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Showing 6313 to 6319 of 6319 entries
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In vitro and in silico pharmaceutical activities of the methylated cyclic pentapeptide, persipeptides.

Journal of applied microbiology

Bakhtiyarizadeh M, Mohammadipanah F, Ghasemi JB.
PMID: 34297456
J Appl Microbiol. 2021 Jul 23; doi: 10.1111/jam.15231. Epub 2021 Jul 23.

AIMS: The persipeptides were recognized as a promising source of multiple pharmaceutical activities which were revealed following structure-activity prediction and examination in experimental analysis.METHODS AND RESULTS: The profile of toxicity, antioxidant, anti-inflammatory, anti-diabetic and anti-ageing activity of persipeptides and...

Hydroxychloroquine and azithromycin used alone or combined are not effective against SARS-CoV-2 ex vivo and in a hamster model.

Antiviral research

Cochin M, Touret F, Driouich JS, Moureau G, Petit PR, Laprie C, Solas C, de Lamballerie X, Nougairède A.
PMID: 34838583
Antiviral Res. 2022 Jan;197:105212. doi: 10.1016/j.antiviral.2021.105212. Epub 2021 Nov 24.

Drug repositioning has been used extensively since the beginning of the COVID-19 pandemic in an attempt to identify antiviral molecules for use in human therapeutics. Hydroxychloroquine and azithromycin have shown inhibitory activity against SARS-CoV-2 replication in different cell lines....

Natural Xanthine Oxidase Inhibitor 5-.

Molecules (Basel, Switzerland)

Zhang D, Zhao M, Li Y, Zhang D, Yang Y, Li L.
PMID: 34885887
Molecules. 2021 Dec 01;26(23). doi: 10.3390/molecules26237307.

Xanthine oxidase (XOD) inhibition has long been considered an effective anti-hyperuricemia strategy. To identify effective natural XOD inhibitors with little side effects, we performed a XOD inhibitory assay-coupled isolation of compounds from

Circulating Regulatory T Cells Expressing Tumor Necrosis Factor Receptor Type 2 Contribute to Sepsis-Induced Immunosuppression in Patients During Septic Shock.

The Journal of infectious diseases

Gaborit BJ, Chaumette T, Chauveau M, Asquier-Khati A, Roquilly A, Boutoille D, Josien R, Salomon BL, Asehnoune K.
PMID: 34019653
J Infect Dis. 2021 Dec 15;224(12):2160-2169. doi: 10.1093/infdis/jiab276.

BACKGROUND: Septic shock remains a major cause of death that can be complicated by long-term impairment in immune function. Among regulatory T (Treg) cells, the tumor necrosis factor receptor 2 positive (TNFR2pos) Treg-cell subset endorses significant immunosuppressive functions in...

Within-individual repeatability in telomere length: A meta-analysis in nonmammalian vertebrates.

Molecular ecology

Kärkkäinen T, Briga M, Laaksonen T, Stier A.
PMID: 34455645
Mol Ecol. 2021 Aug 29; doi: 10.1111/mec.16155. Epub 2021 Aug 29.

Telomere length is increasingly used as a biomarker of long-term somatic state and future survival prospects. While most studies have overlooked this aspect, biological interpretations based on a given telomere length will benefit from considering the level of within-individual...

Design and methods for a quasi-experimental pilot study to evaluate the impact of dual active ingredient insecticide-treated nets on malaria burden in five regions in sub-Saharan Africa.

Malaria journal

Gansané A, Candrinho B, Mbituyumuremyi A, Uhomoibhi P, NFalé S, Mohammed AB, Guelbeogo WM, Sanou A, Kangoye D, Debe S, Kagone M, Hakizimana E, Uwimana A, Tuyishime A, Ingabire CM, Singirankabo JH, Koenker H, Marrenjo D, Abilio AP, Salvador C, Savaio B, Okoko OO, Maikore I, Obi E, Awolola ST, Adeogun A, Babarinde D, Ali O, Guglielmo F, Yukich J, Scates S, Sherrard-Smith E, Churcher T, Fornadel C, Shannon J, Kawakyu N, Beylerian E, Digre P, Tynuv K, Gogue C, Mwesigwa J, Wagman J, Adeleke M, Adeolu AT, Robertson M.
PMID: 35012559
Malar J. 2022 Jan 10;21(1):19. doi: 10.1186/s12936-021-04026-0.

BACKGROUND: Vector control tools have contributed significantly to a reduction in malaria burden since 2000, primarily through insecticidal-treated bed nets (ITNs) and indoor residual spraying. In the face of increasing insecticide resistance in key malaria vector species, global progress...

Effects of a one-week research program on the graduate school pipeline and graduate student professional development.

Miller S, Dunn V, Swartz S, Antoine ALC.
UIID-AD: 4163
2016;

During a one-week school break in 2015 at the University of Colorado Boulder, 20 undergraduate students, paired with 20 graduate student mentors, conducted engineering research. The goal of this program was to increase retention of undergraduates in engineering as...

Showing 6313 to 6319 of 6319 entries