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Showing 553 to 558 of 558 entries
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Intrahepatic Cholestasis of Pregnancy.

Geburtshilfe und Frauenheilkunde

Jurk SM, Kremer AE, Schleussner E.
PMID: 34393257
Geburtshilfe Frauenheilkd. 2021 Aug;81(8):940-947. doi: 10.1055/a-1522-5178. Epub 2021 Aug 09.

Intrahepatic cholestasis of pregnancy (ICP) is a rare but potentially serious complication of pregnancy, the main symptom of which is intense pruritus with elevated serum levels of bile acids. The elevated serum bile acid concentration is regarded as a...

The Modulating Effect of Ursodeoxycholic Acid on Liver Tissue Cyclooxygenase-2 Expression Following Extended Hepatectomy.

Cureus

Papakonstantinou D, Paspala A, Pikoulis E, Perrea DN, Machairas A, Agrogiannis G, Machairas N, Patapis P, Zavras NJ.
PMID: 34268031
Cureus. 2021 Jun 07;13(6):e15500. doi: 10.7759/cureus.15500. eCollection 2021 Jun.

INTRODUCTION: Hepatic regeneration is a complex process involving a multitude of well-timed molecular operations. Ursodeoxycholic acid (UDCA) is postulated to exert a protective effect against oxidative stress and enzymatic degradation of the extracellular matrix, in turn potentiating the regenerative...

Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations.

Journal of hepatology

Vasavan T, Deepak S, Jayawardane IA, Lucchini M, Martin C, Geenes V, Yang J, Lövgren-Sandblom A, Seed PT, Chambers J, Stone S, Kurlak L, Dixon PH, Marschall HU, Gorelik J, Chappell L, Loughna P, Thornton J, Pipkin FB, Hayes-Gill B, Fifer WP, Williamson C.
PMID: 33276032
J Hepatol. 2021 May;74(5):1087-1096. doi: 10.1016/j.jhep.2020.11.038. Epub 2020 Dec 01.

BACKGROUND & AIMS: Intrahepatic cholestasis of pregnancy (ICP) is associated with an increased risk of stillbirth. This study aimed to assess the relationship between bile acid concentrations and fetal cardiac dysfunction in patients with ICP who were or were...

Proof-of-concept study to evaluate the safety and efficacy of saroglitazar in patients with primary biliary cholangitis.

Journal of hepatology

Vuppalanchi R, Caldwell SH, Pyrsopoulos N, deLemos AS, Rossi S, Levy C, Goldberg DS, Mena EA, Sheikh A, Ravinuthala R, Shaikh F, Bainbridge JD, Parmar DV, Chalasani NP.
PMID: 34487750
J Hepatol. 2022 Jan;76(1):75-85. doi: 10.1016/j.jhep.2021.08.025. Epub 2021 Sep 04.

BACKGROUND & AIM: Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with dual agonistic properties (α/γ). Due to a strong mechanistic rationale, we aimed to test the safety and efficacy of saroglitazar in patients with primary biliary cholangitis...

Outcome of pregnancy in patients with primary sclerosing cholangitis.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Wronka KM, Bik E, Milkiewicz P.
PMID: 34518127
Dig Liver Dis. 2021 Sep 10; doi: 10.1016/j.dld.2021.08.015. Epub 2021 Sep 10.

BACKGROUND: Data on the clinical course of primary sclerosing cholangitis (PSC) during pregnancy remain scarce. Herein, we assessed the maternal and fetal outcomes of pregnancy in this condition.METHODS: We reviewed 104 consecutive female outpatients with PSC using a structured...

Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life.

Hepatic medicine : evidence and research

Sivakumar T, Kowdley KV.
PMID: 34483690
Hepat Med. 2021 Aug 28;13:83-92. doi: 10.2147/HMER.S256692. eCollection 2021.

Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic immune-mediated liver disease characterized by injury to intrahepatic bile ducts that may ultimately progress to cirrhosis and liver failure and result in the need for...

Showing 553 to 558 of 558 entries