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Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects.

Bioorganic chemistry

Amin NH, Hamed MIA, Abdel-Fattah MM, Abusabaa AHA, El-Saadi MT.
PMID: 34619468
Bioorg Chem. 2021 Nov;116:105394. doi: 10.1016/j.bioorg.2021.105394. Epub 2021 Sep 30.

Novel diarylpyrazole (5a-d, 6a-e, 12, 13, 14, 15a-c and 11a-g) derivatives were designed, synthesized and evaluated for their dual COX-2/sEH inhibitory activities via recombinant enzyme assays to explore their anti-inflammatory activities and cardiovascular safety profiles. Comprehensively, the structures of...

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Amin NH, Hamed MIA, Abdel-Fattah MM, et al. Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects. Bioorg Chem. 2021;116:105394doi: 10.1016/j.bioorg.2021.105394.
Amin, N. H., Hamed, M. I. A., Abdel-Fattah, M. M., Abusabaa, A. H. A., & El-Saadi, M. T. (2021). Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects. Bioorganic chemistry, 116105394. https://doi.org/10.1016/j.bioorg.2021.105394
Amin, Noha H, et al. "Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects." Bioorganic chemistry vol. 116 (2021): 105394. doi: https://doi.org/10.1016/j.bioorg.2021.105394
Amin NH, Hamed MIA, Abdel-Fattah MM, Abusabaa AHA, El-Saadi MT. Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects. Bioorg Chem. 2021 Nov;116:105394. doi: 10.1016/j.bioorg.2021.105394. Epub 2021 Sep 30. PMID: 34619468.
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Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals.

Chemico-biological interactions

Sayed AM, Abdel-Fattah MM, Arab HH, Mohamed WR, Hassanein EHM.
PMID: 34737150
Chem Biol Interact. 2021 Oct 29;351:109732. doi: 10.1016/j.cbi.2021.109732. Epub 2021 Oct 29.

AIMS: The use of methotrexate (MTX), a classical immunosuppressant and anti-cancer agent, is associated with multiple organ toxicities, including the intestinal injury. Components of the renin-angiotensin system are expressed in the intestinal epithelium and mucosal immune cells where they...

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Sayed AM, Abdel-Fattah MM, Arab HH, et al. Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals. Chem Biol Interact. 2021;351:109732doi: 10.1016/j.cbi.2021.109732.
Sayed, A. M., Abdel-Fattah, M. M., Arab, H. H., Mohamed, W. R., & Hassanein, E. H. M. (2021). Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals. Chemico-biological interactions, 351109732. https://doi.org/10.1016/j.cbi.2021.109732
Sayed, Ahmed M, et al. "Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals." Chemico-biological interactions vol. 351 (2021): 109732. doi: https://doi.org/10.1016/j.cbi.2021.109732
Sayed AM, Abdel-Fattah MM, Arab HH, Mohamed WR, Hassanein EHM. Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals. Chem Biol Interact. 2021 Oct 29;351:109732. doi: 10.1016/j.cbi.2021.109732. Epub 2021 Oct 29. PMID: 34737150.
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Diffusiophoretic Focusing of Suspended Colloids.

Physical review letters

Shi N, Nery-Azevedo R, Abdel-Fattah AI, Squires TM.
PMID: 28036214
Phys Rev Lett. 2016 Dec 16;117(25):258001. doi: 10.1103/PhysRevLett.117.258001. Epub 2016 Dec 15.

Using a microfluidic system to impose and maintain controlled, steady-state multicomponent pH and electrolyte gradients, we present systems where the diffusiophoretic migration of suspended colloids leads them to focus at a particular position, even in steady-state gradients. We show...

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Shi N, Nery-Azevedo R, Abdel-Fattah AI, et al. Diffusiophoretic Focusing of Suspended Colloids. Phys Rev Lett. 2016;117(25):258001doi: 10.1103/PhysRevLett.117.258001.
Shi, N., Nery-Azevedo, R., Abdel-Fattah, A. I., & Squires, T. M. (2016). Diffusiophoretic Focusing of Suspended Colloids. Physical review letters, 117(25), 258001. https://doi.org/10.1103/PhysRevLett.117.258001
Shi, Nan, et al. "Diffusiophoretic Focusing of Suspended Colloids." Physical review letters vol. 117,25 (2016): 258001. doi: https://doi.org/10.1103/PhysRevLett.117.258001
Shi N, Nery-Azevedo R, Abdel-Fattah AI, Squires TM. Diffusiophoretic Focusing of Suspended Colloids. Phys Rev Lett. 2016 Dec 16;117(25):258001. doi: 10.1103/PhysRevLett.117.258001. Epub 2016 Dec 15. PMID: 28036214.
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Efficient conversion of sulfones into beta-keto sulfones by N-acylbenzotriazoles.

The Journal of organic chemistry

Katritzky AR, Abdel-Fattah AA, Wang M.
PMID: 12585885
J Org Chem. 2003 Feb 21;68(4):1443-6. doi: 10.1021/jo026636l.

Acyclic sulfones 4a-f and alicyclic sulfone 7 react with readily available N-acylbenzotriazoles 3a-g (derived from aliphatic, aromatic, and heteroaromatic carboxylic acids) to provide the corresponding beta-keto sulfones 5a-n and 8a-c, respectively, in good to excellent yields.

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Katritzky AR, Abdel-Fattah AA, Wang M. Efficient conversion of sulfones into beta-keto sulfones by N-acylbenzotriazoles. J Org Chem. 2003;68(4):1443-6doi: 10.1021/jo026636l.
Katritzky, A. R., Abdel-Fattah, A. A., & Wang, M. (2003). Efficient conversion of sulfones into beta-keto sulfones by N-acylbenzotriazoles. The Journal of organic chemistry, 68(4), 1443-6. https://doi.org/10.1021/jo026636l
Katritzky, Alan R, et al. "Efficient conversion of sulfones into beta-keto sulfones by N-acylbenzotriazoles." The Journal of organic chemistry vol. 68,4 (2003): 1443-6. doi: https://doi.org/10.1021/jo026636l
Katritzky AR, Abdel-Fattah AA, Wang M. Efficient conversion of sulfones into beta-keto sulfones by N-acylbenzotriazoles. J Org Chem. 2003 Feb 21;68(4):1443-6. doi: 10.1021/jo026636l. PMID: 12585885.
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Rasmussen's pseudoaneurysm- case report.

Respiratory medicine case reports

Albogami S, Touman AA.
PMID: 30181948
Respir Med Case Rep. 2018 Aug 25;25:150-153. doi: 10.1016/j.rmcr.2018.08.017. eCollection 2018.

BACKGROUND: Pulmonary aneurysms and pseudoaneurysms have various etiologies; however, the term Rasmussen's pseudoaneurysm refers specifically to a focal dilatation of a branch of the pulmonary artery into adjacent tuberculous cavity. The incidence of such tuberculosis related pulmonary vascular complication...

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Albogami S, Touman AA. Rasmussen's pseudoaneurysm- case report. Respir Med Case Rep. 2018;25:150-153doi: 10.1016/j.rmcr.2018.08.017.
Albogami, S., & Touman, A. A. (2018). Rasmussen's pseudoaneurysm- case report. Respiratory medicine case reports, 25150-153. https://doi.org/10.1016/j.rmcr.2018.08.017
Albogami, Saeed, and Touman, Abdelfattah A. "Rasmussen's pseudoaneurysm- case report." Respiratory medicine case reports vol. 25 (2018): 150-153. doi: https://doi.org/10.1016/j.rmcr.2018.08.017
Albogami S, Touman AA. Rasmussen's pseudoaneurysm- case report. Respir Med Case Rep. 2018 Aug 25;25:150-153. doi: 10.1016/j.rmcr.2018.08.017. eCollection 2018. PMID: 30181948; PMCID: PMC6120435.
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Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks.

Research (Washington, D.C.)

Mishriki S, Abdel Fattah AR, Kammann T, Sahu RP, Geng F, Puri IK.
PMID: 31549098
Research (Wash D C). 2019 Feb 04;2019:9854593. doi: 10.34133/2019/9854593. eCollection 2019.

A contactless label-free method using a diamagnetophoretic ink to rapidly print three-dimensional (3D) scaffold-free multicellular structures is described. The inks consist of MCF-7 cells that are suspended in a culture medium to which a paramagnetic salt, diethylenetriaminepentaacetic acid gadolinium...

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Mishriki S, Abdel Fattah AR, Kammann T, et al. Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks. Research (Wash D C). 2019;2019:9854593doi: 10.34133/2019/9854593.
Mishriki, S., Abdel Fattah, A. R., Kammann, T., Sahu, R. P., Geng, F., & Puri, I. K. (2019). Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks. Research (Washington, D.C.), 20199854593. https://doi.org/10.34133/2019/9854593
Mishriki, S, et al. "Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks." Research (Washington, D.C.) vol. 2019 (2019): 9854593. doi: https://doi.org/10.34133/2019/9854593
Mishriki S, Abdel Fattah AR, Kammann T, Sahu RP, Geng F, Puri IK. Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks. Research (Wash D C). 2019 Feb 04;2019:9854593. doi: 10.34133/2019/9854593. eCollection 2019. PMID: 31549098; PMCID: PMC6750075.
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Molecular Assembly of Surfactant Mixtures in Oil-Swollen Micelles: Implications for High Salinity Colloidal Stability.

The journal of physical chemistry. B

Chen H, Gizzatov A, Abdel-Fattah AI.
PMID: 31887039
J Phys Chem B. 2020 Jan 23;124(3):568-576. doi: 10.1021/acs.jpcb.9b09929. Epub 2020 Jan 10.

Alkylbenzene sulfonates are one of the most important synthetic surfactant families, considering their wide applicability, cost-effectiveness, and overall consumption levels. Nevertheless, their low salt tolerance (especially divalent ion contents) prevented their wider applications such as enhanced oil recovery in...

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Chen H, Gizzatov A, Abdel-Fattah AI. Molecular Assembly of Surfactant Mixtures in Oil-Swollen Micelles: Implications for High Salinity Colloidal Stability. J Phys Chem B. 2020;124(3):568-576doi: 10.1021/acs.jpcb.9b09929.
Chen, H., Gizzatov, A., & Abdel-Fattah, A. I. (2020). Molecular Assembly of Surfactant Mixtures in Oil-Swollen Micelles: Implications for High Salinity Colloidal Stability. The journal of physical chemistry. B, 124(3), 568-576. https://doi.org/10.1021/acs.jpcb.9b09929
Chen, Hsieh, et al. "Molecular Assembly of Surfactant Mixtures in Oil-Swollen Micelles: Implications for High Salinity Colloidal Stability." The journal of physical chemistry. B vol. 124,3 (2020): 568-576. doi: https://doi.org/10.1021/acs.jpcb.9b09929
Chen H, Gizzatov A, Abdel-Fattah AI. Molecular Assembly of Surfactant Mixtures in Oil-Swollen Micelles: Implications for High Salinity Colloidal Stability. J Phys Chem B. 2020 Jan 23;124(3):568-576. doi: 10.1021/acs.jpcb.9b09929. Epub 2020 Jan 10. PMID: 31887039.
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Association analysis of resistance to cereal cyst nematodes (.

Breeding science

Dababat AA, Ferney GH, Erginbas-Orakci G, Dreisigacker S, Imren M, Toktay H, Elekcioglu HI, Mekete T, Nicol JM, Ansari O, Ogbonnaya F.
PMID: 28163585
Breed Sci. 2016 Dec;66(5):692-702. doi: 10.1270/jsbbs.15158. Epub 2016 Oct 25.

To identify loci linked to nematode resistance genes, a total of 126 of CIMMYT advanced spring wheat lines adapted to semi-arid conditions were screened for resistance to

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Dababat AA, Ferney GH, Erginbas-Orakci G, et al. Association analysis of resistance to cereal cyst nematodes (. Breed Sci. 2016;66(5):692-702doi: 10.1270/jsbbs.15158.
Dababat, A. A., Ferney, G. H., Erginbas-Orakci, G., Dreisigacker, S., Imren, M., Toktay, H., Elekcioglu, H. I., Mekete, T., Nicol, J. M., Ansari, O., & Ogbonnaya, F. (2016). Association analysis of resistance to cereal cyst nematodes (. Breeding science, 66(5), 692-702. https://doi.org/10.1270/jsbbs.15158
Dababat, Abdelfattah A, et al. "Association analysis of resistance to cereal cyst nematodes (." Breeding science vol. 66,5 (2016): 692-702. doi: https://doi.org/10.1270/jsbbs.15158
Dababat AA, Ferney GH, Erginbas-Orakci G, Dreisigacker S, Imren M, Toktay H, Elekcioglu HI, Mekete T, Nicol JM, Ansari O, Ogbonnaya F. Association analysis of resistance to cereal cyst nematodes (. Breed Sci. 2016 Dec;66(5):692-702. doi: 10.1270/jsbbs.15158. Epub 2016 Oct 25. PMID: 28163585; PMCID: PMC5282747.
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Author Correction: Kilohertz frame-rate two-photon tomography.

Nature methods

Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K.
PMID: 31388143
Nat Methods. 2019 Sep;16(9):932. doi: 10.1038/s41592-019-0545-1.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Kazemipour A, Novak O, Flickinger D, et al. Author Correction: Kilohertz frame-rate two-photon tomography. Nat Methods. 2019;16(9):932doi: 10.1038/s41592-019-0545-1.
Kazemipour, A., Novak, O., Flickinger, D., Marvin, J. S., Abdelfattah, A. S., King, J., Borden, P. M., Kim, J. J., Al-Abdullatif, S. H., Deal, P. E., Miller, E. W., Schreiter, E. R., Druckmann, S., Svoboda, K., Looger, L. L., & Podgorski, K. (2019). Author Correction: Kilohertz frame-rate two-photon tomography. Nature methods, 16(9), 932. https://doi.org/10.1038/s41592-019-0545-1
Kazemipour, Abbas, et al. "Author Correction: Kilohertz frame-rate two-photon tomography." Nature methods vol. 16,9 (2019): 932. doi: https://doi.org/10.1038/s41592-019-0545-1
Kazemipour A, Novak O, Flickinger D, Marvin JS, Abdelfattah AS, King J, Borden PM, Kim JJ, Al-Abdullatif SH, Deal PE, Miller EW, Schreiter ER, Druckmann S, Svoboda K, Looger LL, Podgorski K. Author Correction: Kilohertz frame-rate two-photon tomography. Nat Methods. 2019 Sep;16(9):932. doi: 10.1038/s41592-019-0545-1. PMID: 31388143.
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Biodegradation of feather waste by keratinase produced from newly isolated .

Journal, genetic engineering & biotechnology

Abdel-Fattah AM, El-Gamal MS, Ismail SA, Emran MA, Hashem AM.
PMID: 30733740
J Genet Eng Biotechnol. 2018 Dec;16(2):311-318. doi: 10.1016/j.jgeb.2018.05.005. Epub 2018 May 28.

Keratinase are proteolytic enzymes which have gained much attention to convert keratinous wastes that cause huge environmental pollution problems. Ten microbial isolates were screened for their keratinase production. The most potent isolate produce 25.2 U/ml under static condition and...

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Abdel-Fattah AM, El-Gamal MS, Ismail SA, et al. Biodegradation of feather waste by keratinase produced from newly isolated . J Genet Eng Biotechnol. 2018;16(2):311-318doi: 10.1016/j.jgeb.2018.05.005.
Abdel-Fattah, A. M., El-Gamal, M. S., Ismail, S. A., Emran, M. A., & Hashem, A. M. (2018). Biodegradation of feather waste by keratinase produced from newly isolated . Journal, genetic engineering & biotechnology, 16(2), 311-318. https://doi.org/10.1016/j.jgeb.2018.05.005
Abdel-Fattah, Azza M, et al. "Biodegradation of feather waste by keratinase produced from newly isolated ." Journal, genetic engineering & biotechnology vol. 16,2 (2018): 311-318. doi: https://doi.org/10.1016/j.jgeb.2018.05.005
Abdel-Fattah AM, El-Gamal MS, Ismail SA, Emran MA, Hashem AM. Biodegradation of feather waste by keratinase produced from newly isolated . J Genet Eng Biotechnol. 2018 Dec;16(2):311-318. doi: 10.1016/j.jgeb.2018.05.005. Epub 2018 May 28. PMID: 30733740; PMCID: PMC6353909.
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Biological activities of lactobacilli relevant to cardiovascular health in skim milk.

Food science and biotechnology

Abd El-Fattah A, Sakr S, El-Dieb SM, Elkashef H.
PMID: 30263698
Food Sci Biotechnol. 2017 Dec 22;26(6):1613-1623. doi: 10.1007/s10068-017-0219-7. eCollection 2017.

In this study, skim milk was fermented using 14

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Abd El-Fattah A, Sakr S, El-Dieb SM, et al. Biological activities of lactobacilli relevant to cardiovascular health in skim milk. Food Sci Biotechnol. 2017;26(6):1613-1623doi: 10.1007/s10068-017-0219-7.
Abd El-Fattah, A., Sakr, S., El-Dieb, S. M., & Elkashef, H. (2017). Biological activities of lactobacilli relevant to cardiovascular health in skim milk. Food science and biotechnology, 26(6), 1613-1623. https://doi.org/10.1007/s10068-017-0219-7
Abd El-Fattah, Alaa, et al. "Biological activities of lactobacilli relevant to cardiovascular health in skim milk." Food science and biotechnology vol. 26,6 (2017): 1613-1623. doi: https://doi.org/10.1007/s10068-017-0219-7
Abd El-Fattah A, Sakr S, El-Dieb SM, Elkashef H. Biological activities of lactobacilli relevant to cardiovascular health in skim milk. Food Sci Biotechnol. 2017 Dec 22;26(6):1613-1623. doi: 10.1007/s10068-017-0219-7. eCollection 2017. PMID: 30263698; PMCID: PMC6049713.
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Transcriptomic Response of Resistant (PI613981-.

Frontiers in plant science

Ballester AR, Norelli J, Burchard E, Abdelfattah A, Levin E, González-Candelas L, Droby S, Wisniewski M.
PMID: 29201037
Front Plant Sci. 2017 Nov 16;8:1981. doi: 10.3389/fpls.2017.01981. eCollection 2017.

No abstract available.

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Ballester AR, Norelli J, Burchard E, et al. Transcriptomic Response of Resistant (PI613981-. Front Plant Sci. 2017;8:1981doi: 10.3389/fpls.2017.01981.
Ballester, A. R., Norelli, J., Burchard, E., Abdelfattah, A., Levin, E., González-Candelas, L., Droby, S., & Wisniewski, M. (2017). Transcriptomic Response of Resistant (PI613981-. Frontiers in plant science, 81981. https://doi.org/10.3389/fpls.2017.01981
Ballester, Ana-Rosa, et al. "Transcriptomic Response of Resistant (PI613981-." Frontiers in plant science vol. 8 (2017): 1981. doi: https://doi.org/10.3389/fpls.2017.01981
Ballester AR, Norelli J, Burchard E, Abdelfattah A, Levin E, González-Candelas L, Droby S, Wisniewski M. Transcriptomic Response of Resistant (PI613981-. Front Plant Sci. 2017 Nov 16;8:1981. doi: 10.3389/fpls.2017.01981. eCollection 2017. PMID: 29201037; PMCID: PMC5696741.
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