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Showing 13 to 24 of 139 entries
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Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis.

Journal of Cancer

Lu TC, Zhao GH, Chen YY, Chien CY, Huang CH, Lin KH, Chen SL.
PMID: 27390612
J Cancer. 2016 Jun 28;7(10):1360-73. doi: 10.7150/jca.15155. eCollection 2016.

Tumor suppressor protein p53 plays important roles in initiating cell cycle arrest and promoting tumor cell apoptosis. Previous studies have shown that p53 is either mutated or defective in approximately 50% of human cancers; therefore restoring normal p53 activity...

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Lu TC, Zhao GH, Chen YY, et al. Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. J Cancer. 2016;7(10):1360-73doi: 10.7150/jca.15155.
Lu, T. C., Zhao, G. H., Chen, Y. Y., Chien, C. Y., Huang, C. H., Lin, K. H., & Chen, S. L. (2016). Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. Journal of Cancer, 7(10), 1360-73. https://doi.org/10.7150/jca.15155
Lu, Tsung Chi, et al. "Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis." Journal of Cancer vol. 7,10 (2016): 1360-73. doi: https://doi.org/10.7150/jca.15155
Lu TC, Zhao GH, Chen YY, Chien CY, Huang CH, Lin KH, Chen SL. Transduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis. J Cancer. 2016 Jun 28;7(10):1360-73. doi: 10.7150/jca.15155. eCollection 2016. PMID: 27390612; PMCID: PMC4934045.
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S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study.

Translational oncology

Singh N, Bharara Singh A.
PMID: 32619819
Transl Oncol. 2020 Oct;13(10):100814. doi: 10.1016/j.tranon.2020.100814. Epub 2020 Jun 30.

Novel coronavirus disease 2019 (COVID-19) is the biggest threat to human being globally. The first case was identified in a patient with flu symptoms along with severe acute respiratory syndrome in Wuhan, China in December 2019 and now it...

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Singh N, Bharara Singh A. S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. Transl Oncol. 2020;13(10):100814doi: 10.1016/j.tranon.2020.100814.
Singh, N., & Bharara Singh, A. (2020). S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. Translational oncology, 13(10), 100814. https://doi.org/10.1016/j.tranon.2020.100814
Singh, Nishant, and Bharara Singh, Anuradha. "S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study." Translational oncology vol. 13,10 (2020): 100814. doi: https://doi.org/10.1016/j.tranon.2020.100814
Singh N, Bharara Singh A. S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. Transl Oncol. 2020 Oct;13(10):100814. doi: 10.1016/j.tranon.2020.100814. Epub 2020 Jun 30. PMID: 32619819; PMCID: PMC7324311.
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Concurrent .

Cancers

Malarikova D, Berkova A, Obr A, Blahovcova P, Svaton M, Forsterova K, Kriegova E, Prihodova E, Pavlistova L, Petrackova A, Zemanova Z, Trneny M, Klener P.
PMID: 32751805
Cancers (Basel). 2020 Jul 31;12(8). doi: 10.3390/cancers12082120.

Mantle cell lymphoma (MCL) is a subtype of B-cell lymphoma with a large number of recurrent cytogenetic/molecular aberrations. Approximately 5-10% of patients do not respond to frontline immunochemotherapy. Despite many useful prognostic indexes, a reliable marker of chemoresistance is...

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Malarikova D, Berkova A, Obr A, et al. Concurrent . Cancers (Basel). 2020;12(8)doi: 10.3390/cancers12082120.
Malarikova, D., Berkova, A., Obr, A., Blahovcova, P., Svaton, M., Forsterova, K., Kriegova, E., Prihodova, E., Pavlistova, L., Petrackova, A., Zemanova, Z., Trneny, M., & Klener, P. (2020). Concurrent . Cancers, 12(8), . https://doi.org/10.3390/cancers12082120
Malarikova, Diana, et al. "Concurrent ." Cancers vol. 12,8 (2020). doi: https://doi.org/10.3390/cancers12082120
Malarikova D, Berkova A, Obr A, Blahovcova P, Svaton M, Forsterova K, Kriegova E, Prihodova E, Pavlistova L, Petrackova A, Zemanova Z, Trneny M, Klener P. Concurrent . Cancers (Basel). 2020 Jul 31;12(8). doi: 10.3390/cancers12082120. PMID: 32751805; PMCID: PMC7466084.
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p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer.

Oncology letters

Yang CM, Kang MK, Jung WJ, Joo JS, Kim YJ, Choi Y, Kim HP.
PMID: 33613715
Oncol Lett. 2021 Mar;21(3):226. doi: 10.3892/ol.2021.12487. Epub 2021 Jan 24.

One of the most commonly used drugs in chemotherapy, 5-fluorouracil (5-FU) has been shown to be effective in only 10-15% of patients with colon cancer. Thus, studies of the mechanisms affecting 5-FU sensitivity in these patients are necessary. The...

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Yang CM, Kang MK, Jung WJ, et al. p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncol Lett. 2021;21(3):226doi: 10.3892/ol.2021.12487.
Yang, C. M., Kang, M. K., Jung, W. J., Joo, J. S., Kim, Y. J., Choi, Y., & Kim, H. P. (2021). p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncology letters, 21(3), 226. https://doi.org/10.3892/ol.2021.12487
Yang, Chul Min, et al. "p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer." Oncology letters vol. 21,3 (2021): 226. doi: https://doi.org/10.3892/ol.2021.12487
Yang CM, Kang MK, Jung WJ, Joo JS, Kim YJ, Choi Y, Kim HP. p53 expression confers sensitivity to 5-fluorouracil via distinct chromatin accessibility dynamics in human colorectal cancer. Oncol Lett. 2021 Mar;21(3):226. doi: 10.3892/ol.2021.12487. Epub 2021 Jan 24. PMID: 33613715; PMCID: PMC7856692.
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Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and mitoxantrone.

Journal of materials chemistry. B

Mitha AT, Rekha MR.
PMID: 32262091
J Mater Chem B. 2014 Dec 07;2(45):8005-8016. doi: 10.1039/c4tb01298d. Epub 2014 Oct 22.

Co-delivery of the anticancer drug, mitoxantrone (MTO) and the gene encoding tumor suppressor protein p53 was evaluated towards anticancer combinatorial therapy. The nanoplatforms developed herein are assembled by coupling β-cyclodextrin and the cationic polymer, polyethyleneimine to a hydrophilic polymer,...

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Mitha AT, Rekha MR. Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and mitoxantrone. J Mater Chem B. 2014;2(45):8005-8016doi: 10.1039/c4tb01298d.
Mitha, A. T., & Rekha, M. R. (2014). Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and mitoxantrone. Journal of materials chemistry. B, 2(45), 8005-8016. https://doi.org/10.1039/c4tb01298d
Mitha, A T, and Rekha, M R. "Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and mitoxantrone." Journal of materials chemistry. B vol. 2,45 (2014): 8005-8016. doi: https://doi.org/10.1039/c4tb01298d
Mitha AT, Rekha MR. Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and mitoxantrone. J Mater Chem B. 2014 Dec 07;2(45):8005-8016. doi: 10.1039/c4tb01298d. Epub 2014 Oct 22. PMID: 32262091.
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Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes.

Frontiers in veterinary science

Quinlan S, May S, Weeks R, Yuan H, Luff J.
PMID: 33748203
Front Vet Sci. 2021 Mar 03;8:570982. doi: 10.3389/fvets.2021.570982. eCollection 2021.

Cutaneous papillomaviruses are oncogenic viruses that cause severe, persistent infections that can develop into skin cancers within ultraviolet (UV)-exposed skin of immunodeficient individuals, such as those with X-linked severe combined immunodeficiency (XSCID). A canine research model of XSCID exhibits...

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Quinlan S, May S, Weeks R, et al. Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes. Front Vet Sci. 2021;8:570982doi: 10.3389/fvets.2021.570982.
Quinlan, S., May, S., Weeks, R., Yuan, H., & Luff, J. (2021). Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes. Frontiers in veterinary science, 8570982. https://doi.org/10.3389/fvets.2021.570982
Quinlan, Sarah, et al. "Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes." Frontiers in veterinary science vol. 8 (2021): 570982. doi: https://doi.org/10.3389/fvets.2021.570982
Quinlan S, May S, Weeks R, Yuan H, Luff J. Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes. Front Vet Sci. 2021 Mar 03;8:570982. doi: 10.3389/fvets.2021.570982. eCollection 2021. PMID: 33748203; PMCID: PMC7965962.
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Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status.

Molecular biology reports

Avşar Abdik E.
PMID: 34213707
Mol Biol Rep. 2021 Jun;48(6):5187-5198. doi: 10.1007/s11033-021-06521-8. Epub 2021 Jul 02.

Breast cancer progression and metastasis are associated with stromal cells in the tumor microenvironment. Adipocytes are the most abundant cells surrounding breast stromal tissue, promote tumor progression through the induction of Epithelial-to-Mesenchymal Transition (EMT) which is negatively regulated by...

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Avşar Abdik E. Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status. Mol Biol Rep. 2021;48(6):5187-5198doi: 10.1007/s11033-021-06521-8.
Avşar Abdik, E. (2021). Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status. Molecular biology reports, 48(6), 5187-5198. https://doi.org/10.1007/s11033-021-06521-8
Avşar Abdik, Ezgi. "Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status." Molecular biology reports vol. 48,6 (2021): 5187-5198. doi: https://doi.org/10.1007/s11033-021-06521-8
Avşar Abdik E. Differentiated pre-adipocytes promote proliferation, migration and epithelial-mesenchymal transition in breast cancer cells of different p53 status. Mol Biol Rep. 2021 Jun;48(6):5187-5198. doi: 10.1007/s11033-021-06521-8. Epub 2021 Jul 02. PMID: 34213707.
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[No title available]

Proceedings of the National Academy of Sciences of the United States of America

Chan AB, Parico GCG, Fribourgh JL, Ibrahim LH, Bollong MJ, Partch CL, Lamia KA.
PMID: 34183418
Proc Natl Acad Sci U S A. 2021 Jul 06;118(27). doi: 10.1073/pnas.2101416118.

Disruption of circadian rhythms increases the risk of several types of cancer. Mammalian cryptochromes (CRY1 and CRY2) are circadian transcriptional repressors that are related to DNA-repair enzymes. While CRYs lack DNA-repair activity, they modulate the transcriptional response to DNA...

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Chan AB, Parico GCG, Fribourgh JL, et al. . Proc Natl Acad Sci U S A. 2021;118(27)doi: 10.1073/pnas.2101416118.
Chan, A. B., Parico, G. C. G., Fribourgh, J. L., Ibrahim, L. H., Bollong, M. J., Partch, C. L., & Lamia, K. A. (2021). . Proceedings of the National Academy of Sciences of the United States of America, 118(27), . https://doi.org/10.1073/pnas.2101416118
Chan, Alanna B, et al. "." Proceedings of the National Academy of Sciences of the United States of America vol. 118,27 (2021). doi: https://doi.org/10.1073/pnas.2101416118
Chan AB, Parico GCG, Fribourgh JL, Ibrahim LH, Bollong MJ, Partch CL, Lamia KA. . Proc Natl Acad Sci U S A. 2021 Jul 06;118(27). doi: 10.1073/pnas.2101416118. PMID: 34183418; PMCID: PMC8271769.
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Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.

Molecular therapy. Nucleic acids

Ma W, Qiu Z, Bai Z, Dai Y, Li C, Chen X, Song X, Shi D, Zhou Y, Pan Y, Liao Y, Liao M, Zhou Z.
PMID: 34703652
Mol Ther Nucleic Acids. 2021 Sep 20;26:678-693. doi: 10.1016/j.omtn.2021.09.007. eCollection 2021 Dec 03.

The excessive and ectopic pulmonary artery smooth muscle cells (PASMCs) are crucial to the pathogenesis of pulmonary arteriole (PA) remodeling in pulmonary arterial hypertension (PAH). We previously found that microRNA (miR)-30a was significantly increased in acute myocardial infarction (AMI)...

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Ma W, Qiu Z, Bai Z, et al. Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension. Mol Ther Nucleic Acids. 2021;26:678-693doi: 10.1016/j.omtn.2021.09.007.
Ma, W., Qiu, Z., Bai, Z., Dai, Y., Li, C., Chen, X., Song, X., Shi, D., Zhou, Y., Pan, Y., Liao, Y., Liao, M., & Zhou, Z. (2021). Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension. Molecular therapy. Nucleic acids, 26678-693. https://doi.org/10.1016/j.omtn.2021.09.007
Ma, Wenrui, et al. "Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension." Molecular therapy. Nucleic acids vol. 26 (2021): 678-693. doi: https://doi.org/10.1016/j.omtn.2021.09.007
Ma W, Qiu Z, Bai Z, Dai Y, Li C, Chen X, Song X, Shi D, Zhou Y, Pan Y, Liao Y, Liao M, Zhou Z. Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension. Mol Ther Nucleic Acids. 2021 Sep 20;26:678-693. doi: 10.1016/j.omtn.2021.09.007. eCollection 2021 Dec 03. PMID: 34703652; PMCID: PMC8517099.
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p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis.

Oncotarget

Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, Budanov AV.
PMID: 31857853
Oncotarget. 2019 Dec 10;10(65):6997-7009. doi: 10.18632/oncotarget.27367. eCollection 2019 Dec 10.

SESTRINs (SESN1-3) are proteins encoded by an evolutionarily conserved gene family that plays an important role in the regulation of cell viability and metabolism in response to stress. Many of the effects of SESTRINs are mediated by negative and...

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Ding B, Haidurov A, Chawla A, et al. p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget. 2019;10(65):6997-7009doi: 10.18632/oncotarget.27367.
Ding, B., Haidurov, A., Chawla, A., Parmigiani, A., van de Kamp, G., Dalina, A., Yuan, F., Lee, J. H., Chumakov, P. M., Grossman, S. R., & Budanov, A. V. (2019). p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget, 10(65), 6997-7009. https://doi.org/10.18632/oncotarget.27367
Ding, Boxiao, et al. "p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis." Oncotarget vol. 10,65 (2019): 6997-7009. doi: https://doi.org/10.18632/oncotarget.27367
Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, Budanov AV. p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget. 2019 Dec 10;10(65):6997-7009. doi: 10.18632/oncotarget.27367. eCollection 2019 Dec 10. PMID: 31857853; PMCID: PMC6916756.
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Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo.

OncoTargets and therapy

Liu F, Lv RB, Liu Y, Hao Q, Liu SJ, Zheng YY, Li C, Zhu C, Wang M.
PMID: 32581555
Onco Targets Ther. 2020 Jun 03;13:4957-4969. doi: 10.2147/OTT.S246706. eCollection 2020.

BACKGROUND: Both salinomycin (SAL) and sulforaphane (SFN) exert their antitumorigenic effects in various types of cancer We investigated whether combining salinomycin (SAL, an antibiotic ionophore) with sulforaphane (SFN, a phytochemical) exerted synergistic antiproliferative and proapoptotic activities in colorectal cancer...

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Liu F, Lv RB, Liu Y, et al. Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo. Onco Targets Ther. 2020;13:4957-4969doi: 10.2147/OTT.S246706.
Liu, F., Lv, R. B., Liu, Y., Hao, Q., Liu, S. J., Zheng, Y. Y., Li, C., Zhu, C., & Wang, M. (2020). Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo. OncoTargets and therapy, 134957-4969. https://doi.org/10.2147/OTT.S246706
Liu, Fang, et al. "Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo." OncoTargets and therapy vol. 13 (2020): 4957-4969. doi: https://doi.org/10.2147/OTT.S246706
Liu F, Lv RB, Liu Y, Hao Q, Liu SJ, Zheng YY, Li C, Zhu C, Wang M. Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo. Onco Targets Ther. 2020 Jun 03;13:4957-4969. doi: 10.2147/OTT.S246706. eCollection 2020. PMID: 32581555; PMCID: PMC7276212.
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Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer.

Journal of applied biomedicine

Molavi G, Samadi N, Hashemzadeh S, Halimi M, Hosseingholi EZ.
PMID: 34907725
J Appl Biomed. 2020 Aug;18(2):46-53. doi: 10.32725/jab.2020.008. Epub 2020 Jun 17.

Breast cancer is the most common malignancy among females worldwide. Recent studies have shown extra-ribosomal roles of the moonlight ribosomal proteins in the development of human cancers. Accurate quantification of the gene expression level is based on the selection...

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Molavi G, Samadi N, Hashemzadeh S, et al. Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer. J Appl Biomed. 2020;18(2):46-53doi: 10.32725/jab.2020.008.
Molavi, G., Samadi, N., Hashemzadeh, S., Halimi, M., & Hosseingholi, E. Z. (2020). Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer. Journal of applied biomedicine, 18(2), 46-53. https://doi.org/10.32725/jab.2020.008
Molavi, Ghader, et al. "Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer." Journal of applied biomedicine vol. 18,2 (2020): 46-53. doi: https://doi.org/10.32725/jab.2020.008
Molavi G, Samadi N, Hashemzadeh S, Halimi M, Hosseingholi EZ. Moonlight human ribosomal protein L13a downregulation is associated with p53 and HER2/neu expression in breast cancer. J Appl Biomed. 2020 Aug;18(2):46-53. doi: 10.32725/jab.2020.008. Epub 2020 Jun 17. PMID: 34907725.
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Showing 13 to 24 of 139 entries