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Showing 121 to 122 of 122 entries
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Defining Properly Collected Urine: Thresholds to Improve the Accuracy of Urinalysis for Microscopic Hematuria Evaluation in Women.

The Journal of urology

Chen A, Caron A, Jackson NJ, Kanji F, Kuhlmann P, Le CH, Eilber KS, Anger JT, Ackerman AL.
PMID: 34544262
J Urol. 2022 Feb;207(2):385-391. doi: 10.1097/JU.0000000000002200. Epub 2021 Sep 21.

PURPOSE: Microscopic hematuria is one of the most common office consults for urologists. While revised guidelines have risk-stratified patients to reduce unnecessary screening, they do not provide guidance concerning specimen quality. We sought to define "properly collected" specimens using...

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.

ACS central science

Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA.
PMID: 34079898
ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30.

Transcriptional coregulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic loss-of-function studies have recently implicated the transcriptional coactivator, ENL, as a selective requirement for the survival of acute leukemia...

Showing 121 to 122 of 122 entries