraftment and prognosis in pediatric patients with Ewing sarcoma, osteosarcoma, and rhabdomyosarcoma. We used immunodeficient mice to establish 30...

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Castillo-Ecija H, Pascual-Pasto G, Perez-Jaume S, et al. Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. J Pathol Clin Res. 2021;7(4):338-349doi: 10.1002/cjp2.210.
Castillo-Ecija, H., Pascual-Pasto, G., Perez-Jaume, S., Resa-Pares, C., Vila-Ubach, M., Monterrubio, C., Jimenez-Cabaco, A., Baulenas-Farres, M., Muñoz-Aznar, O., Salvador, N., Cuadrado-Vilanova, M., Olaciregui, N. G., Balaguer-Lluna, L., Burgueño, V., Vicario, F. J., Manzanares, A., Castañeda, A., Santa-Maria, V., Cruz, O., Celis, V., Morales La Madrid, A., Garraus, M., Gorostegui, M., Vancells, M., Carrasco, R., Krauel, L., Torner, F., Suñol, M., Lavarino, C., Mora, J., & Carcaboso, A. M. (2021). Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. The journal of pathology. Clinical research, 7(4), 338-349. https://doi.org/10.1002/cjp2.210
Castillo-Ecija, Helena, et al. "Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas." The journal of pathology. Clinical research vol. 7,4 (2021): 338-349. doi: https://doi.org/10.1002/cjp2.210
Castillo-Ecija H, Pascual-Pasto G, Perez-Jaume S, Resa-Pares C, Vila-Ubach M, Monterrubio C, Jimenez-Cabaco A, Baulenas-Farres M, Muñoz-Aznar O, Salvador N, Cuadrado-Vilanova M, Olaciregui NG, Balaguer-Lluna L, Burgueño V, Vicario FJ, Manzanares A, Castañeda A, Santa-Maria V, Cruz O, Celis V, Morales La Madrid A, Garraus M, Gorostegui M, Vancells M, Carrasco R, Krauel L, Torner F, Suñol M, Lavarino C, Mora J, Carcaboso AM. Prognostic value of patient-derived xenograft engraftment in pediatric sarcomas. J Pathol Clin Res. 2021 Jul;7(4):338-349. doi: 10.1002/cjp2.210. Epub 2021 Apr 09. PMID: 33837665; PMCID: PMC8185364.
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