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Correction.

Xenobiotica; the fate of foreign compounds in biological systems

[No authors listed]
PMID: 32981447
Xenobiotica. 2021 Feb;51(2):249. doi: 10.1080/00498254.2020.1828541. Epub 2020 Sep 28.

No abstract available.

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Correction. Xenobiotica. 2020;51(2):249doi: 10.1080/00498254.2020.1828541.
(2021). Correction. Xenobiotica; the fate of foreign compounds in biological systems, 51(2), 249. https://doi.org/10.1080/00498254.2020.1828541
"Correction." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,2 (2021): 249. doi: https://doi.org/10.1080/00498254.2020.1828541
Correction. Xenobiotica. 2021 Feb;51(2):249. doi: 10.1080/00498254.2020.1828541. Epub 2020 Sep 28. PMID: 32981447.
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[No title available]

Xenobiotica; the fate of foreign compounds in biological systems

Säll C, Fogt Hjorth C.
PMID: 34913834
Xenobiotica. 2021 Dec 29;1-15. doi: 10.1080/00498254.2021.2018628. Epub 2021 Dec 29.

1. NDec is a novel, oral, fixed-dose formulation of decitabine and tetrahydrouridine that is currently being developed for the treatment of patients with sickle cell disease. Here, we examine the potential for both components of NDec to interact with...

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Säll C, Fogt Hjorth C. . Xenobiotica. 2021;1-15doi: 10.1080/00498254.2021.2018628.
Säll, C., & Fogt Hjorth, C. (2021). . Xenobiotica; the fate of foreign compounds in biological systems, 1-15. https://doi.org/10.1080/00498254.2021.2018628
Säll, Carolina, and Fogt Hjorth, Christian. "." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-15. doi: https://doi.org/10.1080/00498254.2021.2018628
Säll C, Fogt Hjorth C. . Xenobiotica. 2021 Dec 29;1-15. doi: 10.1080/00498254.2021.2018628. Epub 2021 Dec 29. PMID: 34913834.
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Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes.

Xenobiotica; the fate of foreign compounds in biological systems

Nakamura S, Yamashita R, Miyauchi Y, Tanaka Y, Ishii Y.
PMID: 34727004
Xenobiotica. 2021 Nov;51(11):1247-1254. doi: 10.1080/00498254.2021.2001075. Epub 2021 Nov 11.

Adenine-related compounds are allosteric inhibitors of UDP-glucuronosyltransferase (UGT) in rat liver microsomes (RLM) and human UGT isoforms treated with detergent or pore-forming peptide, alamethicin.To clarify whether the same is true beyond species, the effects of adenine-related compounds on 4-methylumbelliferone...

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Nakamura S, Yamashita R, Miyauchi Y, et al. Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica. 2021;51(11):1247-1254doi: 10.1080/00498254.2021.2001075.
Nakamura, S., Yamashita, R., Miyauchi, Y., Tanaka, Y., & Ishii, Y. (2021). Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1247-1254. https://doi.org/10.1080/00498254.2021.2001075
Nakamura, Shoji, et al. "Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1247-1254. doi: https://doi.org/10.1080/00498254.2021.2001075
Nakamura S, Yamashita R, Miyauchi Y, Tanaka Y, Ishii Y. Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica. 2021 Nov;51(11):1247-1254. doi: 10.1080/00498254.2021.2001075. Epub 2021 Nov 11. PMID: 34727004.
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Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from .

Xenobiotica; the fate of foreign compounds in biological systems

Niwa T, Arima J, Michihiro Y.
PMID: 34605737
Xenobiotica. 2021 Nov;51(11):1229-1235. doi: 10.1080/00498254.2021.1989520. Epub 2021 Oct 14.

The effects of psychotropic agents such as fluvoxamine, fluoxetine, paroxetine, milnacipran, and fluphenazine on dopamine formation from

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Niwa T, Arima J, Michihiro Y. Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from . Xenobiotica. 2021;51(11):1229-1235doi: 10.1080/00498254.2021.1989520.
Niwa, T., Arima, J., & Michihiro, Y. (2021). Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from . Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1229-1235. https://doi.org/10.1080/00498254.2021.1989520
Niwa, Toshiro, et al. "Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from ." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1229-1235. doi: https://doi.org/10.1080/00498254.2021.1989520
Niwa T, Arima J, Michihiro Y. Role of amino acids at positions 34, 296, and 486 of cytochrome P450 2D6 in the stimulatory and inhibitory effects of psychotropic agents on dopamine formation from . Xenobiotica. 2021 Nov;51(11):1229-1235. doi: 10.1080/00498254.2021.1989520. Epub 2021 Oct 14. PMID: 34605737.
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Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review.

Xenobiotica; the fate of foreign compounds in biological systems

Dos Santos SP, Morissugui SS, Gimenez Martins APD, Fernandes GMM, Russo A, Galbiatti-Dias ALS, Castanhole-Nunes MMU, Francisco JLE, Pavarino ÉC, Goloni-Bertollo EM.
PMID: 34096444
Xenobiotica. 2021 Nov;51(11):1326-1334. doi: 10.1080/00498254.2021.1938291. Epub 2021 Nov 02.

The study was conducted to evaluate the frequency of polymorphisms in

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Dos Santos SP, Morissugui SS, Gimenez Martins APD, et al. Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review. Xenobiotica. 2021;51(11):1326-1334doi: 10.1080/00498254.2021.1938291.
Dos Santos, S. P., Morissugui, S. S., Gimenez Martins, A. P. D., Fernandes, G. M. M., Russo, A., Galbiatti-Dias, A. L. S., Castanhole-Nunes, M. M. U., Francisco, J. L. E., Pavarino, �. �. C., & Goloni-Bertollo, E. M. (2021). Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review. Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1326-1334. https://doi.org/10.1080/00498254.2021.1938291
Dos Santos, Stéphanie Piacenti, et al. "Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1326-1334. doi: https://doi.org/10.1080/00498254.2021.1938291
Dos Santos SP, Morissugui SS, Gimenez Martins APD, Fernandes GMM, Russo A, Galbiatti-Dias ALS, Castanhole-Nunes MMU, Francisco JLE, Pavarino ÉC, Goloni-Bertollo EM. Evaluation of molecular markers GSTM1 and GSTT1 and clinical factors in breast cancer: case-control study and literature review. Xenobiotica. 2021 Nov;51(11):1326-1334. doi: 10.1080/00498254.2021.1938291. Epub 2021 Nov 02. PMID: 34096444.
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The Metabolism and Excretion of the Dipeptidyl Peptidase 4 Inhibitor [.

Xenobiotica; the fate of foreign compounds in biological systems

Lu J, Bian Y, Zhang H, Tang D, Tian X, Zhou X, Xu Z, Xiong Y, Gu Z, Yu Z, Wang T, Ding J, Yu Q, Ding J.
PMID: 34743655
Xenobiotica. 2021 Nov 07;1-12. doi: 10.1080/00498254.2021.2002973. Epub 2021 Nov 07.

1. The metabolism and excretion of cetagliptin were investigated in healthy male subjects after a single oral dose of 100mg/50μCi [

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Lu J, Bian Y, Zhang H, et al. The Metabolism and Excretion of the Dipeptidyl Peptidase 4 Inhibitor [. Xenobiotica. 2021;1-12doi: 10.1080/00498254.2021.2002973.
Lu, J., Bian, Y., Zhang, H., Tang, D., Tian, X., Zhou, X., Xu, Z., Xiong, Y., Gu, Z., Yu, Z., Wang, T., Ding, J., Yu, Q., & Ding, J. (2021). The Metabolism and Excretion of the Dipeptidyl Peptidase 4 Inhibitor [. Xenobiotica; the fate of foreign compounds in biological systems, 1-12. https://doi.org/10.1080/00498254.2021.2002973
Lu, Jinmiao, et al. "The Metabolism and Excretion of the Dipeptidyl Peptidase 4 Inhibitor [." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-12. doi: https://doi.org/10.1080/00498254.2021.2002973
Lu J, Bian Y, Zhang H, Tang D, Tian X, Zhou X, Xu Z, Xiong Y, Gu Z, Yu Z, Wang T, Ding J, Yu Q, Ding J. The Metabolism and Excretion of the Dipeptidyl Peptidase 4 Inhibitor [. Xenobiotica. 2021 Nov 07;1-12. doi: 10.1080/00498254.2021.2002973. Epub 2021 Nov 07. PMID: 34743655.
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Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine .

Xenobiotica; the fate of foreign compounds in biological systems

Li Y, Wang Y, Zhang N, Zhou S, Peng Y, Zheng J.
PMID: 34160341
Xenobiotica. 2021 Nov;51(11):1303-1317. doi: 10.1080/00498254.2021.1946204. Epub 2021 Nov 03.

Venlafaxine (VLF), an antidepressant agent, is widely used to combat major depressive disorders, particularly for the treatment of selective serotonin reuptake inhibitor-resistant depression. VLF has been shown to cause liver injury. The present study aimed to investigate the metabolic...

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Li Y, Wang Y, Zhang N, et al. Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine . Xenobiotica. 2021;51(11):1303-1317doi: 10.1080/00498254.2021.1946204.
Li, Y., Wang, Y., Zhang, N., Zhou, S., Peng, Y., & Zheng, J. (2021). Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine . Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1303-1317. https://doi.org/10.1080/00498254.2021.1946204
Li, Yilin, et al. "Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine ." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1303-1317. doi: https://doi.org/10.1080/00498254.2021.1946204
Li Y, Wang Y, Zhang N, Zhou S, Peng Y, Zheng J. Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine . Xenobiotica. 2021 Nov;51(11):1303-1317. doi: 10.1080/00498254.2021.1946204. Epub 2021 Nov 03. PMID: 34160341.
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Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of .

Xenobiotica; the fate of foreign compounds in biological systems

Song H, Bai W, Sun X, Qiu B, Guo N, Guo C, Hu Y, Dong Z.
PMID: 34979850
Xenobiotica. 2022 Jan 03;1-7. doi: 10.1080/00498254.2021.2023913. Epub 2022 Jan 03.

The aim of this study was to evaluate the impact of genetic polymorphisms in the pharmacokinetics of metabolism and transportation of lenvatinib in the Chinese population.Sixty-three healthy Chinese individuals were recruited and administered with a single dose of 4...

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Song H, Bai W, Sun X, et al. Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of . Xenobiotica. 2022;1-7doi: 10.1080/00498254.2021.2023913.
Song, H., Bai, W., Sun, X., Qiu, B., Guo, N., Guo, C., Hu, Y., & Dong, Z. (2022). Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of . Xenobiotica; the fate of foreign compounds in biological systems, 1-7. https://doi.org/10.1080/00498254.2021.2023913
Song, Haojing, et al. "Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ." Xenobiotica; the fate of foreign compounds in biological systems vol. (2022): 1-7. doi: https://doi.org/10.1080/00498254.2021.2023913
Song H, Bai W, Sun X, Qiu B, Guo N, Guo C, Hu Y, Dong Z. Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of . Xenobiotica. 2022 Jan 03;1-7. doi: 10.1080/00498254.2021.2023913. Epub 2022 Jan 03. PMID: 34979850.
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Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver.

Xenobiotica; the fate of foreign compounds in biological systems

Zhang Y, Sato R, Fukami T, Nakano M, Nakajima M.
PMID: 34779706
Xenobiotica. 2021 Nov 30;1-8. doi: 10.1080/00498254.2021.2007553. Epub 2021 Nov 30.

Pirfenidone is a first-line drug for the treatment of idiopathic pulmonary fibrosis. The primary metabolic pathways of pirfenidone in humans are 5-hydroxylation and subsequent oxidation to 5-carboxylpirfenidone. The aims of this study were to determine the cytochrome P450 isoforms...

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Zhang Y, Sato R, Fukami T, et al. Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica. 2021;1-8doi: 10.1080/00498254.2021.2007553.
Zhang, Y., Sato, R., Fukami, T., Nakano, M., & Nakajima, M. (2021). Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica; the fate of foreign compounds in biological systems, 1-8. https://doi.org/10.1080/00498254.2021.2007553
Zhang, Yongjie, et al. "Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-8. doi: https://doi.org/10.1080/00498254.2021.2007553
Zhang Y, Sato R, Fukami T, Nakano M, Nakajima M. Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver. Xenobiotica. 2021 Nov 30;1-8. doi: 10.1080/00498254.2021.2007553. Epub 2021 Nov 30. PMID: 34779706.
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MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages.

Xenobiotica; the fate of foreign compounds in biological systems

Lin CC, Law BF, Hettick JM.
PMID: 34775880
Xenobiotica. 2021 Dec 02;1-17. doi: 10.1080/00498254.2021.2005851. Epub 2021 Dec 02.

Occupational exposure to 4,4'-methylene diphenyl diisocyanate (MDI), the most widely used monomeric diisocyanate, is one of the leading causes of occupational asthma (OA). Previously, we identified

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Lin CC, Law BF, Hettick JM. MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages. Xenobiotica. 2021;1-17doi: 10.1080/00498254.2021.2005851.
Lin, C. C., Law, B. F., & Hettick, J. M. (2021). MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages. Xenobiotica; the fate of foreign compounds in biological systems, 1-17. https://doi.org/10.1080/00498254.2021.2005851
Lin, Chen-Chung, et al. "MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-17. doi: https://doi.org/10.1080/00498254.2021.2005851
Lin CC, Law BF, Hettick JM. MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages. Xenobiotica. 2021 Dec 02;1-17. doi: 10.1080/00498254.2021.2005851. Epub 2021 Dec 02. PMID: 34775880.
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In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor.

Xenobiotica; the fate of foreign compounds in biological systems

Ma J, Kaushik D, Yeh S, Northcutt V, Babiak J, Risher N, Weetall M, Moon YC, Welch EM, Molony L, O'Keefe K, Kong R.
PMID: 34846990
Xenobiotica. 2021 Nov 30;1-42. doi: 10.1080/00498254.2021.2010287. Epub 2021 Nov 30.

Emvododstat was identified as a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of acute myeloid leukaemia and COVID-19. The objective of this paper is to evaluate the metabolism, pharmacokinetics, and drug interaction...

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Ma J, Kaushik D, Yeh S, et al. In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor. Xenobiotica. 2021;1-42doi: 10.1080/00498254.2021.2010287.
Ma, J., Kaushik, D., Yeh, S., Northcutt, V., Babiak, J., Risher, N., Weetall, M., Moon, Y. C., Welch, E. M., Molony, L., O'Keefe, K., & Kong, R. (2021). In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor. Xenobiotica; the fate of foreign compounds in biological systems, 1-42. https://doi.org/10.1080/00498254.2021.2010287
Ma, Jiyuan, et al. "In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor." Xenobiotica; the fate of foreign compounds in biological systems vol. (2021): 1-42. doi: https://doi.org/10.1080/00498254.2021.2010287
Ma J, Kaushik D, Yeh S, Northcutt V, Babiak J, Risher N, Weetall M, Moon YC, Welch EM, Molony L, O'Keefe K, Kong R. In Vitro Metabolism, Pharmacokinetics and Drug Interaction Potentials of Emvododstat, a DHODH Inhibitor. Xenobiotica. 2021 Nov 30;1-42. doi: 10.1080/00498254.2021.2010287. Epub 2021 Nov 30. PMID: 34846990.
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Assessment of Drug-Drug Interactions of CC-90001, a Potent and Selective Inhibitor of c-Jun N-terminal Kinase.

Xenobiotica; the fate of foreign compounds in biological systems

Tong Z, Gaudy A, Tatosian D, Ramirez-Valle F, Liu H, Chen J, Hoffmann M, Surapaneni S.
PMID: 35000550
Xenobiotica. 2022 Jan 08;1-29. doi: 10.1080/00498254.2022.2027553. Epub 2022 Jan 08.

1. CC-90001 is predominantly metabolized via glucuronidation, while oxidative metabolism is a minor pathway in human hepatocytes and liver microsomes.

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Tong Z, Gaudy A, Tatosian D, et al. Assessment of Drug-Drug Interactions of CC-90001, a Potent and Selective Inhibitor of c-Jun N-terminal Kinase. Xenobiotica. 2022;1-29doi: 10.1080/00498254.2022.2027553.
Tong, Z., Gaudy, A., Tatosian, D., Ramirez-Valle, F., Liu, H., Chen, J., Hoffmann, M., & Surapaneni, S. (2022). Assessment of Drug-Drug Interactions of CC-90001, a Potent and Selective Inhibitor of c-Jun N-terminal Kinase. Xenobiotica; the fate of foreign compounds in biological systems, 1-29. https://doi.org/10.1080/00498254.2022.2027553
Tong, Zeen, et al. "Assessment of Drug-Drug Interactions of CC-90001, a Potent and Selective Inhibitor of c-Jun N-terminal Kinase." Xenobiotica; the fate of foreign compounds in biological systems vol. (2022): 1-29. doi: https://doi.org/10.1080/00498254.2022.2027553
Tong Z, Gaudy A, Tatosian D, Ramirez-Valle F, Liu H, Chen J, Hoffmann M, Surapaneni S. Assessment of Drug-Drug Interactions of CC-90001, a Potent and Selective Inhibitor of c-Jun N-terminal Kinase. Xenobiotica. 2022 Jan 08;1-29. doi: 10.1080/00498254.2022.2027553. Epub 2022 Jan 08. PMID: 35000550.
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Showing 25 to 36 of 73 entries