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Showing 2929 to 2936 of 2936 entries
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TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle.

Cancers

Rajendraprasad G, Eibes S, Boldú CG, Barisic M.
PMID: 34885104
Cancers (Basel). 2021 Nov 29;13(23). doi: 10.3390/cancers13235995.

Microtubule-targeting agents (MTAs) have been used for decades to treat different hematologic and solid cancers. The mode of action of these drugs mainly relies on their ability to bind tubulin subunits and/or microtubules and interfere with microtubule dynamics. In...

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Rajendraprasad G, Eibes S, Boldú CG, et al. TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13235995.
Rajendraprasad, G., Eibes, S., Boldú, C. G., & Barisic, M. (2021). TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle. Cancers, 13(23), . https://doi.org/10.3390/cancers13235995
Rajendraprasad, Girish, et al. "TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13235995
Rajendraprasad G, Eibes S, Boldú CG, Barisic M. TH588 and Low-Dose Nocodazole Impair Chromosome Congression by Suppressing Microtubule Turnover within the Mitotic Spindle. Cancers (Basel). 2021 Nov 29;13(23). doi: 10.3390/cancers13235995. PMID: 34885104; PMCID: PMC8657032.
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Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast.

Genetics

Garge RK, Cha HJ, Lee C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM.
PMID: 34849907
Genetics. 2021 Aug 26;219(1). doi: 10.1093/genetics/iyab101.

Thiabendazole (TBZ) is an FDA-approved benzimidazole widely used for its antifungal and antihelminthic properties. We showed previously that TBZ is also a potent vascular disrupting agent and inhibits angiogenesis at the tissue level by dissociating vascular endothelial cells in...

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Garge RK, Cha HJ, Lee C, et al. Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. Genetics. 2021;219(1)doi: 10.1093/genetics/iyab101.
Garge, R. K., Cha, H. J., Lee, C., Gollihar, J. D., Kachroo, A. H., Wallingford, J. B., & Marcotte, E. M. (2021). Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. Genetics, 219(1), . https://doi.org/10.1093/genetics/iyab101
Garge, Riddhiman K, et al. "Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast." Genetics vol. 219,1 (2021). doi: https://doi.org/10.1093/genetics/iyab101
Garge RK, Cha HJ, Lee C, Gollihar JD, Kachroo AH, Wallingford JB, Marcotte EM. Discovery of new vascular disrupting agents based on evolutionarily conserved drug action, pesticide resistance mutations, and humanized yeast. Genetics. 2021 Aug 26;219(1). doi: 10.1093/genetics/iyab101. PMID: 34849907; PMCID: PMC8633126.
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The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions.

Frontiers in cell and developmental biology

Yang WT, Hong SR, He K, Ling K, Shaiv K, Hu J, Lin YC.
PMID: 33748109
Front Cell Dev Biol. 2021 Mar 04;9:622302. doi: 10.3389/fcell.2021.622302. eCollection 2021.

Cilia, which either generate coordinated motion or sense environmental cues and transmit corresponding signals to the cell body, are highly conserved hair-like structures that protrude from the cell surface among diverse species. Disruption of ciliary functions leads to numerous...

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Yang WT, Hong SR, He K, et al. The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions. Front Cell Dev Biol. 2021;9:622302doi: 10.3389/fcell.2021.622302.
Yang, W. T., Hong, S. R., He, K., Ling, K., Shaiv, K., Hu, J., & Lin, Y. C. (2021). The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions. Frontiers in cell and developmental biology, 9622302. https://doi.org/10.3389/fcell.2021.622302
Yang, Wen-Ting, et al. "The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions." Frontiers in cell and developmental biology vol. 9 (2021): 622302. doi: https://doi.org/10.3389/fcell.2021.622302
Yang WT, Hong SR, He K, Ling K, Shaiv K, Hu J, Lin YC. The Emerging Roles of Axonemal Glutamylation in Regulation of Cilia Architecture and Functions. Front Cell Dev Biol. 2021 Mar 04;9:622302. doi: 10.3389/fcell.2021.622302. eCollection 2021. PMID: 33748109; PMCID: PMC7970040.
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Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents.

Bioorganic & medicinal chemistry

Hong Y, Zhu YY, He Q, Gu SX.
PMID: 34995858
Bioorg Med Chem. 2021 Dec 30;55:116597. doi: 10.1016/j.bmc.2021.116597. Epub 2021 Dec 30.

The α- and β-tubulins are the major polypeptide components of microtubules (MTs), which are attractive targets for anticancer drug development. Indole derivatives display a variety of biological activities including antitumor activity. In recent years, a great number of indole...

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Hong Y, Zhu YY, He Q, et al. Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents. Bioorg Med Chem. 2021;55:116597doi: 10.1016/j.bmc.2021.116597.
Hong, Y., Zhu, Y. Y., He, Q., & Gu, S. X. (2021). Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents. Bioorganic & medicinal chemistry, 55116597. https://doi.org/10.1016/j.bmc.2021.116597
Hong, Yu, et al. "Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents." Bioorganic & medicinal chemistry vol. 55 (2021): 116597. doi: https://doi.org/10.1016/j.bmc.2021.116597
Hong Y, Zhu YY, He Q, Gu SX. Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents. Bioorg Med Chem. 2021 Dec 30;55:116597. doi: 10.1016/j.bmc.2021.116597. Epub 2021 Dec 30. PMID: 34995858.
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Proteomic analysis of purified Newcastle disease virus particles.

Proteome science

Ren X, Xue C, Kong Q, Zhang C, Bi Y, Cao Y.
PMID: 22571704
Proteome Sci. 2012 May 09;10(1):32. doi: 10.1186/1477-5956-10-32.

BACKGROUND: Newcastle disease virus (NDV) is an enveloped RNA virus, bearing severe economic losses to the poultry industry worldwide. Previous virion proteomic studies have shown that enveloped viruses carry multiple host cellular proteins both internally and externally during their...

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Ren X, Xue C, Kong Q, et al. Proteomic analysis of purified Newcastle disease virus particles. Proteome Sci. 2012;10(1):32doi: 10.1186/1477-5956-10-32.
Ren, X., Xue, C., Kong, Q., Zhang, C., Bi, Y., & Cao, Y. (2012). Proteomic analysis of purified Newcastle disease virus particles. Proteome science, 10(1), 32. https://doi.org/10.1186/1477-5956-10-32
Ren, Xiangpeng, et al. "Proteomic analysis of purified Newcastle disease virus particles." Proteome science vol. 10,1 (2012): 32. doi: https://doi.org/10.1186/1477-5956-10-32
Ren X, Xue C, Kong Q, Zhang C, Bi Y, Cao Y. Proteomic analysis of purified Newcastle disease virus particles. Proteome Sci. 2012 May 09;10(1):32. doi: 10.1186/1477-5956-10-32. PMID: 22571704; PMCID: PMC3413529.
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Drivers of neutral and adaptive differentiation in pike (Esox lucius) populations from contrasting environments.

Molecular ecology

Sunde J, Yıldırım Y, Tibblin P, Bekkevold D, Skov C, Nordahl O, Larsson P, Forsman A.
PMID: 34874594
Mol Ecol. 2021 Dec 07; doi: 10.1111/mec.16315. Epub 2021 Dec 07.

Understanding how eco-evolutionary processes and environmental factors drive population differentiation and adaptation are key challenges in evolutionary biology of relevance for biodiversity protection. Differentiation requires at least partial reproductive separation, which may result from different modes of isolation such...

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Sunde J, Yıldırım Y, Tibblin P, et al. Drivers of neutral and adaptive differentiation in pike (Esox lucius) populations from contrasting environments. Mol Ecol. 2021;doi: 10.1111/mec.16315.
Sunde, J., Yıldırım, Y., Tibblin, P., Bekkevold, D., Skov, C., Nordahl, O., Larsson, P., & Forsman, A. (2021). Drivers of neutral and adaptive differentiation in pike (Esox lucius) populations from contrasting environments. Molecular ecology, . https://doi.org/10.1111/mec.16315
Sunde, Johanna, et al. "Drivers of neutral and adaptive differentiation in pike (Esox lucius) populations from contrasting environments." Molecular ecology vol. (2021). doi: https://doi.org/10.1111/mec.16315
Sunde J, Yıldırım Y, Tibblin P, Bekkevold D, Skov C, Nordahl O, Larsson P, Forsman A. Drivers of neutral and adaptive differentiation in pike (Esox lucius) populations from contrasting environments. Mol Ecol. 2021 Dec 07; doi: 10.1111/mec.16315. Epub 2021 Dec 07. PMID: 34874594.
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Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung.

Thoracic cancer

Ohtaki Y, Kaira K, Yajima T, Erkhem-Ochir B, Kawashima O, Kamiyoshihara M, Igai H, Onozato R, Ibe T, Kosaka T, Nakazawa S, Nagashima T, Oyama T, Shirabe K.
PMID: 34453496
Thorac Cancer. 2021 Oct;12(20):2666-2679. doi: 10.1111/1759-7714.14102. Epub 2021 Aug 28.

OBJECTIVES: Various drug-sensitivity markers have been reported to be associated with tumor progression and chemotherapy resistance. Detailed expression profiles of sensitivity markers for cytotoxic chemotherapy in pulmonary large cell neuroendocrine carcinoma (LCNEC) remain unclear. Herein, we aimed to clarify...

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Ohtaki Y, Kaira K, Yajima T, et al. Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thorac Cancer. 2021;12(20):2666-2679doi: 10.1111/1759-7714.14102.
Ohtaki, Y., Kaira, K., Yajima, T., Erkhem-Ochir, B., Kawashima, O., Kamiyoshihara, M., Igai, H., Onozato, R., Ibe, T., Kosaka, T., Nakazawa, S., Nagashima, T., Oyama, T., & Shirabe, K. (2021). Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thoracic cancer, 12(20), 2666-2679. https://doi.org/10.1111/1759-7714.14102
Ohtaki, Yoichi, et al. "Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung." Thoracic cancer vol. 12,20 (2021): 2666-2679. doi: https://doi.org/10.1111/1759-7714.14102
Ohtaki Y, Kaira K, Yajima T, Erkhem-Ochir B, Kawashima O, Kamiyoshihara M, Igai H, Onozato R, Ibe T, Kosaka T, Nakazawa S, Nagashima T, Oyama T, Shirabe K. Comprehensive expressional analysis of chemosensitivity-related markers in large cell neuroendocrine carcinoma of the lung. Thorac Cancer. 2021 Oct;12(20):2666-2679. doi: 10.1111/1759-7714.14102. Epub 2021 Aug 28. PMID: 34453496; PMCID: PMC8520808.
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The Structure Biology of Tau and Clue for Aggregation Inhibitor Design.

The protein journal

Wang D, Huang X, Yan L, Zhou L, Yan C, Wu J, Su Z, Huang Y.
PMID: 34401998
Protein J. 2021 Oct;40(5):656-668. doi: 10.1007/s10930-021-10017-6. Epub 2021 Aug 17.

Tau is a microtubule-associated protein that is mainly expressed in central and peripheral nerve systems. Tau binds to tubulin and regulates assembly and stabilization of microtubule, thus playing a critical role in neuron morphology, axon development and navigation. Tau...

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Wang D, Huang X, Yan L, et al. The Structure Biology of Tau and Clue for Aggregation Inhibitor Design. Protein J. 2021;40(5):656-668doi: 10.1007/s10930-021-10017-6.
Wang, D., Huang, X., Yan, L., Zhou, L., Yan, C., Wu, J., Su, Z., & Huang, Y. (2021). The Structure Biology of Tau and Clue for Aggregation Inhibitor Design. The protein journal, 40(5), 656-668. https://doi.org/10.1007/s10930-021-10017-6
Wang, Dan, et al. "The Structure Biology of Tau and Clue for Aggregation Inhibitor Design." The protein journal vol. 40,5 (2021): 656-668. doi: https://doi.org/10.1007/s10930-021-10017-6
Wang D, Huang X, Yan L, Zhou L, Yan C, Wu J, Su Z, Huang Y. The Structure Biology of Tau and Clue for Aggregation Inhibitor Design. Protein J. 2021 Oct;40(5):656-668. doi: 10.1007/s10930-021-10017-6. Epub 2021 Aug 17. PMID: 34401998.
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Showing 2929 to 2936 of 2936 entries