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Showing 13 to 24 of 37 entries
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Validation of a UV Spectrometric Method for the Assay of Tolfenamic Acid in Organic Solvents.

Journal of pharmaceutics

Ahmed S, Mustaan N, Sheraz MA, Nabi SA, Ahmad I.
PMID: 26783497
J Pharm (Cairo). 2015;2015:216249. doi: 10.1155/2015/216249. Epub 2015 Dec 10.

The present study has been carried out to validate a UV spectrometric method for the assay of tolfenamic acid (TA) in organic solvents. TA is insoluble in water; therefore, a total of thirteen commonly used organic solvents have been...

Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-κB Signaling.

Biomolecules & therapeutics

Shao HJ, Lou Z, Jeong JB, Kim KJ, Lee J, Lee SH.
PMID: 25593642
Biomol Ther (Seoul). 2015 Jan;23(1):39-44. doi: 10.4062/biomolther.2014.088. Epub 2015 Jan 01.

Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-κB) is a sequence-specific transcription factor and plays a key role in the development and...

Crystal structures of tolfenamic acid polymorphic forms I and II with precise hydrogen-atom positions for nuclear magnetic resonance studies.

Acta crystallographica. Section E, Crystallographic communications

Blade H, Blundell CD, Vitorica-Yrezabal IJ.
PMID: 32939293
Acta Crystallogr E Crystallogr Commun. 2020 Aug 11;76:1421-1426. doi: 10.1107/S2056989020010841. eCollection 2020 Sep 01.

The structures of tolfenamic acid [TFA; 2-(3-chloro-2-methyl-anilino)benzoic acid, C

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses.

The Science of the total environment

Chandramohan S, Mallord JW, Mathesh K, Sharma AK, Mahendran K, Kesavan M, Gupta R, Chutia K, Pawde A, Prakash NV, Ravichandran P, Saikia D, Shringarpure R, Timung A, Galligan TH, Green RE, Prakash VM.
PMID: 34861305
Sci Total Environ. 2021 Nov 30;809:152088. doi: 10.1016/j.scitotenv.2021.152088. Epub 2021 Nov 30.

Population declines of Gyps vultures across the Indian subcontinent were caused by unintentional poisoning by the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Subsequently, a number of other NSAIDs have been identified as toxic to vultures, while one, meloxicam, is safe...

PrbP modulates biofilm formation in Liberibacter crescens.

Environmental microbiology

Pan L, Gardner CL, Beliakoff R, da Silva D, Zuo R, Pagliai FA, Padgett-Pagliai KA, Merli ML, Bahadiroglu E, Gonzalez CF, Lorca GL.
PMID: 34431209
Environ Microbiol. 2021 Nov;23(11):7121-7138. doi: 10.1111/1462-2920.15740. Epub 2021 Sep 07.

In Liberibacter asiaticus, PrbP is a transcriptional regulatory protein involved in survival and persistence during host infection. Tolfenamic acid was previously found to inhibit interactions between PrbP and the promotor region of rplK, resulting in reduced survival of L....

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.

Acta pharmacologica Sinica

Zhu ZY, Liu YD, Gong Y, Jin W, Topchiy E, Turdi S, Gao YF, Culver B, Wang SY, Ge W, Zha WL, Ren J, Pei ZH, Qin X.
PMID: 33767380
Acta Pharmacol Sin. 2021 Mar 25; doi: 10.1038/s41401-021-00635-2. Epub 2021 Mar 25.

Alzheimer's disease (AD) is associated with high incidence of cardiovascular events but the mechanism remains elusive. Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase (ALDH2) activity in elderly AD patients. In the...

Solvates of selected fenamic acids with substituted pyridines: structure, thermal stability and desolvation.

Acta crystallographica Section B, Structural science, crystal engineering and materials

Bouanga Boudiombo JS, Jacobs A.
PMID: 27910834
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2016 Dec 01;72:836-845. doi: 10.1107/S2052520616014128. Epub 2016 Nov 05.

Mefenamic acid (MA) formed solvates with 2-picoline (2PIC), 3-picoline (3PIC), 4-picoline (4PIC) and 3-chloropyridine (3CLPYR). The solvates crystallized in the space group P\bar 1 with the carboxylic acid of MA hydrogen-bonded to the nitrogen of the substituted pyridine. Tolfenamic...

Drug Repurposing: Tolfenamic Acid Inactivates PrbP, a Transcriptional Accessory Protein in .

Frontiers in microbiology

Gardner CL, Pagliai FA, Pan L, Bojilova L, Torino MI, Lorca GL, Gonzalez CF.
PMID: 27803694
Front Microbiol. 2016 Oct 18;7:1630. doi: 10.3389/fmicb.2016.01630. eCollection 2016.

CLIBASIA_01510, PrbP, is a predicted RNA polymerase binding protein in

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses.

The Science of the total environment

Chandramohan S, Mallord JW, Mathesh K, Sharma AK, Mahendran K, Kesavan M, Gupta R, Chutia K, Pawde A, Prakash NV, Ravichandran P, Saikia D, Shringarpure R, Timung A, Galligan TH, Green RE, Prakash VM.
PMID: 34861305
Sci Total Environ. 2021 Nov 30;809:152088. doi: 10.1016/j.scitotenv.2021.152088. Epub 2021 Nov 30.

Population declines of Gyps vultures across the Indian subcontinent were caused by unintentional poisoning by the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Subsequently, a number of other NSAIDs have been identified as toxic to vultures, while one, meloxicam, is safe...

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis.

Acta pharmacologica Sinica

Zhu ZY, Liu YD, Gong Y, Jin W, Topchiy E, Turdi S, Gao YF, Culver B, Wang SY, Ge W, Zha WL, Ren J, Pei ZH, Qin X.
PMID: 33767380
Acta Pharmacol Sin. 2022 Jan;43(1):39-49. doi: 10.1038/s41401-021-00635-2. Epub 2021 Mar 25.

Alzheimer's disease (AD) is associated with high incidence of cardiovascular events but the mechanism remains elusive. Our previous study reveals a tight correlation between cardiac dysfunction and low mitochondrial aldehyde dehydrogenase (ALDH2) activity in elderly AD patients. In the...

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses.

The Science of the total environment

Chandramohan S, Mallord JW, Mathesh K, Sharma AK, Mahendran K, Kesavan M, Gupta R, Chutia K, Pawde A, Prakash NV, Ravichandran P, Saikia D, Shringarpure R, Timung A, Galligan TH, Green RE, Prakash VM.
PMID: 34861305
Sci Total Environ. 2021 Nov 30;809:152088. doi: 10.1016/j.scitotenv.2021.152088. Epub 2021 Nov 30.

Population declines of Gyps vultures across the Indian subcontinent were caused by unintentional poisoning by the non-steroidal anti-inflammatory drug (NSAID) diclofenac. Subsequently, a number of other NSAIDs have been identified as toxic to vultures, while one, meloxicam, is safe...

Synthesis, characterization and (in vitro and in silico) biological activity of a series of dioxouranium(VI) complexes with non-steroidal anti-inflammatory drugs.

Journal of inorganic biochemistry

Perontsis S, Chasapis CT, Hatzidimitriou AG, Psomas G.
PMID: 34273715
J Inorg Biochem. 2021 Oct;223:111534. doi: 10.1016/j.jinorgbio.2021.111534. Epub 2021 Jul 09.

The reaction of the dioxouranium(VI) ion with a series of non-steroidal anti-inflammatory drugs (NSAIDs), namely mefenamic acid, indomethacin, diclofenac, diflunisal and tolfenamic acid, as ligands in the absence or presence of diverse N,N'-donors (1,10-phenanthroline,2,2'-bipyridine or 2,2'-bipyridylamine) as co-ligands led...

Showing 13 to 24 of 37 entries